Neuroimage-Clinical最新文献

{"title":"Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study","authors":"Jun Kanzawa ,&nbsp;Ryo Kurokawa ,&nbsp;Tsunehiko Takamura ,&nbsp;Nobuhiro Nohara ,&nbsp;Kouhei Kamiya ,&nbsp;Yoshiya Moriguchi ,&nbsp;Yasuhiro Sato ,&nbsp;Yumi Hamamoto ,&nbsp;Tomotaka Shoji ,&nbsp;Tomohiko Muratsubaki ,&nbsp;Motoaki Sugiura ,&nbsp;Shin Fukudo ,&nbsp;Yoshiyuki Hirano ,&nbsp;Yusuke Sudo ,&nbsp;Rio Kamashita ,&nbsp;Sayo Hamatani ,&nbsp;Noriko Numata ,&nbsp;Koji Matsumoto ,&nbsp;Eiji Shimizu ,&nbsp;Naoki Kodama ,&nbsp;Osamu Abe","doi":"10.1016/j.nicl.2025.103737","DOIUrl":"10.1016/j.nicl.2025.103737","url":null,"abstract":"<div><div>Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103737"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional near-infrared spectroscopy in neurodegenerative diseases – A systematic review","authors":"Franziska Albrecht ,&nbsp;Alexander Kvist ,&nbsp;Erika Franzén","doi":"10.1016/j.nicl.2025.103733","DOIUrl":"10.1016/j.nicl.2025.103733","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review and summarize alterations found in resting-state activity as measured via functional near-infrared spectroscopy (fNIRS) in neurodegenerative diseases.</div></div><div><h3>Background</h3><div>fNIRS is a novel and emerging neuroimaging method suitable for a variety of study designs. Resting-state is the measure of brain activity in the absence of a task, which has been investigated for yielding information about neurodegenerative diseases, mainly using magnetic resonance imaging. We aimed to systematically review the usage of resting-state fNIRS (rsfNIRS) in neurodegenerative diseases.</div></div><div><h3>Inclusion criteria</h3><div>Studies investigating people diagnosed with a neurodegenerative disease and resting-state activity obtained with fNIRS using at least two channels.</div></div><div><h3>Methods</h3><div>We searched three databases for publications. After the screening, 16 studies were included in the systematic review. The quality of the studies was assessed, and data were extracted. Data were qualitatively synthesized and in the case of at least 10 similar studies, a meta-analysis was planned.</div></div><div><h3>Results</h3><div>Most studies investigated Mild cognitive impairment (50%), followed by Alzheimer’s disease (25%). Other neurodegenerative diseases encompassed Parkinson’s disease, Multiple sclerosis, and Amyotrophic lateral sclerosis. All studies reported oxygenated hemoglobin. Still, studies were heterogeneous in terms of study design, measurement duration, fNIRS device, montage, pre-processing, and analyses. A meta-analysis was not considered possible due to this heterogeneity.</div></div><div><h3>Conclusion</h3><div>rsfNIRS shows promise in neurodegenerative disease, as most studies have observed resting-state alterations when compared to healthy controls. However, inconsistencies across studies limit data comparison and meta-analysis. Hence, we strongly advocate the application of fNIRS reporting guidelines and the establishment of rsfNIRS-specific guidelines. This will ensure reliable and comparable results in future research.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103733"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and functional changes of Post-Stroke Depression: A multimodal magnetic resonance imaging study","authors":"Qiuhong Lu ,&nbsp;Shunzu Lu ,&nbsp;Xue Wang ,&nbsp;Yanlan Huang ,&nbsp;Jie Liu ,&nbsp;Zhijian Liang","doi":"10.1016/j.nicl.2025.103743","DOIUrl":"10.1016/j.nicl.2025.103743","url":null,"abstract":"<div><div>This study investigated changes in gray matter volume (GMV), white matter microstructure, and spontaneous brain activity in post-stroke depression (PSD) using multiple MRI techniques, including neurite orientation dispersion and density imaging (NODDI). Changes in GMV, neurite density index (NDI), orientation dispersion index (ODI), fraction of isotropic water (ISO), diffusion tensor imaging (DTI) parameters, and the amplitude of frequency fluctuations (ALFF) were assessed between PSD (n = 20), post-stroke without depression (n = 20), and normal control (n = 20) groups. Receiver operating characteristic (ROC) curve analysis was performed to test the classification performance of the variant parameters of each MRI modality, each single MRI modality and multiple MRI modality. Compared to patients with post-stroke without depression (non-PSD), those with PSD showed increased ODI and ISO in the widespread white matter, as well as increased ALFF in the left pallidum. No significant differences in the GMV or DTI parameters were observed between the two groups. Furthermore, the ODI of the right superior longitudinal fasciculus and NODDI showed the best classification performance for PSD at their respective comparison level (the areas under the ROC curves (AUC) = 0.917(0.000), 0.933(0.000)). The model of NODDI-derived parameters combined with non-diffusion MRI modality parameters (i.e., GMV and ALFF) showed better diagnostic performance than that of DTI-derived parameters. These findings suggest that PSD is associated with structural and functional abnormalities that may contribute to depressive symptoms. Additionally, NODDI showed its advantages in the description of structural alterations in emotion-related white matter pathways and classification performance in PSD.