Progress in Biophysics & Molecular Biology最新文献

{"title":"Unraveling cerebral ultrastructural alterations in TLR4-mediated neuroinflammation via transmission electron microscopy: a systematic preclinical review","authors":"Eulália Rebeca Silva-Araújo ,&nbsp;Raul Manhães-de-Castro ,&nbsp;Ana Elisa Toscano ,&nbsp;Henrique José Cavalcanti Bezerra Gouveia ,&nbsp;Mônica Rodrigues de Sá ,&nbsp;Gedeone Bezerra de Almeida Júnior ,&nbsp;Assíria Natali da Silva ,&nbsp;Eduardo Padrón-Hernández","doi":"10.1016/j.pbiomolbio.2025.12.006","DOIUrl":"10.1016/j.pbiomolbio.2025.12.006","url":null,"abstract":"<div><div>Ultrastructural alterations in the central nervous system—such as synaptic dysfunction, axonal injury, and demyelination—contribute to the cognitive and sensorimotor deficits observed in neurological damage, in which TLR4-mediated neuroinflammation is a key pathological feature. This systematic review synthesizes evidence from 20 rodent studies employing transmission electron microscopy (TEM) to investigate central ultrastructural alterations induced by neuroinflammation, with a focus on the brain. A search was performed on Embase, PubMed, Scopus, and Web of Science databases. Study quality was assessed using the SYRCLE Risk of Bias tool for in vivo/ex vivo studies and an adapted QUIN tool for in vitro studies. Most studies have modeled neuroinflammation through LPS-infection or toxic insults, which have been implicated in disorders ranging from early brain injury to late-onset neurodegeneration, such as Alzheimer's disease. We observed that ultrastructural alterations originate from changes in glial morphology and function, subsequently affecting intracellular organelles and the extracellular space, thereby compromising cellular metabolism and neural integrity. TEM results show vascularized regions and protective barriers, enriched in glial cells, are particularly susceptible to early ultrastructural impairment. The damage extends to myelin architecture and axonal structure, which exhibit aberrant characteristics. Although the molecular mechanisms of neuroinflammation are well characterized, its ultrastructural consequences remain poorly explored. Elucidating these alterations through TEM studies provides a basis for targeted therapeutic strategies in neuroinflammation-related conditions.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 146-161"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic hyperthermia's potential in triple-negative breast cancer treatment","authors":"Taslima Musa Zerin,&nbsp;Brian W. Booth","doi":"10.1016/j.pbiomolbio.2026.02.001","DOIUrl":"10.1016/j.pbiomolbio.2026.02.001","url":null,"abstract":"<div><div>About 10–15% of all instances of breast cancer are triple-negative breast cancer (TNBC). TNBCs are not responsive to hormonal or anti-HER2 therapies because they lack estrogen and progesterone receptors and have low HER2 levels. TNBC is a highly aggressive subtype of breast cancer and has a prognosis often worse than that of other subtypes. Usually, chemotherapy and surgery are combined since this is a very efficient way to remove tumors. Chemotherapy medications that effectively remove cancer cells may adversely affect healthy cells and have severe repercussions, which can impair patients' psychological well-being and quality of life (QOL). To minimize adverse effects, improve patient quality of life, and maintain therapeutic efficacy, a more targeted therapy approach for TNBC should be explored. Magnetic hyperthermia (MHT) is a passive-targeting, minimally invasive treatment for TNBC that minimizes the requirement for other severe, well-established therapies having both short- and long-term toxicities for patients. MHT involves heating magnetic nanoparticles (MNPs) in an alternating magnetic field (AMF) to heat local tissues/cells without killing normal epithelial cells, as they are more temperature-resistant than tumor cells. Additionally, MNPs can bind chemotherapeutics, nucleic acids, synthetic antibodies, or radionuclide compounds, a strategy considered for drug delivery. This review summarizes the implications and current treatment options for TNBC, highlighting the use of MNPs for MHT as a potential treatment strategy.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 255-266"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum mechanics as a tool to decipher the mutational landscape of human disease","authors":"Eustathia-Irene Zavitsanou ,&nbsp;Argyris Dallis ,&nbsp;Athanasios Balaskas ,&nbsp;Sotirios Zarogiannis ,&nbsp;Erasmia Rouka","doi":"10.1016/j.pbiomolbio.2025.11.004","DOIUrl":"10.1016/j.pbiomolbio.2025.11.004","url":null,"abstract":"<div><div>Quantum mechanics (QM) is emerging as a powerful framework for studying disease-related mutations at the atomic and subatomic levels, providing mechanistic insights beyond those of classical models. In this review, we examined primary research to evaluate the extent to which QM is used to understand mutational mechanisms across various disease contexts. Our search was conducted in PubMed using the keywords “quantum mechanics” AND “mutations.” We also reviewed the reference lists of the retrieved articles for relevant