Neuroimage-Clinical最新文献

{"title":"Auditory sensory processing measures using EEG and MEG predict symptom recovery in first-episode psychosis with a single-tone paradigm","authors":"F. López-Caballero,&nbsp;B.A. Coffman,&nbsp;M. Curtis,&nbsp;A.L. Sklar,&nbsp;S. Yi,&nbsp;D.F. Salisbury","doi":"10.1016/j.nicl.2024.103730","DOIUrl":"10.1016/j.nicl.2024.103730","url":null,"abstract":"<div><div>Predicting symptom progression in first-episode psychosis (FEP) is crucial for tailoring treatment and improving outcomes. Temporal lobe function, indicated by neurophysiological biomarkers like N100, predicts symptom progression and correlates with untreated psychosis. Our recent report showed that source-localized magnetoencephalography (MEG) M100 responses to tones in an oddball paradigm predicted recovery in FEP positive symptoms. This study expands these results with a simpler single-tone paradigm, with both MEG and EEG, and measuring associations across symptom dimensions. We recorded MEG (M100) and EEG (N100) in 29 FEP individuals and assessed symptom severity at baseline and after ∼ 7 months using the Positive and Negative Syndrome Scale (PANSS). Sequential regression analyses predicted symptom change (ΔPANSS) from Duration of untreated Active Psychosis (DAP) and baseline M100, controlling for baseline symptoms. Identical regressions were conducted in a subsample measuring N100 with EEG (n = 24). Smaller baseline M100 predicted worse symptom recovery at follow-up, independent of baseline symptom severity. Longer DAP showed a similar predictive effect, but this relationship was accounted for by M100. Regressions revealed M100 predictions were mostly related to general psychopathology. Identical results were found for N100 measured with EEG. Temporal lobe dysfunction in FEP, especially poor auditory sensory processing, indicates a worse recovery trajectory in general psychopathology. Longer untreated psychosis worsens temporal lobe function, predicting poorer progression. N100 measured with EEG and a single-tone task could be a cost-effective tool for informing clinicians about overall symptom progression, guiding treatment resource allocation and interventions.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103730"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative modeling of brain MRI data identifies small subcortical volumes and associations with cognitive function in youth with fetal alcohol spectrum disorder (FASD)","authors":"Blake A. Gimbel ,&nbsp;Donovan J. Roediger ,&nbsp;Mary E. Anthony ,&nbsp;Abigail M. Ernst ,&nbsp;Kent A. Tuominen ,&nbsp;Bryon A. Mueller ,&nbsp;Erik de Water ,&nbsp;Madeline N. Rockhold ,&nbsp;CIFASD,&nbsp;Jeffrey R. Wozniak","doi":"10.1016/j.nicl.2024.103722","DOIUrl":"10.1016/j.nicl.2024.103722","url":null,"abstract":"<div><h3>Aim</h3><div>To quantify regional subcortical brain volume anomalies in youth with fetal alcohol spectrum disorder (FASD), assess the relative sensitivity and specificity of abnormal volumes in FASD vs. a comparison group, and examine associations with cognitive function.</div></div><div><h3>Method</h3><div>Participants: 47 children with FASD and 39 typically-developing comparison participants, ages 8–17 years, who completed physical evaluations, cognitive and behavioral testing, and an MRI brain scan. A large normative MRI dataset that controlled for sex, age, and intracranial volume was used to quantify the developmental status of 7 bilateral subcortical regional volumes. Z-scores were calculated based on volumetric differences from the normative sample. T-tests compared subcortical volumes across groups. Percentages of atypical volumes are reported as are sensitivity and specificity in discriminating groups. Lastly, Pearson correlations examined the relationships between subcortical volumes and neurocognitive performance.</div></div><div><h3>Results</h3><div>Participants with FASD demonstrated lower mean volumes across a majority of subcortical regions relative to the comparison group with prominent group differences in the bilateral hippocampi and bilateral caudate. More individuals with FASD (89%) had one or more abnormally small volume compared to 72% of the comparison group. The bilateral hippocampi, bilateral putamen, and right pallidum were most sensitive in discriminating those with FASD from the comparison group. Exploratory analyses revealed associations between subcortical volumes and cognitive functioning that differed across groups.</div></div><div><h3>Conclusion</h3><div>In this sample, youth with FASD had a greater number of atypically small subcortical volumes than individuals without FASD. Findings suggest MRI may have utility in identifying individuals with structural brain anomalies resulting from PAE.