Progress in Biophysics & Molecular Biology最新文献_第2页

In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments. 细胞集体迁移的体外调控：理解物理和化学微环境的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-28 DOI: 10.1016/j.pbiomolbio.2024.11.005

Chang-Xing Li, Zi-Xu Zhao, Dan-Bo Su, Da-Chuan Yin, Ya-Jing Ye

{"title":"In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments.","authors":"Chang-Xing Li, Zi-Xu Zhao, Dan-Bo Su, Da-Chuan Yin, Ya-Jing Ye","doi":"10.1016/j.pbiomolbio.2024.11.005","DOIUrl":"10.1016/j.pbiomolbio.2024.11.005","url":null,"abstract":"<p><p>Collective cell migration is the primary mode of cellular movement during embryonic morphogenesis, tissue repair and regeneration, and cancer invasion. Distinct from single-cell migration, collective cell migration involves complex intercellular signaling cascades and force transmission. Consequently, cell collectives exhibit intricate and diverse migration patterns under the influence of the microenvironment in vivo. Investigating the patterns and mechanisms of collective cell migration within complex environmental factors in vitro is essential for elucidating collective cell migration in vivo. This review elucidates the influence of physical and chemical factors in vitro microenvironment on the migration patterns and efficiency of cell collectives, thereby enhancing our comprehension of the phenomenon. Furthermore, we concisely present the effects of characteristic properties of common biomaterials on collective cell migration during tissue repair and regeneration, as well as the features and applications of tumor models of different dimensions (2D substrate or 3D substrate) in vitro. Finally, we highlight the challenges facing the research of collective cell migration behaviors in vitro microenvironment and propose that modulating collective cell migration may represent a potential strategy to promote tissue repair and regeneration and to control tumor invasion and metastasis.</p>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"23-40"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on salt-induced DNA compaction and charge inversion. 盐诱导 DNA 压实和电荷反转综述

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-20 DOI: 10.1016/j.pbiomolbio.2024.11.003

Khadka B Chhetri

引用次数: 0

Electrical impedance sensing in stem cell research: Insights, applications, and future directions. 干细胞研究中的电阻抗传感：见解、应用和未来方向。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-16 DOI: 10.1016/j.pbiomolbio.2024.11.004

Hassan Moghtaderi, Saeed Mohahammadi, Golfam Sadeghian, Mahua Choudhury, Ahmed Al-Harrasi, Shaikh Mizanoor Rahman

{"title":"Electrical impedance sensing in stem cell research: Insights, applications, and future directions.","authors":"Hassan Moghtaderi, Saeed Mohahammadi, Golfam Sadeghian, Mahua Choudhury, Ahmed Al-Harrasi, Shaikh Mizanoor Rahman","doi":"10.1016/j.pbiomolbio.2024.11.004","DOIUrl":"10.1016/j.pbiomolbio.2024.11.004","url":null,"abstract":"<p><p>The exceptional differentiation abilities of stem cells make them ideal candidates for cell replacement therapies. Considering their great potential, researchers should understand how stem cells interact with other cell types. The production of high-quality differentiated cells is crucial for favorable treatment and makes them an ideal choice for clinical applications. Label-free stem cell monitoring approaches are anticipated to be more effective in this context, as they ensure quality of differentiation while preserving the therapeutic potential. Electric cell-substrate impedance sensing (ECIS) is a nonintrusive technique that enables cell quantification through continuous monitoring of adherent cell behavior using electronic transcellular impedance measurements. This technique also facilitates the study of cell growth, motility, differentiation, drug effects, and cell barrier functions. Therefore, numerous studies have identified ECIS as an effective method for monitoring stem cell quality and differentiation. In this review, we discuss the current understanding of ECIS's achievements in examining cell behaviors and the potential applications of ECIS arrays in preclinical stem cell research. Moreover, we highlight our present knowledge concerning ECIS's contributions in examining cell behaviors and speculate about the future uses of ECIS arrays in preclinical stem cell research. This review also aims to stimulate research on electrochemical biosensors for future applications in regenerative medicine.</p>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A physical perspective on lithium therapy 从物理角度看锂疗法

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-14 DOI: 10.1016/j.pbiomolbio.2024.11.002

