Progress in Biophysics & Molecular Biology最新文献

Lipid droplet - organelle crosstalk and its implication in cancer 脂滴-细胞器串扰及其在癌症中的意义。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-05-15 DOI: 10.1016/j.pbiomolbio.2025.05.002

Jing Quan , Chunhong Zhang , Xue Chen , Xinfei Cai , Xiangjian Luo

引用次数: 0

Advances in the mechanisms of HIF-1α-enhanced tumor glycolysis and its relation to dedifferentiation hif -1α-增强肿瘤糖酵解机制及其与去分化关系的研究进展。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-05-13 DOI: 10.1016/j.pbiomolbio.2025.05.003

Yu Zeng , Yonggang Tao , Guotu Du , Tianyu Huang , Shicheng Chen , Longmei Fan , Neng Zhang

{"title":"Advances in the mechanisms of HIF-1α-enhanced tumor glycolysis and its relation to dedifferentiation","authors":"Yu Zeng , Yonggang Tao , Guotu Du , Tianyu Huang , Shicheng Chen , Longmei Fan , Neng Zhang","doi":"10.1016/j.pbiomolbio.2025.05.003","DOIUrl":"10.1016/j.pbiomolbio.2025.05.003","url":null,"abstract":"<div><div>Metabolic reprogramming, a hallmark of malignancy, enables tumor cells to adapt to the harsh and dynamic tumor microenvironment (TME) by altering metabolic pathways. Hypoxia, prevalent in solid tumors, activates hypoxia inducible factor 1α (HIF-1α). HIF-1α drives metabolic reprogramming, enhancing glycolysis primarily through the Warburg effect to reduce oxygen dependence and facilitate tumor cell growth/proliferation. The above process is associated with accelerated tumor cell dedifferentiation and enhanced stemness, generating cancer stem cells (CSCs) which possesses the potential for self-renewal and differentiation that can differentiate into a wide range of subtypes of tumor cells and fuel tumor heterogeneity, metastasis, and recurrence, complicating therapy. This review examines the HIF-1α-glycolysis-dedifferentiation crosstalk mechanisms, expecting that indirect inhibition of HIF-1α by targeting metabolic enzymes, metabolites, or their signaling pathways will offer an effective therapeutic strategy to improve the cancer treatment outcomes.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The key role of Piezo1 channels in ferroptosis after spinal cord injury and the therapeutic potential of Piezo1 inhibitors Piezo1通道在脊髓损伤后铁下垂中的关键作用及Piezo1抑制剂的治疗潜力

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-05-06 DOI: 10.1016/j.pbiomolbio.2025.05.001

Qianxi Li, Chenyu Li, Xinyu Liu, Zixuan Guo, Xinxin Li, Xin Zhang

{"title":"The key role of Piezo1 channels in ferroptosis after spinal cord injury and the therapeutic potential of Piezo1 inhibitors","authors":"Qianxi Li, Chenyu Li, Xinyu Liu, Zixuan Guo, Xinxin Li, Xin Zhang","doi":"10.1016/j.pbiomolbio.2025.05.001","DOIUrl":"10.1016/j.pbiomolbio.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Ferroptosis has been confirmed to be one of the key mechanisms of neuronal injury and dysfunction after spinal cord injury (SCI). Mechanical stresses such as deformation, compression, and stretching not only directly cause physical damage to spinal cord tissue at the moment of SCI, but also promote the development of ferroptosis through various pathways. However, the mechanism of ferroptosis after SCI remains unclear, which hinders the development of therapeutic methods.</div></div><div><h3>Objective</h3><div>This article aims to review the key mechanisms by which mechanical stress affects ferroptosis after SCI, including its impact on the structure and function of the endoplasmic reticulum (ER) and mitochondria, its role in triggering inflammatory responses, and its activation of mechanosensitive channels. Special emphasis is placed on the role of Piezo1 channels, which are key factors in cell mechanosensation and ion homeostasis regulation. The review explores how Piezo1 channels are upregulated by mechanical stress after SCI and participate in the ferroptosis process by mediating ion flow and other mechanisms.</div></div><div><h3>Conclusions</h3><div>Inhibiting Piezo1 channels may be a potential therapeutic strategy for SCI. This review summarizes the therapeutic potential of Piezo1 inhibitors by sorting out existing studies, hoping to provide a theoretical basis for effective therapeutic strategies targeting ferroptosis after SCI.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 132-140"},"PeriodicalIF":3.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From gene editing to tumor eradication: The CRISPR revolution in cancer therapy 从基因编辑到肿瘤根除：癌症治疗中的CRISPR革命

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-04-16 DOI: 10.1016/j.pbiomolbio.2025.04.003

Ashiq Ali , Urooj Azmat , Aisha Khatoon , Kaynaat Akbar , Bilal Murtaza , Ziyi Ji , Urooj Irshad , Zhongjing Su