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103722"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex hormones shape EEG-based functional connectivity in early-stage Parkinson’s disease patients","authors":"Matteo Conti ,&nbsp;Roberta Bovenzi ,&nbsp;Mariangela Pierantozzi ,&nbsp;Clara Simonetta ,&nbsp;Valerio Ferrari ,&nbsp;Jacopo Bissacco ,&nbsp;Rocco Cerroni ,&nbsp;Claudio Liguori ,&nbsp;Francesca Di Giuliano ,&nbsp;Nicola Biagio Mercuri ,&nbsp;Tommaso Schirinzi ,&nbsp;Alessandro Stefani","doi":"10.1016/j.nicl.2024.103721","DOIUrl":"10.1016/j.nicl.2024.103721","url":null,"abstract":"<div><div>Parkinson’s disease (PD) epidemiology and clinical features are sexually dimorphic. However, there are no data based on EEG functional connectivity (FC). Likewise, the contribution of sex hormones on brain FC has never been evaluated. Here, we aimed to investigate the association between biological sex and sex hormones on cortical FC changes in PD using high-density EEG. This study involved 69 early-stage PD patients (F/M 27/42) and 69 age-matched healthy controls (HC) (F/M 30/39). Sex hormone levels (total-testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH)) were assessed in PD patients. Data were recorded with a 64-channel EEG system. Source reconstruction method was used to identify brain activity. Cortico-cortical FC was analysed based on the weighted phase-lag index (wPLI) in θ-α-β-low γ bands. Network-based statistic (NBS) was used to compare FC between genders in HC and PD and to study the relationship between FC and sex hormones in PD. PD exhibited a hypoconnected network at θ and α bands and a hyperconnected network at β band compared to HC. Male HC showed a hyperconnected network at α-band compared to female HC. Conversely, males with PD showed a hypoconnected network at α-band compared to females with PD. In females and males with PD, E2 positively correlated with α-FC, while gonadotropins positively correlated with β-FC. TT positively correlated with the θ-FC only in males. Sex hormones shape EEG-FC in both males and females with PD, supporting their major influence on PD pathophysiology.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103721"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depth-electrode stimulation and concurrent functional MRI in humans: Factors influencing heating with body coil transmission","authors":"Hiroyuki Oya ,&nbsp;Ralph Adolphs ,&nbsp;Matthew A. Howard ,&nbsp;J. Michael Tyszka","doi":"10.1016/j.nicl.2025.103741","DOIUrl":"10.1016/j.nicl.2025.103741","url":null,"abstract":"<div><div>Electrical-stimulation fMRI (es-fMRI) combines direct stimulation of the brain via implanted electrodes with simultaneous rapid functional magnetic resonance imaging of the evoked response. Widely used to map effective functional connectivity in animal studies, its application to the human brain has been limited due to safety concerns. In particular, the method requires reliable prediction and minimization of local tissue heating close to the electrodes, which will vary with imaging parameters and hardware configurations. Electrode leads for such experiments typically remain connected to stimulators outside the magnet room and cannot therefore be treated as electrically short at the radio frequencies employed for 1.5 T and 3 T fMRI. The potential for significant absorption and scattering of radiofrequency energy from excitation pulses during imaging is therefore a major concern. We report a series of temperature measurements conducted in human brain phantoms at two independent imaging centers to characterize factors effecting RF heating of electrically long leads with body coil transmission at 3 Tesla for temporal RMS RF transmit fields (<span><math><msub><mfenced><mrow><msubsup><mi>B</mi><mrow><mn>1</mn></mrow><mo>+</mo></msubsup></mrow></mfenced><mrow><mi>rms</mi></mrow></msub></math></span>) up to 3.5 µT including multiband echo planar imaging and 3D T2w turbo spin echo imaging. Under all conditions tested, with one exception, the temperature rise measured immediately adjacent to electrode contacts in a head-torso phantom with body coil RF transmission was less than 0.75 °C. We provide detailed quantification across a range of configurations and conclude with specific recommendations for cable routing that will help ensure the safety of es-fMRI in humans and provide essential data to institutional review boards.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103741"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy","authors":"Xiang Huang ,&nbsp;Yingying Zhang ,&nbsp;Qiuxing Lin ,&nbsp;Kailing Huang ,&nbsp;Yuming Li ,&nbsp;Peiwen Liu ,&nbsp;Danyang Cao ,&nbsp;Wenhao Li ,&nbsp;Wei Li ,&nbsp;Xiuli Li ,&nbsp;Qiyong Gong ,&nbsp;Dong Zhou ,&nbsp;Dongmei An","doi":"10.1016/j.nicl.2025.103744","DOIUrl":"10.1016/j.nicl.2025.103744","url":null,"abstract":"<div><h3>Objective</h3><div>Recent studies revealed the effect of valproate (VPA) on brain structural changes in idiopathic generalized epilepsy (IGE). We aimed to investigate the volume of the entire hippocampus and subfields in patients with IGE, and explored their associations with VPA use.