Progress in Biophysics & Molecular Biology最新文献

Roles of gastric cancer-derived exosomes in the occurrence of metastatic hepatocellular carcinoma.

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-28 DOI: 10.1016/j.pbiomolbio.2025.01.005

Jie Zhou, Yuan-Kun Gou, Dong Guo, Ming-Yi Wang, Peng Liu

{"title":"Roles of gastric cancer-derived exosomes in the occurrence of metastatic hepatocellular carcinoma.","authors":"Jie Zhou, Yuan-Kun Gou, Dong Guo, Ming-Yi Wang, Peng Liu","doi":"10.1016/j.pbiomolbio.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.pbiomolbio.2025.01.005","url":null,"abstract":"Gastric cancer (GC), particularly in East Asia, is among the most prevalent cancers with high mortality rates. According to recent epidemiological data, patients with GC account for over a quarter of all cancer incidences and approximately one third of cancer-related deaths in East Asia. Liver metastasis (LM) is not only a common form of GC distant metastasis but also poses a major challenge to the prognosis and treatment of patients with advanced GC. Increasing evidence has shown that the gut-liver axis plays a pivotal role in maintaining the stomach-liver-gut homeostasis. Exosomes are small secreted vesicles enriched with specific proteins, lipids, and nucleic acids. These vesicles exhibit significant activities in signal transmission to adjacent or distant cells in the gut-liver axis, as well as in remodeling the tumor microenvironment. Some research have pointed out that exosomes promote LM of various cancers. However, there still lack of complete and systematic review on how exosomes affect GC-LM. In this article, we present a comprehensive description to explore the role of GC-derived exosomes in the occurrence and development of metastatic hepatocellular carcinoma (HCC).","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vinculin: A new target for the diagnosis and treatment of disease.

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-23 DOI: 10.1016/j.pbiomolbio.2025.01.004

Jiqiang Li, Weiming Wang, Zipeng Lin, Zhenyu Liu, Ruilin Zhang, Runwen Li, Jie Zhang, Youkun Zheng, Dalian Qin, Ya Wu, Yong Liu

引用次数: 0

The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures. 细胞中分子组织的主要来源。自组织和自我调节的动态生物结构图谱。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-11 DOI: 10.1016/j.pbiomolbio.2025.01.003

Ildefonso M De la Fuente, Jesus M Cortes, Iker Malaina, Gorka Pérez-Yarza, Luis Martinez, José I López, Maria Fedetz, Jose Carrasco-Pujante

{"title":"The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures.","authors":"Ildefonso M De la Fuente, Jesus M Cortes, Iker Malaina, Gorka Pérez-Yarza, Luis Martinez, José I López, Maria Fedetz, Jose Carrasco-Pujante","doi":"10.1016/j.pbiomolbio.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.pbiomolbio.2025.01.003","url":null,"abstract":"One of the most important goals of contemporary biology is to understand the principles of the molecular order underlying the complex dynamic architecture of cells. Here, we present an overview of the main driving forces involved in the cellular molecular complexity and in the emergent functional dynamic structures, spanning from the most basic molecular organization levels to the complex emergent integrative systemic behaviors. First, we address the molecular information processing which is essential in many complex fundamental mechanisms such as the epigenetic memory, alternative splicing, regulation of transcriptional system, and the adequate self-regulatory adaptation to the extracellular environment. Next, we approach the biochemical self-organization, which is central to understand the emergency of metabolic rhythms, circadian oscillations, and spatial traveling waves. Such a complex behavior is also fundamental to understand the temporal compartmentalization of the cellular metabolism and the dynamic regulation of many physiological activities. Numerous examples of biochemical self-organization are considered here, which show that practically all the main physiological processes in the cell exhibit this type of dynamic molecular organization. Finally, we focus on the biochemical self-assembly which, at a primary level of organization, is a basic but important mechanism for the order in the cell allowing biomolecules in a disorganized state to form complex aggregates necessary for a plethora of essential structures and physiological functions. In total, more than 500 references have been compiled in this review. Due to these main sources of order, systemic functional structures emerge in the cell, driving the metabolic functionality towards the biological complexity.","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The regulatory role of integrin in gastric cancer tumor microenvironment and drug resistance. 整合素在胃癌肿瘤微环境及耐药中的调控作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-09 DOI: 10.1016/j.pbiomolbio.2025.01.001

