Progress in Biophysics & Molecular Biology最新文献_第8页

Research progress on the role of reactive oxygen species in the initiation, development and treatment of breast cancer 关于活性氧在乳腺癌的发生、发展和治疗中的作用的研究进展

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-02-20 DOI: 10.1016/j.pbiomolbio.2024.02.005

Jing Zhong, Yan Tang

{"title":"Research progress on the role of reactive oxygen species in the initiation, development and treatment of breast cancer","authors":"Jing Zhong, Yan Tang","doi":"10.1016/j.pbiomolbio.2024.02.005","DOIUrl":"10.1016/j.pbiomolbio.2024.02.005","url":null,"abstract":"<div><p>According to international cancer data, breast cancer (BC) is the leading type of cancer in women. Although significant progress has been made in treating BC, metastasis and drug resistance continue to be the primary causes of mortality for many patients. Reactive oxygen species (ROS) play a dual role in vivo: normal levels can maintain the body's normal physiological function; however, high levels of ROS below the toxicity threshold can lead to mtDNA damage, activation of proto-oncogenes, and inhibition of tumor suppressor genes, which are important causes of BC. Differences in the production and regulation of ROS in different BC subtypes have important implications for the development and treatment of BC. ROS can also serve as an important intracellular signal transduction factor by affecting the antioxidant system, activating MAPK and PI3K/AKT, and other signal pathways to regulate cell cycle and change the relationship between cells and the activity of metalloproteinases, which significantly impacts the metastasis of BC. Hypoxia in the BC microenvironment increases ROS production levels, thereby inducing the expression of hypoxia inducible factor-1α (HIF-1α) and forming “ROS- HIF-1α-ROS” cycle that exacerbates BC development. Many anti-BC therapies generate sufficient toxic ROS to promote cancer cell apoptosis, but because the basal level of ROS in BC cells exceeds that of normal cells, this leads to up-regulation of the antioxidant system, drug efflux, and apoptosis inhibition, rendering BC cells resistant to the drug. ROS crosstalks with tumor vessels and stromal cells in the microenvironment, increasing invasiveness and drug resistance in BC.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"188 ","pages":"Pages 1-18"},"PeriodicalIF":3.8,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139918105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma 间充质干细胞及其细胞外囊泡对神经母细胞瘤的治疗效果。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-02-17 DOI: 10.1016/j.pbiomolbio.2024.02.004

Mohsen Karami Fath , Samaneh Mohammad Bagherzadeh Torbati , Vahid Saqagandomabadi , Omid Yousefi Afshar , Mohammad Khalilzad , Sara Abedi , Afshin Moliani , Danyal Daneshdoust , Ghasem Barati

{"title":"The therapeutic effect of MSCs and their extracellular vesicles on neuroblastoma","authors":"Mohsen Karami Fath , Samaneh Mohammad Bagherzadeh Torbati , Vahid Saqagandomabadi , Omid Yousefi Afshar , Mohammad Khalilzad , Sara Abedi , Afshin Moliani , Danyal Daneshdoust , Ghasem Barati","doi":"10.1016/j.pbiomolbio.2024.02.004","DOIUrl":"10.1016/j.pbiomolbio.2024.02.004","url":null,"abstract":"<div><p>Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties. MSCs could be engineered to express anticancer agents (i.e., growth factors, cytokines, pro-apoptotic agents) or deliver oncolytic viruses in the tumor microenvironment. As many functions of MSCs are mediated through their secretome, researchers have tried to use extracellular vesicles (EVs) from MSCs for targeted therapy of neuroblastoma. Here, we reviewed the studies to figure out whether the use of MSCs could be worthwhile in neuroblastoma therapy or not. Native MSCs have shown a promoting or inhibiting role in cancers including neuroblastoma. Therefore, MSCs are proposed as a vehicle to deliver anticancer agents such as oncolytic viruses to the neuroblastoma tumor microenvironment. Although modified MSCs or their EVs have been shown to suppress the tumorigenesis of neuroblastoma, further pre-clinical and clinical studies are required to come to a conclusion.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"187 ","pages":"Pages 51-60"},"PeriodicalIF":3.8,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responses to commentaries on “The gene: An appraisal” 对 "基因 "评论的回应：评价 "的评论。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-02-14 DOI: 10.1016/j.pbiomolbio.2024.02.002

