Neuroimage-Clinical最新文献

{"title":"Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers","authors":"Thang M. Le ,&nbsp;Takeyuki Oba ,&nbsp;Chiang-Shan R. Li","doi":"10.1016/j.nicl.2025.103762","DOIUrl":"10.1016/j.nicl.2025.103762","url":null,"abstract":"<div><div>Individuals engaging in problem drinking show impaired proactive pain avoidance. As successful pain avoidance is intrinsically rewarding, this impairment suggests reward deficiency, as hypothesized for those with alcohol and substance misuse. Nevertheless, how reward circuit dysfunctions impact avoidance learning and contribute to drinking behavior remains poorly understood. Here, we combined functional imaging and a probabilistic learning go/nogo task to examine the neural processes underlying proactive pain avoidance learning in 103 adult drinkers. We hypothesized that greater drinking severity would be associated with poorer avoidance learning and that the deficits would be accompanied by weakened activity and connectivity of the reward circuit. Our behavioral findings indeed showed a negative relationship between drinking severity and learning from successful pain avoidance. We identified hypoactivation of the posterior cingulate cortex (PCC), a brain region important in avoidance, as the neural correlate of lower learning rate in association with problem drinking. The reward circuit, including the medial orbitofrontal cortex, ventral tegmental area, and substantia nigra, also exhibited diminished activation and connectivity with the PCC with greater drinking severity and learning deficits. Finally, path modeling suggested a pathway in which problem drinking disengaged the reward circuit. The weakened circuit subsequently induced PCC hypoactivation, resulting in poorer pain avoidance learning. As the learning dysfunction worsened alcohol use, the pathway represents a self-perpetuating cycle of drinking and distress. Together, these findings substantiate a role of reward deficiency in problem drinkers’ compromised proactive avoidance, thus identifying a potential target for intervention aimed at mitigating harmful alcohol use.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103762"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Association between clinical features and decreased degree centrality and variability in dynamic functional connectivity in the obsessive-compulsive disorder” [Neuroimage: Clinical 44 (2024) 1–9/103665]","authors":"Changjun Teng ,&nbsp;Wei Zhang ,&nbsp;Da Zhang ,&nbsp;Xiaomeng Shi ,&nbsp;Xin Wu ,&nbsp;Huifen Qiao ,&nbsp;Ning Zhang ,&nbsp;Xiao Hu ,&nbsp;Chengbin Guan","doi":"10.1016/j.nicl.2024.103675","DOIUrl":"10.1016/j.nicl.2024.103675","url":null,"abstract":"","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103675"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural processing of social reciprocity in autism","authors":"Afton M. Bierlich ,&nbsp;Irene Sophia Plank ,&nbsp;Nanja T. Scheel ,&nbsp;Daniel Keeser ,&nbsp;Christine M. Falter-Wagner","doi":"10.1016/j.nicl.2025.103793","DOIUrl":"10.1016/j.nicl.2025.103793","url":null,"abstract":"<div><div>Social reciprocity and interpersonal synchrony implicitly mediate social interactions to facilitate natural exchanges. These processes are altered in autism, but it is unclear how such alterations manifest at the neural level during social interaction processing. Using task-based fMRI, we investigated the neural correlates of interpersonal synchrony during basic reciprocal interactions in a preregistered study. Participants communicated with a virtual partner by sending visual signals. Analyses showed comparable activation patterns and experienced synchrony ratings between autistic and non-autistic participants, as well as between interactions with virtual partners who had high or low synchronous responses. An exploratory whole brain analysis for the effect of task revealed significant activation of the inferior frontal gyrus, insular cortex, and anterior inferior parietal lobe; areas associated with cognitive control, rhythmic temporal coordination, and action observation. This activation was independent of the virtual partner’s response synchrony and was similar for autistic and non-autistic participants. These results provide an initial look into the neural basis of processing social reciprocity in autism, particularly when individuals are part of an interaction, and hint that the neural processing of social reciprocity may be spared in autism when their partners’ behavior is predictable.