</div></div><div><h3>Methods</h3><div>A total of 211 patients with IGE and 97 healthy controls (HCs) were enrolled in this study. All participants underwent T1-weighted images. Each hippocampus was segmented into seven subfields using HippUnfold. The volumes of bilateral hippocampi and each hippocampal subfield were evaluated. Spearman correlation analyses were performed to identify VPA use related abnormalities in IGE. Subgroup analyses for juvenile myoclonic epilepsy (JME), epilepsy with generalized tonic–clonic seizures alone (GTCA), and absence epilepsy (AE) were conducted.</div></div><div><h3>Results</h3><div>The volumes of bilateral hippocampi were reduced in IGE compared with HCs. Subgroup analysis showed significant volume reductions in right hippocampus and its subfields in GTCA. Additionally, significant volume reductions were detected in bilateral hippocampal volumes and subfields in IGE patients currently taking VPA compared with HCs. A negative correlation was observed between the left CA2 volume and the age of onset.</div></div><div><h3>Conclusions</h3><div>Our study revealed volume reductions in bilateral hippocampi in IGE, as well as in the right hippocampus and its subfields in GTCA. Abnormalities in both subfields and the whole hippocampus were associated with VPA use. These findings suggest that VPA may have more extensive neuroanatomical effects in IGE, potentially accounting for the heterogeneity observed in neuroimaging studies.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103744"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boostering diagnosis of frontotemporal lobar degeneration with AI-driven neuroimaging – A systematic review and meta-analysis","authors":"Qiong Wu ,&nbsp;Dimitra Kiakou ,&nbsp;Karsten Mueller ,&nbsp;Wolfgang Köhler ,&nbsp;Matthias L. Schroeter","doi":"10.1016/j.nicl.2025.103757","DOIUrl":"10.1016/j.nicl.2025.103757","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Frontotemporal lobar degeneration (FTLD) as the second most common dementia encompasses a range of syndromes and often shows overlapping symptoms with other subtypes or neurodegenerative diseases, which poses a significant clinical diagnostic challenge. Recent advancements in artificial intelligence (AI), specifically the application of machine learning (ML) algorithms to neuroimaging, have significantly progressed in addressing this challenge. This study aims to assess the diagnostic and predictive efficacy of neuroimaging feature-based AI algorithms for FTLD.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and <em>meta</em>-analysis following PRISMA guidelines. We searched Pubmed, Scopus, and Web of Science for English-language, peer-reviewed studies using the following three umbrella terms: artificial intelligence, frontotemporal lobar degeneration, and neuroimaging modality. Our survey focused on computer-aided diagnosis for FTLD, employing machine/deep learning with neuroimaging radiomic features.</div></div><div><h3>Results</h3><div>The <em>meta</em>-analysis includes 75 articles with 20,601 subjects, including 8,051 FTLD patients. The results reveal that FTLD can be automatically classified against healthy controls (HC) with pooled sensitivity and specificity of 86% and 89%, respectively. Likewise, FTLD versus Alzheimer’s disease (AD) classification exhibits pooled sensitivity and specificity of 84% and 81%, while FTLD versus Parkinson’s disease (PD) demonstrates pooled sensitivity and specificity of 84% and 75%, respectively. Classification performance distinguishing FTLD from atypical Parkinsonian syndromes (APS) showed pooled sensitivity and specificity of 84% and 79%, respectively. Multiclass classification sensitivity ranges from 42% to 100%, with lower sensitivity occurring in higher class distinctions (e.g., 5-class and 11-class).</div></div><div><h3>Discussion</h3><div>Our study demonstrates the effectiveness of utilizing neuroimaging features to distinguish FTLD from HC, AD, APS, and PD in binary classification. Utilizing deep learning with multimodal neuroimaging data to differentiate FTLD subtypes and perform multiclassification among FTLD and other neurodegenerative disease holds promise for expediting diagnosis. In sum, the <em>meta</em>-analysis supports translation of machine learning tools in combination with imaging to clinical routine paving the way to precision medicine.