From traditional medicine to modern oncology: Scutellarin, a promising natural compound in cancer treatment

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Shadi Vesaghhamedani , Seyedeh Shabnam Mazloumi Kiapey , Arezoo Gowhari Shabgah , Sedigheh Amiresmaili , Abbas Jahanara , Maziar Oveisee , Aliakbar Shekarchi , Seyed Mohammad Gheibihayat , Farhad Jadidi-Niaragh , Jamshid Gholizadeh Navashenaq
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引用次数: 2

Abstract

Natural substances are increasingly being used as cancer treatments. Scutellarin, as a flavonoid, recently has been identified in a Chinese herbal extract called Erigeron breviscapus (Vant.). Scutellarin is being researched for its potential benefits due to the discovery that it possesses a variety of biological effects, such as neuroprotective, anti-bacterial, and anti-viral properties. In addition to these biological functions, scutellarin has also been found to have anti-tumor properties. The underlying mechanisms of scutellarin's anticancer activity involve its ability to inhibit various signaling pathways, such as Jak/STAT, ERK/AMPK, and Wnt/β-catenin. Additionally, scutellarin activates intrinsic and extrinsic apoptotic pathways, which causes the death of tumor cells, interrupts the cell cycle, and promotes its arrest. By limiting metastasis, angiogenesis, drug resistance, and other tumorigenic processes, scutellarin also reduces the aggressiveness of tumors. Despite its promising anticancer activity, scutellarin faces several challenges in its clinical development, including poor solubility, bioavailability, and pharmacokinetic properties. Therefore, it has been suggested that certain modifications can enhance the pharmacogenetic capabilities of scutellarin to decrease its limited water solubility. In conclusion, scutellarin represents a potential candidate for cancer treatment and further studies are needed to explore its clinical utility and optimize its therapeutic potential.

从传统医学到现代肿瘤学:在癌症治疗中有前途的天然化合物黄芩素
天然物质越来越多地被用作癌症治疗。黄芩素是一种黄酮类化合物,最近在一种名为灯盏细辛(Vant.)的中草药提取物中被发现。由于发现黄芩素具有多种生物作用,如神经保护、抗菌和抗病毒特性,因此正在研究其潜在益处。除了这些生物学功能外,黄芩素还被发现具有抗肿瘤特性。灯盏花素抗癌活性的潜在机制涉及其抑制各种信号通路的能力,如Jak/STAT、ERK/AMPK和Wnt/β-catenin。此外,灯盏花素激活内源性和外源性凋亡途径,导致肿瘤细胞死亡,中断细胞周期,并促进其停滞。通过限制转移、血管生成、耐药性和其他致瘤过程,灯盏花素还降低了肿瘤的侵袭性。尽管灯盏花素具有良好的抗癌活性,但其临床开发仍面临一些挑战,包括溶解性、生物利用度和药代动力学特性差。因此,有人认为,某些修饰可以增强黄芩苷的药理作用,降低其有限的水溶性。总之,灯盏花素是癌症治疗的潜在候选药物,需要进一步研究以探索其临床应用并优化其治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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