Neuroimage-Clinical最新文献

{"title":"Spectral peak analysis and intrinsic neural timescales as markers for the state of consciousness","authors":"Ezequiel Pablo Espinosa ,&nbsp;Di Zang ,&nbsp;Andrea Buccellato ,&nbsp;Zengxin Qi ,&nbsp;Xuehai Wu ,&nbsp;Samira Abbasi ,&nbsp;Yasir Catal ,&nbsp;Stephan Lechner ,&nbsp;Federico Zilio ,&nbsp;Georg Northoff","doi":"10.1016/j.nicl.2024.103698","DOIUrl":"10.1016/j.nicl.2024.103698","url":null,"abstract":"<div><div>Resting state EEG in patients with disorders of consciousness (DOC) is characterized by an increase of power in the delta frequency band and a concurrent decrease in the alpha range, equivalent to a weakening or disappearance of the alpha peak. Prolongation of Intrinsic Neural Timescales (INTs) is also associated with DOCs. Together, this raises the question whether the decreased alpha peak relates to the prolonged INTs and, importantly, how that can be used for diagnosing the state of consciousness in DOC individuals. Analyzing resting state EEG recordings from both healthy subjects and DOC patients, we measure INTs through autocorrelation window (ACW) and utilize peak analysis to quantify the weakening of the alpha peak. First, we replicate previous findings of prolonged ACW in DOC patients. We then identify significantly lower alpha peak measures in DOC compared to controls. Interestingly, spectral peaks shift from the alpha to the theta range in several DOC subjects while such change is absent in healthy controls. Next, our study reveals a close relationship between ACW and alpha peak in both healthy and DOC subjects, a correlation that holds for theta peaks in DOC. Further, the prolonged ACW correlates with the state of consciousness, as quantified by the Coma Recovery Scale-Revised (CRS-R), and mediates the relationship between theta peak and CRS-R. Finally, through split analyses and machine learning, we show that ACW and alpha peak measures conjointly distinguish healthy controls and DOC patients with high accuracy (95.5%). In conclusion, we demonstrate that the prolongation of ACW, together with spectral peak measures, holds promise to serve as additional EEG biomarkers for diagnosing the state of consciousness in DOC subjects.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103698"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain network hierarchy reorganization in subthreshold depression","authors":"Xiaolong Yin ,&nbsp;Junchao Yang ,&nbsp;Qing Xiang ,&nbsp;Lixin Peng ,&nbsp;Jian Song ,&nbsp;Shengxiang Liang ,&nbsp;Jingsong Wu","doi":"10.1016/j.nicl.2024.103594","DOIUrl":"10.1016/j.nicl.2024.103594","url":null,"abstract":"<div><h3>Background</h3><p>Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD.</p></div><div><h3>Methods</h3><p>A total of 43 patients with StD and 43 healthy controls matched for age, gender and years of education participated in this study. Alterations in the hierarchy of StD brain networks were depicted by connectome gradient analysis. We assessed changes in network hierarchy by comparing gradient scores in each network in patients with StD and healthy controls. The study compared different brain subdivisions if there was a different network. Finally, we analysed the relationship between the altered gradient scores and clinical characteristics.</p></div><div><h3>Results</h3><p>Patients with StD had contracted network hierarchy and suppressed cortical range gradients. In the principal gradient, the gradient scores of default mode network were significantly reduced in patients with StD compared to controls. In the default network, the subdivisions of reduced gradient scores were mainly located in the precuneus, superior temporal gyrus, and anterior and posterior cingulate gyrus. Reduced gradient scores in the default mode network, the anterior and posterior cingulate gyrus were correlated with severity of depression.</p></div><div><h3>Conclusions</h3><p>The network hierarchy of the StD changed and was significantly correlated with depressive symptoms and severity. These results provided new insights into further understanding of the neural mechanisms of StD.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103594"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000330/pdfft?md5=b74f0c09ebfbb4c6423a71a1908a07e0&pid=1-s2.0-S2213158224000330-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140149157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between low-moderate prenatal alcohol exposure and brain development in childhood","authors":"Deanne K. Thompson ,&nbsp;Claire E. Kelly ,&nbsp;Thijs Dhollander ,&nbsp;Evelyne Muggli ,&nbsp;Stephen Hearps ,&nbsp;Sharon Lewis ,&nbsp;Thi-Nhu-Ngoc Nguyen ,&nbsp;Alicia Spittle ,&nbsp;Elizabeth J. Elliott ,&nbsp;Anthony Penington ,&nbsp;Jane Halliday ,&nbsp;Peter J. Anderson","doi":"10.1016/j.nicl.2024.103595","DOIUrl":"10.1016/j.nicl.2024.103595","url":null,"abstract":"<div><h3>Background</h3><p>The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied.