Neuroimage-Clinical最新文献

{"title":"Differential patterns of axonal loss associated with threat-related adversity in atypical depression and non-atypical depression","authors":"Huifeng Zhang ,&nbsp;Lei Ding ,&nbsp;Lanxiang He ,&nbsp;Rubai Zhou ,&nbsp;Wenxian Lu ,&nbsp;Tenghuan Xu ,&nbsp;Ye Wu ,&nbsp;Daihui Peng","doi":"10.1016/j.nicl.2025.103786","DOIUrl":"10.1016/j.nicl.2025.103786","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) encompasses a broad spectrum of heterogeneous symptoms arising from distinct etiological mechanisms. Phenotypic markers of psychopathology are most likely influenced by exposure to childhood maltreatment, yielding distinct subtypes within conventional diagnostic boundaries. However, the biological interactions between MDD subtypes and types of childhood trauma remain unclear.</div></div><div><h3>Methods</h3><div>50 atypical depression (AD) patients, 97 non-AD patients and 50 healthy controls were included to complete multi-shell diffusion MRI scans and clinical assessments. Differential tractography was performed to clarify the axonal injury between the AD and non-AD groups. Moreover, correlational tractography was employed to individually assess the relationship between quantitative anisotropy (QA) and all types of childhood trauma in each depressed subgroup.</div></div><div><h3>Results</h3><div>Our study found that AD and non-AD patients had differential axonal loss primarily involving the bilateral superior longitudinal fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, parietal aslant tract, and corpus callosum. Furthermore, AD patients showed significantly negative associations between QA values, childhood trauma total scores, and threat-related adversity, while significantly positive associations were observed in non-AD patients. However, similar phenomena were not observed for deprivation-related adversities.</div></div><div><h3>Discussion</h3><div>Our findings indicate differential spatial patterns of axonal alterations associated with threat-related adversity in atypical depression and non-atypical depression. Efforts to attenuate the consequences of childhood maltreatment for MDD should consider the associations between specific patterns of adversity and specific clinical manifestations.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103786"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain network in relation to language in school-aged extremely preterm children: A diffusion tensor imaging study","authors":"M. Boumeester ,&nbsp;E. Blom ,&nbsp;T. Boerma ,&nbsp;F. Lammertink ,&nbsp;M.P. van den Heuvel ,&nbsp;J. Dudink ,&nbsp;M.J.N.L. Benders ,&nbsp;E. Roze","doi":"10.1016/j.nicl.2025.103782","DOIUrl":"10.1016/j.nicl.2025.103782","url":null,"abstract":"<div><div>Between 22 and 45 % of children born preterm experience difficulties with expressive and receptive language when they reach school age. Little is currently known about the neural mechanisms behind their linguistic performance. This study investigates the brain areas and white matter connections that form the structural language network in extremely preterm-born children who have reached school age. Structural brain connectivity was quantified using diffusion-weighted imaging (DWI) and tractography in <em>n</em> = 58 (62 % female) extremely preterm-born children aged 8–12 years. Language outcomes were assessed using the CELF-4-NL Recalling Sentences subtest. Language scores were below average in <em>n</em> = 13 (22 %) children. Language outcomes related significantly to a subnetwork of 16 brain regions (<em>p</em> = 0.012). The network comprised brain regions from the left hemisphere including the pars orbitalis, middle and superior frontal gyrus, frontal pole, pre- and postcentral gyrus, superior temporal gyrus, insula, caudate nucleus, thalamus, and putamen. In the right hemisphere, the anterior cingulate was part of the network. These findings suggest that extremely preterm children rely mostly on their left hemisphere during language processing, which is similar to typically developing children. However, they seem to use compensatory neural pathways that include brain areas right next to the areas typically involved in language processing. These areas include the pars orbitalis (adjacent to Broca’s area) and the putamen and caudate nucleus (adjacent to the limbic system). It is important to note that language difficulties were not necessarily related to brain injury around birth.