Dana Kamp

{"title":"A physical perspective on lithium therapy","authors":"Dana Kamp","doi":"10.1016/j.pbiomolbio.2024.11.002","DOIUrl":"10.1016/j.pbiomolbio.2024.11.002","url":null,"abstract":"<div><div>Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They have recently gathered attention due to their potential preventive effect in viral infections. Though the therapeutic effect of lithium was documented by Cade in the late 1940s, its underlying mechanism of action is still disputed. Acute lithium exposure has an activating effect on excitable organic tissue and organisms, and is highly toxic. Lithium exposure is associated with a strong metabolic response in the organism, with large changes in phospholipid and cholesterol expression. Opposite to acute exposure, this metabolic response alleviates excessive cellular activity. The presence of lithium ions strongly affects lipid conformation and membrane phase unlike other alkali ions, with consequences for membrane permeability, buffer property and excitability. This review investigates how lithium ions affect lipid membrane composition and function, and how lithium response might in fact be the body’s attempt to counteract the physical presence of lithium ions at cell level. Ideas for further research in microbiology and drug development are discussed.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 55-74"},"PeriodicalIF":3.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases 细胞间受体-配体结合动力学在疾病中的测量方法、影响因素和应用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-02 DOI: 10.1016/j.pbiomolbio.2024.11.001

Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng

{"title":"Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases","authors":"Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng","doi":"10.1016/j.pbiomolbio.2024.11.001","DOIUrl":"10.1016/j.pbiomolbio.2024.11.001","url":null,"abstract":"<div><div>Receptor-ligand binding on contacting cells dictates the extent of transmembrane signaling through membrane receptors during cell communication, influencing both the physiological and pathological activities of cells. This process is integral to fundamental biological mechanisms including signal transduction, cancer metastasis, immune responses, and inflammatory cascades, all of which are profoundly influenced by the cell microenvironment. This article provides an overview of the kinetic theory of receptor-ligand binding and examines methods for measuring this interaction, along with their respective advantages and disadvantages. Furthermore, it comprehensively explores the factors that impact receptor-ligand binding, encompassing protein-membrane interactions, the bioelectric microenvironment, auxiliary factors, hydrogen bond strength, pH levels, cis and trans interactions between ligands and receptors. The application of receptor-ligand binding kinetics in various diseases such as immunity, cancer, and inflammation are also discussed. Additionally, the investigation into how functional substances alter receptor-ligand binding dynamics within specific cellular microenvironments presents a promising new approach to treating related diseases.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 43-54"},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies 骨肉瘤中的 m6A 甲基化调节因子和 ncRNA：潜在的治疗策略

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-10-25 DOI: 10.1016/j.pbiomolbio.2024.10.003

Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng

{"title":"m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies","authors":"Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng","doi":"10.1016/j.pbiomolbio.2024.10.003","DOIUrl":"10.1016/j.pbiomolbio.2024.10.003","url":null,"abstract":"<div><div>Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%–15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades. The most pervasive and abundant modification of internal transcripts in eukaryotic messenger RNAs (mRNAs) is N6-methyladenosine (m6A), and it is regulated by m6A methylation regulators. A number of recent studies have demonstrated that m6A modifications can regulate the biological activities of tumour cells and are intimately linked with cancer development, prognosis, drug resistance, and therapy. N6-methyladenosine modification of Non-coding RNA (ncRNA) has likewise shown a broad potential in gene regulation and tumor biology. Epigenetic changes induced by mRNAs and ncRNAs methylation are important for a better understanding of OS development and targeted drug development. Therefore, this paper summarises the biological functions of m6A-modified regulators in osteosarcoma and the role of mutual regulation between m6A and ncRNAs in osteosarcoma. Furthermore, the potential clinical applications of m6A modifications in OS are presented for consideration. It provides new directions for the future research and clinical treatment strategies of osteosarcoma.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 34-42"},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear membrane: A key potential therapeutic target for lipid metabolism 核膜：脂质代谢的一个关键潜在治疗靶点。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-10-19 DOI: 10.1016/j.pbiomolbio.2024.10.002