</p></div><div><h3>Aim</h3><p>To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE.</p></div><div><h3>Methods</h3><p>Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). <em>T₁</em>-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre density and cross-section (FDC) metrics were computed for diffusion images. Brain measures were compared between PAE groups adjusted for age and sex, then additionally for intracranial volume.</p></div><div><h3>Results</h3><p>After adjustments, the right caudal anterior cingulate cortex volume (<em>p</em>_FDR = 0.045) and area (<em>p</em>_FDR = 0.008), and right cingulum tract cross-sectional area (p_FWE &lt; 0.05) were smaller in children exposed to alcohol throughout gestation compared with no PAE.</p></div><div><h3>Conclusion</h3><p>This study reports a relationship between low-moderate PAE throughout gestation and cingulate cortex and cingulum tract alterations, suggesting a teratogenic vulnerability. Further investigation is warranted.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103595"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000342/pdfft?md5=5577d6a07bcc6ec27a7102de4be0170e&pid=1-s2.0-S2213158224000342-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Inaccurate reference leads to tripling of reported FND prevalence","authors":"","doi":"10.1016/j.nicl.2023.103537","DOIUrl":"10.1016/j.nicl.2023.103537","url":null,"abstract":"","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103537"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158223002280/pdfft?md5=7be2ad3e60bc6d926b4da2173575b7e7&pid=1-s2.0-S2213158223002280-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional magnetic resonance imaging alternations in suicide attempts individuals and their association with gene expression","authors":"Yurong Jiang ,&nbsp;Yujing Zhou ,&nbsp;Yingying Xie ,&nbsp;Junzi Zhou ,&nbsp;Mengjing Cai ,&nbsp;Jie Tang ,&nbsp;Feng Liu ,&nbsp;Juanwei Ma ,&nbsp;Huaigui Liu","doi":"10.1016/j.nicl.2024.103645","DOIUrl":"10.1016/j.nicl.2024.103645","url":null,"abstract":"<div><h3>Background</h3><p>Functional Magnetic Resonance Imaging (fMRI) has shown brain activity alterations in individuals with a history of attempted suicide (SA) who are diagnosed with depression disorder (DD) or bipolar disorder (BD). However, patterns of spontaneous brain activity and their genetic correlations need further investigation.</p></div><div><h3>Methods</h3><p>A voxel-based meta-analysis of 19 studies including 26 datasets, involving 742 patients with a history of SA and 978 controls (both nonsuicidal patients and healthy controls) was conducted. We examined fMRI changes in SA patients and analyzed the association between these changes and gene expression profiles using data from the Allen Human Brain Atlas by partial least squares regression analysis.</p></div><div><h3>Results</h3><p>SA patients demonstrated increased spontaneous brain activity in several brain regions including the bilateral inferior temporal gyrus, hippocampus, fusiform gyrus, and right insula, and decreased activity in areas like the bilateral paracentral lobule and inferior frontal gyrus. Additionally, 5,077 genes were identified, exhibiting expression patterns associated with SA-related fMRI alterations. Functional enrichment analyses demonstrated that these SA-related genes were enriched for biological functions including glutamatergic synapse and mitochondrial structure. Concurrently, specific expression analyses showed that these genes were specifically expressed in the brain tissue, in neurons cells, and during early developmental periods.</p></div><div><h3>Conclusion</h3><p>Our findings suggest a neurobiological basis for fMRI abnormalities in SA patients with DD or BD, potentially guiding future genetic and therapeutic research.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103645"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000846/pdfft?md5=56e252b53890b72e28938425d4c6c178&pid=1-s2.0-S2213158224000846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of cannabis abstinence on cognition and resting state network activity in people with multiple sclerosis: A preliminary study","authors":"Cecilia Meza ,&nbsp;Cristiana Stefan ,&nbsp;W. Richard Staines ,&nbsp;Anthony Feinstein","doi":"10.1016/j.nicl.2024.103622","DOIUrl":"10.1016/j.nicl.2024.103622","url":null,"abstract":"<div><p>We previously reported that people with multiple sclerosis (pwMS) who have been using cannabis frequently over many years can have significant cognitive improvements accompanied by concomitant task-specific changes in brain activation following 28 days of cannabis abstinence. We now hypothesize that the default Mode Network (DMN), known to modulate cognition, would also show