Progress in Biophysics & Molecular Biology最新文献_第10页

The quantum cell 量子电池

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-05-01 Epub Date: 2024-02-22 DOI: 10.1016/j.pbiomolbio.2024.02.003

John S. Torday

{"title":"The quantum cell","authors":"John S. Torday","doi":"10.1016/j.pbiomolbio.2024.02.003","DOIUrl":"10.1016/j.pbiomolbio.2024.02.003","url":null,"abstract":"<div><p>There is a consensus that we are conscious of something greater than ourselves, as if we are derived from some other primordial set of principles. Classical or Newtonian physics is based on the Laws of Nature. Conversely, in a recent series of articles, it has been hypothesized that the cell was formed from lipid molecules submerged in the primordial ocean that covered the earth 100 million years after it formed. Since lipids are amphiphiles, with both a positively- and negatively-charged pole, the negatively-charged pole is miscible in water. Under the influence of earth's gravity, the lipid molecules stand up perpendicularly to the surface of the water, packing together until the negative charge neutralizes the Van der Waals force for surface tension, causing the lipid molecules to ‘leap’ into the micellar form as a sphere with a semi-permeable membrane. Particles in the water freely enter and exit such spheres based on mass action. Over time such protocells evolved Symbiogenesis, encountering factors that posed existential threats, assimilating them to form physiology to maintain homeostatic control. Importantly, when differentiated lung or bone cells are exposed to zero gravity, they lose their phenotypic identity in their evolved state, which has been interpreted as transiting from local to non-local consciousness.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"188 ","pages":"Pages 24-30"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of photobiomodulation in accelerating bone repair 光生物调节在加速骨修复中的作用。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-05-01 Epub Date: 2024-03-16 DOI: 10.1016/j.pbiomolbio.2024.03.002

Ping Lu , Jinfeng Peng , Jie Liu , Lili Chen

引用次数: 0

Electromagnetic fields regulate iron metabolism in living organisms: A review of effects and mechanism 电磁场调节生物体内的铁代谢：效应和机制综述

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-05-01 Epub Date: 2024-03-04 DOI: 10.1016/j.pbiomolbio.2024.03.001

Chenxiao Zhen , Gejing Zhang , Shenghang Wang , Jianping Wang , Yanwen Fang , Peng Shang

{"title":"Electromagnetic fields regulate iron metabolism in living organisms: A review of effects and mechanism","authors":"Chenxiao Zhen , Gejing Zhang , Shenghang Wang , Jianping Wang , Yanwen Fang , Peng Shang","doi":"10.1016/j.pbiomolbio.2024.03.001","DOIUrl":"10.1016/j.pbiomolbio.2024.03.001","url":null,"abstract":"<div><p>The emergence, evolution, and spread of life on Earth have all occurred in the geomagnetic field, and its extensive biological effects on living organisms have been documented. The charged characteristics of metal ions in biological fluids determine that they are affected by electromagnetic field forces, thus affecting life activities. Iron metabolism, as one of the important metal metabolic pathways, keeps iron absorption and excretion in a relatively balanced state, and this process is precisely and completely controlled. It is worth paying attention to how the iron metabolism process of living organisms is changed when exposed to electromagnetic fields. In this paper, the processes of iron absorption, storage and excretion in animals (mammals, fish, arthropods), plants and microorganisms exposed to electromagnetic field were summarized in detail as far as possible, in order to discover the regulation of iron metabolism by electromagnetic field. Studies and data on the effects of electromagnetic field exposure on iron metabolism in organisms show that exposure profiles vary widely across species and cell lines. This process involves a variety of factors, and the complexity of the results is not only related to the magnetic flux density/operating frequency/exposure time and the heterogeneity of the observed object. A systematic review of the biological regulation of iron metabolism by electromagnetic field exposure will not only contributes to a more comprehensive understanding of its biological effects and mechanism, but also is necessary to improve human awareness of the health related risks of electromagnetic field exposure.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"188 ","pages":"Pages 43-54"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079610724000233/pdfft?md5=18cb3adb31284906ec25b6d5f9d18432&pid=1-s2.0-S0079610724000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140046005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hypothesis of teleological evolution, via endogenous acetylcholine, nitric oxide, and calmodulin pathways 通过内源性乙酰胆碱、一氧化氮和钙调素途径进行目的论进化的假说。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-05-01 Epub Date: 2024-03-28 DOI: 10.1016/j.pbiomolbio.2024.03.003

Amelia Lewis

{"title":"A hypothesis of teleological evolution, via endogenous acetylcholine, nitric oxide, and calmodulin pathways","authors":"Amelia Lewis","doi":"10.1016/j.pbiomolbio.2024.03.003","DOIUrl":"10.1016/j.pbiomolbio.2024.03.003","url":null,"abstract":"<div><p>The Extended Evolutionary Synthesis (EES) addresses the issues in evolutionary biology which cannot be explained by neo-Darwinian theory. The EES paradigm recognises teleology and agency in living systems, and identifies that organisms can directly affect their evolutionary trajectory in a goal-directed manner, yet the physiological pathways via which this occurs remain unidentified. Here, I propose a physiological pathway via which organisms can alter their genotype and phenotype by making behavioural decisions with respect their activity levels, partitioning of resources either toward growth, defence against disease, or their behavioural response to stressors. Specifically, I hypothesize that agential, teleological decisions mediated by acetylcholine result in induced nitric oxide (NO) activity, which regulates metabolism, blood flow, and immune response. Nitric oxide, however, is also a key epigenetic molecule, being involved in DNA acetylation, methylation, and de-methylation. Further, NO alters the histone complexes which scaffold nuclear DNA strands, and is thus a good candidate in identifying a system which allows an organisms to make teleological genetic changes. The proposed mechanisms of inheritance of these genetic changes is via the paternal line, whereby epigenetic changes in the somatic Sertoli cells in animals are transcribed by mRNA and included in the germline cells – the male gametes. The microsporangium in plants, and the sporophore cells in fungi, meanwhile, are proposed to form similar systems in response to sensory detection of stressors. Whilst the hypothesis is presented as a simplified model for future testing, it opens new avenues for study in evolutionary biology.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"188 ","pages":"Pages 68-76"},"PeriodicalIF":3.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140327424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWN: The dysregulated autophagy in osteoarthritis: Revisiting molecular profile. 骨关节炎中失调的自噬：重新审视分子特征