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103793"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis","authors":"Harold H.G. Tan ,&nbsp;Abram D. Nitert ,&nbsp;Kevin van Veenhuijzen ,&nbsp;Stefan Dukic ,&nbsp;Martine J.E. van Zandvoort ,&nbsp;Jeroen Hendrikse ,&nbsp;Michael A. van Es ,&nbsp;Jan H. Veldink ,&nbsp;Henk-Jan Westeneng ,&nbsp;Leonard H. van den Berg","doi":"10.1016/j.nicl.2025.103749","DOIUrl":"10.1016/j.nicl.2025.103749","url":null,"abstract":"<div><h3>Background</h3><div>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with frequent extra-motor involvement. In the present study, we investigated whether specific cognitive and behavioral deficits in ALS correlate with distinct extra-motor neurodegeneration patterns on brain MRI.</div></div><div><h3>Methods</h3><div>We performed multimodal brain MRI and Edinburgh cognitive and behavioral ALS screen (ECAS) in 293 patients and 237 controls. Follow-up data were acquired from 171 patients with a median duration of 7.9 months. Domain-level cognitive scores from the ECAS were compared with grey and white matter MRI parameters. Interaction analyses between patients and controls were performed to explore whether correlates were specific to ALS, rather than related to normal aging. Follow-up data were used to assess changes of domain-associated brain structures over time.</div></div><div><h3>Results</h3><div>Language impairment was significantly associated with (left predominant) frontal, temporal, parietal and subcortical grey matter neurodegeneration. Letter fluency with widespread cortical and subcortical grey matter involvement. Memory dysfunction with hippocampal and medial-temporal atrophy. Executive impairment was exclusively correlated with widespread white matter impairment. Visuospatial scores did not correlate with MRI parameters. Interaction analyses between patients and controls showed that most ECAS-MRI correlations were stronger in ALS than in controls (75.7% significant in grey matter, 52.7% in white matter). Longitudinal analyses showed that all grey matter structures associated with cognitive domains worsened over time while, for this study population, ECAS domain scores did not decline significantly.</div></div><div><h3>Conclusions</h3><div>MRI can capture the heterogeneity of cognitive and behavioral involvement in ALS and provides a useful longitudinal biomarker for progression of extra-motor neurodegeneration.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103749"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents","authors":"Zhou Lan ,&nbsp;Sheryl Foster ,&nbsp;Molly Charney ,&nbsp;Max van Grinsven ,&nbsp;Katherine Breedlove ,&nbsp;Kasia Kozlowska ,&nbsp;Alexander Lin","doi":"10.1016/j.nicl.2025.103767","DOIUrl":"10.1016/j.nicl.2025.103767","url":null,"abstract":"<div><h3>Objectives</h3><div>Functional neurological disorder (FND) in children and adolescents is a biopsychosocially complex condition characterized by a wide range of neurological symptoms. Using magnetic resonance spectroscopy to study neurometabolites has become an important approach to studying the mechanisms of FND. Unlike previous studies focusing on concentration-level analysis, this study examines conditional dependencies between six neurometabolites: N-acetyl aspartate, creatine, glutathione, choline, myo-inositol, and glutamate. Conditional dependence implies that two neurometabolites have joint variability that is not mediated by other neurometabolites.</div></div><div><h3>Methods</h3><div>A Bayesian graphical lasso approach was used to estimate neurometabolites’ conditional dependencies in three regions of interest: the anterior default mode network (aDMN), supplementary motor area (SMA), and posterior default mode network (pDMN). We introduce the term <em>neurometabolic network</em> (NMetNet) to describe these conditional dependencies.