Neuroimage-Clinical最新文献

{"title":"Corrigendum to \"Impact of adult-onset multiple sclerosis on MRI-based intracranial volume: A study in clinically discordant monozygotic twins\" [NeuroImage Clin. 42 (2024) 103597].","authors":"Matin Mortazavi, Lisa Ann Gerdes, Öznur Hizarci, Tania Kümpfel, Katja Anslinger, Frank Padberg, Sophia Stöcklein, Daniel Keeser, Birgit Ertl-Wagner","doi":"10.1016/j.nicl.2024.103669","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103669","url":null,"abstract":"","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":" ","pages":"103669"},"PeriodicalIF":3.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion mapping and functional characterization of hemiplegic children with different patterns of hand manipulation","authors":"Antonino Errante , Francesca Bozzetti , Alessandro Piras , Laura Beccani , Mariacristina Filippi , Stefania Costi , Adriano Ferrari , Leonardo Fogassi","doi":"10.1016/j.nicl.2024.103575","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103575","url":null,"abstract":"<div><p>Brain damage in children with unilateral cerebral palsy (UCP) affects motor function, with varying severity, making it difficult the performance of daily actions. Recently, qualitative and semi-quantitative methods have been developed for lesion classification, but studies on mild to moderate hand impairment are lacking. The present study aimed to characterize lesion topography and preserved brain areas in UCP children with specific patterns of hand manipulation. A homogeneous sample of 16 UCP children, aged 9 to 14 years, was enrolled in the study. Motor assessment included the characterization of the specific pattern of hand manipulation, by means of unimanual and bimanual measures (Kinematic Hand Classification, KHC; Manual Ability Classification System, MACS; House Functional Classification System, HFCS; Melbourne Unilateral Upper Limb Assessment, MUUL; Assisting Hand Assessment, AHA). The MRI morphological study included multiple methods: (a) qualitative lesion classification, (b) semi-quantitative classification (sq-MRI), (c) voxel-based morphometry comparing UCP and typically developed children (VBM-DARTEL), and (d) quantitative brain tissue segmentation (q-BTS). In addition, functional MRI was used to assess spared functional activations and cluster lateralization in the ipsilesional and contralesional hemispheres of UCP children during the execution of simple movements and grasping actions with the more affected hand. Lesions most frequently involved the periventricular white matter, corpus callosum, posterior limb of the internal capsule, thalamus, basal ganglia and brainstem. VMB-DARTEL analysis allowed to detect mainly white matter lesions. Both sq-MRI classification and q-BTS identified lesions of thalamus, brainstem, and basal ganglia. In particular, UCP patients with <em>synergic</em> hand pattern showed larger involvement of subcortical structures, as compared to those with <em>semi-functional</em> hand. Furthermore, sparing of gray matter in basal ganglia and thalamus was positively correlated with MUUL and AHA scores. Concerning white matter, q-BTS revealed a larger damage of fronto-striatal connections in patients with <em>synergic</em> hand, as compared to those with <em>semi-functional</em> hand. The volume of these connections was correlated to unimanual function (MUUL score). The fMRI results showed that all patients, but one, including those with cortical lesions, had activation in ipsilesional areas, regardless of lesion timing. Children with <em>synergic</em> hand showed more lateralized activation in the ipsilesional hemisphere both during grasping and simple movements, while children with <em>semi-functional</em> hand exhibited more bilateral activation during grasping. The study demonstrates that lesion localization, rather than lesion type based on the timing of their occurrence, is more associated with the functional level of hand manipulation. Overall, the preservation of subcortical structures and white ma","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103575"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000147/pdfft?md5=1a77ec4dee45b19a28d5e42cdf8a45df&pid=1-s2.0-S2213158224000147-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139727007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression","authors":"Lijun