IF 4.5 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-24 DOI: 10.1016/j.pbiomolbio.2024.03.004

Liang Liu, Jie Wang, Lu Liu, Wenling Shi, Huajie Gao, Lun Liu

引用次数: 0

Why death and aging ? All memories are imperfect 为什么会死亡和衰老？所有记忆都是不完美的

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-01 Epub Date: 2024-02-03 DOI: 10.1016/j.pbiomolbio.2024.02.001

William B. Miller Jr , František Baluška , Arthur S. Reber , Predrag Slijepčević

{"title":"Why death and aging ? All memories are imperfect","authors":"William B. Miller Jr , František Baluška , Arthur S. Reber , Predrag Slijepčević","doi":"10.1016/j.pbiomolbio.2024.02.001","DOIUrl":"10.1016/j.pbiomolbio.2024.02.001","url":null,"abstract":"<div><p>Recent papers have emphasized the primary role of cellular information management in biological and evolutionary development. In this framework, intelligent cells collectively measure environmental cues to improve informational validity to support natural cellular engineering as collaborative decision-making and problem-solving in confrontation with environmental stresses. These collective actions are crucially dependent on cell-based memories as acquired patterns of response to environmental stressors. Notably, in a cellular self-referential framework, all biological information is ambiguous. This conditional requirement imposes a previously unexplored derivative. All cellular memories are imperfect. From this atypical background, a novel theory of aging and death is proposed. Since cellular decision-making is memory-dependent and biology is a continuous natural learning system, the accumulation of previously acquired imperfect memories eventually overwhelms the flexibility cells require to react adroitly to contemporaneous stresses to support continued cellular homeorhetic balance. The result is a gradual breakdown of the critical ability to efficiently measure environmental information and effect cell-cell communication. This age-dependent accretion governs senescence, ultimately ending in death as an organism-wide failure of cellular networking. This approach to aging and death is compatible with all prior theories. Each earlier approach illuminates different pertinent cellular signatures of this ongoing, obliged, living process.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"187 ","pages":"Pages 21-35"},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial for online collection — The gene: An appraisal 在线收藏编辑 - 基因：评价

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-01 Epub Date: 2024-01-03 DOI: 10.1016/j.pbiomolbio.2024.01.001

Denis Noble

引用次数: 0

The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma 间充质干细胞及其细胞外囊泡对神经母细胞瘤的治疗效果。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-01 Epub Date: 2024-02-17 DOI: 10.1016/j.pbiomolbio.2024.02.004

Mohsen Karami Fath , Samaneh Mohammad Bagherzadeh Torbati , Vahid Saqagandomabadi , Omid Yousefi Afshar , Mohammad Khalilzad , Sara Abedi , Afshin Moliani , Danyal Daneshdoust , Ghasem Barati

{"title":"The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma","authors":"Mohsen Karami Fath , Samaneh Mohammad Bagherzadeh Torbati , Vahid Saqagandomabadi , Omid Yousefi Afshar , Mohammad Khalilzad , Sara Abedi , Afshin Moliani , Danyal Daneshdoust , Ghasem Barati","doi":"10.1016/j.pbiomolbio.2024.02.004","DOIUrl":"10.1016/j.pbiomolbio.2024.02.004","url":null,"abstract":"<div><p>Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties. MSCs could be engineered to express anticancer agents (i.e., growth factors, cytokines, pro-apoptotic agents) or deliver oncolytic viruses in the tumor microenvironment. As many functions of MSCs are mediated through their secretome, researchers have tried to use extracellular vesicles (EVs) from MSCs for targeted therapy of neuroblastoma. Here, we reviewed the studies to figure out whether the use of MSCs could be worthwhile in neuroblastoma therapy or not. Native MSCs have shown a promoting or inhibiting role in cancers including neuroblastoma. Therefore, MSCs are proposed as a vehicle to deliver anticancer agents such as oncolytic viruses to the neuroblastoma tumor microenvironment. Although modified MSCs or their EVs have been shown to suppress the tumorigenesis of neuroblastoma, further pre-clinical and clinical studies are required to come to a conclusion.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"187 ","pages":"Pages 51-60"},"PeriodicalIF":3.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The holism of evolution as consciousness 作为意识的进化的整体性

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-01 Epub Date: 2024-01-29 DOI: 10.1016/j.pbiomolbio.2024.01.004

John S. Torday

引用次数: 0

Amyloid oligomers and their membrane toxicity - A perspective study 淀粉样蛋白寡聚体及其膜毒性--一项透视研究

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-03-01 Epub Date: 2024-01-10 DOI: 10.1016/j.pbiomolbio.2024.01.002

Alessandro Nutini

引用次数: 0