Songlin Wu, Abdel Nasser B Singab, Guimei Lin, Yulu Wang, Huaibo Zhu, Guang Yang, Jiaqi Chen, Jiaxuan Li, Peiyao Li, Di Zhao, Jing Tian, Lan Ye

{"title":"The regulatory role of integrin in gastric cancer tumor microenvironment and drug resistance.","authors":"Songlin Wu, Abdel Nasser B Singab, Guimei Lin, Yulu Wang, Huaibo Zhu, Guang Yang, Jiaqi Chen, Jiaxuan Li, Peiyao Li, Di Zhao, Jing Tian, Lan Ye","doi":"10.1016/j.pbiomolbio.2025.01.001","DOIUrl":"10.1016/j.pbiomolbio.2025.01.001","url":null,"abstract":"Gastric cancer (GC) remains a significant global health burden due to its high aggressiveness, early metastasis, and poor prognosis. Despite advances in chemotherapy and targeted therapies, drug resistance remains a major obstacle to improving patient outcomes. Integrins, a family of transmembrane receptors, play a pivotal role in mediating tumor growth, invasion, and drug resistance by interacting with the tumor microenvironment (TME) and regulating signaling pathways such as Wnt/β-catenin, FAK, and MAPK. This review highlights the critical functions of various integrin subunits (e.g., α5, αv, β1, β3, β6) in promoting GC progression and their involvement in chemoresistance mechanisms. Additionally, integrins modulate immune cell infiltration and stromal cell interactions within the TME, further complicating GC treatment. Emerging evidence suggests that targeting integrins, either through inhibitors or integrin-specific therapeutic strategies, holds potential in overcoming drug resistance and improving clinical outcomes. This review underscores the need for further exploration of integrins as therapeutic targets in GC and suggests promising avenues for integrin-based therapies in personalized medicine.","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"130-136"},"PeriodicalIF":3.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell RNA sequencing in ovarian cancer: Current progress and future prospects. 卵巢癌单细胞RNA测序：目前进展和未来展望。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-06 DOI: 10.1016/j.pbiomolbio.2025.01.002

Chong Zhi-Xiong

引用次数: 0

Effects of extremely low frequency magnetic fields on animal cancer and DNA damage: A systematic review and meta-analysis. 极低频磁场对动物癌症和DNA损伤的影响：系统综述和荟萃分析。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-31 DOI: 10.1016/j.pbiomolbio.2024.12.005

Christian Brabant, Germain Honvo, Céline Demonceau, Ezio Tirelli, François Léonard, Olivier Bruyère

{"title":"Effects of extremely low frequency magnetic fields on animal cancer and DNA damage: A systematic review and meta-analysis.","authors":"Christian Brabant, Germain Honvo, Céline Demonceau, Ezio Tirelli, François Léonard, Olivier Bruyère","doi":"10.1016/j.pbiomolbio.2024.12.005","DOIUrl":"10.1016/j.pbiomolbio.2024.12.005","url":null,"abstract":"The objective of this systematic review and meta-analysis was to assess the carcinogenic effects of extremely low frequency magnetic fields (ELF-MF) by analyzing animal and comet assay studies. We have performed a global meta-analysis on all the animal studies on the relation between ELF-MF and cancer incidence and separate meta-analyses on the incidence of cancer, leukemia, lymphoma, breast cancer, brain cancer and DNA damage assessed with the comet assay. Of the 5145 references identified, 71 studies have been included in our systematic review and 22 studies in our meta-analyses. Our global meta-analysis indicated that ELF-MF exposure had no significant impact on the incidence of cancers in rodents (19 studies, OR = 1.10; 95% CI 0.91-1.32). However, our separate meta-analyses showed that ELF-MF increased the odds of developing leukemia in mice (4 studies, OR = 4.45; 95% CI 1.90-10.38) but not in rats. Our systematic review also suggests that ELF-MF can damage DNA in certain cell types like brain cells. Nevertheless, a meta-analysis on three comet assay studies indicated that ELF-MF did not increase DNA damage in neuroblastoma cells (SMD = -0.08; 95% CI -0.18-0.01). Overall, our results suggest that exposure to ELF-MF does not represent a major hazard for mammals and the carcinogenic effects of these magnetic fields could be limited to leukemia.","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"137-156"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases. 电磁辐射和光子发射在神经元通讯和神经退行性疾病中的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-26 DOI: 10.1016/j.pbiomolbio.2024.12.004

Aysin Erboz, Elif Kesekler, Pier Luigi Gentili, Vladimir N Uversky, Orkid Coskuner-Weber