{"title":"From gene editing to tumor eradication: The CRISPR revolution in cancer therapy","authors":"Ashiq Ali , Urooj Azmat , Aisha Khatoon , Kaynaat Akbar , Bilal Murtaza , Ziyi Ji , Urooj Irshad , Zhongjing Su","doi":"10.1016/j.pbiomolbio.2025.04.003","DOIUrl":"10.1016/j.pbiomolbio.2025.04.003","url":null,"abstract":"<div><div>Cancer continues to be a significant worldwide health concern, characterized by high rates of occurrence and death. Unfortunately, existing treatments frequently fall short of delivering satisfying therapeutic outcomes. Immunotherapy has ushered in a new era in the treatment of solid tumors, yet its effectiveness is still constrained and comes with unwanted side effects. The advancement of cutting-edge technology, propelled by gene analysis and manipulation at the molecular scale, shows potential for enhancing these therapies. The advent of genome editing technologies, including CRISPR-Cas9, can greatly augment the efficacy of cancer immunotherapy. This review explores the mechanism of CRISPR-Cas9-mediated genome editing and its wide range of tools. The study focuses on analyzing the effects of CRISPR-induced double-strand breaks (DSBs) on cancer immunotherapy, specifically by gene knockdown or knockin. In addition, the study emphasizes the utilization of CRISPR-Cas9-based genome-wide screening to identify targets, the potential of spatial CRISPR genomics, and the extensive applications and difficulties of CRISPR-Cas9 in fundamental research, translational medicine, and clinical environments.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 114-131"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of phosphatidylethanolamine-binding protein (PEBP) family in various diseases: Mechanisms and therapeutic potential 磷脂酰乙醇胺结合蛋白（PEBP）家族在多种疾病中的作用：机制和治疗潜力

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-04-10 DOI: 10.1016/j.pbiomolbio.2025.04.002

Yeying Teng , Haiping Xue , Xiaoliang Deng , Yanqun Luo , Tao Wu

引用次数: 0

Advances in the study of epithelial mesenchymal transition in cancer progression: Role of miRNAs 癌症进展中上皮间充质转化的研究进展：miRNAs 的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-04-02 DOI: 10.1016/j.pbiomolbio.2025.04.001

Jia Zhang , Runting Yin , Yongwang Xue , Rong Qin , Xuequan Wang , Shuming Wu , Jun Zhu , Yan-Shuang Li , Cai Zhang , Yuan Wei

{"title":"Advances in the study of epithelial mesenchymal transition in cancer progression: Role of miRNAs","authors":"Jia Zhang , Runting Yin , Yongwang Xue , Rong Qin , Xuequan Wang , Shuming Wu , Jun Zhu , Yan-Shuang Li , Cai Zhang , Yuan Wei","doi":"10.1016/j.pbiomolbio.2025.04.001","DOIUrl":"10.1016/j.pbiomolbio.2025.04.001","url":null,"abstract":"<div><div>Epithelial-mesenchymal transition (EMT) has been extensively studied for its roles in tumor metastasis, the generation and maintenance of cancer stem cells and treatment resistance. Epithelial mesenchymal plasticity allows cells to switch between various states within the epithelial-mesenchymal spectrum, resulting in a mixed epithelial/mesenchymal phenotypic profile. This plasticity underlies the acquisition of multiple malignant features during cancer progression and poses challenges for EMT in tumors. MicroRNAs (miRNAs) in the microenvironment affect numerous signaling processes through diverse mechanisms, influencing physiological activities. This paper reviews recent advances in EMT, the role of different hybrid states in tumor progression, and the important role of miRNAs in EMT. Furthermore, it explores the relationship between miRNA-based EMT therapies and their implications for clinical practice, discussing how ongoing developments may enhance therapeutic outcomes.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 69-90"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelin: A possible proton capacitor for energy storage during sleep and energy supply during wakefulness 髓磷脂：一种可能的质子电容器，用于睡眠时的能量储存和清醒时的能量供应。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-03-28 DOI: 10.1016/j.pbiomolbio.2025.03.001

Alessandro Maria Morelli , Ann Saada , Felix Scholkmann

引用次数: 0

Cell detachment: A review of techniques, challenges, and opportunities for advancing biomedical research and applications 细胞分离：关于推进生物医学研究和应用的技术、挑战和机遇的综述。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-02-27 DOI: 10.1016/j.pbiomolbio.2025.02.004

Polina Vertegel , Pavel Milkin , Anton Murashko , Mikhail Parker , Kristina Peranidze , Natalia Emashova , Sergiy Minko , Vladimir Reukov