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103743"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa","authors":"Katrien F.M. Bracké ,&nbsp;Laura Monteiro Rente Dias ,&nbsp;Marisha N. Meijer ,&nbsp;Cathelijne P.M. Steegers ,&nbsp;Laurinde F. den Heijer ,&nbsp;Tess van der Harst ,&nbsp;Marjolein H.G. Dremmen ,&nbsp;Meike W. Vernooij ,&nbsp;Gwen C. Dieleman ,&nbsp;Tonya White","doi":"10.1016/j.nicl.2025.103745","DOIUrl":"10.1016/j.nicl.2025.103745","url":null,"abstract":"<div><h3>Objective</h3><div>Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent findings. Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN.</div></div><div><h3>Methods</h3><div>Functional MRI (fMRI) of brain resting-state functional connectivity (RS-FC) of female adolescents with first-onset AN (n = 56) were compared to age- and education-matched typically developing (TD) adolescents (n = 64). To account for the severity of underweight, separate analyses were performed to investigate differences in RS-FC between underweight AN participants and TD adolescents, as well as between underweight (n = 30) and weight-restored AN (n = 26) participants. Clinical outcomes, i.e. body mass index and eating disorder (ED) symptoms, were assessed at baseline and one-year follow-up. Independent component analyses (ICA) were used to extract the brain networks of interest: the default mode (DMN), left and right frontoparietal (FPN), and the insular (IN) networks. Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms.</div></div><div><h3>Results</h3><div>Underweight AN participants had lower RS-FC between the DMN-IN, as well as between the FPN-IN compared to the TD adolescents. After correction for multiple testing, no significant differences in RS-FC were found between underweight AN participants and weight-restored AN participants, as well as between the whole AN group and the TD group. RS-FC was not associated with the severity of clinical symptoms at baseline nor at one-year of follow-up.</div></div><div><h3>Conclusion</h3><div>AN is associated with changes in RS-FC between the FPN-IN and DMN-IN during the underweight state. These changes in RS-FC were no longer observed in weight-restored AN participants, emphasizing the impact of underweight on RS-FC in AN. Changes in these brain networks may partly explain the impaired cognitive control and difficulties with emotion and behavioral regulation in individuals with AN during the underweight state.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103745"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task","authors":"A.A. Vergani ,&nbsp;S. Mazzeo ,&nbsp;V. Moschini ,&nbsp;R. Burali ,&nbsp;M. Lassi ,&nbsp;L.G. Amato ,&nbsp;J. Carpaneto ,&nbsp;G. Salvestrini ,&nbsp;C. Fabbiani ,&nbsp;G. Giacomucci ,&nbsp;C. Morinelli ,&nbsp;F. Emiliani ,&nbsp;M. Scarpino ,&nbsp;S. Bagnoli ,&nbsp;A. Ingannato ,&nbsp;B. Nacmias ,&nbsp;S. Padiglioni ,&nbsp;S. Sorbi ,&nbsp;V. Bessi ,&nbsp;A. Grippo ,&nbsp;A. Mazzoni","doi":"10.1016/j.nicl.2025.103760","DOIUrl":"10.1016/j.nicl.2025.103760","url":null,"abstract":"<div><div>Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease stages lack well-defined electrophysiological correlates, creating a critical gap in the identification of robust biomarkers for early diagnosis and intervention. In this study, we analysed event-related potentials (ERPs) recorded during a sustained visual attention task in a cohort of 178 individuals (119 SCD, 40 MCI, and 19 healthy subjects, HS) to investigate sensory and cognitive processing alterations associated with these conditions. SCD patients exhibited significant attenuation in both sensory (P1, N1, P2) and cognitive (P300, P600, P900) components compared to HS, with cognitive components showing performance-related gains. In contrast, MCI patients did not show a further decrease in any ERP component compared to SCD. Instead, they exhibited compensatory enhancements, reversing the downward trend observed in SCD. This compensation resulted in a non-monotonic pattern of ERP alterations across clinical conditions, suggesting that MCI patients engage neural mechanisms to counterbalance sensory and cognitive deficits. These findings support the use of electrophysiological markers in support of medical decision-making, enhancing personalized prognosis and guiding targeted interventions in cognitive decline.