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103782"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers","authors":"Thang M. Le ,&nbsp;Takeyuki Oba ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.nicl.2025.103762","DOIUrl":"10.1016/j.nicl.2025.103762","url":null,"abstract":"<div><div>Individuals engaging in problem drinking show impaired proactive pain avoidance. As successful pain avoidance is intrinsically rewarding, this impairment suggests reward deficiency, as hypothesized for those with alcohol and substance misuse. Nevertheless, how reward circuit dysfunctions impact avoidance learning and contribute to drinking behavior remains poorly understood. Here, we combined functional imaging and a probabilistic learning go/nogo task to examine the neural processes underlying proactive pain avoidance learning in 103 adult drinkers. We hypothesized that greater drinking severity would be associated with poorer avoidance learning and that the deficits would be accompanied by weakened activity and connectivity of the reward circuit. Our behavioral findings indeed showed a negative relationship between drinking severity and learning from successful pain avoidance. We identified hypoactivation of the posterior cingulate cortex (PCC), a brain region important in avoidance, as the neural correlate of lower learning rate in association with problem drinking. The reward circuit, including the medial orbitofrontal cortex, ventral tegmental area, and substantia nigra, also exhibited diminished activation and connectivity with the PCC with greater drinking severity and learning deficits. Finally, path modeling suggested a pathway in which problem drinking disengaged the reward circuit. The weakened circuit subsequently induced PCC hypoactivation, resulting in poorer pain avoidance learning. As the learning dysfunction worsened alcohol use, the pathway represents a self-perpetuating cycle of drinking and distress. Together, these findings substantiate a role of reward deficiency in problem drinkers’ compromised proactive avoidance, thus identifying a potential target for intervention aimed at mitigating harmful alcohol use.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103762"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal structural covariance network in major depressive disorder: Evidence from the REST-meta-MDD project","authors":"Changmin Chen ,&nbsp;Yuhan Liu ,&nbsp;Yu Sun ,&nbsp;Wenhao Jiang ,&nbsp;Yonggui Yuan ,&nbsp;Zhao Qing ,&nbsp;DIRECT Consortium","doi":"10.1016/j.nicl.2025.103794","DOIUrl":"10.1016/j.nicl.2025.103794","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) is a common mental illness associated with brain morphological abnormalities. Although extensive studies have examined gray matter volume (GMV) changes in MDD, inconsistencies persist in reported findings. In the current study, we employed source-based morphometry (SBM) and structural covariance network (SCN) analyses to a large multi-center sample from the REST-meta-MDD database, aiming to characterize robust results of structural abnormalities in MDD.</div></div><div><h3>Methods</h3><div>We analyzed 798 MDD patients and 974 healthy controls (HCs) from the REST-meta-MDD consortium. Voxel-based morphometry was applied to generate GMV maps. SBM was used to adaptively parcellate brain into different components, and SCN was constructed based on SBM components. Volume scores in each component and SCNs between the components were both compared between MDD and HC groups, as well as between first-episode drug-naive (FEDN) and recurrent MDD subgroups.</div></div><div><h3>Results</h3><div>SBM identified 20 stable components. Three components encompassing the middle temporal gyrus, middle orbitofrontal gyrus and superior frontal gyrus exhibited volumetric differences between the MDD and HC groups. Volume differences were observed in the cingulate cortex and medial frontal gyrus between the FEDN and recurrent groups. SCN analysis revealed 9 aberrant pairs in MDD vs. HCs, and 7 pairs in FEDN vs. recurrent groups. All aberrant component pairs in the SCN implicated the prefrontal cortex.</div></div><div><h3>Conclusions</h3><div>These findings demonstrated brain structural deficits in MDD, and highlighted the prefrontal cortex as a central hub of SCN alterations. Our findings advance the understanding of MDD’s neural mechanisms and suggest directions for diagnostic research.