</div></div><div><h3>Results</h3><div>Children and adolescents with FND (vs. healthy controls) showed a loss of conditional dependencies related to creatine and glutathione between the aDMN and SMA/pDMN. Glutathione is the primary antioxidant in the brain. Creatine plays a key role in maintaining bioenergetics and also acts as an antioxidant.</div></div><div><h3>Conclusions</h3><div>These findings suggest that FND is characterized by dysregulated bioenergetics and increased vulnerability to oxidative stress. Understanding NMetNet in FND offers novel insights into the disorder’s neurobiology, with implications for therapeutic interventions to restore energy homeostasis and oxidative balance.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103767"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cerebellar activation patterns in Alzheimer’s disease: An activation likelihood estimation Meta-Analysis","authors":"Jessica A. Bernard ,&nbsp;Ivan A. Herrejon ,&nbsp;Emily An ,&nbsp;Yamilet Cina ,&nbsp;Sameera Dabbiru ,&nbsp;Jack Dempsey ,&nbsp;Elise Marrie ,&nbsp;Michele Medina ,&nbsp;Jessica Praytor","doi":"10.1016/j.nicl.2025.103770","DOIUrl":"10.1016/j.nicl.2025.103770","url":null,"abstract":"<div><div>The past decade has seen an increased interest in the cerebellum, particularly in non-motor behaviors. Emerging work across model systems and in humans has also implicated the cerebellum in Alzheimer’s Disease (AD) and in mild cognitive impairment (MCI). While the cerebellum is not seen as being central to the etiology of the disease, it is however recognized as being increasingly important, and most certainly not immune from disease-related pathology and atrophy. In cognitively normal older adults (OA), the cerebellum has been conceptualized as being critical scaffolding for cortical function. This scaffolding may extend to AD and MCI. With respect to functional imaging, this is largely unexplored in AD, as this is a nascent literature. While there are very few studies focused on the cerebellum in AD at this stage, <em>meta</em>-analysis provides a powerful tool for expanding our knowledge of the cerebellum in neurodegenerative disease, and, in turn, for hypothesis generation. We took advantage of activation likelihood estimation (ALE) <em>meta</em>-analysis to investigate overlap in functional activation present in the existing literature. We focused on AD, but also included an exploratory analysis of MCI, based on papers available in our AD search. Our analysis included a total of 29 studies, representing data from 236 individuals with AD, 159 with MCI, and 382 OA. Across these studies, there is no significant overlap in cerebellar activation in AD, though this is present in MCI. Analyses of group differences also suggest that across studies, there are patterns indicative of both greater and reduced activation in AD/MCI relative to OA. Across all findings, overlap was primarily centered on Crus I and Lobule VI. These findings suggest that cerebellar function is negatively impacted in AD, which in turn may impact behavior and symptomatology.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103770"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional near-infrared spectroscopy in neurodegenerative diseases – A systematic review","authors":"Franziska Albrecht ,&nbsp;Alexander Kvist ,&nbsp;Erika Franzén","doi":"10.1016/j.nicl.2025.103733","DOIUrl":"10.1016/j.nicl.2025.103733","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review and summarize alterations found in resting-state activity as measured via functional near-infrared spectroscopy (fNIRS) in neurodegenerative diseases.</div></div><div><h3>Background</h3><div>fNIRS is a novel and emerging neuroimaging method suitable for a variety of study designs. Resting-state is the measure of brain activity in the absence of a task, which has been investigated for yielding information about neurodegenerative diseases, mainly using magnetic resonance imaging. We aimed to systematically review the usage of resting-state fNIRS (rsfNIRS) in neurodegenerative diseases.</div></div><div><h3>Inclusion criteria</h3><div>Studies investigating people diagnosed with a neurodegenerative disease and resting-state activity obtained with fNIRS using at least two channels.