Neuroimage-Clinical最新文献

{"title":"Characterising grey-white matter relationships in recent-onset psychosis and its association with cognitive function","authors":"Yoshito Saito ,&nbsp;Christos Pantelis ,&nbsp;Vanessa Cropley ,&nbsp;Liliana Laskaris ,&nbsp;Cassandra M.J. Wannan ,&nbsp;Warda T. Syeda","doi":"10.1016/j.nicl.2025.103824","DOIUrl":"10.1016/j.nicl.2025.103824","url":null,"abstract":"<div><div>Individuals with recent-onset psychosis (ROP) present widespread grey matter (GM) reductions and white matter (WM) abnormalities. While prior studies used univariate approaches, understanding how multiple GM regions relate to WM tracts is important, as psychosis involves network-level brain dysfunction. Understanding characteristic GM-WM patterns may also clarify the basis of cognitive impairments, which are potentially linked to network dysfunction in psychosis. Using multivariate analysis, we examined whole-brain GM-WM relationships and their association with cognitive abilities in ROP.</div><div>We used T1 and diffusion-weighted images from 71 non-affective ROP individuals (age 22.09 ± 3.08) and 71 matched controls (age 22.05 ± 3.21). We performed multiblock partial least squares correlation (MB-PLS-C) to identify GM-WM patterns based on GM thickness or surface area and WM fractional anisotropy (FA), and examined their associations with cognitive abilities.</div><div>MB-PLS-C identified a ‘GM thickness’–‘WM FA’ pattern representing group differences, explaining 12.38 % of the variance and associated with frontal and temporal GM regions and seven WM tracts around subcortical structures. MB-PLS-C also identified a ‘GM surface area’–‘WM FA’ pattern showing group differences, explaining 18.92 % and related with cingulate, frontal, temporal, and parietal GM regions and 15 WM tracts, including the inferior cerebellar peduncle and corona radiata. The ‘GM thickness’–‘WM FA’ pattern describing group differences was significantly correlated with processing speed in ROP.</div><div>MB-PLS-C identified differential whole-brain GM-WM relationships, indicating a potential signature of brain alterations in ROP. Our findings of a relationship between processing speed and GM-WM patterns for GM thickness have implications for our understanding of brain-behaviour relationships in psychosis.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103824"},"PeriodicalIF":3.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults with down syndrome exhibit altered somatosensory cortical inhibition","authors":"Jiraros Meejang ,&nbsp;Morgan T. Busboom ,&nbsp;Sarah E. Baker ,&nbsp;Yasra Arif ,&nbsp;Olyvia Kastner ,&nbsp;Tony W. Wilson ,&nbsp;Max J. Kurz","doi":"10.1016/j.nicl.2025.103797","DOIUrl":"10.1016/j.nicl.2025.103797","url":null,"abstract":"<div><div>Down syndrome (DS) is a developmental genetic disorder that is associated with an accelerated aging profile and high probability of early incidence Alzheimer’s disease like symptoms. It is well established that there are morphological differences in the brains of adults with DS, but the net impact of the genetic disruption on cortical function remains poorly understood. To address this knowledge gap, we used magnetoencephalographic (MEG) brain imaging to assess the somatosensory cortical activity elicited by a paired-pulse electrical stimulation of the right median nerve of adults with DS (N = 19; Age = 28.05 ± 7.9 yrs.) and neurotypical controls (NT) (N = 21; Age = 30.81 ± 8.2 yrs.). sLORETA was used to image neural responses to the somatosensory stimulation, which were centered on the left central sulcus posterior to the motor hand knob region. Our results revealed that adults with DS had weaker somatosensory cortical activity after the second electrical stimulation in the paired-pulse paradigm (DS = 594.1 ± 194.22 AU; NT = 750.48 ± 256.6; P = 0.038) and a pronounced hyper-gating response (DS = 78.9 ± 6.8 %; NT = 87.4 ± 9.9 %; P = 0.003). Together, these results suggest that adults with DS may have an imbalance in the excitatory/inhibitory ratio. These novel data enhance our understanding of the neurophysiological aberrations associated with DS and may hold promise in understanding the origins of Alzheimer’s disease like symptoms in this population. Future studies should examine whether these inhibitory alterations are restricted to the sensorimotor cortices or extend across the brain.