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103794"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural processing of social reciprocity in autism","authors":"Afton M. Bierlich ,&nbsp;Irene Sophia Plank ,&nbsp;Nanja T. Scheel ,&nbsp;Daniel Keeser ,&nbsp;Christine M. Falter-Wagner","doi":"10.1016/j.nicl.2025.103793","DOIUrl":"10.1016/j.nicl.2025.103793","url":null,"abstract":"<div><div>Social reciprocity and interpersonal synchrony implicitly mediate social interactions to facilitate natural exchanges. These processes are altered in autism, but it is unclear how such alterations manifest at the neural level during social interaction processing. Using task-based fMRI, we investigated the neural correlates of interpersonal synchrony during basic reciprocal interactions in a preregistered study. Participants communicated with a virtual partner by sending visual signals. Analyses showed comparable activation patterns and experienced synchrony ratings between autistic and non-autistic participants, as well as between interactions with virtual partners who had high or low synchronous responses. An exploratory whole brain analysis for the effect of task revealed significant activation of the inferior frontal gyrus, insular cortex, and anterior inferior parietal lobe; areas associated with cognitive control, rhythmic temporal coordination, and action observation. This activation was independent of the virtual partner’s response synchrony and was similar for autistic and non-autistic participants. These results provide an initial look into the neural basis of processing social reciprocity in autism, particularly when individuals are part of an interaction, and hint that the neural processing of social reciprocity may be spared in autism when their partners’ behavior is predictable.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103793"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medulla oblongata dominated synaptic density network degeneration in amyotrophic lateral sclerosis","authors":"Ting Zou ,&nbsp;Manliu Hou ,&nbsp;Honghao Han ,&nbsp;Xuyang Wang ,&nbsp;Huafu Chen ,&nbsp;Yongxiang Tang ,&nbsp;Rong Li ,&nbsp;Shuo Hu","doi":"10.1016/j.nicl.2025.103814","DOIUrl":"10.1016/j.nicl.2025.103814","url":null,"abstract":"<div><h3>Background</h3><div>Amyotrophic lateral sclerosis (ALS) is a brain network disorder closely associated with synaptic loss in the upper and lower motor neurons. However, the <em>in vivo</em> synaptic network changes and their progressive processes remain unclear. Here, we aim to investigate the synaptic density network connectivity and the likely sequences of synaptic loss in patients with ALS.</div></div><div><h3>Methods</h3><div>We examined data from 21 patients diagnosed with ALS and 25 sex- and age-matched healthy controls (HCs) who underwent PET imaging with the SV2A radioligand [¹⁸F]SynVesT-1. The individual synaptic density similarity network was constructed for each patient by calculating the similarity between interregional synaptic density distributions. The synaptic network connectivity changes were investigated, followed by an examination of the local synaptic density in regions that showed significant network alterations. Finally, we constructed the voxel-wise and ROI-wise causal synaptic covariance network (cSCN) by applying Granger causality analysis. This allowed us to identify the sequence of synaptic loss in these brain regions.</div></div><div><h3>Results</h3><div>We observed an overall decrease in synaptic density network connectivity in ALS patients compared to controls, with the highest nodal degree in the right medulla oblongata. Specifically, the reduced connections were dominantly between the medulla oblongata and the striatum, frontal lobe, occipital lobe, as well as between the striatum and the frontal lobe, occipital lobe. Furthermore, patients with ALS displayed significantly synaptic loss in those brain regions. The cSCN analyses showed that as the disease progresses, the cortical synaptic loss sequences of ALS extend from the medulla oblongata to the regions including the striatum, frontal lobe, occipital lobe, and parietal lobe.</div></div><div><h3>Conclusions</h3><div>These findings suggest that synaptic density network degeneration in ALS may follow a bottom-up transmission pattern, primarily involving in the medulla oblongata-striatum-neocortex network, which have the potential to capture new network-based targets for clinical therapy in the progression of ALS.