Neuroimage-Clinical最新文献

筛选
英文 中文
Can repetitive transcranial magnetic stimulation promote recovery of consciousness in patients with disorders of consciousness? A randomized controlled trial
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103802
Zhenyu Liu , Shanshan Wu , Shuwei Wang , Huijuan Wu , Hongliang Gao , Xiao Lu
{"title":"Can repetitive transcranial magnetic stimulation promote recovery of consciousness in patients with disorders of consciousness? A randomized controlled trial","authors":"Zhenyu Liu ,&nbsp;Shanshan Wu ,&nbsp;Shuwei Wang ,&nbsp;Huijuan Wu ,&nbsp;Hongliang Gao ,&nbsp;Xiao Lu","doi":"10.1016/j.nicl.2025.103802","DOIUrl":"10.1016/j.nicl.2025.103802","url":null,"abstract":"<div><h3>Background</h3><div>Disorders of consciousness (DoC) are characterized by a broad decline in background excitatory synaptic activity and varying levels of cerebral network disruption. Repetitive transcranial magnetic stimulation (rTMS), a neuromodulatory technique, is anticipated to assist the recovery of consciousness. Nonetheless, ongoing debates persist regarding its effectiveness, in light of the inconsistent results of recent research.</div></div><div><h3>Objective</h3><div>The purpose of this study is to investigate the efficacy of rTMS in promoting recovery of consciousness in patients with DoC and to probe its impact on activity of cerebral functional networks.</div></div><div><h3>Methods</h3><div>Forty-eight patients with DoC were included in this randomized controlled trial (Chinese Clinical Trial Registry: ChiCTR2100044930). Twenty-four patients in the control group accepted conventional therapy. Another 24 patients in the rTMS group received extra rTMS over the dorsolateral prefrontal cortex (DLPFC) once per workday during a 4-week intervention phase. Primary outcome was the proportion of patients emerging improvement on level of consciousness (LOC) based on coma recovery scale- revised (CRS-R) at the end of intervention. Furthermore, other behavioral scales such as the clinical global impression-improvement (CGI-I) and resting state-electroencephalography (rs-EEG) microstate were employed as secondary outcomes. Different microstates served as tools to detect the activity of respective corresponding resting state cerebral functional networks.</div></div><div><h3>Results</h3><div>In comparison to the control group, the rTMS group exhibited a higher proportion of patients emerging improvement on LOC at post-intervention, with a risk ratio of 3.06 (95 % CI 1.54 to 6.09, P = 0.001). The distribution of patients with each grade of CGI-I across the groups also implied a trend that favored the rTMS group (common odds ratio:0.20, 95 % CI 0.065 to 0.63, P = 0.006). With respect to microstate E, the rTMS group had a significantly reduced global explained variance (GEV) was observed in the rTMS group (Z = -2.61, P<sub>bonf</sub> = 0.027).</div></div><div><h3>Conclusion</h3><div>High-frequency rTMS over the DLPFC could promote recovery of consciousness in patients with DoC. It might get involved in modulating the balance among cerebral functional networks and facilitating consciousness recovery.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103802"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network-targeted transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI) 网络靶向经颅磁刺激(TMS)治疗轻度认知障碍
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103819
Joy L. Taylor , Priyanka Bhatt , Beatriz Hernandez , Michael Iv , Maheen M. Adamson , Alesha Heath , Jerome A. Yesavage , Margaret Windy McNerney
{"title":"Network-targeted transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI)","authors":"Joy L. Taylor ,&nbsp;Priyanka Bhatt ,&nbsp;Beatriz Hernandez ,&nbsp;Michael Iv ,&nbsp;Maheen M. Adamson ,&nbsp;Alesha Heath ,&nbsp;Jerome A. Yesavage ,&nbsp;Margaret Windy McNerney","doi":"10.1016/j.nicl.2025.103819","DOIUrl":"10.1016/j.nicl.2025.103819","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial magnetic stimulation (TMS) is a promising non-pharmacological intervention for treatment of mild cognitive impairment (MCI) and early Alzheimer’s disease (AD). Yet, we know little about precisely where stimulation would be ideal to improve cognitive function.