Neuroimage-Clinical最新文献

{"title":"Alterations of long-range association fibers in patients with anti-N-methyl-D-aspartate receptor encephalitis","authors":"Xiaodong Chen ,&nbsp;Ling Fang ,&nbsp;Yiying Huang ,&nbsp;Yu Huang ,&nbsp;Yi Lu ,&nbsp;Jinhui Wang ,&nbsp;Chunxin Liu ,&nbsp;Huanquan Liao ,&nbsp;Liemin Zhou ,&nbsp;Wei Qiu ,&nbsp;Yaqing Shu","doi":"10.1016/j.nicl.2025.103808","DOIUrl":"10.1016/j.nicl.2025.103808","url":null,"abstract":"<div><h3>Background</h3><div>Patients with anti-NMDAR encephalitis typically exhibit impaired cognitive integration, which relies on the integrity of long-range association fibers connecting diverse brain regions. However, the microstructural integrity of long-range association fibers in this population remains unknown.</div></div><div><h3>Methods</h3><div>Diffusion tensor imaging (DTI) data were collected from 32 patients with anti-NMDAR encephalitis and 30 healthy controls. Patients were further categorized into early and delayed immunotherapy subgroups based on a 2-week threshold for immunotherapy initiation. The diffusion properties of major long-range association fibers were quantified at both the bundle and node levels.</div></div><div><h3>Results</h3><div>Compared with healthy controls, patients exhibited widespread microstructural damage within long-range association fibers, with more severe alterations in the delayed immunotherapy subgroup (FDR-corrected <em>p</em> &lt; 0.05). In this subgroup(n = 14), radial diffusivity (RD) of left inferior fronto-occipital fasciculus (IFOF), left inferior longitudinal fasciculus (ILF), left superior longitudinal fascicles (SLF), and bilateral arcuate fascicles correlated significantly with global cognition (MMSE, FDR-corrected <em>p</em> &lt; 0.05). Notably, RD also strongly correlated with working memory in the delayed immunotherapy subgroup, showing bundle-wise associations for IFOF (left: <em>r =</em> -0.8315, <em>p =</em> 0.0112; right: <em>r =</em> -0.7044, <em>p =</em> 0.0295), ILF (left: <em>r =</em> -0.7473, <em>p =</em> 0.0243), SLF (left: <em>r =</em> -0.7562, <em>p =</em> 0.0243; right<em>: r =</em> -0.6599, <em>p =</em> 0.0391), and arcuate fasciculus (left: <em>r =</em> -0.7240, <em>p =</em> 0.0272; right: <em>r =</em> -0.6835, <em>p =</em> 0.0333), with left-hemisphere predominance confirmed by node-wise analyses of IFOF, ILF, SLF, and arcuate fasciculus (FDR-corrected <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Our findings highlight widespread microstructural damage in long-range association fibers in patients with anti-NMDAR encephalitis, particularly in those with delayed immunotherapy. This damage may serve as the neurophysiological basis for cognitive impairments, with working memory being most affected.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103808"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of resting-state fMRI graph measures in hypoxic encephalopathy after cardiac arrest","authors":"Puck Lange ,&nbsp;Marlous Verhulst ,&nbsp;Anil Man Tuladhar ,&nbsp;Prejaas Tewarie ,&nbsp;Hanneke Keijzer ,&nbsp;Catharina J.M. Klijn ,&nbsp;Cornelia Hoedemaekers ,&nbsp;Michiel Blans ,&nbsp;Bart Tonino ,&nbsp;Frederick J.A. Meijer ,&nbsp;Rick C. Helmich ,&nbsp;Jeannette Hofmeijer","doi":"10.1016/j.nicl.2025.103763","DOIUrl":"10.1016/j.nicl.2025.103763","url":null,"abstract":"<div><h3>Introduction</h3><div>Current multimodal prediction models can determine the prognosis of about half of comatose cardiac arrest patients. We investigated whether whole-brain graph-theoretical measures from early resting-state functional magnetic resonance imaging (fMRI) three days after cardiac arrest discriminate between good and poor outcome and improve outcome prediction.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study on comatose cardiac arrest patients on intensive care units. Resting-state fMRI three days after cardiac arrest was used to quantify whole-brain functional connectivity, global efficiency, clustering coefficient, and modularity. Neurological outcome at six months was classified as good or poor (Cerebral Performance Category 1–2 vs 3–5). Logistic regression models were used to examine between-group differences and study the additional value of graph-theoretical measures to clinical and EEG-based prediction.