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103797"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing Autism and ADHD subtypes using cortical signatures of the T1w/T2w-ratio and morphometry","authors":"Linn B. Norbom ,&nbsp;Bilal Syed ,&nbsp;Rikka Kjelkenes ,&nbsp;Jaroslav Rokicki ,&nbsp;Antoine Beauchamp ,&nbsp;Stener Nerland ,&nbsp;Azadeh Kushki ,&nbsp;Evdokia Anagnostou ,&nbsp;Paul Arnold ,&nbsp;Jennifer Crosbie ,&nbsp;Elizabeth Kelley ,&nbsp;Robert Nicolson ,&nbsp;Russell Schachar ,&nbsp;Margot J. Taylor ,&nbsp;Lars T. Westlye ,&nbsp;Christian K. Tamnes ,&nbsp;Jason P. Lerch","doi":"10.1016/j.nicl.2025.103736","DOIUrl":"10.1016/j.nicl.2025.103736","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental conditions that share genetic etiology and frequently co-occur. Given this comorbidity and well-established clinical heterogeneity, identifying individuals with similar brain signatures may be valuable for predicting clinical outcomes and tailoring treatment strategies. Cortical myelination is a prominent developmental process, and its disruption is a candidate mechanism for both disorders. Yet, no studies have attempted to identify subtypes using T1w/T2w-ratio, a magnetic resonance imaging (MRI) based proxy for intracortical myelin. Moreover, cortical variability arises from numerous biological pathways, and multimodal approaches can integrate cortical metrics into a single network. We analyzed data from 310 individuals aged 2.6–23.6 years, obtained from the Province of Ontario Neurodevelopmental (POND) Network consisting of individuals diagnosed with ASD (n = 136), ADHD (n = 100), and typically developing (TD) individuals (n = 74). We first tested for differences in T1w/T2w-ratio between diagnostic categories and controls. We then performed unimodal (T1w/T2w-ratio) and multimodal (T1w/T2w-ratio, cortical thickness, and surface area) spectral clustering to identify diagnostic-blind subgroups. Linear models revealed no statistically significant case-control differences in T1w/T2w-ratio. Unimodal clustering mostly isolated single individual- or minority clusters, driven by image quality and intensity outliers. Multimodal clustering suggested three distinct subgroups, which transcended diagnostic boundaries, showing separate cortical patterns but similar clinical and cognitive profiles. T1w/T2w-ratio features were the most relevant for demarcation, followed by surface area. While our analysis revealed no significant case-control differences, multimodal clustering incorporating the T1w/T2w-ratio among cortical features holds promise for identifying biologically similar subsets of individuals with neurodevelopmental conditions.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103736"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotransmitter imbalance, glutathione depletion and concomitant susceptibility increase in Parkinson’s disease","authors":"Su Yan ,&nbsp;Bingfang Duan ,&nbsp;Yuanhao Li ,&nbsp;Hongquan Zhu ,&nbsp;Zhaoqi Shi ,&nbsp;Xiaoxiao Zhang ,&nbsp;Yuanyuan Qin ,&nbsp;Wenzhen Zhu","doi":"10.1016/j.nicl.2025.103740","DOIUrl":"10.1016/j.nicl.2025.103740","url":null,"abstract":"<div><h3>Background</h3><div>Emerging insights into the pathophysiology of Parkinson’s disease (PD) underscore the involvement of dysregulated neurotransmission, iron accumulation and oxidative stress. Nonetheless, the excitatory and inhibitory neurometabolites, the antioxidant glutathione (GSH), and magnetic susceptibility are seldom studied together in the clinical PD literature.</div></div><div><h3>Methods</h3><div>We acquired MEGA-PRESS and multi-echo gradient echo sequences from 60 PD patients and 47 healthy controls (HCs). Magnetic resonance spectroscopy voxels were respectively positioned in the midbrain to quantify neurotransmitter including γ-aminobutyric acid (GABA) and glutamate plus glutamine, and in the left striatum to estimate GSH levels. Group differences in metabolite levels normalized to total creatine (Cr) and their clinical relevance were determined. Furthermore, relationships among GSH levels, neurotransmitter estimates and susceptibility values were explored in both PD patients and HCs.</div></div><div><h3>Results</h3><div>PD patients exhibited reduced midbrain GABA levels (P = 0.034, P_FDR = 0.136), diminished GSH in the left striatum (P = 0.032, P_FDR = 0.096), and increased susceptibility values in the substantia nigra (P_FDR &lt; 0.001). Mesencephalic choline levels were correlated with the severity of rapid eye movement sleep behavior disorders symptoms, whereas striatal N-acetylaspartate levels were linked to Hoehn-Yahr stage and motor symptom severity. Notably, the disruption of associations between striatal GSH levels and susceptibility values in globus pallidus, as well as midbrain GABA levels, were evident in PD.</div></div><div><h3>Conclusions</h3><div>These findings offer compelling evidence for metabolic dysregulation in PD, characterized by a concomitant reduction in GABA and GSH levels, alongside iron deposition.