Kang ,&nbsp;Wei Wang ,&nbsp;Zhaowen Nie ,&nbsp;Qian Gong ,&nbsp;Lihua Yao ,&nbsp;Dan Xiang ,&nbsp;Nan Zhang ,&nbsp;Ning Tu ,&nbsp;Hongyan Feng ,&nbsp;Xiaofen Zong ,&nbsp;Hanping Bai ,&nbsp;Gaohua Wang ,&nbsp;Fei Wang ,&nbsp;Lihong Bu ,&nbsp;Zhongchun Liu","doi":"10.1016/j.nicl.2024.103581","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103581","url":null,"abstract":"<div><p>Arterial spin labeling (ASL) can be used to detect differences in perfusion for multiple brain regions thought to be important in major depressive disorder (MDD). However, the potential of cerebral blood flow (CBF) to predict MDD and its correlations between the blood lipid levels and immune markers, which are closely related to MDD and brain function change, remain unclear. The 451 individuals − 298 with MDD and 133 healthy controls who underwent MRI at a single time point with arterial spin labelling and a high resolution T1-weighted structural scan. A proportion of MDD also provided blood samples for analysis of lipid and immune markers. We performed CBF case-control comparisons, random forest model construction, and exploratory correlation analyses. Moreover, we investigated the relationship between gray matter volume (GMV), blood lipids, and the immune system within the same sample to assess the differences in CBF and GMV. We found that the left inferior parietal but supramarginal and angular gyrus were significantly different between the MDD patients and HCs (voxel-wise P &lt; 0.001, cluster-wise FWE correction). And bilateral inferior temporal (ITG), right middle temporal gyrus and left precentral gyrus CBF predict MDD (the area under the receiver operating characteristic curve of the random forest model is 0.717) and that CBF is a more sensitive predictor of MDD than GMV. The left ITG showed a positive correlation trend with immunoglobulin G (r = 0.260) and CD4 counts (r = 0.283). The right ITG showed a correlation trend with Total Cholesterol (r = −0.249) and tumour necrosis factor-alpha (r = −0.295). Immunity and lipids were closely related to CBF change, with the immunity relationship potentially playing a greater role. The interactions between CBF, plasma lipids and immune index could therefore represent an MDD pathophysiological mechanism. The current findings provide evidence for targeted regulation of CBF or immune properties in MDD.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103581"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000202/pdfft?md5=80ee3ec6dcfe0ffac183ad343861b124&pid=1-s2.0-S2213158224000202-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive brain structural abnormality in cerebral small vessel disease assessed with MR imaging by using causal network analysis","authors":"Ronghua Mu ,&nbsp;Xiaoyan Qin ,&nbsp;Wei Zheng ,&nbsp;Peng Yang ,&nbsp;Bingqin Huang ,&nbsp;Xiqi Zhu","doi":"10.1016/j.nicl.2024.103672","DOIUrl":"10.1016/j.nicl.2024.103672","url":null,"abstract":"<div><h3>Aims</h3><p>Cerebral small vessel disease (CSVD) is a complex condition characterized by a combination of microcirculation disorders and neurodegenerative processes, CSVD is associated with structural abnormalities in multiple brain regions. However, the progressive pattern of structural changes remains unknown.</p></div><div><h3>Methods</h3><p>In order to detail the progressive structural changes in CSVD patients according to the degree of cognitive impairment, we recruited 121 CSVD patients and 104 healthy controls (HCs). Voxel-based morphometry was employed to measure the gray matter volume (GMV) of each participant. According to the VICCCS-2 diagnostic criteria, patients were initially divided into three stage groups, then we investigated the GMV changes in each stage and their causal relationships using causal structure covariance network (CaSCN) analysis.</p></div><div><h3>Results</h3><p>Overall, patients with CSVD presented stage-specific GMV alterations compared with HCs. With the worsening of cognitive impairment, the decrease in gray matter volume starts from the right hippocampus and gradually spreads to the cortical-subcortical brain regions. Importantly, the right hippocampus in CSVD patients plays a driving role in the directional network and forms both positive and negative causal effect networks with cortical-subcortical brain regions.