data. All review articles were excluded. The final number of selected articles was thirty-four. These studies were categorized into two main modules: QM applications in non-communicable diseases and QM-based approaches to infectious diseases. In non-communicable diseases, especially cancer and neurodegeneration, QM simulations help clarify how mutations influence enzymatic catalysis, protein dynamics, and drug-target interactions, thereby improving our understanding of DNA repair, metabolic reprogramming, and resistance to targeted therapies. In communicable diseases, QM approaches can reveal how alterations in pathogens' genetic material impact protein–receptor interactions, virulence, and treatment effectiveness. Our findings highlight QM's role in shifting from discovery to therapeutics and underscore its applications in biomedicine. These advances could speed up drug development and personalized medicine.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 69-78"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in targeting regions of interest for In situ cryo-electron tomography of cellular architecture","authors":"Christopher Eugenio Williem ,&nbsp;Viranitasya Stephanie Himawan ,&nbsp;Maykel T.E. Manawan ,&nbsp;Sun Theo Constan Lotebulo Ndruru ,&nbsp;Dicky Annas ,&nbsp;Jia Hong Pan ,&nbsp;Mega Safithri ,&nbsp;I Made Artika ,&nbsp;Robertus Wahyu N. Nugroho","doi":"10.1016/j.pbiomolbio.2026.01.002","DOIUrl":"10.1016/j.pbiomolbio.2026.01.002","url":null,"abstract":"<div><div>Cryogenic electron tomography (cryo-ET) enables <em>in situ</em> structural analysis of macromolecular assemblies within their native cellular environments, spanning more than four orders of magnitude in spatial scale, from micrometre-level cellular context accessed through correlative imaging to near–sub-nanometre resolution achieved through subtomogram averaging (STA). This review summarises recent advances in mapping cellular architecture, encompassing membrane-bound organelles, cytoskeletal networks, adhesion complexes, and discrete cellular subsystems such as cilia and the nuclear pore complex (NPC). We discuss the principal challenges associated with cellular cryo-ET, including specimen thickness and electron transparency limitations, structural heterogeneity, the transient nature of many assemblies, restricted targeting precision, unreliable molecular identification, preparation-induced artefacts, and labelling constraints. Recent strategies developed to address these challenges are reviewed, with particular emphasis on innovations in sample preparation and their integration with cryo-focused ion beam milling (cryo-FIB), cryo-correlative light and electron microscopy (cryo-CLEM), STA, and complementary volume-imaging approaches such as cryo-scanning transmission electron tomography (cryo-STET) and cryo-soft X-ray tomography (cryo-SXT). We further highlight emerging density-based modelling strategies that enable molecular interpretation when sufficient resolution is achieved, as well as two-dimensional (2D) template-matching approaches. Collectively, these developments position cryo-ET as a central framework for interrogating cellular ultrastructure in its native context.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 222-245"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in constitutive modeling of arterial wall tissue mechanics: from theoretical frameworks to clinical application","authors":"Qian Fan ,&nbsp;Dezhong Qi ,&nbsp;Qiang Xiao ,&nbsp;Xiaoqiang Zhou","doi":"10.1016/j.pbiomolbio.2025.12.005","DOIUrl":"10.1016/j.pbiomolbio.2025.12.005","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) is a leading cause of mortality worldwide, and the mechanical behavior of arterial wall tissue (AWT) is central to its initiation and progression. This review surveys advances in constitutive models of AWT over the past two decades, with the aim of improving understanding of vascular mechanics and informing clinical practice. Five major computational frameworks are evaluated—elastic, viscoelastic, hyperelastic, structural solid models, and growth and remodeling (G&amp;R) models—which collectively provide insights into stress–strain relationships and mechanobiological interactions under physiological and pathological conditions. Simple elastic formulations cannot capture the intrinsic nonlinearity of AWT. Nonlinear elastic and pseudo-elastic models are better suited for large deformations and anisotropy, especially under cyclic loading. Viscoelastic models effectively represent time-dependent responses to pulsatile blood flow. Structural solid models, including layered anisotropic, equivalent homogeneous, and generalized structure tensor formulations, predict the mechanical behavior of individual wall layers with high fidelity. Extending beyond instantaneous mechanics, G&amp;R models embed these constitutive relations within higher-level frameworks to simulate long-term adaptations to altered hemodynamics, such as hypertension, aneurysm progression, or vascular graft remodeling. Future research should focus on developing dynamic models that more accurately simulate pulsatile loading, refining the characterization of AWT heterogeneity and anisotropy, and establishing multiscale and multi-physics frameworks to connect cellular processes with tissue-level behavior. Integrating big data and machine learning offers additional potential for robust parameter identification and predictive modeling. In conclusion, this review provides a comprehensive evaluation of AWT constitutive modeling, from fundamental elasticity-based approaches to advanced G&amp;R frameworks. By identifying limitations and outlining future directions, it highlights the role of biomechanics in advancing personalized medicine, improving CVD diagnosis and treatment, and promoting deeper understanding of disease mechanisms.