</div></div><div><h3>Objective</h3><div>To examine the network functional connectivity (fc) characteristics of prefrontal and parietal stimulation sites, given that these sites have led to improved cognitive function in TMS studies involving MCI-AD and unimpaired participants.</div></div><div><h3>Methods</h3><div>Resting-state functional MRI data were acquired from 32 MCI participants at the baseline visit of an ongoing TMS trial and used to compute connectivity with prefrontal and parietal stimulation locations, selected on the basis of previous TMS studies. The TMS seed maps were examined for extent of spatial overlap with eight canonical networks. After identifying the network most likely to be targeted by TMS, we applied strategies that may provide purer targeting. Finally, we examined network connectivity in relation to participants’ behavioral characteristics because of the potential for TMS treatment to be personalized.</div></div><div><h3>Results</h3><div>The prefrontal TMS seed map overlapped primarily with the salience network. The prefrontal site is also notable for its anti-correlated connectivity with the AD-vulnerable posterior cingulate cortex (PCC). The parietal TMS seed map showed the expected strong positive connectivity with the PCC and other default network regions. Nonetheless, this particular parietal site may simultaneously modulate the fronto-parietal network. Strategies to improve network targeting and to personalize TMS are reported as secondary findings.</div></div><div><h3>Conclusion</h3><div>These results can be applied to network-targeted brain stimulation for MCI and early AD treatment. Greater precision and personalization of TMS offer the promise of achieving better outcomes for individuals with MCI or mild AD dementia.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103819"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of traumatic brain Injury, post-traumatic stress disorder on Amyloid-β associated network hyperconnectivity and progression of gray matter atrophy 创伤性脑损伤、创伤后应激障碍对淀粉样蛋白-β相关网络超连通性和灰质萎缩进展的影响
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103810
Susanne G. Mueller
{"title":"The effects of traumatic brain Injury, post-traumatic stress disorder on Amyloid-β associated network hyperconnectivity and progression of gray matter atrophy","authors":"Susanne G. Mueller","doi":"10.1016/j.nicl.2025.103810","DOIUrl":"10.1016/j.nicl.2025.103810","url":null,"abstract":"<div><h3>Background</h3><div>Amyloid-β associated network hypersynchrony is an early manifestation of pre-clinical Alzheimer’s Disease (AD). The overall goal was to investigate a. how TBI and PTSD influence hypersynchrony expression and b. how progressing gray matter atrophy affects hypersynchrony expression.</div></div><div><h3>Methods</h3><div>T1-weighted images, resting-state fMRIs and amyloid-β SUVRs were obtained from 234 DoD-ADNI subjects with or without TBI and/or PTSD. The denoised BOLD signal from 382 rois was extracted with CONN and dynamic resting state analysis was used to identify 8 states including one corresponding to a hypersynchrony state (HSS). SuStaIn with gray matter volumes and amyloid-β SUVR as inputs was used to identify 2 subtypes with progressive gray matter loss.</div></div><div><h3>Results</h3><div>HSS dwell-time correlated positively with amyloid-β (Kendall tau = 0.125,p = 0.047) and tau Braak stage 5&amp;6 SUVR (Kendall tau = 0.200,p = 0.035). TBI increased the likelihood to observe the HSS (81 % with vs. 18 % wo TBI p &lt; 0.001) as did a diagnosis of PTSD (67.4 % with vs. 32.6 % wo PTSD, p = 0.003). The SuStaIn subtypes differed mostly by the timing of the amyloid-β build-up but not by atrophy pattern. Subtype 2 had higher amyloid-β loads and longer HSS dwell-times than subtype 1 that had higher CAPS scores than subtype 2. Gray matter atrophy did not influence HSS dwell-time.</div></div><div><h3>Conclusion</h3><div>TBI and PTSD increased the likelihood to observe HSS. HSS dwell time was determined by AD pathology severity. The subtype characteristics indicate that PTSD drives gray matter loss in subtype 1 and AD pathology that in subtype 2. Severity of gray matter atrophy influenced neither HSS occurrence nor intensity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103810"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural connectome manifold changes related to body mass index and their associations with eating psychopathology 身体质量指数相关的结构连接体多样性变化及其与饮食精神病理的关系