</p></div><div><h3>Conclusions</h3><p>This study reveals the significance of the right hippocampus as an early pathological area in CSVD patients and its causal impact on brain GMV changes with disease progression, shedding light on structural brain damage hierarchy and compensatory mechanisms.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103672"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221315822400113X/pdfft?md5=120bb78dc1595894fb23ae52088841ee&pid=1-s2.0-S221315822400113X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting state connectivity biomarkers of seizure freedom after epilepsy surgery","authors":"Eva Martinez-Lizana,&nbsp;Armin Brandt,&nbsp;Matthias Dümpelmann,&nbsp;Andreas Schulze-Bonhage","doi":"10.1016/j.nicl.2024.103673","DOIUrl":"10.1016/j.nicl.2024.103673","url":null,"abstract":"<div><p>Alterations in brain networks may cause the lowering of the seizure threshold and hypersynchronization that underlie the recurrence of unprovoked seizures in epilepsy. The aim of this work is to estimate functional network characteristics, which may help predicting outcome of epilepsy surgery.</p><p>Twenty patients were studied (11 females, 9 males, mean age 33 years) with scalp-recorded HD-EEG in resting state (eyes closed, no interictal discharges) before intracranial evaluation, which allowed the precise determination of the epileptogenic zone. Dipole source time courses in the brain were estimated using Weighted Minimum Norm Estimate based on HD-EEG signals. Information inflow and outflow of atlas-based brain regions were computed using partial directed connectivity. A set of graph measures for pairwise connections in standard EEG frequency bands was calculated.</p><p>After epilepsy surgery 10 patients were seizure-free (Engel 1a) and 10 patients continued suffering from seizures (Engel outcome worse than 1a). Inflow of the regions containing the epileptogenic zone in the beta and delta frequency bands was significantly lower in patients who achieved seizure-freedom after surgery, compared with patients who continued to have seizures (p = 0.012, and p = 0.026, respectively). Average path length in the beta frequency band was significantly higher in patients who achieved seizure freedom (p = 0.012). In the delta frequency band, local efficiency and clustering coefficient were significantly higher in patients who achieved seizure freedom (0.033, 0.046).</p><p>In patients who achieved seizure freedom after surgery, the preoperative analysis of the epileptic network exhibited stronger separation of the region containing the seizure onset zone, with less inflow of information. In contrast, shorter paths within the epileptic network may facilitate hypersynchronous neuronal activity and thus the recurrence of seizures in non-seizure free patients. This study supports the hypothesis that epileptic network properties might help to define suitable candidates for epilepsy surgery.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103673"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224001141/pdfft?md5=d4c497901eca9022e5ea1105081c8835&pid=1-s2.0-S2213158224001141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and vascular risk factors for ischemic stroke and cortical morphometry in individuals without a history of stroke: A UK Biobank observational cohort study","authors":"Jiawei Liu ,&nbsp;Yingying Xie ,&nbsp;Feng Liu ,&nbsp;Wen Qin ,&nbsp;Chunshui Yu","doi":"10.1016/j.nicl.2024.103683","DOIUrl":"10.1016/j.nicl.2024.103683","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Stroke risk factors may contribute to cognitive decline and dementia by altering brain tissue integrity. If their effects on brain are nonnegligible, the target regions for stroke rehabilitation with brain stimulation identified by cross-sectional case-control studies may be biased due to the pre-existing brain differences caused by these risk factors. Here, we investigated the effects of stroke risk factors on cortical thickness (CT) and surface area (SA) in individuals without a history of stroke.