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 114-145"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable hydrogel: A promising frontier in cancer therapy","authors":"Amirhamzeh Farajollahi","doi":"10.1016/j.pbiomolbio.2025.12.002","DOIUrl":"10.1016/j.pbiomolbio.2025.12.002","url":null,"abstract":"<div><div>The past decade has seen growing interest in injectable hydrogels for cancer therapy due to their tunable polymer backbones and high chemical versatility. Researchers are engineering injectable hydrogel platforms for chemotherapy, immunotherapy, and combination regimens to overcome limitations of conventional treatments. These materials enable localized, targeted delivery by encapsulating anti-tumor agents within a gel matrix, allowing sustained and controlled release that boosts efficacy while reducing systemic side effects. This review summarizes methods for preparing injectable hydrogels and highlights their key applications in cancer treatment, including strategies for payload loading, release modulation, and site-specific administration. We discuss how hydrogel composition, crosslinking chemistry, and microstructure govern therapeutic performance and biocompatibility, and we survey designs that integrate immune modulators, chemotherapeutics, or multi-modal agents for synergistic effects. Remaining challenges—such as predictable degradation, scalable manufacturing, in vivo stability, and regulatory translation—are examined, along with opportunities for improving targeting, responsiveness, and combination-therapy compatibility. Finally, we outline research directions needed to accelerate clinical translation, including standardized characterization, long-term safety studies, and optimized delivery protocols. By consolidating recent advances and identifying gaps, this review aims to guide future development of injectable hydrogels that can meaningfully enhance therapeutic outcomes for cancer patients.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"46"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hypoxia-inducible factor 1 in the oncogenic progression of Kaposi's sarcoma-associated herpes virus","authors":"Koushik Chakraborty ,&nbsp;Monalisha Ghosh ,&nbsp;Dristi Majumdar ,&nbsp;Tathagata Choudhuri","doi":"10.1016/j.pbiomolbio.2026.01.001","DOIUrl":"10.1016/j.pbiomolbio.2026.01.001","url":null,"abstract":"<div><div>The development of modern molecular biology helps us to identify the link between Kaposi's sarcoma-associated herpesvirus (KSHV) and multiple human malignancies by infecting B-lymphocyte or endothelial cells. Infection with KSHV plays a crucial role in stabilizing hypoxia-inducible factor-1 (HIF-1) and promoting its transcriptional activity. The association of KSHV and HIF-1 is essential for KSHV latency, reactivation, and associated disease phenotypes. In this review, we have discussed the detailed mechanisms of HIF-1 activation by KSHV infection. Based on the available evidence, we summarize the impact of HIF-1 activation on cellular metabolism, Angiogenesis, and lytic reactivation of KSHV in the proliferation and oncogenic progression of KSHV-infected B-lymphocyte or endothelial cells.</div><div>Furthermore, more studies reveal a deeper understanding of the interaction between KSHV and HIF-1. The modulatory impact of HIF-1 on the KSHV life cycle and oncogenic progression require further investigation. To advance this research, clinical trials targeting HIF-1 should commence in the near future.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 167-175"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macromolecular crowding and protein aggregation: Friend, foe or contextual force?","authors":"Isabella V. Gimón ,&nbsp;Conner Sandefur ,&nbsp;Santiago Schnell","doi":"10.1016/j.pbiomolbio.2025.12.001","DOIUrl":"10.1016/j.pbiomolbio.2025.12.001","url":null,"abstract":"<div><div>Protein aggregation plays a dual role in cellular biology, enabling essential functions such as intracellular organization, signaling, and storage, while also contributing to pathological states associated with misfolding and toxicity. However, existing literature lacks an integrated framework for predicting when crowding will favor productive assembly versus drive pathological outcomes—a gap that has hindered both mechanistic understanding and therapeutic development. This review examines how macromolecular crowding—an intrinsic feature of the intracellular environment—shapes protein aggregation outcomes by modulating key physicochemical