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103760"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area","authors":"Pavel Filip ,&nbsp;Andrej Lasica ,&nbsp;Dimitra Kiakou ,&nbsp;Karsten Mueller ,&nbsp;Jiří Keller ,&nbsp;Dušan Urgošík ,&nbsp;Daniel Novák ,&nbsp;Robert Jech","doi":"10.1016/j.nicl.2025.103750","DOIUrl":"10.1016/j.nicl.2025.103750","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is a well-established, effective treatment for dystonia. Substantial variability of therapeutic success has been the one of the drivers of an ongoing debate about proper stimulation site and settings, with several indications of the notional sweet spot pointing to the lower GPi or even subpallidal area.</div></div><div><h3>Methods</h3><div>The presented patient-blinded, random-order study with cross-sectional verification against healthy controls enrolled 17 GPi DBS idiopathic, cervical or generalised dystonia patients to compare the effect of the stimulation in the upper and lower GPi area, with the focus on sensorimotor network connectivity and local activity measured using functional magnetic resonance.</div></div><div><h3>Results</h3><div>Stimulation brought both these parameters to levels closer to the state detected in healthy controls. This effect was much more pronounced during the stimulation in the lower GPi area or beneath it than in slightly higher positions, with stimulation-related changes detected by both metrics of interest in the sensorimotor cortex, striatum, thalamus and cerebellum.</div></div><div><h3>Conclusions</h3><div>All in all, this study not only replicated the results of previous studies on GPi DBS as a modality restoring sensorimotor network connectivity and local activity in dystonia towards the levels in healthy population, but also showed that lower GPi area or even subpallidal structures, be it white matter or even small, but essential nodes in the zona incerta as nucleus basalis of Meynert, are important regions to consider when programming DBS in dystonia patients.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103750"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease","authors":"John McFadden ,&nbsp;Julian Matthews ,&nbsp;Lauren Scott ,&nbsp;Karl Herholz ,&nbsp;Ben Dickie ,&nbsp;Hamied Haroon ,&nbsp;Oliver Sparasci ,&nbsp;Saadat Ahmed ,&nbsp;Natalia Kyrtata ,&nbsp;Geoffrey J.M. Parker ,&nbsp;Hedley C.A. Emsley ,&nbsp;Joel Handley ,&nbsp;Maélène Lohezic ,&nbsp;Laura M. Parkes","doi":"10.1016/j.nicl.2025.103746","DOIUrl":"10.1016/j.nicl.2025.103746","url":null,"abstract":"<div><div>Cerebrovascular disease is an important contributor to dementia with reductions in cerebral blood flow (CBF) potentially compromising oxygen supply. In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO₂). We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO₂, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO₂, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. ATT rose by 132 ms per 10 point increase in QRisk and there was a trend for reduced CBF. Compensatory increases in OEF occurred in association with modified ATT and CBF, preserving CMRO₂. There was no regional variation to these relationships. Cognitive impairment was associated with prolonged ATT. These findings demonstrate the potential use of multi-delay time ASL and Quantitative Susceptibility Mapping for the early detection of cerebrovascular changes and provide evidence for compensatory increases in oxygen extraction in the presence of reduced blood flow.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103746"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143316184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity abnormalities in clinical variants of progressive supranuclear palsy","authors":"Irene Sintini ,&nbsp;Farwa Ali ,&nbsp;Yehkyoung Stephens ,&nbsp;Heather M. Clark ,&nbsp;Julie A. Stierwalt ,&nbsp;Mary M. Machulda ,&nbsp;Ryota Satoh ,&nbsp;Keith A. Josephs ,&nbsp;Jennifer L. Whitwell","doi":"10.1016/j.nicl.2024.103727","DOIUrl":"10.1016/j.nicl.2024.103727","url":null,"abstract":"<div><div>Progressive supranuclear palsy (PSP) can present with different clinical variants which show distinct, but partially overlapping, patterns of neurodegeneration and tau deposition in a network of regions including cerebellar dentate, superior cerebellar peduncle, midbrain, thalamus, basal ganglia, and frontal