Vinculin: A new target for the diagnosis and treatment of disease

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology Pub Date : 2025-01-23 DOI:10.1016/j.pbiomolbio.2025.01.004

Jiqiang Li , Weiming Wang , Zipeng Lin , Zhenyu Liu , Ruilin Zhang , Runwen Li , Jie Zhang , Youkun Zheng , Dalian Qin , Ya Wu , Yong Liu

引用次数: 0

Abstract

Vinculin, a crucial adhesion plaque protein, plays a significant role in cell morphology and tissue development. Dysregulation of focal adhesion proteins has been linked to numerous diseases, including cardiovascular conditions, gastrointestinal disorders, and cancer. Recent studies increasingly highlight vinculin's involvement in the progression of these diseases; however, a comprehensive review remains lacking. Therefore, an in-depth and timely review is essential to consolidate the latest findings on vinculin's role in disease mechanisms. This study aims to examine how vinculin coordinates a complex network of signaling pathways across various pathological contexts.

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长春素：疾病诊断和治疗的新靶点。

Vinculin是一种重要的粘附斑块蛋白，在细胞形态和组织发育中起着重要作用。局灶黏附蛋白的失调与许多疾病有关，包括心血管疾病、胃肠道疾病和癌症。最近的研究越来越强调vinculin参与这些疾病的进展；然而，仍然缺乏全面的审查。因此，深入和及时的审查是必要的，以巩固最新的研究结果，在疾病机制中的作用。本研究旨在研究在不同病理背景下，vinculin如何协调一个复杂的信号通路网络。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.