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103757"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter microstructural integrity mediates associations between prenatal endocrine-disrupting chemicals exposure and intelligence in adolescents","authors":"Shi-Ming Wang ,&nbsp;Hui-Ju Wen ,&nbsp;Fan Huang ,&nbsp;Chien-Wen Sun ,&nbsp;Chih-Mao Huang ,&nbsp;Shu-Li Wang","doi":"10.1016/j.nicl.2025.103758","DOIUrl":"10.1016/j.nicl.2025.103758","url":null,"abstract":"<div><div>Per- and polyfluoroalkyl substances (PFAS) and phthalic acid esters (PAEs) are well-known endocrine-disrupting chemicals (EDCs) that potentially affect child neurodevelopment. We aimed to investigate the effects of prenatal exposure to PFAS and PAEs on macro- and micro-structural brain development and intelligence in adolescents using multimodal neuroimaging techniques. We employed structural magnetic resonance imaging (MRI) and various diffusion MRI techniques, including diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and neurite orientation dispersion and density imaging (NODDI), to assess the gray-matter macrostructure and white-matter microstructural integrity and complexity. Participants were drawn from a birth cohort of 52 mother–child pairs in central Taiwan recruited in 2001, and the adolescent intelligence quotient (IQ) scores were assessed using the Wechsler Intelligence Scale. Nine PFAS concentrations of cord blood and maternal serum samples were obtained from the children’s mothers during the third trimester of pregnancy (27–40 weeks) using a liquid chromatography system coupled to a triple-quadrupole mass spectrometer, while maternal urinary phthalates were used to evaluate PAEs exposure. Our results showed significant associations between prenatal exposure to PFAS and phthalates with changes in specific fronto-parietal regions of the adolescent male brain, including reduced cortical thickness in the inferior frontal gyrus and right superior parietal cortex, which are involved in language, memory, and executive function. A dose–response association was observed, with higher levels of PFAS and PAE exposure modulating altered white-matter fiber integrity in the superior cerebellar peduncle and inferior cerebellar peduncle of the male and female adolescent brains. In addition, higher levels of prenatal exposure to EDCs were associated with lower IQ scores in adolescents. Mediation analyses further revealed that white-matter microstructure of inter-hemispheric and cerebellar fibers mediated the association between prenatal EDC exposure and adolescent IQ scores in female adolescents. Our multimodal human neuroimaging findings suggest that prenatal exposure to EDCs may have long-lasting effects on neuroanatomical development, neural fiber connectivity, and intelligence in adolescents, and highlight the importance of using advanced diffusion imaging techniques, including DKI and NODDI, to detect neurodevelopmental changes and their brain-behavioral consequences with the risks associated with these environmental exposures.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103758"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoperfusion regions linked to National Institutes of Health Stroke Scale scores in acute stroke","authors":"Hana Kim ,&nbsp;Alex Teghipco ,&nbsp;Chris Rorden ,&nbsp;Julius Fridriksson ,&nbsp;Mathew Chaves ,&nbsp;Argye E. Hillis","doi":"10.1016/j.nicl.2025.103761","DOIUrl":"10.1016/j.nicl.2025.103761","url":null,"abstract":"<div><h3>Background</h3><div>The National Institutes of Health Stroke Scale (NIHSS) is widely used to assess stroke severity. While prior studies have identified subcortical regions where infarcts correlate with NIHSS scores, stroke symptoms can also arise from hypoperfusion, not just infarcts. Understanding the potential for neurological recovery post-reperfusion is essential for guiding treatment decisions. The goal of this study was to identify brain regions where hypoperfusion correlates with NIHSS scores, using computed tomography perfusion (CTP) scans in cases of acute ischemic stroke.</div></div><div><h3>Methods</h3><div>In this prospective observational study, we analyzed CTP scans and NIHSS scores from 89 patients in the acute phase. We employed a unique support vector regression approach to overcome limitations of traditional mass univariate analyses. Additionally, we used stability selection to identify the most consistent features across subsets, reducing overfitting and ensuring robust predictive models. We verified the consistency of results through nested cross-validation.</div></div><div><h3>Results</h3><div>Both cortical and subcortical areas, including white matter tracts, showed associations with NIHSS scores. These regions aligned with functions such as language, spatial attention, sensory, and motor skills, all assessed by the NIHSS.