lobe. We sought to determine whether disruptions in functional connectivity within this PSP network measured using resting-state functional MRI (rs-fMRI) differed between PSP-Richardson’s syndrome (PSP-RS) and the cortical and subcortical clinical variants of PSP. Structural MRI and rs-fMRI scans were collected for 36 PSP-RS, 25 PSP-cortical and 34 PSP-subcortical participants who met the Movement Disorder Society PSP clinical criteria. Ninety participants underwent flortaucipir-PET scans. MRIs were processed using CONN Toolbox. Functional connectivity between regions of the PSP network was compared between each PSP group and 83 healthy controls, and between the PSP groups, covarying for age. The effect of flortaucipir uptake and clinical scores on connectivity was assessed. Connectivity was reduced in PSP-RS compared to controls throughout the network, involving cerebellar dentate, midbrain, basal ganglia, thalamus, and frontal regions. Frontal regions showed reduced connectivity to other regions in the network in PSP-cortical, particularly the thalamus, caudate and substantia nigra. Disruptions in connectivity in PSP-subcortical were less pronounced, with the strongest disruption between the pallidum and striatum. There was moderate evidence that elevated subcortical flortaucipir uptake correlated with both increased and reduced connectivity between regions of the PSP network. Lower connectivity within the PSP network correlated with worse performance on clinical tests, including PSP rating scale. Patterns of disrupted functional connectivity revealed both variant-specific and shared disease pathways within the PSP network among PSP clinical variants, providing insight into disease heterogeneity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103727"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential tractography identifies a distinct pattern of white matter alterations in essential tremor with or without resting tremor","authors":"Alessia Sarica ,&nbsp;Vera Gramigna ,&nbsp;Fulvia Arcuri ,&nbsp;Marianna Crasà ,&nbsp;Camilla Calomino ,&nbsp;Rita Nisticò ,&nbsp;Maria Giovanna Bianco ,&nbsp;Andrea Quattrone ,&nbsp;Aldo Quattrone","doi":"10.1016/j.nicl.2025.103734","DOIUrl":"10.1016/j.nicl.2025.103734","url":null,"abstract":"<div><div>Essential Tremor (ET) is characterized by action tremor often associated with resting tremor (rET). Although previous studies have identified widespread brain white matter (WM) alterations in ET patients, differences between ET and rET have been less explored. In this study we employed differential tractography to investigate WM microstructural alterations in these tremor disorders.</div><div>We conducted a Diffusion Tensor Imaging (DTI) study on age- and sex-matched cohorts: 25 healthy controls (HC), 30 ET, and 30 rET patients. Differential tractography using DSI Studio was employed to pairwise compare fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) among cohorts.</div><div>ET and rET patients compared to HC exhibited similar widespread MD increase especially in basal ganglia and brainstem projections. WM changes were more pronounced in the left cerebral hemisphere and cerebellum (crus I and II) in ET, while in rET patients WM alterations were prevalent in right cerebral hemisphere and cerebellum crus I. Small FA decrease was found in rET but not in ET patients. ET patients showed changes in the left non-decussating dentato-rubro-thalamic tract (ndDRTT), whereas rET patients showed changes in both left ndDRTT and right decussating DRTT. In conclusion, our findings confirmed the DRTT involvement in essential tremor and demonstrated that ET and rET exhibited similar microstructural WM changes in the brain, with different hemispheric involvement—greater on the left side in ET and on the right side in rET—suggesting that these tremor disorders may be distinct subtypes of the same disease.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103734"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reshaped functional connectivity gradients in acute ischemic stroke","authors":"Cemal Koba ,&nbsp;Joan Falcó-Roget ,&nbsp;Alessandro Crimi","doi":"10.1016/j.nicl.2025.103755","DOIUrl":"10.1016/j.nicl.2025.103755","url":null,"abstract":"<div><div>Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the “correct” positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that (1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and (2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements along a reduced set of brain axes that are not completely detached from white matter damage.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103755"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}