an improved pattern of activation align with cognitive improvement following 28 days of drug abstinence. Thirty three cognitively impaired pwMS who were frequent cannabis users underwent a neuropsychological assessment and fMRI at baseline. Individuals were then assigned to a cannabis continuation (CC, n = 15) or withdrawal (CW, n = 18) group and the cognitive and imaging assessments were repeated after 28 days. Compliance with cannabis withdrawal was checked with regular urine monitoring. Following acquisition of resting state fMRI (rs-fMRI), data were processed using independent component analysis (ICA) to identify the DMN spatial map. Between and within group analyses were carried out using dual regression for voxel-wise comparisons of the DMN. Clusters of voxels were considered statistically significant if they survived threshold-free cluster enhancement (TFCE) correction at p &lt; 0.05. The two groups were well matched demographically and neurologically at baseline. The dual regression analysis revealed no between group differences at baseline in the DMN. By day 28, the CW group in comparison to the CC group had increased activation in the left posterior cingulate, and right, angular gyrus (p &lt; 0.05 for both, TFCE). A within group analysis for the CC group revealed no changes in resting state (RS) networks. Within group analysis of the CW group revealed increased activation at day 28 versus baseline in the left posterior cingulate, right angular gyrus, left hippocampus (BA 36), and the right medial prefrontal cortex (p &lt; 0.05). The CW group showed significant improvements in multiple cognitive domains. In summary, our study revealed that abstaining from cannabis for 28 days reverses activation of DMN activity in pwMS in association with improved cognition across several domains.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103622"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000615/pdfft?md5=d9bdc95e60dc5908dfaa506569befb19&pid=1-s2.0-S2213158224000615-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Concerning the Publication: Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda. Perez DL et al. Neuroimage Clin. 2021;30:102623","authors":"David L. Perez ,&nbsp;Timothy R. Nicholson ,&nbsp;Ali A. Asadi-Pooya ,&nbsp;Matthew Butler ,&nbsp;Alan J. Carson ,&nbsp;Anthony S. David ,&nbsp;Quinton Deeley ,&nbsp;Ibai Diez ,&nbsp;Mark J. Edwards ,&nbsp;Alberto J. Espay ,&nbsp;Jeannette M. Gelauff ,&nbsp;Johannes Jungilligens ,&nbsp;Mark Hallett ,&nbsp;Richard A.A. Kanaan ,&nbsp;Marina A.J. Tijssen ,&nbsp;Kasia Kozlowska ,&nbsp;W. Curt LaFrance Jr ,&nbsp;Ramesh S. Marapin ,&nbsp;Carine W. Maurer ,&nbsp;Antje A.T.S. Reinders ,&nbsp;Selma Aybek","doi":"10.1016/j.nicl.2024.103573","DOIUrl":"10.1016/j.nicl.2024.103573","url":null,"abstract":"","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103573"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000123/pdfft?md5=204a8ef614e6cdf3453e1db622844587&pid=1-s2.0-S2213158224000123-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review","authors":"Noa van der Knaap ,&nbsp;Marcel J.H. Ariës ,&nbsp;Iwan C.C. van der Horst ,&nbsp;Jacobus F.A. Jansen","doi":"10.1016/j.nicl.2024.103589","DOIUrl":"10.1016/j.nicl.2024.103589","url":null,"abstract":"<div><p>Many Coronavirus Disease 2019 (COVID-19) patients are suffering from long-term neuropsychological sequelae. These patients may benefit from a better understanding of the underlying neuropathophysiological mechanisms and identification of potential biomarkers and treatment targets. Structural clinical neuroimaging techniques have limited ability to visualize subtle cerebral abnormalities and to investigate brain function. This scoping review assesses the merits and potential of advanced neuroimaging techniques in COVID-19 using literature including advanced neuroimaging or postmortem analyses in adult COVID-19 patients published from the start of the pandemic until December 2023. Findings were summarized according to distinct categories of reported cerebral abnormalities revealed by different imaging techniques. Although no unified COVID-19-specific pattern could be subtracted, a broad range of cerebral abnormalities were revealed by advanced neuroimaging (likely attributable to hypoxic, vascular, and inflammatory pathology), even in absence of structural clinical imaging findings. These abnormalities are validated by postmortem examinations. This scoping review emphasizes the added value of advanced neuroimaging compared to structural clinical imaging and highlights implications for brain functioning and long-term consequences in COVID-19.