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103817
Yurim Jang , Jong Young Namgung , Eunchan Noh , Bo-yong Park
{"title":"Structural connectome manifold changes related to body mass index and their associations with eating psychopathology","authors":"Yurim Jang ,&nbsp;Jong Young Namgung ,&nbsp;Eunchan Noh ,&nbsp;Bo-yong Park","doi":"10.1016/j.nicl.2025.103817","DOIUrl":"10.1016/j.nicl.2025.103817","url":null,"abstract":"<div><div>Brain connectome analysis provides insights into body mass index (BMI)-related brain topology and cognitive functions. While alterations in the brain connectome have been observed in individuals with high BMI, evidence regarding BMI-based structural connectome alteration remains limited. In this study, we analyzed diffusion magnetic resonance imaging tractography-derived structural connectivity from 283 neurologically healthy participants by generating low-dimensional features using dimensionality reduction techniques. Two key metrics were calculated: manifold eccentricity, which indicates the relative distance of each brain region from the center of the low-dimensional manifold space, and manifold differentiation, which represents the distance between brain regions within the manifold space. Our findings revealed that individuals with high BMI exhibited greater expansion and differentiation in the control, default mode, and somatomotor networks, reflecting increased network segregation. In contrast, the visual and limbic networks displayed higher integration. Furthermore, network communication measures based on search information and path transitivity indicated less efficient communication between low-level sensory and higher-order transmodal networks in individuals with high BMI. Finally, significant associations were identified between the manifold features in the prefrontal and somatomotor regions and eating behaviors, as assessed by self-report measures from the Eating Disorder Examination Questionnaire (EDEQ) and the Three-Factor Eating Questionnaire (TFEQ). These results highlight the critical role of structural connectome organization in describing BMI and eating behaviors.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103817"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states 颅脑损伤后的脑活动动态表明状态转换能量增加,对低阶状态的偏好增加
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103799
Nate Roy , S. Parker Singleton , Keith Jamison , Pratik Mukherjee , Sudhin A. Shah , Amy Kuceyeski
{"title":"Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states","authors":"Nate Roy ,&nbsp;S. Parker Singleton ,&nbsp;Keith Jamison ,&nbsp;Pratik Mukherjee ,&nbsp;Sudhin A. Shah ,&nbsp;Amy Kuceyeski","doi":"10.1016/j.nicl.2025.103799","DOIUrl":"10.1016/j.nicl.2025.103799","url":null,"abstract":"<div><div>Traumatic Brain Injury (TBI) can cause structural damage to the neural tissue and white matter connections in the brain, disrupting its functional coactivation patterns. Although there are a wealth of studies investigating TBI-related changes in the brain’s structural and functional connectomes, fewer studies have investigated TBI-related changes to the brain’s dynamic landscape. Network control theory is a framework that integrates structural connectomes and functional time-series to quantify brain dynamics. Using this approach, we analyzed longitudinal trajectories of brain dynamics from acute to chronic injury phases in two cohorts of individuals with mild and moderate to severe TBI, and compared them to non-brain-injured, age- and sex-matched control individuals’ trajectories. Our analyses suggest individuals with mild TBI initially have brain activity dynamics similar to controls but then shift in the subacute and chronic stages of the injury (1 month and 12 months post-injury) to favor lower-order visual-dominant states compared to higher-order default mode dominant states. We further find that, compared to controls, individuals with mild TBI have overall decreased entropy and increased transition