Keith Baverstock

{"title":"Responses to commentaries on “The gene: An appraisal”","authors":"Keith Baverstock","doi":"10.1016/j.pbiomolbio.2024.02.002","DOIUrl":"10.1016/j.pbiomolbio.2024.02.002","url":null,"abstract":"<div><p>The central conclusions of “The Gene: An Appraisal” are that genetic variance does not underpin biological evolution, and, therefore, that genes are not Mendel's units of inheritance. In this response, I will address the criticisms I have received via commentaries on that paper by defending the following statements:</p><p>1. Epistasis does not explain the power-law fitness profile of the Long-Term Evolution Experiment (LTEE). The data from the evolution of <em>natural systems</em> displays the power-law form ubiquitously. Epistasis plays no role in evolution.</p><p>2. The common characteristics of living things (natural systems) are described by the principle of least action in de Maupertuis's original form, which is synonymous with the 2nd law of thermodynamics and Newton's 2nd law of motion in its complete form, i.e., F = dp/dt. Organisms strive to achieve free energy balance with their environments.</p><p>3. Based on an appraisal of the scientific environment between 1880 and 1911, I conclude that Johannsen's genotype conception was perhaps, the only option available to him.</p><p>4. The power-law fitness profile of the LTEE falsifies Fisher's Genetical Theory of Natural Selection, Johannsen's genotype conception, and the idea that ‘Darwinian evolution’ is an exception to the generic thermodynamic process of evolution in natural systems.</p><p>5. The use of the technique of genome-wide association to identify the causes and the likelihoods of inherited common diseases and behavioural traits is a ‘wild goose chase’ because genes are not the units of inheritance.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"188 ","pages":"Pages 31-42"},"PeriodicalIF":3.8,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S007961072400018X/pdfft?md5=e7aa3c3acf34cfb11fa23fbe39cdab86&pid=1-s2.0-S007961072400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why death and aging ? All memories are imperfect 为什么会死亡和衰老？所有记忆都是不完美的

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-02-03 DOI: 10.1016/j.pbiomolbio.2024.02.001

William B. Miller Jr , František Baluška , Arthur S. Reber , Predrag Slijepčević

{"title":"Why death and aging ? All memories are imperfect","authors":"William B. Miller Jr , František Baluška , Arthur S. Reber , Predrag Slijepčević","doi":"10.1016/j.pbiomolbio.2024.02.001","DOIUrl":"10.1016/j.pbiomolbio.2024.02.001","url":null,"abstract":"<div><p>Recent papers have emphasized the primary role of cellular information management in biological and evolutionary development. In this framework, intelligent cells collectively measure environmental cues to improve informational validity to support natural cellular engineering as collaborative decision-making and problem-solving in confrontation with environmental stresses. These collective actions are crucially dependent on cell-based memories as acquired patterns of response to environmental stressors. Notably, in a cellular self-referential framework, all biological information is ambiguous. This conditional requirement imposes a previously unexplored derivative. All cellular memories are imperfect. From this atypical background, a novel theory of aging and death is proposed. Since cellular decision-making is memory-dependent and biology is a continuous natural learning system, the accumulation of previously acquired imperfect memories eventually overwhelms the flexibility cells require to react adroitly to contemporaneous stresses to support continued cellular homeorhetic balance. The result is a gradual breakdown of the critical ability to efficiently measure environmental information and effect cell-cell communication. This age-dependent accretion governs senescence, ultimately ending in death as an organism-wide failure of cellular networking. This approach to aging and death is compatible with all prior theories. Each earlier approach illuminates different pertinent cellular signatures of this ongoing, obliged, living process.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"187 ","pages":"Pages 21-35"},"PeriodicalIF":3.8,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The holism of evolution as consciousness 作为意识的进化的整体性

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-01-29 DOI: 10.1016/j.pbiomolbio.2024.01.004