</div></div><div><h3>Methods</h3><div>We searched three databases for publications. After the screening, 16 studies were included in the systematic review. The quality of the studies was assessed, and data were extracted. Data were qualitatively synthesized and in the case of at least 10 similar studies, a meta-analysis was planned.</div></div><div><h3>Results</h3><div>Most studies investigated Mild cognitive impairment (50%), followed by Alzheimer’s disease (25%). Other neurodegenerative diseases encompassed Parkinson’s disease, Multiple sclerosis, and Amyotrophic lateral sclerosis. All studies reported oxygenated hemoglobin. Still, studies were heterogeneous in terms of study design, measurement duration, fNIRS device, montage, pre-processing, and analyses. A meta-analysis was not considered possible due to this heterogeneity.</div></div><div><h3>Conclusion</h3><div>rsfNIRS shows promise in neurodegenerative disease, as most studies have observed resting-state alterations when compared to healthy controls. However, inconsistencies across studies limit data comparison and meta-analysis. Hence, we strongly advocate the application of fNIRS reporting guidelines and the establishment of rsfNIRS-specific guidelines. This will ensure reliable and comparable results in future research.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103733"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired spatial dynamic functional network connectivity and neurophysiological correlates in functional hemiparesis","authors":"E. Premi ,&nbsp;V. Cantoni ,&nbsp;A. Benussi ,&nbsp;A. Iraji ,&nbsp;V.D. Calhoun ,&nbsp;D. Corbo ,&nbsp;R. Gasparotti ,&nbsp;M. Tinazzi ,&nbsp;B. Borroni ,&nbsp;M. Magoni","doi":"10.1016/j.nicl.2025.103731","DOIUrl":"10.1016/j.nicl.2025.103731","url":null,"abstract":"<div><div>The present study investigated spatial dynamic functional network connectivity (dFNC) in patients with functional hemiparesis (i.e., functional stroke mimics, FSM). The aim of this work was to assess static functional connectivity (large-scale) networks and dynamic brain states, which represent distinct dFNC patterns that reoccur in time and across subjects. Resting-state fMRI data were collected from 15 patients with FSM (mean age = 42.3 ± 9.4, female = 80 %) and 52 age-matched healthy controls (HC, mean age = 42.1 ± 8.6, female = 73 %).</div><div>Each patient underwent a resting-state functional MRI scan for spatial dFNC evaluation and transcranial magnetic stimulation protocols for indirect assessment of GABAergic and glutamatergic transmission. We considered three dynamic brain networks, i.e., the somatomotor network (SMN), the default mode network (DMN) and the salience network (SN), each summarized into four distinct recurring spatial configurations. Compared to HC, patients with FSM showed significant decreased dwell time, e.g. the time each individual spends in each spatial state of each network, in state 2 of the SMN (HC <em>vs</em>. FSM, 13.5 ± 27.1 <em>vs.</em> 1.9 ± 4.1, <em>p</em> = 0.044). Conversely, as compared to HC, FSM spent more time in state 1 of the DMN (10.8 ± 14.9 <em>vs.</em> 27.3 ± 38.9, <em>p</em> = 0.037) and in state 3 of the SN (23.1 ± 23.0 <em>vs.</em> 38.8 ± 38.2, <em>p</em> = 0.002). We found a significant correlation between the dwell time of impaired functional state of the SMN and measures of GABAergic neurotransmission (<em>r</em> = 0.581, <em>p</em> = 0.037). Specifically, longer impaired dwell time was associated with greater GABAergic inhibition. These findings demonstrate that FSM present altered functional brain network dynamics, which correlate with measures of GABAergic neurotransmission. Both dFNC and GABAergic neurotransmission may serve as potential targets for future intervention strategies.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103731"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa","authors":"Katrien F.M. Bracké ,&nbsp;Laura Monteiro Rente Dias ,&nbsp;Marisha N. Meijer ,&nbsp;Cathelijne P.M. Steegers ,&nbsp;Laurinde F. den Heijer ,&nbsp;Tess van der Harst ,&nbsp;Marjolein H.G. Dremmen ,&nbsp;Meike W. Vernooij ,&nbsp;Gwen C. Dieleman ,&nbsp;Tonya White","doi":"10.1016/j.nicl.2025.103745","DOIUrl":"10.1016/j.nicl.2025.103745","url":null,"abstract":"<div><h3>Objective</h3><div>Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent findings. Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN.</div></div><div><h3>Methods</h3><div>Functional MRI (fMRI) of brain resting-state functional connectivity (RS-FC) of female adolescents with first-onset AN (n = 56) were compared to age- and education-matched typically developing (TD) adolescents (n = 64). To account for the severity of underweight, separate analyses were performed to investigate differences in RS-FC between underweight AN participants and TD adolescents, as well as between underweight (n = 30) and weight-restored AN (n = 26) participants. Clinical outcomes, i.e. body mass index and eating disorder (ED) symptoms, were assessed at baseline and one-year follow-up. Independent component analyses (ICA) were used to extract the brain networks of interest: the default mode (DMN), left and right frontoparietal (FPN), and the insular (IN) networks. Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms.</div></div><div><h3>Results</h3><div>Underweight AN participants had lower RS-FC between the DMN-IN, as well as between the FPN-IN compared to the TD adolescents. After correction for multiple testing, no significant differences in RS-FC were found between underweight AN participants and weight-restored AN participants, as well as between the whole AN group and the TD group. RS-FC was not associated with the severity of clinical symptoms at baseline nor at one-year of follow-up.</div></div><div><h3>Conclusion</h3><div>AN is associated with changes in RS-FC between the FPN-IN and DMN-IN during the underweight state. These changes in RS-FC were no longer observed in weight-restored AN participants, emphasizing the impact of underweight on RS-FC in AN. Changes in these brain networks may partly explain the impaired cognitive control and difficulties with emotion and behavioral regulation in individuals with AN during the underweight state.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103745"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143182388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and functional changes of Post-Stroke Depression: A multimodal magnetic resonance imaging study","authors":"Qiuhong Lu ,&nbsp;Shunzu Lu ,&nbsp;Xue Wang ,&nbsp;Yanlan Huang ,&nbsp;Jie Liu ,&nbsp;Zhijian Liang","doi":"10.1016/j.nicl.2025.103743","DOIUrl":"10.1016/j.nicl.2025.103743","url":null,"abstract":"<div><div>This study investigated changes in gray matter volume (GMV), white matter microstructure, and spontaneous brain activity in post-stroke depression (PSD) using multiple MRI techniques, including neurite orientation dispersion and density imaging (NODDI). Changes in GMV, neurite density index (NDI), orientation dispersion index (ODI), fraction of isotropic water (ISO), diffusion tensor imaging (DTI) parameters, and the amplitude of frequency fluctuations (ALFF) were assessed between PSD (n = 20), post-stroke without depression (n = 20), and normal control (n = 20) groups. Receiver operating characteristic (ROC) curve analysis was performed to test the classification performance of the variant parameters of each MRI modality, each single MRI modality and multiple MRI modality. Compared to patients with post-stroke without depression (non-PSD), those with PSD showed increased ODI and ISO in the widespread white matter, as well as increased ALFF in the left pallidum. No significant differences in the GMV or DTI parameters were observed between the two groups. Furthermore, the ODI of the right superior longitudinal fasciculus and NODDI showed the best classification performance for PSD at their respective comparison level (the areas under the ROC curves (AUC) = 0.917(0.000), 0.933(0.000)). The model of NODDI-derived parameters combined with non-diffusion MRI modality parameters (i.e., GMV and ALFF) showed better diagnostic performance than that of DTI-derived parameters. These findings suggest that PSD is associated with structural and functional abnormalities that may contribute to depressive symptoms. Additionally, NODDI showed its advantages in the description of structural alterations in emotion-related white matter pathways and classification performance in PSD.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103743"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}