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103740"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased glymphatic system activity and thalamic vulnerability in drug-naive somatic depression: Evidenced by DTI-ALPS index","authors":"Zipeng Deng ,&nbsp;Wei Wang ,&nbsp;Zhaowen Nie ,&nbsp;Simeng Ma ,&nbsp;Enqi Zhou ,&nbsp;Xinhui Xie ,&nbsp;Qian Gong ,&nbsp;Lihua Yao ,&nbsp;Lihong Bu ,&nbsp;Lijun Kang ,&nbsp;Zhongchun Liu","doi":"10.1016/j.nicl.2025.103769","DOIUrl":"10.1016/j.nicl.2025.103769","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a significant contributor to global disease burden, with somatic symptoms frequently complicating its diagnosis and treatment. Recent advances in neuroimaging have provided insights into the neurobiological underpinnings of MDD, yet the role of the glymphatic system remains largely unexplored. This study aimed to assess glymphatic function in drug-naïve somatic depression (SMD) patients using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. A total of 272 participants, including somatic depression patients (SMD), pure depression (PMD), and healthy controls (HC), were enrolled. We collected T1-weighted (T1w) and DTI (diffusion tensor image) scans and clinical data of all participants. The DTI-ALPS indices were calculated and compared among three groups. Gray matter regions associated with the DTI-ALPS index were identified by voxel-based morphometry analysis (VBM), revealing a cluster located in the thalamus. Then, we performed partial correlation analyses to further investigate the relationships between the DTI-ALPS index, thalamic volume, and clinical data. The DTI-ALPS index was significantly higher in the MDD group compared to the HC group, particularly in the SMD group. Furthermore, a significant positive correlation was observed between the DTI-ALPS index and thalamic volume, with lower DTI-ALPS values associated with reduced thalamic volumes, especially in the SMD group. Our findings suggest heightened glymphatic activity in MDD patients, especially SMD patients, and a potential link between glymphatic function and thalamic vulnerability. Therefore, the thalamus’ vulnerability to glymphatic system function may play a role in the pathophysiology of depression, particularly somatic depression, suggesting that both the glymphatic system and the thalamus could serve as potential therapeutic or intervention targets for future treatments.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103769"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered functional connectivity of brainstem ARAS nuclei unveils the mechanisms of disorders of consciousness in sTBI: an exploratory study","authors":"Peng Zhang ,&nbsp;Yinan Zhou ,&nbsp;Haoqi Ni ,&nbsp;Zhaoneng Huang ,&nbsp;Can Tang ,&nbsp;Qichuan Zhuge ,&nbsp;Lun Dong ,&nbsp;Jun Zhang","doi":"10.1016/j.nicl.2025.103787","DOIUrl":"10.1016/j.nicl.2025.103787","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the functional connectivity (FC) characteristics of Ascending Reticular Activating System (ARAS) in patients with disorders of consciousness (DOC) following severe traumatic brain injury (sTBI), while introducing the Linear support vector machine (LSVM) to predict the recovery of consciousness.</div></div><div><h3>Methods</h3><div>Resting-state MRI was used to measure FC changes between the brainstem ARAS nuclei and whole-brain voxels. We compared the differences in FC between sTBI patients and healthy controls, as well as between the wake and DOC groups. Furthermore, the LSVM model for consciousness recovery was developed based on the Z-values of regions of interest (ROIs) and/or scale to distinguish the prognosis of sTBI patients.</div></div><div><h3>Results</h3><div>A total of 28 sTBI patients with DOC and 30 healthy controls were included, with no significant baseline differences (<em>p</em> &gt; 0.05). Using the brainstem ARAS nuclei as the ROI, we observed increased FC in the subcortical regions compared to healthy controls. The strength of FC was significantly different between patients who recovered consciousness and those who did not at 6 months post-sTBI (AlphaSim corrected, p &lt; 0.05, Cluster &gt; 154). Furthermore, the LSVM model demonstrated strong predictive performance, with an area under the receiver operating characteristic curve of 0.81–0.98.</div></div><div><h3>Conclusions</h3><div>Our study suggest that the disruption FC of ARAS from the subcortex to the cortex may be associated with DOC and prognosis in sTBI patients. Furthermore, the LSVM model shows potential value in distinguishing the recovery of consciousness.