{"title":"Cell detachment: A review of techniques, challenges, and opportunities for advancing biomedical research and applications","authors":"Polina Vertegel , Pavel Milkin , Anton Murashko , Mikhail Parker , Kristina Peranidze , Natalia Emashova , Sergiy Minko , Vladimir Reukov","doi":"10.1016/j.pbiomolbio.2025.02.004","DOIUrl":"10.1016/j.pbiomolbio.2025.02.004","url":null,"abstract":"<div><div>Culturing living cells outside the body is a complex process involving various techniques. Despite advances, harvesting cells remains challenging, especially in light of new emerging and scaled-up cell culture technologies. Enzymatic adherent cell harvesting is the most used and robust technology but can harm cells. Non-enzymatic detachment methods offer advantages but also present challenges. Thermo-responsive polymers require precise control of the molecular characteristics and thickness of the thermoresponsive films, which makes this method less robust and more expensive. This review highlights the importance of controlling harvested cell quality and its relationship to cell binding and detachment mechanisms. Many alternative methods have not been extensively analyzed, and their impact on cell quality beyond standard viability assays is not yet known. Developing robust cell harvesting methods for bioreactor microcarriers is a rapidly growing challenge as the cell manufacturing industry expands. Microcarriers with stimuli-responsive coatings face challenges similar to those observed for laboratory-scale cell dishes and bring an additional aspect of the need for microbead recycling consideration. All that together underlines the importance of the research in biomaterials and biotechnology for cell manufacturing.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 50-68"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing targeted therapies in pancreatic cancer: Leveraging molecular abberrations for therapeutic success 推进胰腺癌靶向治疗：利用分子畸变获得治疗成功。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-02-21 DOI: 10.1016/j.pbiomolbio.2025.02.003

Tanvi Gupta , Mohd Murtaza

{"title":"Advancing targeted therapies in pancreatic cancer: Leveraging molecular abberrations for therapeutic success","authors":"Tanvi Gupta , Mohd Murtaza","doi":"10.1016/j.pbiomolbio.2025.02.003","DOIUrl":"10.1016/j.pbiomolbio.2025.02.003","url":null,"abstract":"<div><div>Pancreatic cancer is one of the most deadly with poor prognosis and overall survival rate due to the dense stroma in the tumors which often is challenging for the delivery of drug to penetrate deep inside the tumor bed and usually results in the progression of cancer. The conventional treatment such as chemotherapy, radiotherapy or surgery shows a minimal benefit in the survival due to the drug resistance, poor penetration, less radiosensitivity or recurrence of tumor. There is an urgent demand to develop molecular-level targeted therapies to achieve therapeutic efficacy in the pancreatic ductal adenocarcinoma (PDAC) patients. The precision oncology focuses on the unique attributes of the patient such as epigenome, proteome, genome, microbiome, lifestyle and diet habits which contributes to promote oncogenesis. The targeted therapy helps to target the mutated proteins responsible for controlling growth, division and metastasis of tumor in the cancer cells. It is very important to consider all the attributes of the patient to provide the suitable personalized treatment to avoid any severe side effects. In this review, we have laid emphasis on the precision medicine; the utmost priority is to improve the survival of cancer patients by targeting molecular mutations through transmembrane proteins, inhibitors, signaling pathways, immunotherapy, gene therapy or the use of nanocarriers for the delivery at the tumor site. It will become beneficial therapeutic window to be considered for the advanced stage pancreatic cancer patients to prolong their survival rate.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 19-32"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletogenesis and acupuncture points 骨骼形成与穴位。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-02-18 DOI: 10.1016/j.pbiomolbio.2025.02.001

Evgeniy Andreyev, Volodymyr Krasnoholovets

{"title":"Skeletogenesis and acupuncture points","authors":"Evgeniy Andreyev, Volodymyr Krasnoholovets","doi":"10.1016/j.pbiomolbio.2025.02.001","DOIUrl":"10.1016/j.pbiomolbio.2025.02.001","url":null,"abstract":"<div><div>The formation of the embryo begins with a “calcium wave” that contributes to the creation of heterogeneities, and then some of them solidify. The further development and a collective information architecture of the embryo is controlled by the so-called morphogenetic field, whose nature is mainly associated with a physical inerton field that is a substructure of the quantum mechanical matter waves, which plays the role of information field in biological systems. The inerton field takes on the function of organising the geometry and topology of the developing system, which we associate with the concept of positional information. Hence, any extended element or system in the body can be specified by certain relative coordinates, or radius vectors drawn from the origin to a given point. Such special points we associate with the patterns of formation of the musculoskeletal system. This work demonstrates an unequivocal correspondence between the functional formations that exist within the bony structures of the skeleton, which we can name ossification centres, or points, and classical acupuncture areas, which involve a number of nerves, muscles, vessels, and tendons. Histologically, there are various kinds of endings around the acupoints and their complexity is responsible for the acupuncture sensation in these places. It is shown that each ossification centre can be associated with a multiple of two number of acupuncture areas located in the immediate vicinity of the ossification centre. With this approach, all 1112 generally recognised acupuncture points find their ossification centres on the tubular bones and axial skeleton.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 33-49"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0