energy demand in the sub-acute and chronic stages that correlates with poorer attention performance. Finally, we found that the asymmetry in top-down to bottom-up transition energies increased in subacute and chronic stages of mild TBI, possibly indicating decreased efficacy of top-down inhibition. We replicate most findings with the moderate to severe TBI dataset, indicating their robustness, with the notable exception of finding the opposite correlation between global transition energy and mean reaction time (MRT). We attribute differences to the cohorts’ varied injury severity, with perhaps a stronger compensatory mechanism in moderate to severe TBI. Overall, our findings reveal shifting brain dynamics after mild to severe TBI that relate to behavioral measures of attention, shedding light on post-injury mechanisms of recovery.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103799"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington’s disease: a [18F]SynVesT-1 study zQ175DN小鼠亨廷顿病模型突触密度变化的评估:一项[18F]SynVesT-1研究
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103800
Liesbeth Everix , Franziska Zajicek , Annemie Van Eetveldt , Longbin Liu , Jonathan Bard , Steven Staelens , Daniele Bertoglio
{"title":"Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington’s disease: a [18F]SynVesT-1 study","authors":"Liesbeth Everix ,&nbsp;Franziska Zajicek ,&nbsp;Annemie Van Eetveldt ,&nbsp;Longbin Liu ,&nbsp;Jonathan Bard ,&nbsp;Steven Staelens ,&nbsp;Daniele Bertoglio","doi":"10.1016/j.nicl.2025.103800","DOIUrl":"10.1016/j.nicl.2025.103800","url":null,"abstract":"<div><div>Huntington’s disease (HD) is a neurodegenerative disorder characterized by involuntary movements, cognitive decline and psychiatric problems. HD has been associated with synaptic dysfunction and loss of the synaptic vesicle protein 2A (SV2A). SV2A can readily be quantified via positron emission tomography (PET) using the selective and high affinity SV2A radiotracer [<sup>18</sup>F]SynVesT-1 that we previously characterized in C57BL/6J mice. Here, we performed dynamic [<sup>18</sup>F]SynVesT-1 PET to characterize SV2A levels at various disease stages in another HD mouse model, zQ175DN, at 3 and 6 months (M) (longitudinal) and 10 M and 16 M (cross-sectional). We also conducted <em>ex vivo</em> SV2A immunofluorescent staining and [<sup>3</sup>H]UCB-J and [<sup>3</sup>H]SynVesT-1 autoradiography at 16 M. Dynamic [<sup>18</sup>F]SynVesT-1 PET revealed comparable <em>V</em><sub>T(IDIF)</sub> values between male and female 3 M and 6 M old zQ175DN mice. A significant age effect was found in the motor cortex and hippocampus between 3 M and 6 M. From 3 M to 10 M, no significant difference was found between heterozygous and wild-type mice. At 16 M, however, significant <em>V</em><sub>T(IDIF)</sub> differences were observed between genotypes in the motor cortex (−9.1 ± 3.5 %, <em>p</em> = 0.038), hippocampus (−7.5 ± 3.3, <em>p</em> = 0.036) and thalamus (−8.9 ± 3.1 %, <em>p</em> = 0.016). <em>Ex vivo</em> analyses did not confirm the observed deficits at 16 M, likely due to the decreased sensitivity compared to PET. However, [<sup>3</sup>H]SynVesT-1 and [<sup>3</sup>H]UCB-J autoradiography displayed the same outcome, ruling out a radioligand-specific effect. [<sup>18</sup>F]SynVesT-1 PET identified mild SV2A deficits in the zQ175DN model of HD at 16 M, whereas no significant SV2A deficits were detected at younger ages.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103800"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder 伏隔核亚区基线静息状态功能连通性在重度抑郁症抗抑郁治疗中的作用
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103842
Yun Wang , Jingjing Zhou , Xiongying Chen , Rui Liu , Zhifang Zhang , Yuan Feng , Yuan Zhou , Gang Wang
