Progress in Biophysics & Molecular Biology最新文献_第9页

Piezo1：the potential new therapeutic target for fibrotic diseases Piezo1：纤维疾病的潜在新治疗靶点。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-16 DOI: 10.1016/j.pbiomolbio.2023.09.001

Xin Liu , Weipin Niu , Shuqing Zhao , Wenjuan Zhang , Ying Zhao , Jing Li

{"title":"Piezo1：the potential new therapeutic target for fibrotic diseases","authors":"Xin Liu , Weipin Niu , Shuqing Zhao , Wenjuan Zhang , Ying Zhao , Jing Li","doi":"10.1016/j.pbiomolbio.2023.09.001","DOIUrl":"10.1016/j.pbiomolbio.2023.09.001","url":null,"abstract":"<div><p>Fibrosis is a pathological process that occurs in various organs, characterized by excessive deposition of extracellular matrix (ECM), leading to structural damage and, in severe cases, organ failure. Within the fibrotic microenvironment, mechanical forces play a crucial role in shaping cell behavior and function, yet the precise molecular mechanisms underlying how cells sense and transmit these mechanical cues, as well as the physical aspects of fibrosis progression, remain less understood. Piezo1, a mechanosensitive ion channel protein, serves as a pivotal mediator, converting mechanical stimuli into electrical or chemical signals. Accumulating evidence suggests that Piezo1 plays a central role in ECM formation and hemodynamics in the mechanical transduction of fibrosis expansion. This review provides an overview of the current understanding of the role of Piezo1 in fibrosis progression, encompassing conditions such as myocardial fibrosis, pulmonary fibrosis, renal fibrosis, and other fibrotic diseases. The main goal is to pave the way for potential clinical applications in the field of fibrotic diseases.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"184 ","pages":"Pages 42-49"},"PeriodicalIF":3.8,"publicationDate":"2023-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10673539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of nanomaterials as potential quorum quenchers for disease: Recent advances and challenges 纳米材料作为疾病潜在群体猝灭剂的应用：最新进展和挑战。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-02 DOI: 10.1016/j.pbiomolbio.2023.08.005

Saad Alghamdi , Krisha Khandelwal , Soumya Pandit , Arpita Roy , Subhasree Ray , Ahad Amer Alsaiari , Abdulelah Aljuaid , Mazen Almehmadi , Mamdouh Allahyani , Rohit Sharma , Jigisha Anand , Ahmad Adnan Alshareef

{"title":"Application of nanomaterials as potential quorum quenchers for disease: Recent advances and challenges","authors":"Saad Alghamdi , Krisha Khandelwal , Soumya Pandit , Arpita Roy , Subhasree Ray , Ahad Amer Alsaiari , Abdulelah Aljuaid , Mazen Almehmadi , Mamdouh Allahyani , Rohit Sharma , Jigisha Anand , Ahmad Adnan Alshareef","doi":"10.1016/j.pbiomolbio.2023.08.005","DOIUrl":"10.1016/j.pbiomolbio.2023.08.005","url":null,"abstract":"<div><p>Chemical signal molecules are used by bacteria to interact with one another. Small hormone-like molecules known as autoinducers<span><span> are produced, released, detected, and responded to during chemical communication. Quorum Sensing (QS) is the word for this procedure; it allows bacterial populations to communicate and coordinate group behavior. Several research has been conducted on using inhibitors to prevent QS and minimize the detrimental consequences. Through the enzymatic breakdown of the autoinducer component, by preventing the formation of autoinducers, or by blocking their reception by adding some compounds (inhibitors) that can mimic the autoinducers, a technique known as “quorum quenching” (QQ) disrupts microbial communication. Numerous techniques, including colorimetry, electrochemistry, </span>bioluminescence<span><span>, chemiluminescence, fluorescence, chromatography-mass </span>spectroscopy, and many more, can be used to test QS/QQ. They all permit quantitative and qualitative measurements of QS/QQ molecules. The mechanism of QS and QQ, as well as the use of QQ in the prevention of biofilms, are all elaborated upon in this writing, along with the fundamental study of nanoparticle (NP)in QQ. Q.</span></span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"184 ","pages":"Pages 13-31"},"PeriodicalIF":3.8,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10227317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A revised central dogma for the 21st century: All biology is cognitive information processing 21世纪修正后的中心教条：所有生物学都是认知信息处理