parameters: volume exclusion, electrostatic interactions, aggregate morphology, cytoplasmic viscosity, and liquid–liquid phase separation. We demonstrate that crowding acts not as a universal promoter or inhibitor of aggregation, but rather as a context-dependent modulator that amplifies latent vulnerabilities in proteins predisposed to misfolding while facilitating productive assembly in properly regulated systems. By analyzing the mechanistic continuum between functional and pathological aggregation, we provide a framework for interpreting how identical molecular forces yield divergent biological outcomes depending on protein properties, environmental conditions, and cellular regulation. This perspective clarifies how the intracellular milieu governs aggregation dynamics and identifies promising avenues for therapeutic intervention, including strategic modulation of crowding conditions to promote protective assemblies while suppressing toxic aggregates in misfolding-related diseases. We conclude by outlining future directions toward quantitative, predictive models that integrate molecular mechanism with physiological context, bridging the gap between in vitro biophysics and in vivo cellular function.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 79-98"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating bone remodeling through magnetic field: Approach targeting metabolic dysregulation in diabetic osteoporosis","authors":"Chunqin Li ,&nbsp;Xige Dong ,&nbsp;Mengxu Sun ,&nbsp;Yuanfen Xie ,&nbsp;Beilei Wang ,&nbsp;Jiaxin Qin ,&nbsp;Na Wang ,&nbsp;Huanhuan Lv","doi":"10.1016/j.pbiomolbio.2026.01.004","DOIUrl":"10.1016/j.pbiomolbio.2026.01.004","url":null,"abstract":"<div><div>Diabetes mellitus, a chronic metabolic disorder associated with high risk of cardiovascular disease, kidney disease, neuropathy and bone disorder, has emerged as a globally epidemic public health issue. Osteoporosis, the most common bone disease in middle-aged and elderly populations, demonstrates a particularly high prevalence in individuals with diabetes mellitus. This correlation underscores the urgent need to develop innovative strategies to improve the quality of life for patients with diabetic osteoporosis. Magnetic field-based physical therapy, a non-invasive therapeutic modality, presents distinct advantages over conventional treatments. Recent advances in biomagnetic research have unveiled novel biological and therapeutic effects of magnetic fields, with accumulating evidence supporting their potential clinical applications in bone-related disorders. This review critically examines the mechanistic links between diabetes mellitus and the deterioration of bone health, the therapeutic effects of both dynamic and static magnetic fields on diabetes-associated complications, with a specific focus on skeletal outcomes, and the prospective applications of magnetic fields intervention for maintaining bone health in diabetes mellitus. Ultimately, this review aims to propose novel therapeutic strategies for managing osteoporosis in diabetes mellitus through magnetic approaches.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"199 ","pages":"Pages 197-208"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bench to Bone: Clinical promise of exosome-enhanced scaffolds in orthopedic regeneration","authors":"Asrin Emami ,&nbsp;Iman Menbari Oskouie","doi":"10.1016/j.pbiomolbio.2025.10.001","DOIUrl":"10.1016/j.pbiomolbio.2025.10.001","url":null,"abstract":"<div><div>Bone regeneration remains one of the greatest challenges in orthopedic medicine, particularly in cases of complex fractures, nonhealing bones, or large bone defects. Traditional treatments, such as autologous grafts, allogeneic grafts, synthetic materials, or drug therapies, often face limitations, including donor-site pain, immune rejection, and limited ability to stimulate true bone healing. A promising new approach involves the use of exosome-enhanced scaffolds, which combine the structural support of biomaterial scaffolds with the potent regenerative effects of exosomes. Exosomes are nanosized vesicles secreted by cells such as mesenchymal stem cells, osteoblasts, and macrophages. They carry proteins, lipids, and regulatory RNAs that play crucial roles in coordinating bone formation, angiogenesis, and immune modulation. When incorporated into scaffolds, exosomes promote osteogenesis, stimulate vascularization, and facilitate tissue remodeling, thereby creating an optimal microenvironment for bone repair. Preclinical studies have demonstrated accelerated healing, enhanced bone strength, and improved overall bone quality, while early clinical trials indicate that these therapies are both safe and effective. Current research efforts focus on optimizing exosome isolation, understanding their interactions with scaffolds, and developing controlled delivery systems. This strategy holds great promise for transforming orthopedic care by providing patient-specific, biologically active treatments for even the most challenging bone defects.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"198 ","pages":"Pages 32-38"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}