John S. Torday

引用次数: 0

A landscape of consciousness: Toward a taxonomy of explanations and implications 意识的景观：意识的景观：解释和影响的分类法。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-01-26 DOI: 10.1016/j.pbiomolbio.2023.12.003

Robert Lawrence Kuhn

{"title":"A landscape of consciousness: Toward a taxonomy of explanations and implications","authors":"Robert Lawrence Kuhn","doi":"10.1016/j.pbiomolbio.2023.12.003","DOIUrl":"10.1016/j.pbiomolbio.2023.12.003","url":null,"abstract":"<div><p>Diverse explanations or theories of consciousness are arrayed on a roughly physicalist-to-nonphysicalist landscape of essences and mechanisms. Categories: Materialism Theories (philosophical, neurobiological, electromagnetic field, computational and informational, homeostatic and affective, embodied and enactive, relational, representational, language, phylogenetic evolution); Non-Reductive Physicalism; Quantum Theories; Integrated Information Theory; Panpsychisms; Monisms; Dualisms; Idealisms; Anomalous and Altered States Theories; Challenge Theories. There are many subcategories, especially for Materialism Theories. Each explanation is self-described by its adherents, critique is minimal and only for clarification, and there is no attempt to adjudicate among theories. The implications of consciousness explanations or theories are assessed with respect to: meaning/purpose/value (if any); AI consciousness; virtual immortality; and survival beyond death. A Landscape of Consciousness, I suggest, offers perspective.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"190 ","pages":"Pages 28-169"},"PeriodicalIF":3.8,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079610723001128/pdfft?md5=e1401856928d55a631d4e6e91b35ae72&pid=1-s2.0-S0079610723001128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising application of pulsed electromagnetic fields on tissue repair and regeneration 脉冲电磁场在组织修复和再生方面的应用前景广阔。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-01-26 DOI: 10.1016/j.pbiomolbio.2024.01.003

Dan-bo Su, Zi-xu Zhao, Da-chuan Yin, Ya-jing Ye

{"title":"Promising application of pulsed electromagnetic fields on tissue repair and regeneration","authors":"Dan-bo Su, Zi-xu Zhao, Da-chuan Yin, Ya-jing Ye","doi":"10.1016/j.pbiomolbio.2024.01.003","DOIUrl":"10.1016/j.pbiomolbio.2024.01.003","url":null,"abstract":"<div><p>Tissue repair and regeneration is a vital biological process in organisms, which is influenced by various internal mechanisms and microenvironments. Pulsed electromagnetic fields (PEMFs) are becoming a potential medical technology due to its advantages of effectiveness and non-invasiveness. Numerous studies have demonstrated that PEMFs can stimulate stem cell proliferation and differentiation, regulate inflammatory reactions, accelerate wound healing, which is of great significance for tissue regeneration and repair, providing a solid basis for enlarging its clinical application. However, some important issues such as optimal parameter system and potential deep mechanisms remain to be resolved due to PEMFs window effect and biological complexity. Thus, it is of great importance to comprehensively summarizing and analyzing the literature related to the biological effects of PEMFs in tissue regeneration and repair. This review expounded the biological effects of PEMFs on stem cells, inflammation response, wound healing and musculoskeletal disorders in order to improve the application value of PEMFs in medicine. It is believed that with the continuous exploration of biological effects of PEMFs, it will be applied increasingly widely to tissue repair and other diseases.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"187 ","pages":"Pages 36-50"},"PeriodicalIF":3.8,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid oligomers and their membrane toxicity - A perspective study 淀粉样蛋白寡聚体及其膜毒性--一项透视研究

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-01-10 DOI: 10.1016/j.pbiomolbio.2024.01.002

Alessandro Nutini

引用次数: 0

Editorial for online collection — The gene: An appraisal 在线收藏编辑 - 基因：评价

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-01-03 DOI: 10.1016/j.pbiomolbio.2024.01.001

Denis Noble

引用次数: 0

Darwinian evolution has become dogma; AI can rescue what is salvageable 达尔文进化论已成为教条；人工智能可拯救可拯救的东西