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.05.005

William B. Miller Jr. , František Baluška , Arthur S. Reber

{"title":"A revised central dogma for the 21st century: All biology is cognitive information processing","authors":"William B. Miller Jr. , František Baluška , Arthur S. Reber","doi":"10.1016/j.pbiomolbio.2023.05.005","DOIUrl":"10.1016/j.pbiomolbio.2023.05.005","url":null,"abstract":"<div><p>Crick's Central Dogma has been a foundational aspect of 20th century biology, describing an implicit relationship governing the flow of information in biological systems in biomolecular terms. Accumulating scientific discoveries support the need for a revised Central Dogma to buttress evolutionary biology's still-fledgling migration from a Neodarwinian canon. A reformulated Central Dogma to meet contemporary biology is proposed: all biology is cognitive information processing. Central to this contention is the recognition that life is the self-referential state, instantiated within the cellular form. Self-referential cells act to sustain themselves and to do so, cells must be in consistent harmony with their environment. That consonance is achieved by the continuous assimilation of environmental cues and stresses as information to self-referential observers. All received cellular information must be analyzed to be deployed as cellular problem-solving to maintain homeorhetic equipoise. However, the effective implementation of information is definitively a function of orderly information management. Consequently, effective cellular problem-solving is information processing and management. The epicenter of that cellular information processing is its self-referential internal measurement. All further biological self-organization initiates from this obligate activity. As the internal measurement by cells of information is self-referential by definition, self-reference is biological self-organization, underpinning 21st century Cognition-Based Biology.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 34-48"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Method versatility in RNA extraction-free PCR detection of SARS-CoV-2 in saliva samples 唾液样本中严重急性呼吸系统综合征冠状病毒2型无RNA提取PCR检测方法的多功能性

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.06.004

Orchid M. Allicock, Devyn Yolda-Carr, Rebecca Earnest, Mallery I. Breban, Noel Vega, Isabel M. Ott, Chaney Kalinich, Tara Alpert, Mary E Petrone, Anne L. Wyllie

{"title":"Method versatility in RNA extraction-free PCR detection of SARS-CoV-2 in saliva samples","authors":"Orchid M. Allicock, Devyn Yolda-Carr, Rebecca Earnest, Mallery I. Breban, Noel Vega, Isabel M. Ott, Chaney Kalinich, Tara Alpert, Mary E Petrone, Anne L. Wyllie","doi":"10.1016/j.pbiomolbio.2023.06.004","DOIUrl":"10.1016/j.pbiomolbio.2023.06.004","url":null,"abstract":"<div><p>Early in the pandemic, a simple, open-source, RNA extraction-free RT-qPCR protocol for SARS-CoV-2 detection in saliva was developed and made widely available. This simplified approach (SalivaDirect) requires only sample treatment with proteinase K prior to PCR testing. However, feedback from clinical laboratories highlighted a need for a flexible workflow that can be seamlessly integrated into their current health and safety requirements for the receiving and handling of potentially infectious samples. To address these varying needs, we explored additional pre-PCR workflows. We built upon the original SalivaDirect workflow to include an initial incubation step (95 °C for 30 min, 95 °C for 5 min or 65 °C for 15 min) with or without addition of proteinase K. The limit of detection for the workflows tested did not significantly differ from that of the original SalivaDirect workflow. When tested on de-identified saliva samples from confirmed COVID-19 individuals, these workflows also produced comparable virus detection and assay sensitivities, as determined by RT-qPCR analysis. Exclusion of proteinase K did not negatively affect the sensitivity of the assay. The addition of multiple heat pretreatment options to the SalivaDirect protocol increases the accessibility of this cost-effective SARS-CoV-2 test as it gives diagnostic laboratories the flexibility to implement the workflow which best suits their safety protocols.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 103-108"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Investigation of thermal stability characteristic in family A DNA polymerase - A theoretical study A家族DNA聚合酶热稳定性特征的研究——一项理论研究。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.05.003