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103814"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A one year longitudinal study of cortical myelination changes following pediatric mild traumatic brain injury","authors":"Jessica R. McQuaid ,&nbsp;Tracey V. Wick ,&nbsp;Josef Ling ,&nbsp;Andrew B. Dodd ,&nbsp;Divyasree Sasi Kumar ,&nbsp;Upasana Nathaniel ,&nbsp;Samuel D. Miller ,&nbsp;Vadim Zotev ,&nbsp;Harm J. van der Horn ,&nbsp;John P. Phillips ,&nbsp;Richard A. Campbell ,&nbsp;Robert E. Sapien ,&nbsp;Timothy B. Meier ,&nbsp;Andrew R. Mayer","doi":"10.1016/j.nicl.2025.103837","DOIUrl":"10.1016/j.nicl.2025.103837","url":null,"abstract":"<div><div>The impact of pediatric mild traumatic brain injury (pmTBI) on cortical (i.e., grey matter) myelination is not yet understood, especially for interactions with neurodevelopment. The current study examined the impact of pmTBI on cortical myelination relative to healthy controls (HC) by estimating myelin content using the T₁w/T₂w ratio method. Data were obtained from pmTBI (<em>N</em> = 217) participants at approximately 7 days (Visit 1 [V1]), 4 months (Visit 2 [V2]), and 1 year (Visit 3 [V3]) post-injury, with equivalent sampling points for age and sex-matched HC (<em>N</em> = 180). Clinical results suggested only partial recovery from post-concussive symptoms from V1 to V3, with similar incomplete recovery of sleep, functional outcomes, behavior, and long-term memory. Myelin content increased with chronological age and as a function of individual aging across study visits in a hemisphere specific fashion (left &gt; right), most visibly within the posterior parietal lobe. Myelin content was also greater for females relative to males. There was evidence of both a reduction in myelination within the posterior parietal cortex for the pmTBI group at 4 months post-injury, as well as evidence of increased myelination within the left prefrontal cortex at one-year post-injury. However, neither of these findings survived various sensitivity analyses, suggesting that there were minimal effects of pmTBI on cortical myelin content in general. In summary, although rapid changes in myelin content existed as a function of neurodevelopment, there was little evidence to suggest that pmTBI permanently altered cortical myelin development trajectories.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"48 ","pages":"Article 103837"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia","authors":"Melanie A. Matyi ,&nbsp;Hamsanandini Radhakrishnan ,&nbsp;Christopher A. Olm ,&nbsp;Jeffrey S. Phillips ,&nbsp;Philip A. Cook ,&nbsp;Emma Rhodes ,&nbsp;James C. Gee ,&nbsp;David J. Irwin ,&nbsp;Corey T. McMillan ,&nbsp;Lauren Massimo","doi":"10.1016/j.nicl.2025.103853","DOIUrl":"10.1016/j.nicl.2025.103853","url":null,"abstract":"<div><h3>Background</h3><div>The organization of the brain into distinct networks increases (i.e., differentiation) during development and decreases (i.e., de-differentiation) during healthy aging, changes that are associated with improvements and worsening of cognition, respectively. Given that behavioral variant frontotemporal degeneration (bvFTD) is a neurodegenerative disease associated with executive dysfunction and selective vulnerability of the salience network, we tested the hypotheses that bvFTD structural networks are de-differentiated compared to cognitively normal controls (CNC) and that network de-differentiation relates to worse executive function.</div></div><div><h3>Methods</h3><div>In a sample of 90 patients with bvFTD and 71 age-matched CNC with diffusion MRI data we generated probabilistic tractography maps and calculated system segregation, a metric that compares within-network to between-network connectivity, to reflect the extent to which brain networks were differentiated. Patients with bvFTD also completed tests of executive function (digit span backwards, phonemic fluency, category fluency) and a control task (lexical retrieval). We assessed group differences in system segregation, reflecting network differentiation, and, within bvFTD, associations between system segregation and neuropsychological test performance.</div></div><div><h3>Results</h3><div>Compared to CNC, patients with bvFTD exhibited lower system segregation of the salience (<em>p</em> &lt; 0.001) and global brain network (<em>p</em> = 0.008). In bvFTD, lower salience network system segregation was associated with worse executive function (<em>p_corrected</em> = 0.021) but not lexical retrieval.</div></div><div><h3>Conclusions</h3><div>Results demonstrate associations between executive dysfunction and salience network de-differentiation in patients with bvFTD. Our findings indicate that brain network de-differentiation, reflecting reduced neural capacity for specialized processing, may contribute to the emergence of executive dysfunction in bvFTD.