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103787"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical overview of the use of amyloid-PET Centiloid values in clinical trials and research","authors":"Leonardo Iaccarino ,&nbsp;Samantha C. Burnham ,&nbsp;Ilke Tunali ,&nbsp;Jian Wang ,&nbsp;Michael Navitsky ,&nbsp;Anupa K. Arora ,&nbsp;Michael J. Pontecorvo","doi":"10.1016/j.nicl.2025.103765","DOIUrl":"10.1016/j.nicl.2025.103765","url":null,"abstract":"<div><div>The density of brain amyloid-beta neuritic plaque accumulation, a marker of Alzheimer’s disease (AD), can be visualized and quantified using amyloid-positron emission tomography (PET). Amyloid-PET data can be obtained using different tracers and methodologies; therefore, comparison across studies can be difficult. The introduction of Centiloids in 2015 allowed for the transformation of amyloid-PET quantitative data to a common scale, enhancing comparability across studies and potentially enabling pooled analysis. Since then, Centiloid values have been used increasingly in research and clinical trials for multiple purposes, being tested and validated with a variety of clinical, biomarker and pathological standards of truth. In clinical trials, Centiloid values have been used for patient selection, to confirm the presence of AD pathology, as well as for treatment monitoring, especially in trials of disease-modifying treatments such as amyloid-targeting therapies. Building on their widespread adoption, Centiloid values are increasingly being integrated into commercially available software solutions for quantifying amyloid-PET, paving the way for real-world applications at the community level. This article addresses frequently asked questions about Centiloid definition, implementation, interpretation, and caveats, and also summarizes the available literature on published thresholds, ultimately supporting wider access and informed use of Centiloid values in Alzheimer’s disease research.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103765"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term BCI intervention enhances functional brain connectivity associated with motor performance in chronic stroke","authors":"Khosrov A. Grigoryan ,&nbsp;Karsten Mueller ,&nbsp;Matthias Wagner ,&nbsp;Diaa Masri ,&nbsp;Kerrin J. Pine ,&nbsp;Arno Villringer ,&nbsp;Bernhard Sehm","doi":"10.1016/j.nicl.2025.103772","DOIUrl":"10.1016/j.nicl.2025.103772","url":null,"abstract":"<div><h3>Background</h3><div>Evidence suggests that brain-computer interface (BCI)-based rehabilitation strategies show promise in overcoming the limited recovery potential in the chronic phase of stroke. However, the specific mechanisms driving motor function improvements are not fully understood.</div></div><div><h3>Objective</h3><div>We aimed at elucidating the potential functional brain connectivity changes induced by BCI training in participants with chronic stroke.</div></div><div><h3>Methods</h3><div>A longitudinal crossover design was employed with two groups of participants over the span of 4 weeks to allow for within-subject (n = 21) and cross-group comparisons. Group 1 (n = 11) underwent a 6-day motor imagery-based BCI training during the second week, whereas Group 2 (n = 10) received the same training during the third week. Before and after each week, both groups underwent resting state functional MRI scans (4 for Group 1 and 5 for Group 2) to establish a baseline and monitor the effects of BCI training.</div></div><div><h3>Results</h3><div>Following BCI training, an increased functional connectivity was observed between the medial prefrontal cortex of the default mode network (DMN) and motor-related areas, including the premotor cortex, superior parietal cortex, SMA, and precuneus. Moreover, these changes were correlated with the increased motor function as confirmed with upper-extremity Fugl-Meyer assessment scores, measured before and after the training.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that BCI training can enhance brain connectivity, underlying the observed improvements in motor function. They provide a basis for developing novel rehabilitation approaches using non-invasive brain stimulation for targeting functionally relevant brain regions, thereby augmenting BCI-induced neuroplasticity and enhancing motor recovery.