Seddigheh Borhani, Seyed Shahriar Arab

{"title":"Investigation of thermal stability characteristic in family A DNA polymerase - A theoretical study","authors":"Seddigheh Borhani, Seyed Shahriar Arab","doi":"10.1016/j.pbiomolbio.2023.05.003","DOIUrl":"10.1016/j.pbiomolbio.2023.05.003","url":null,"abstract":"<div><p><span>DNA polymerases create complementary DNA strands<span><span> in living cells and are crucial to genome transmission and maintenance. These enzymes<span> possess similar human right-handed folds which contain thumb, fingers, and palm subdomains and contribute to polymerization activities. These enzymes are classified into seven evolutionary families, A, B, C, D, X, Y, and RT, based on amino acid sequence analysis and biochemical characteristics. Family A DNA polymerases exist in an extended range of organisms including mesophilic, thermophilic, and hyper-thermophilic bacteria, participate in DNA replication and repair, and have a broad application in </span></span>molecular biology<span> and biotechnology. In this study, we attempted to detect factors that play a role in the thermostability properties of this family member despite their remarkable similarities in structure and function. For this purpose, similarities and differences in </span></span></span>amino acid sequences<span>, structure, and dynamics of these enzymes have been inspected. Our results demonstrated that thermophilic and hyper-thermophilic enzymes have more charged, aromatic, and polar residues than mesophilic ones and consequently show further electrostatic and cation-pi interactions. In addition, in thermophilic enzymes, aliphatic residues tend to position in buried states more than mesophilic enzymes. These residues within their aliphatic parts increase hydrophobic core packing and therefore enhance the thermostability of these enzymes. Furthermore, a decrease in thermophilic cavities volumes assists in the protein compactness enhancement. Moreover, molecular dynamic simulation results revealed that increasing temperature impacts mesophilic enzymes further than thermophilic ones that reflect on polar and aliphatic residues surface area and hydrogen bonds changes.</span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 15-25"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10256746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards solving the mystery of spiral phyllotaxis 解开螺旋叶序之谜

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.04.004

Boris Rozin

引用次数: 0

Biological evolution requires an emergent, self-organizing principle 生物进化需要一个紧急的、自组织的原则

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.06.001

Olen R. Brown , David A. Hullender

{"title":"Biological evolution requires an emergent, self-organizing principle","authors":"Olen R. Brown , David A. Hullender","doi":"10.1016/j.pbiomolbio.2023.06.001","DOIUrl":"10.1016/j.pbiomolbio.2023.06.001","url":null,"abstract":"<div><p><span>In this perspective review, we assess fundamental flaws in Darwinian evolution, including its modern versions. Fixed mutations ‘explain’ microevolution but not macroevolution including speciation events and the origination of all the major body plans of the Cambrian explosion. Complex, multifactorial change is required for speciation events and inevitably requires self-organization beyond what is accomplished by known mechanisms. The assembly of ribosomes and ATP synthase are specific examples. We propose their origin is a model for what is unexplained in biological evolution. Probability of evolution is modeled in Section 9 and values are absurdly improbable. Speciation and higher taxonomic changes become exponentially less probable as the number of required, genetically-based events increase. Also, the power required of the proposed selection mechanism (survival of the fittest) is nil for any biological advance requiring multiple changes, because they regularly occur in multiple generations (different genomes) and would not be selectively conserved by the concept survival of the fittest (a concept ultimately centered on the individual). Thus, survival of the fittest cannot ‘explain’ the origin of the millions of current and </span>extinct species. We also focus on the inadequacies of laboratory chemistry to explain the complex, required biological self-organization seen in cells. We propose that a ‘bioelectromagnetic’ field/principle emerges in living cells. Synthesis by self-organization of massive molecular complexes involves biochemical responses to this emergent field/principle. There are ramifications for philosophy, science, and religion. Physics and mathematics must be more strongly integrated with biology and integration should receive dedicated funding with special emphasis for medical applications; treatment of cancer and genetic diseases are examples.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 75-102"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9883515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Identification and diagnosis of long COVID-19: A scoping review 长期新冠肺炎的识别和诊断：范围界定综述

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.04.008

Sujata Srikanth , Jessica R. Boulos , Tristan Dover , Luigi Boccuto , Delphine Dean