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In this observational study, we used data from the UK Biobank cohort to explore the effects of polygenic risk score for ischemic stroke (PRS&lt;sub&gt;IS&lt;/sub&gt;), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycated hemoglobin (HbA1c), triglycerides (TG), and low-density lipoprotein (LDL) on CT and SA of 62 cerebral regions. We excluded non-Caucasian participants and participants with missing data, unqualified brain images, or a history of stroke or any other brain diseases. We constructed a multivariate linear regression model for each phenotype to simultaneously test the effect of each factor and interaction between factors. The results were verified by sensitivity analyses of SDP or DBP input and adjusting for body-mass index, high-density lipoprotein cholesterol, or smoking and alcohol intake. By excluding participants with abnormal blood pressure, glucose, or lipid, we tested whether vascular risk factor within normal range also affected cortical phenotypes. To determine clinical relevance of our findings, we also investigated the effects of stroke risk factors and cortical phenotypes on cognitive decline assessed by fluid intelligence score (FIQ) and the mediation of cortical phenotype for the association between stroke risk factor and FIQ.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The study consisted of 27 120 eligible participants. Stroke risk factors were associated with 16 CT and two SA phenotypes in both main and sensitivity analyses (all &lt;em&gt;p &lt;&lt;/em&gt; 0.0004, Bonferroni corrected), which could explain portions of variances (partial &lt;em&gt;R&lt;sup&gt;2&lt;/sup&gt;&lt;/em&gt;, median 0.62 % [IQR 0.44–0.75 %] in main analyses) in these phenotypes. Among the 18 cortical phenotypes associated with stroke risk factors, we identified 26 specific predictor-phenotype associations (all &lt;em&gt;p&lt;/em&gt; &lt; 0.0026), including the positive associations between PRS&lt;sub&gt;IS&lt;/sub&gt; and SA and between HbA1c and CT, negative associations of SBP and TG with CT, and mixed associations of PRS&lt;sub&gt;IS&lt;/sub&gt; and DBP with CT. Neither LDL nor interactions between risk factors affected cortical phenotypes. Of the 16 associations between vascular risk factors and cortical phenotypes, ten were still significant after excluding participants with abnormal vascular risk assessments and diagnoses. Stroke risk factors were associated with FIQ in all analyses (&lt;em&gt;p &lt;&lt;/em&gt; 0.0004; partial &lt;em&gt;R&lt;sup&gt;2&lt;/sup&gt;&lt;/em&gt;, range 0.22","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103683"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain network organization in children with prenatal alcohol exposure","authors":"Xiaoyun Liang ,&nbsp;Claire E. Kelly ,&nbsp;Chun-Hung Yeh ,&nbsp;Thijs Dhollander ,&nbsp;Stephen Hearps ,&nbsp;Peter J. Anderson ,&nbsp;Deanne K. Thompson","doi":"10.1016/j.nicl.2024.103690","DOIUrl":"10.1016/j.nicl.2024.103690","url":null,"abstract":"<div><h3>Introduction</h3><div>There is growing evidence suggesting that children with prenatal alcohol exposure (PAE) struggle with cognitively demanding tasks, such as learning, attention, and language. Complex structural network analyses can provide insight into the neurobiological underpinnings of these functions, as they may be sensitive for characterizing the effects of PAE on the brain. However, investigations on how PAE affects brain networks are limited. We aim to compare diffusion magnetic resonance imaging (MRI) tractography-based structural networks between children with low-to-moderate PAE in trimester 1 only (T1) or throughout all trimesters (T1-T3) with those without alcohol exposure prenatally.</div></div><div><h3>Methods</h3><div>Our cohort included three groups of children aged 6 to 8 years: 1) no PAE (n = 24), 2) low-to-moderate PAE during T1 only (n = 30), 3) low-to-moderate PAE throughout T1-T3 (n = 36). Structural networks were constructed using the multi-shell multi-tissue constrained spherical deconvolution tractography technique. Quantitative group-wise analyses were conducted at three levels: (a) at the whole-brain network level, using both network-based statistical analyses and network centrality; and then using network centrality at (b) the modular level, and (c) per-region level, including the regions identified as brain hubs.