Min Zeng , Longgui Chen , YaZhu Wang

引用次数: 0

A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives 回顾骨重塑过程的现状和未来前景：生物学和数学视角。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-10-17 DOI: 10.1016/j.pbiomolbio.2024.10.001

Mehran Bahrami , Hanieh Khonakdar , Armaghan Moghaddam , Saba Nemati Mahand , Poorya Esmaili Bambizi , Benjamin Kruppke , Hossein Ali Khonakdar

{"title":"A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives","authors":"Mehran Bahrami , Hanieh Khonakdar , Armaghan Moghaddam , Saba Nemati Mahand , Poorya Esmaili Bambizi , Benjamin Kruppke , Hossein Ali Khonakdar","doi":"10.1016/j.pbiomolbio.2024.10.001","DOIUrl":"10.1016/j.pbiomolbio.2024.10.001","url":null,"abstract":"<div><div>This review dives into the complex dynamics of bone remodeling, combining biological insights with mathematical perspectives to better understand this fundamental aspect of skeletal health. Bone, being a crucial part of our body, constantly renews itself, and with the growing number of individuals facing bone-related issues, research in this field is vital. In this review, we categorized and classified most common mathematical models used to simulate the mechanical behavior of bone under different loading and health conditions, shedding light on the evolving landscape of bone biology. While current models have effectively captured the essence of healthy bone remodeling, the ever-expanding knowledge in bone biology suggests an update in mathematical methods. Knowing the role of the skeleton in whole-body physiology, and looking at the recent discoveries about activities of bone cells emphasize the urgency of refining our mathematical descriptions of the bone remodeling process. The underexplored impact of bone diseases like osteoporosis, Paget's disease, or breast cancer on bone remodeling also points to the need for intensified research into diverse disease types and their unique effects on bone health. By reviewing a range of bone remodeling models, we show the necessity for tailor-made mathematical models to decipher their roots and enhance patient treatment strategies. Collaboration among scientists from various domains is pivotal to surmount these challenges, ensuring improved accuracy and applicability of mathematical models. Ultimately, this effort aims to deepen our understanding of bone remodeling processes and their broader implications for diverse health conditions.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 16-33"},"PeriodicalIF":3.2,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease 将长非编码 RNA H19 作为肝病治疗策略的靶点

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-09-30 DOI: 10.1016/j.pbiomolbio.2024.09.005

Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan

引用次数: 0

Research progress on the effects and mechanisms of magnetic field on neurodegenerative diseases 磁场对神经退行性疾病的影响和机制的研究进展

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-09-12 DOI: 10.1016/j.pbiomolbio.2024.09.004

Shuxian Ding , Jinhua Li , Yanwen Fang , Xingjie Zhuo , Lili Gu , Xinyue Zhang , Yuanxiao Yang , Min Wei , Zhongcai Liao , Qin Li

{"title":"Research progress on the effects and mechanisms of magnetic field on neurodegenerative diseases","authors":"Shuxian Ding , Jinhua Li , Yanwen Fang , Xingjie Zhuo , Lili Gu , Xinyue Zhang , Yuanxiao Yang , Min Wei , Zhongcai Liao , Qin Li","doi":"10.1016/j.pbiomolbio.2024.09.004","DOIUrl":"10.1016/j.pbiomolbio.2024.09.004","url":null,"abstract":"<div><p>With the progress of modern science and technology, magnetic therapy technology develops rapidly, and many types of magnetic therapy methods continue to emerge, making magnetic therapy one of the main techniques of physiotherapy. With the continuous development of magnetic field research and clinical applications, magnetic therapy, as a non-invasive brain stimulation therapy technology, has attracted much attention due to its potential in the treatment of motor dysfunction, cognitive impairment and speech disorders in patients with neurodegenerative diseases. However, the role of magnetic fields in the prognosis and treatment of neurodegenerative diseases and their mechanisms remain largely unexplored. In this paper, the therapeutic effect and neuroprotective mechanism of the magnetic field on neurodegenerative diseases are reviewed, and the new magnetic therapy techniques are also summarized. Although the neuroprotective mechanism of magnetic field cannot be fully elaborated, it is helpful to promote the application of magnetic field in neurodegenerative diseases and provide a new theoretical basis for the related magnetic field research in the later period.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 35-45"},"PeriodicalIF":3.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0