</div></div><div><h3>Conclusions</h3><div>Our findings reveal that hypoperfusion in specific brain regions, including previously underreported cortical areas, contributes to NIHSS scores in acute stroke. Moreover, this study introduces a novel brain mapping approach using CTP imaging and stability selection, offering a more comprehensive view of acute stroke impairments and the potential for recovery before structural reorganization occurs.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103761"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of neonatal structural MRI scores to predict 6-year motor outcomes of children born very preterm","authors":"Karen H. Mistry ,&nbsp;Samudragupta Bora ,&nbsp;Kerstin Pannek ,&nbsp;Alex M. Pagnozzi ,&nbsp;Simona Fiori ,&nbsp;Andrea Guzzetta ,&nbsp;Robert S. Ware ,&nbsp;Paul B. Colditz ,&nbsp;Roslyn N. Boyd ,&nbsp;Joanne M. George","doi":"10.1016/j.nicl.2024.103725","DOIUrl":"10.1016/j.nicl.2024.103725","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to (1) evaluate associations between Early and Term structural MRI (sMRI) brain abnormality scores and adverse motor outcomes at 6-years corrected age (CA), (2) determine their diagnostic accuracy in predicting adverse motor outcomes and cerebral palsy (CP) at 6-years CA.</div></div><div><h3>Methods</h3><div>Infants born &lt; 31-weeks gestational age (GA) returning for 6-year follow-up were included. Early and Term sMRI were scored using a validated method, deriving white matter, cortical grey matter, deep grey matter, cerebellar and global brain abnormality scores (GBAS). At 6-years CA, Movement Assessment Battery for Children-2nd Edition (MABC-2) was administered. Linear regression assessed associations between Early and Term GBAS/subscale scores and 6-year MABC-2 total score. For diagnostic accuracy, sMRI scores were categorised as none/mild vs moderate/severe, MABC-2 cut-off ≤ 5th percentile, and CP as present/absent.</div></div><div><h3>Results</h3><div>Infants had Early MRI (n = 123) at mean PMA 32.5-weeks (median GA 28.4-weeks; mean birthweight 1101 g) and n = 114 had Term MRI (Mean PMA 40.8-weeks). Nine had CP and n = 116 had MABC-2 scores. Early (B: −1.92; p ≤ 0.001) and Term (B: −1.67; p ≤ 0.01) GBAS were negatively associated with MABC-2 scores. Both Early and Term GBAS had high specificity (Sp) and low sensitivity (Se) in predicting MABC-2 ≤ 5th percentile (Early: Se 36 %, Sp 82 %; Term: Se 28 %, Sp 93 %) and predicted CP with high Se and Sp (Early: Se 78 %, Sp 78 %; Term: Se 75 %, Sp 89 %).</div></div><div><h3>Conclusion</h3><div>High Sp of Early and Term MRI predicting an outcome on MABC-2 may help accurately identify infants unlikely to develop motor impairments at 6-years CA.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103725"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reorganization of cortical individualized differential structural covariance network is associated with regional morphometric changes in chronic subcortical stroke","authors":"Hongchuan Zhang ,&nbsp;Jun Guo ,&nbsp;Jingchun Liu ,&nbsp;Caihong Wang ,&nbsp;Hao Ding ,&nbsp;Tong Han ,&nbsp;Jingliang Cheng ,&nbsp;Chunshui Yu ,&nbsp;Wen Qin","doi":"10.1016/j.nicl.2025.103735","DOIUrl":"10.1016/j.nicl.2025.103735","url":null,"abstract":"<div><div>Patients with chronic subcortical stroke undergo regional and network morphometric reorganizations beyond the lesion site, but the interplay between network and regional reorganization remains poorly understood. We aimed to clarify the reorganization patterns of the individualized differential structural covariance networks (IDSCN) in chronic subcortical stroke and investigate their associations with regional gray matter volume (GMV) changes and functional recovery. Structural MRI from four datasets enrolled 112 patients with chronic subcortical stroke (81 male, age: 55.82 ± 7.79) and 122 matched healthy controls (HC) (74 male; age: 55.28 ± 7.54). Network-based statistics were employed to identify aberrant IDSCN, Spearman correlation was conducted to assess the association between IDSCN and regional GMV alterations, and partial correlation was utilized to investigate the association between abnormal IDSCN and functional recovery. We identified 133 connections with balanced increased and decreased IDSCN. Aberrant IDSCN involved more regions than local GMV alterations, local GMV alteration exhibited intricate correlations with IDSCN, which could explain partly IDSCN reorganization (p &lt; 0.05, corrected). Finally, abnormal IDSCN showed a weak association with long-term clinical recovery (p &lt; 0.01). These findings reinforce the theory of adaptive network reorganization post-stroke and suggest that IDSCN may provide further insights into cortical reorganization and functional rehabilitation beyond regional morphometric measures.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103735"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}