{"title":"Role of baseline resting-state functional connectivity of the nucleus accumbens subregions in antidepressant treatment in major depressive disorder","authors":"Yun Wang ,&nbsp;Jingjing Zhou ,&nbsp;Xiongying Chen ,&nbsp;Rui Liu ,&nbsp;Zhifang Zhang ,&nbsp;Yuan Feng ,&nbsp;Yuan Zhou ,&nbsp;Gang Wang","doi":"10.1016/j.nicl.2025.103842","DOIUrl":"10.1016/j.nicl.2025.103842","url":null,"abstract":"<div><div>The nucleus accumbens (NAc) plays a crucial role in the pathophysiology of major depressive disorder (MDD), and abnormal resting-state functional connectivity (rsFC) of NAc subregions has been found in MDD. However, it is unclear whether the altered rsFC of NAc subregions can predict the efficacy of antidepressant treatment, and whether antidepressants are capable of restoring the altered rsFC of NAc subregions in MDD. The purpose of this study was to investigate the role of rsFC of the NAc subregions in antidepressant treatment for MDD. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 46 unmedicated MDD patients at baseline and after 12 weeks of escitalopram treatment, along with fMRI data from 58 healthy controls (HCs). We examined group differences in rsFC of the NAc subregions between MDD patients and HCs, explored whether the altered rsFC at baseline was associated with treatment efficacy, and evaluated whether antidepressant treatment could normalize rsFC abnormalities in the NAc subregions in MDD. Compared to HCs, MDD patients exhibited decreased rsFC between the NAc subregions and the middle cingulate cortex (MCC). Lower levels of rsFC between the NAc subregions and the MCC at baseline predicted greater improvement in depressive symptoms. Furthermore, rsFC between the NAc subregions and the MCC increased following antidepressant treatment in MDD. Our findings suggest that rsFC alterations between the NAc subregions and the MCC may serve as a potential biomarker for predicting antidepressant treatment efficacy, and that dysfunction in the frontal-ventral striatum circuitry may represent a key therapeutic target for MDD.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"48 ","pages":"Article 103842"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Correspondence between thalamic injury-induced changes in resting-state fMRI of monkeys and their sensorimotor behaviors and neural activities”. [NeuroImage Clin. 45 (2025) 103753] “丘脑损伤引起的猴子静息状态fMRI变化与其感觉运动行为和神经活动之间的对应关系”的更正。神经影像临床,45(2025)103753。
IF 3.6 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2025.103869
Anirban Sengupta , Pai-Feng Yang , Jamie L. Reed , Arabinda Mishra , Feng Wang , Isaac V. Manzanera Esteve , Zhangyan Yang , Li Min Chen , John C. Gore
{"title":"Corrigendum to “Correspondence between thalamic injury-induced changes in resting-state fMRI of monkeys and their sensorimotor behaviors and neural activities”. [NeuroImage Clin. 45 (2025) 103753]","authors":"Anirban Sengupta ,&nbsp;Pai-Feng Yang ,&nbsp;Jamie L. Reed ,&nbsp;Arabinda Mishra ,&nbsp;Feng Wang ,&nbsp;Isaac V. Manzanera Esteve ,&nbsp;Zhangyan Yang ,&nbsp;Li Min Chen ,&nbsp;John C. Gore","doi":"10.1016/j.nicl.2025.103869","DOIUrl":"10.1016/j.nicl.2025.103869","url":null,"abstract":"","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103869"},"PeriodicalIF":3.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normative modeling of brain MRI data identifies small subcortical volumes and associations with cognitive function in youth with fetal alcohol spectrum disorder (FASD) 脑MRI数据的规范建模识别出患有胎儿酒精谱系障碍(FASD)的青少年皮质下体积小,与认知功能相关。
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2024.103722
Blake A. Gimbel , Donovan J. Roediger , Mary E. Anthony , Abigail M. Ernst , Kent A. Tuominen , Bryon A. Mueller , Erik de Water , Madeline N. Rockhold , CIFASD, Jeffrey R. Wozniak
{"title":"Normative modeling of brain MRI data identifies small subcortical volumes and associations with cognitive function in youth with fetal alcohol spectrum disorder (FASD)","authors":"Blake A. Gimbel ,&nbsp;Donovan J. Roediger ,&nbsp;Mary E. Anthony ,&nbsp;Abigail M. Ernst ,&nbsp;Kent A. Tuominen ,&nbsp;Bryon A. Mueller ,&nbsp;Erik de Water ,&nbsp;Madeline N. Rockhold ,&nbsp;CIFASD,&nbsp;Jeffrey R. Wozniak","doi":"10.1016/j.nicl.2024.103722","DOIUrl":"10.1016/j.nicl.2024.103722","url":null,"abstract":"<div><h3>Aim</h3><div>To quantify regional subcortical brain volume anomalies in youth with fetal alcohol spectrum disorder (FASD), assess the relative sensitivity and specificity of abnormal volumes in FASD vs. a comparison group, and examine associations with cognitive function.