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103772"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered neural signalling during reward anticipation in children and early adolescents with high psychotic-like experiences","authors":"Pritha Sen ,&nbsp;Franziska Knolle","doi":"10.1016/j.nicl.2025.103756","DOIUrl":"10.1016/j.nicl.2025.103756","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is associated with abnormalities in neurodevelopmental processes. Furthermore, dysfunctional neural circuits involved in reward processing may be linked to the development of symptoms in schizophrenia and are predictive of long-term functional outcome. It is however unknown whether neural signatures of reward anticipation are detectable in children with high psychotic-like experiences.</div></div><div><h3>Methods</h3><div>Using data from the ABCD study 4.1, we defined a healthy control (N = 50) and a high psychotic-like experience (N = 50) group with a Prodromal Psychosis Syndrome (PPS) score &gt; 3 and distress score &gt; 6 at baseline (9–10 years) and 2nd year follow-up (11–12 years). While undergoing functional MR-imaging, all children completed the Monetary Incentive Delay task. Using the preprocessed ABCD-data, we explored whether behaviour and brain activations for reward and loss anticipation in areas underlying reward processing differed between groups and time-points. Furthermore, we investigated whether those brain activations that showed differences between the groups were predictive of later PPS scores. Additionally, we also employed computational modelling to assess response vigour.</div></div><div><h3>Results</h3><div>While response times did not differ, the computational model revealed that response vigour for salient cues was significantly lower in the high PLEs compared to controls at baseline. We also found that children with high PLEs demonstrated lower activation during reward anticipation in the anterior insula at the baseline time-point; the nucleus accumbens, the putamen, the dorsolateral (dlPFC) and the ventral medial prefrontal cortex at the 2nd year follow-up, and in the caudate at both timepoints, compared to controls. Regression analysis revealed that deactivations in the left anterior insula and left dlPFC, was predictive of later PPS scores.</div></div><div><h3>Conclusion</h3><div>This study reveals that neural alterations during reward anticipation are detectable in children with high PLEs. These dysfunctions in neural activation patterns may serve as potential predictive biomarkers for psychosis.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103756"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural brain alterations and changes in resting-state functional connectivity in patients with trigeminal neuralgia: A meta-analysis","authors":"Lapo Nardoni ,&nbsp;Maria Giulia Tullo ,&nbsp;Giulia Di Stefano ,&nbsp;Marco Fiorelli ,&nbsp;Francesca Caramia","doi":"10.1016/j.nicl.2025.103759","DOIUrl":"10.1016/j.nicl.2025.103759","url":null,"abstract":"<div><h3>Background</h3><div>Trigeminal neuralgia (TN) is a chronic pain condition characterized by severe, electric shock-like pain in one or more branches of the trigeminal nerve. Even though neuroimaging studies have highlighted alterations in brain cortical and subcortical structure and functional connectivity, findings are heterogeneous.</div></div><div><h3>Objective</h3><div>This <em>meta</em>-analysis aims to synthesize structural and functional brain changes in TN patients through a coordinate-based <em>meta</em>-analysis using GingerALE.</div></div><div><h3>Methods</h3><div>A search on PubMed, Google Scholar, and Scopus was conducted to select pertinent publications on structural magnetic resonance imaging (MRI) (brain volume and cortical thickness) and resting-state functional MRI in TN patients that were published before January 2024. Activation likelihood estimation (ALE) was used to identify consistent brain alteration patterns across studies.</div></div><div><h3>Results</h3><div>A total of 1436 papers were identified and, after review based on the predefined inclusion and exclusion criteria, 13 papers (538 patients) discussing structural brain changes and 11 studies (368 patients) discussing resting-state functional connectivity studies were selected for inclusion. Structural and functional alterations in TN were observed in the left thalamus.</div></div><div><h3>Conclusions</h3><div>This <em>meta</em>-analysis provides a comprehensive examination of structural and functional abnormalities in TN patients, highlighting consistent alterations in left thalamus. Future research should identify brain structural and functional changes specific for TN as compared to other forms of chronic pain, explore longitudinal changes correlated to clinical parameters, and perform intra-population studies to address lateralization, to enhance diagnostic and therapeutic outcomes for TN patients.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103759"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}