骨关节炎中失调的自噬：重新审视分子特征

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-24 DOI:10.1016/j.pbiomolbio.2024.03.004

Liang Liu, Jie Wang, Lu Liu, Wenling Shi, Huajie Gao, Lun Liu

引用次数: 0

摘要

骨关节炎（OA）的风险因素多种多样，其中包括肥胖、生活方式、炎症、细胞死亡机制和糖尿病。生物机制的变化被认为是 OA 发病机制的主要调节因素。在不同的人类疾病中都可观察到自噬失调的现象。在 OA 的发病过程中，自噬水平（诱导或抑制）会发生变化。自噬的支持和促进生存功能可延缓 OA 的进展。保护性自噬可防止软骨退化。此外，自噬还能与细胞死亡机制相互作用，通过抑制细胞凋亡和坏死，改善 OA。非编码 RNA 分子可以调控自噬，通过直接和间接控制自噬，它们可以延缓/增加 OA 的发病机理。线粒体的完整性可通过自噬调节来缓解 OA。此外，治疗化合物，尤其是植物化学物质，可刺激软骨细胞中的保护性自噬，防止细胞死亡。保护性自噬具有减少炎症和氧化损伤的能力，而炎症和氧化损伤是导致 OA 发病的两个关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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WITHDRAWN: The dysregulated autophagy in osteoarthritis: Revisiting molecular profile.

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来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.