</div></div><div><h3>Method</h3><div>Participants: 47 children with FASD and 39 typically-developing comparison participants, ages 8–17 years, who completed physical evaluations, cognitive and behavioral testing, and an MRI brain scan. A large normative MRI dataset that controlled for sex, age, and intracranial volume was used to quantify the developmental status of 7 bilateral subcortical regional volumes. Z-scores were calculated based on volumetric differences from the normative sample. T-tests compared subcortical volumes across groups. Percentages of atypical volumes are reported as are sensitivity and specificity in discriminating groups. Lastly, Pearson correlations examined the relationships between subcortical volumes and neurocognitive performance.</div></div><div><h3>Results</h3><div>Participants with FASD demonstrated lower mean volumes across a majority of subcortical regions relative to the comparison group with prominent group differences in the bilateral hippocampi and bilateral caudate. More individuals with FASD (89%) had one or more abnormally small volume compared to 72% of the comparison group. The bilateral hippocampi, bilateral putamen, and right pallidum were most sensitive in discriminating those with FASD from the comparison group. Exploratory analyses revealed associations between subcortical volumes and cognitive functioning that differed across groups.</div></div><div><h3>Conclusion</h3><div>In this sample, youth with FASD had a greater number of atypically small subcortical volumes than individuals without FASD. Findings suggest MRI may have utility in identifying individuals with structural brain anomalies resulting from PAE.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103722"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex hormones shape EEG-based functional connectivity in early-stage Parkinson’s disease patients 性激素塑造早期帕金森病患者基于脑电图的功能连接。
IF 3.4 2区 医学
Neuroimage-Clinical Pub Date : 2025-01-01 DOI: 10.1016/j.nicl.2024.103721
Matteo Conti , Roberta Bovenzi , Mariangela Pierantozzi , Clara Simonetta , Valerio Ferrari , Jacopo Bissacco , Rocco Cerroni , Claudio Liguori , Francesca Di Giuliano , Nicola Biagio Mercuri , Tommaso Schirinzi , Alessandro Stefani
{"title":"Sex hormones shape EEG-based functional connectivity in early-stage Parkinson’s disease patients","authors":"Matteo Conti ,&nbsp;Roberta Bovenzi ,&nbsp;Mariangela Pierantozzi ,&nbsp;Clara Simonetta ,&nbsp;Valerio Ferrari ,&nbsp;Jacopo Bissacco ,&nbsp;Rocco Cerroni ,&nbsp;Claudio Liguori ,&nbsp;Francesca Di Giuliano ,&nbsp;Nicola Biagio Mercuri ,&nbsp;Tommaso Schirinzi ,&nbsp;Alessandro Stefani","doi":"10.1016/j.nicl.2024.103721","DOIUrl":"10.1016/j.nicl.2024.103721","url":null,"abstract":"<div><div>Parkinson’s disease (PD) epidemiology and clinical features are sexually dimorphic. However, there are no data based on EEG functional connectivity (FC). Likewise, the contribution of sex hormones on brain FC has never been evaluated. Here, we aimed to investigate the association between biological sex and sex hormones on cortical FC changes in PD using high-density EEG. This study involved 69 early-stage PD patients (F/M 27/42) and 69 age-matched healthy controls (HC) (F/M 30/39). Sex hormone levels (total-testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH)) were assessed in PD patients. Data were recorded with a 64-channel EEG system. Source reconstruction method was used to identify brain activity. Cortico-cortical FC was analysed based on the weighted phase-lag index (wPLI) in θ-α-β-low γ bands. Network-based statistic (NBS) was used to compare FC between genders in HC and PD and to study the relationship between FC and sex hormones in PD. PD exhibited a hypoconnected network at θ and α bands and a hyperconnected network at β band compared to HC. Male HC showed a hyperconnected network at α-band compared to female HC. Conversely, males with PD showed a hypoconnected network at α-band compared to females with PD. In females and males with PD, E2 positively correlated with α-FC, while gonadotropins positively correlated with β-FC. TT positively correlated with the θ-FC only in males. Sex hormones shape EEG-FC in both males and females with PD, supporting their major influence on PD pathophysiology.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103721"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信