{"title":"Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases.","authors":"Aysin Erboz, Elif Kesekler, Pier Luigi Gentili, Vladimir N Uversky, Orkid Coskuner-Weber","doi":"10.1016/j.pbiomolbio.2024.12.004","DOIUrl":"10.1016/j.pbiomolbio.2024.12.004","url":null,"abstract":"The intersection of electromagnetic radiation and neuronal communication, focusing on the potential role of biophoton emission in brain function and neurodegenerative diseases is an emerging research area. Traditionally, it is believed that neurons encode and communicate information via electrochemical impulses, generating electromagnetic fields detectable by EEG and MEG. Recent discoveries indicate that neurons may also emit biophotons, suggesting an additional communication channel alongside the regular synaptic interactions. This dual signaling system is analyzed for its potential in synchronizing neuronal activity and improving information transfer, with implications for brain-like computing systems. The clinical relevance is explored through the lens of neurodegenerative diseases and intrinsically disordered proteins, where oxidative stress may alter biophoton emission, offering clues for pathological conditions, such as Alzheimer's and Parkinson's diseases. The potential therapeutic use of Low-Level Laser Therapy (LLLT) is also examined for its ability to modulate biophoton activity and mitigate oxidative stress, presenting new opportunities for treatment. Here, we invite further exploration into the intricate roles the electromagnetic phenomena play in brain function, potentially leading to breakthroughs in computational neuroscience and medical therapies for neurodegenerative diseases.","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"87-99"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trees suck. Notes on the physics of transpiration in trees. 树木吸收。关于树木蒸腾作用的物理学注释。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-25 DOI: 10.1016/j.pbiomolbio.2024.12.002

Harvey R Brown, Adrian P Sutton

引用次数: 0

Research progress on N⁶-Methyladenosine modification in angiogenesis, vasculogenic mimicry, and therapeutic implications in breast cancer. n6 -甲基腺苷修饰在乳腺癌血管生成、血管生成模拟及其治疗意义的研究进展。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-20 DOI: 10.1016/j.pbiomolbio.2024.12.003

Jiachen Weng, Yisi Shan, Qingyu Chang, Chenyan Cao, Xuemin Liu

引用次数: 0

Transforming agents: The power of structural modifications in glioblastoma multiforme therapy. 转化剂：结构改变在胶质母细胞瘤多形性治疗中的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-17 DOI: 10.1016/j.pbiomolbio.2024.12.001

Seyedeh Elham Norollahi, Saman Morovat, Arman Keymoradzadeh, Arman Hamzei, Morteza Modaeinama, Nazanin Soleimanmanesh, Yasaman Soleimanmanesh, Ali Najafizadeh, Elahe Bakhshalipour, Babak Alijani, Ali Akbar Samadani

{"title":"Transforming agents: The power of structural modifications in glioblastoma multiforme therapy.","authors":"Seyedeh Elham Norollahi, Saman Morovat, Arman Keymoradzadeh, Arman Hamzei, Morteza Modaeinama, Nazanin Soleimanmanesh, Yasaman Soleimanmanesh, Ali Najafizadeh, Elahe Bakhshalipour, Babak Alijani, Ali Akbar Samadani","doi":"10.1016/j.pbiomolbio.2024.12.001","DOIUrl":"10.1016/j.pbiomolbio.2024.12.001","url":null,"abstract":"Glioblastoma (GBM) is a very deadly type of brain tumor with a poor prognosis and a short survival rate. Recent advancements in understanding GBM's molecular and genetic characteristics have led to the development of various therapeutic and diagnostic strategies. Key elements such as microRNAs, lncRNAs, exosomes, angiogenesis, and chromatin modifications are highlighted, alongside significant epigenetic alterations that impact therapy and diagnosis. Despite these advancements, molecular classifications have not improved patient outcomes due to intratumoral diversity complicating targeted therapies. In this article, it is tried to emphasize the potential of investigating the epigenetic landscape of GBM, particularly identifying patients with diffuse hypermethylation at gene promoters associated with better outcomes. Integrating epigenetic and genetic data has enhanced the identification of glioma subtypes with high diagnostic precision. The reversibility of epigenetic changes offers promising therapeutic prospects, as recent insights into the \"epigenetic orchestra\" suggest new avenues for innovative treatment modalities for this challenging cancer. In this review article, we focus on the roles of translational elements and their alterations in the context of GBM diagnosis and therapy.","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"41-56"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0