</div></div><div><h3>Results</h3><div>Compared with the no PAE group, widespread brain network alterations were observed in the PAE T1-T3 group using network-based statistics, but no alterations were observed for the PAE T1 group. Network alterations were also detected at the module level in the PAE T1-T3 compared with the no PAE group, with lower eigenvector centrality in the module that closely represented the right cortico-basal ganglia-thalamo-cortical network. No significant group differences were found in network centrality at the per-region level, including the hub regions.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that low-to-moderate PAE throughout pregnancy may alter brain structural connectivity, which may explain the neurodevelopmental deficits associated with PAE. It is possible that timing and duration of alcohol exposure are crucial, as PAE in T1 only did not appear to alter brain structural connectivity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103690"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional connectivity of amygdala subregions across different symptom subtypes of obsessive–compulsive disorder patients","authors":"Harah Kwon ,&nbsp;Minji Ha ,&nbsp;Sunah Choi ,&nbsp;Sunghyun Park ,&nbsp;Moonyoung Jang ,&nbsp;Minah Kim ,&nbsp;Jun Soo Kwon","doi":"10.1016/j.nicl.2024.103644","DOIUrl":"10.1016/j.nicl.2024.103644","url":null,"abstract":"<div><h3>Aim</h3><p>Obsessive–compulsive disorder (OCD) is a heterogeneous condition characterized by distinct symptom subtypes, each with varying pathophysiologies and treatment responses. Recent research has highlighted the role of the amygdala, a brain region that is central to emotion processing, in these variations. However, the role of amygdala subregions with distinct functions has not yet been fully elucidated. In this study, we aimed to clarify the biological mechanisms underlying OCD subtype heterogeneity by investigating the functional connectivity (FC) of amygdala subregions across distinct OCD symptom subtypes.</p></div><div><h3>Methods</h3><p>Resting-state functional magnetic resonance images were obtained from 107 medication-free OCD patients and 110 healthy controls (HCs). Using centromedial, basolateral, and superficial subregions of the bilateral amygdala as seed regions, whole-brain FC was compared between OCD patients and HCs and among patients with different OCD symptom subtypes, which included contamination fear and washing, obsessive (i.e., harm due to injury, aggression, sexual, and religious), and compulsive (i.e., symmetry, ordering, counting, and checking) subtypes.</p></div><div><h3>Results</h3><p>Compared to HCs, compulsive-type OCD patients exhibited hypoconnectivity between the left centromedial amygdala (CMA) and bilateral superior frontal gyri. Compared with patients with contamination fear and washing OCD subtypes, patients with compulsive-type OCD showed hypoconnectivity between the left CMA and left frontal cortex.</p></div><div><h3>Conclusions</h3><p>CMA–frontal cortex hypoconnectivity may contribute to the compulsive presentation of OCD through impaired control of behavioral responses to negative emotions. Our findings underscored the potential significance of the distinct neural underpinnings of different OCD manifestations, which could pave the way for more targeted treatment strategies in the future.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103644"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000834/pdfft?md5=3ec12fcf3e3f40efc2058845767e15eb&pid=1-s2.0-S2213158224000834-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative changes in large-scale thalamic circuitry following laser ablation of hypothalamic hamartomas","authors":"Karim Mithani ,&nbsp;Oliver L. Richards ,&nbsp;Mark Ebden ,&nbsp;Noor Malik ,&nbsp;Ladina Greuter ,&nbsp;Hrishikesh Suresh ,&nbsp;Farbod Niazi ,&nbsp;Flavia Venetucci Gouveia ,&nbsp;Elysa Widjaja ,&nbsp;Shelly Weiss ,&nbsp;Elizabeth Donner ,&nbsp;Hiroshi Otsubo ,&nbsp;Ayako Ochi ,&nbsp;Puneet Jain ,&nbsp;Ivanna Yau ,&nbsp;Elizabeth N. Kerr ,&nbsp;James T. Rutka ,&nbsp;James M. Drake ,&nbsp;Alexander G. Weil ,&nbsp;George M Ibrahim","doi":"10.1016/j.nicl.2024.103613","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103613","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Gelastic seizures due to hypothalamic hamartomas (HH) are challenging to treat, in part due to an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser interstitial thermal therapy (MRgLITT) is a promising intervention to disconnect HH from ictal propagation networks, the optimal site of ablation to achieve seizure freedom is not known. In this study, we investigated intraoperative post-ablation changes in resting-state functional connectivity to identify large-scale networks associated with successful disconnection of HH.