{"title":"Identification and diagnosis of long COVID-19: A scoping review","authors":"Sujata Srikanth , Jessica R. Boulos , Tristan Dover , Luigi Boccuto , Delphine Dean","doi":"10.1016/j.pbiomolbio.2023.04.008","DOIUrl":"10.1016/j.pbiomolbio.2023.04.008","url":null,"abstract":"<div><p>Long COVID-19 (LC-19) is a condition that has affected a high percentage of the population that recovered from the initial disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). LC-19 diagnosis is currently poorly defined because of its variable, multisystem, episodic symptoms, and lack of uniformity in the critical time points associated with the disease. Considering the number of cases, workers’ compromised efficiency or inability to return to their duties can affect organizations and impact economies. LC-19 represents a significant burden on multiple levels and effectively reduces quality of life. These factors necessitate the establishment of firm parameters of diagnoses to provide a foundation for ongoing and future studies of clinical characteristics, epidemiology, risk factors, and therapy. In this scoping review, we conducted a literature search across multiple publication sites to identify papers of interest regarding the diagnosis of LC-19. We identified 225 records of interest and categorized them into seven categories. Based on our findings, there are only 11 original papers that outline the diagnostic process in detail with little overlap. This scoping review highlights the lack of consensus regarding the definition and, thereby, the LC-19 diagnosis processes. Due to no clear directive and considering the many unknowns surrounding the natural history of the disease and further recovery/sequelae from COVID-19, continued discussion and agreement on a definition/diagnosis will help future research and management of these patients.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 1-7"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9871184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cross-talk between non-ionizing electromagnetic fields and metastasis; EMT and hybrid E/M may explain the anticancer role of EMFs 非电离电磁场与转移之间的串扰；EMT和杂交E/M可能解释EMFs的抗癌作用

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.06.003

Romina Mehdizadeh , Alireza Madjid Ansari , Flora Forouzesh , Reyhane Ghadirian , Fatemeh Shahriari , Seyed Peyman Shariatpanahi , Mohammad Amin Javidi

{"title":"Cross-talk between non-ionizing electromagnetic fields and metastasis; EMT and hybrid E/M may explain the anticancer role of EMFs","authors":"Romina Mehdizadeh , Alireza Madjid Ansari , Flora Forouzesh , Reyhane Ghadirian , Fatemeh Shahriari , Seyed Peyman Shariatpanahi , Mohammad Amin Javidi","doi":"10.1016/j.pbiomolbio.2023.06.003","DOIUrl":"10.1016/j.pbiomolbio.2023.06.003","url":null,"abstract":"<div><p><span>Recent studies have shown that non-ionizing electromagnetic fields (NIEMFs) in a specific frequency, intensity, and exposure time can have anti-cancer effects on various cancer cells; however, the underlying precise mechanism of action is not transparent. Most cancer deaths are due to metastasis. This important phenomenon plays an inevitable role in different steps of cancer including progression and development. It has different stages including invasion, intravasation, migration, extravasation, and homing. Epithelial-mesenchymal transition (EMT), as well as hybrid E/M state, are biological processes, that involve both natural </span>embryogenesis<span><span> and tissue regeneration, and abnormal conditions including organ fibrosis or metastasis. In this context, some evidence reveals possible footprints of the important EMT-related pathways which may be affected in different EMFs treatments. In this article, critical EMT molecules and/or pathways which can be potentially affected by EMFs (e.g., VEGFR, ROS, P53, PI3K/AKT, </span>MAPK<span>, Cyclin B1, and NF-кB) are discussed to shed light on the mechanism of EMFs anti-cancer effect.</span></span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 49-58"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9883495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis 对组织结构、遗传学、表观遗传学和细胞代谢对致癌作用的相对贡献的批判性评价

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-09-01 DOI: 10.1016/j.pbiomolbio.2023.05.004

Thomas W. Grunt , Gerwin Heller

{"title":"A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis","authors":"Thomas W. Grunt , Gerwin Heller","doi":"10.1016/j.pbiomolbio.2023.05.004","DOIUrl":"10.1016/j.pbiomolbio.2023.05.004","url":null,"abstract":"<div><p><span>Here we contrast several carcinogenesis models. The somatic-mutation-theory posits mutations as main causes of malignancy. However, inconsistencies led to alternative explanations. For example, the tissue-organization-field-theory considers disrupted tissue-architecture as main cause. Both models can be reconciled using systems-biology-approaches, according to which tumors hover in states of self-organized criticality between order and chaos, are emergent results of multiple deviations and are subject to general laws of nature: inevitable variation(mutation) explainable by increased entropy(second-law-of-thermodynamics) or indeterminate decoherence upon measurement of superposed quantum systems(quantum mechanics), followed by Darwinian-selection. Genomic expression is regulated by epigenetics. Both systems cooperate. So cancer is neither just a mutational nor an epigenetic problem. Rather, epigenetics links environmental cues to endogenous </span>genetics<span> engendering a regulatory machinery that encompasses specific cancer-metabolic-networks. Interestingly, mutations occur at all levels of this machinery (oncogenes/tumor-suppressors, epigenetic-modifiers, structure-genes, metabolic-genes). Therefore, in most cases, DNA mutations may be the initial and crucial cancer-promoting triggers.</span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"182 ","pages":"Pages 26-33"},"PeriodicalIF":3.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9878030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1