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"48 ","pages":"Article 103853"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis","authors":"Harold H.G. Tan ,&nbsp;Abram D. Nitert ,&nbsp;Kevin van Veenhuijzen ,&nbsp;Stefan Dukic ,&nbsp;Martine J.E. van Zandvoort ,&nbsp;Jeroen Hendrikse ,&nbsp;Michael A. van Es ,&nbsp;Jan H. Veldink ,&nbsp;Henk-Jan Westeneng ,&nbsp;Leonard H. van den Berg","doi":"10.1016/j.nicl.2025.103749","DOIUrl":"10.1016/j.nicl.2025.103749","url":null,"abstract":"<div><h3>Background</h3><div>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with frequent extra-motor involvement. In the present study, we investigated whether specific cognitive and behavioral deficits in ALS correlate with distinct extra-motor neurodegeneration patterns on brain MRI.</div></div><div><h3>Methods</h3><div>We performed multimodal brain MRI and Edinburgh cognitive and behavioral ALS screen (ECAS) in 293 patients and 237 controls. Follow-up data were acquired from 171 patients with a median duration of 7.9 months. Domain-level cognitive scores from the ECAS were compared with grey and white matter MRI parameters. Interaction analyses between patients and controls were performed to explore whether correlates were specific to ALS, rather than related to normal aging. Follow-up data were used to assess changes of domain-associated brain structures over time.</div></div><div><h3>Results</h3><div>Language impairment was significantly associated with (left predominant) frontal, temporal, parietal and subcortical grey matter neurodegeneration. Letter fluency with widespread cortical and subcortical grey matter involvement. Memory dysfunction with hippocampal and medial-temporal atrophy. Executive impairment was exclusively correlated with widespread white matter impairment. Visuospatial scores did not correlate with MRI parameters. Interaction analyses between patients and controls showed that most ECAS-MRI correlations were stronger in ALS than in controls (75.7% significant in grey matter, 52.7% in white matter). Longitudinal analyses showed that all grey matter structures associated with cognitive domains worsened over time while, for this study population, ECAS domain scores did not decline significantly.</div></div><div><h3>Conclusions</h3><div>MRI can capture the heterogeneity of cognitive and behavioral involvement in ALS and provides a useful longitudinal biomarker for progression of extra-motor neurodegeneration.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103749"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents","authors":"Zhou Lan ,&nbsp;Sheryl Foster ,&nbsp;Molly Charney ,&nbsp;Max van Grinsven ,&nbsp;Katherine Breedlove ,&nbsp;Kasia Kozlowska ,&nbsp;Alexander Lin","doi":"10.1016/j.nicl.2025.103767","DOIUrl":"10.1016/j.nicl.2025.103767","url":null,"abstract":"<div><h3>Objectives</h3><div>Functional neurological disorder (FND) in children and adolescents is a biopsychosocially complex condition characterized by a wide range of neurological symptoms. Using magnetic resonance spectroscopy to study neurometabolites has become an important approach to studying the mechanisms of FND. Unlike previous studies focusing on concentration-level analysis, this study examines conditional dependencies between six neurometabolites: N-acetyl aspartate, creatine, glutathione, choline, myo-inositol, and glutamate. Conditional dependence implies that two neurometabolites have joint variability that is not mediated by other neurometabolites.</div></div><div><h3>Methods</h3><div>A Bayesian graphical lasso approach was used to estimate neurometabolites’ conditional dependencies in three regions of interest: the anterior default mode network (aDMN), supplementary motor area (SMA), and posterior default mode network (pDMN). We introduce the term <em>neurometabolic network</em> (NMetNet) to describe these conditional dependencies.</div></div><div><h3>Results</h3><div>Children and adolescents with FND (vs. healthy controls) showed a loss of conditional dependencies related to creatine and glutathione between the aDMN and SMA/pDMN. Glutathione is the primary antioxidant in the brain. Creatine plays a key role in maintaining bioenergetics and also acts as an antioxidant.</div></div><div><h3>Conclusions</h3><div>These findings suggest that FND is characterized by dysregulated bioenergetics and increased vulnerability to oxidative stress. Understanding NMetNet in FND offers novel insights into the disorder’s neurobiology, with implications for therapeutic interventions to restore energy homeostasis and oxidative balance.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103767"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}