</p></div><div><h3>Methods</h3><p>Children who underwent MRgLITT for HH at two institutions were consecutively recruited and followed for a minimum of one year. Seizure freedom was defined as Engel score of 1A at the last available follow-up. Immediate pre- and post- ablation resting-state functional MRI scans were acquired while maintaining a constant depth of general anesthetic. Multivariable generalized linear models were used to identify intraoperative changes in large-scale connectivity associated with seizure outcomes.</p></div><div><h3>Results</h3><p>Twelve patients underwent MRgLITT for HH, five of whom were seizure-free at their last follow-up. Intraprocedural changes in thalamocortical circuitry involving the anterior cingulate cortex were associated with seizure-freedom. Children who were seizure-free demonstrated an increase and decrease in connectivity to the pregenual and dorsal anterior cingulate cortices, respectively. In addition, children who became seizure-free demonstrated increased thalamic connectivity to the periaqueductal gray immediately following MRgLITT.</p></div><div><h3>Discussion</h3><p>Successful disconnection of HH is associated with intraoperative, large-scale changes in thalamocortical connectivity. These changes provide novel insights into the large-scale basis of gelastic seizures and may represent intraoperative biomarkers of treatment success.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103613"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000524/pdfft?md5=fd4fa7c1869e26d4f0a6dd5b5488fdac&pid=1-s2.0-S2213158224000524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140843237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural covariance, topological organization, and volumetric features of amygdala subnuclei in posttraumatic stress disorder","authors":"Elizabeth M. Haris ,&nbsp;Richard A. Bryant ,&nbsp;Mayuresh S. Korgaonkar","doi":"10.1016/j.nicl.2024.103619","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103619","url":null,"abstract":"<div><p>The amygdala is divided into functional subnuclei which have been challenging to investigate due to functional magnetic resonance imaging (MRI) limitations in mapping small neural structures. Hence their role in the neurobiology of posttraumatic stress disorder (PTSD) remains poorly understood. Examination of covariance of structural MRI measures could be an alternate approach to circumvent this issue. T1-weighted anatomical scans from a 3 T scanner from non-trauma-exposed controls (NEC; n = 71, 75 % female) and PTSD participants (n = 67, 69 % female) were parcellated into 105 brain regions. Pearson’s <em>r</em> partial correlations were computed for three and nine bilateral amygdala subnuclei and every other brain region, corrected for age, sex, and total brain volume. Pairwise correlation comparisons were performed to examine subnuclei covariance profiles between-groups. Graph theory was employed to investigate subnuclei network topology. Volumetric measures were compared to investigate structural changes.</p><p>We found differences between amygdala subnuclei in covariance with the hippocampus for both groups, and additionally with temporal brain regions for the PTSD group. Network topology demonstrated the importance of the right basal nucleus in facilitating network communication only in PTSD. There were no between-group differences for any of the three structural metrics. These findings are in line with previous work that has failed to find structural differences for amygdala subnuclei between PTSD and controls. However, differences between amygdala subnuclei covariance profiles observed in our study highlight the need to investigate amygdala subnuclei functional connectivity in PTSD using higher field strength fMRI for better spatial resolution.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103619"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000585/pdfft?md5=8f31737373f39e04bf0b2b139e95eae9&pid=1-s2.0-S2213158224000585-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}