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103589"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000287/pdfft?md5=eccc069183d7afa5cd550c1fc32aaac6&pid=1-s2.0-S2213158224000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive clinical and imaging trajectories in SWEDD and Parkinson’s disease patients","authors":"Cecilia Boccalini ,&nbsp;Nicolas Nicastro ,&nbsp;Daniela Perani ,&nbsp;Valentina Garibotto","doi":"10.1016/j.nicl.2024.103592","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103592","url":null,"abstract":"<div><p>A proportion of patients clinically diagnosed with Parkinson’s disease (PD) can have a ¹²³I-FP-CIT-SPECT scan without evidence of dopaminergic deficit (SWEDD), generating a debate about the underlying biological mechanisms. This study investigated differences in clinical features, ¹²³I-FP-CIT binding, molecular connectivity, as well as clinical and imaging progression between SWEDD and PD patients.</p><p>We included 36 SWEDD, 49 de novo idiopathic PD, and 49 healthy controls with ¹²³I-FP-CIT-SPECT from the Parkinson’s Progression Markers Initiative. Clinical and imaging 2-year follow-ups were available for 27 SWEDD and 40 PD. Regional-based and voxel-wise analysis assessed dopaminergic integrity in dorsal and ventral striatal, as well as extrastriatal regions, at baseline and follow-up. Molecular connectivity analyses evaluated dopaminergic pathways. Spatial correlation analyses tested whether ¹²³I-FP-CIT-binding alterations would also pertain to the serotoninergic system.</p><p>SWEDD and PD patients showed comparable symptoms at baseline, except for hyposmia, which was more severe for PD. PD showed significantly lower striatal and extrastriatal ¹²³I-FP-CIT-binding compared to SWEDD and controls. SWEDD exhibited lower binding than controls in striatal regions, insula, and olfactory cortex. Both PD and SWEDD showed extensive altered connectivity of dopaminergic pathways, however, with major impairment in the mesocorticolimbic system for SWEDD. Motor symptoms and dopaminergic deficits worsened after 2 years for PD only.</p><p>The limited dopaminergic impairment and its stability over time observed for SWEDD, as well as the presence of extrastriatal ¹²³I-FP-CIT binding alterations and prevalent mesocorticolimbic connectivity impairment, suggest other mechanisms contributing to SWEDD pathophysiology.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103592"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000317/pdfft?md5=8a6d5a97ff53058ff801b76cb499ac2a&pid=1-s2.0-S2213158224000317-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity","authors":"Mónika Gálber ,&nbsp;Szilvia Anett Nagy ,&nbsp;Gergely Orsi ,&nbsp;Gábor Perlaki ,&nbsp;Maria Simon ,&nbsp;Boldizsár Czéh","doi":"10.1016/j.nicl.2024.103632","DOIUrl":"10.1016/j.nicl.2024.103632","url":null,"abstract":"<div><h3>Background</h3><p>Childhood maltreatment (CM) is a major risk factor for the development of major depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence the development of brain architecture, we studied functional connectivity (FC) alterations of neural networks of depressed patients with, or without the history of CM.</p></div><div><h3>Methods</h3><p>Depressed patients with severe childhood maltreatment (<em>n</em> = 18), MDD patients without maltreatment (<em>n</em> = 19), and matched healthy controls (<em>n</em> = 20) were examined with resting state functional MRI. History of maltreatment was assessed with the 28-item Childhood Trauma Questionnaire. Intra- and inter-network FC alterations were evaluated using FMRIB Software Library and CONN toolbox.</p></div><div><h3>Results</h3><p>We found numerous intra- and inter-network FC alterations between the maltreated and the non-maltreated patients. Intra-network FC differences were found in the default mode, visual and auditory networks, and cerebellum. Network modelling revealed several inter-network FC alterations connecting the default mode network with the executive control, salience and cerebellar networks. Increased inter-network FC was found in maltreated patients between the sensory-motor and visual, cerebellar, default mode and salience networks.</p></div><div><h3>Limitations</h3><p>Relatively small sample size, cross-sectional design, and retrospective self-report questionnaire to assess adverse childhood experiences.</p></div><div><h3>Conclusions</h3><p>Our findings confirm that severely maltreated depressed patients display numerous alterations of intra- and inter-network FC strengths, not only in their fronto-limbic circuits, but also in sensory-motor, visual, auditory, and cerebellar networks. These functional alterations may explain that maltreated individuals typically display altered perception and are prone to develop functional neurological symptom disorder (conversion disorder) in adulthood.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103632"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000718/pdfft?md5=a97c5d34105fe2b943bc524d2688fcac&pid=1-s2.0-S2213158224000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}