</div></div><div><h3>Results</h3><div>In seventy included patients (good outcome n = 44, poor n = 26), whole-brain functional connectivity and clustering coefficient (but not global efficiency and modularity) were significantly lower in patients with poor outcome. Connectivity of nodes in posterior brain areas most prominently correlated with outcome. Clustering coefficient showed strong correlation with whole-brain functional connectivity. Patients with continuous EEG patterns differed in whole-brain functional connectivity levels from those with suppressed or epileptiform patterns. Combining functional connectivity or graph measures with clinical and EEG-based predictors slightly improved outcome prediction.</div></div><div><h3>Conclusion</h3><div>fMRI-based whole-brain functional connectivity is a sensitive measure for encephalopathy severity after cardiac arrest, according to relations with established EEG categories and discrimination between good and poor outcome. Additional predictive values for outcome seem small. Graph measures do not provide complementary information.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103763"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reshaped functional connectivity gradients in acute ischemic stroke","authors":"Cemal Koba ,&nbsp;Joan Falcó-Roget ,&nbsp;Alessandro Crimi","doi":"10.1016/j.nicl.2025.103755","DOIUrl":"10.1016/j.nicl.2025.103755","url":null,"abstract":"<div><div>Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the “correct” positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that (1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and (2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements along a reduced set of brain axes that are not completely detached from white matter damage.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103755"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrovascular longitudinal atlas: Changes in cerebral arteries in unruptured intracranial aneurysm patients followed with MRA","authors":"Aichi Chien ,&nbsp;Fernando Vinuela ,&nbsp;Viktor Szeder ,&nbsp;Geoffrey Colby ,&nbsp;Reza Jahan ,&nbsp;Anthony Wang ,&nbsp;Satoshi Tateshima ,&nbsp;Gary Duckwiler ,&nbsp;Noriko Salamon","doi":"10.1016/j.nicl.2025.103766","DOIUrl":"10.1016/j.nicl.2025.103766","url":null,"abstract":"<div><h3>Background</h3><div>Patterns of change in cerebrovascular (CV) morphology associated with aging are highly relevant to the incidence and progression of CV disease, particularly stroke. Intracranial aneurysms (IA), a leading cause of hemorrhagic stroke, are linked with factors such as blood flow, arterial stiffness, and inflammation that may also drive other changes in CV morphology. We worked with a cohort of longitudinally-imaged IA patients to construct the first longitudinal atlas of CV morphology and studied its relationship with disease.</div></div><div><h3>Methods</h3><div>110 IA patients, ranging from 19 to 84 years old at IA detection, were monitored using 3D magnetic resonance angiography (MRA) for a mean of 6.11 (2.60) years with 3.6 (1.3) scans per patient. Using 405 image studies, we applied a machine learning diffeomorphic shape analysis to construct a longitudinal atlas of the cerebral arteries which defined a general trajectory of CV morphological change vs. age. This was paired with a centerline analysis to verify changes in individual arteries.</div></div><div><h3>Results</h3><div>Patient characteristics influenced the speed of CV shape change (e.g. diabetes mellitus, faster, p = 0.016), while other factors mapped to older CV age (e.g. hypertension, p = 0.0004). In parallel, we found that groups including autosomal dominant polycystic kidney disease (p = 0.0004), sex (p = 0.005), smoking (p = 0.046), and IA growth (p = 0.020) shared CV morphology characteristics. The centerline analysis validated changes consistent with the longitudinal atlas.</div></div><div><h3>Conclusion</h3><div>A general CV trajectory of increasing artery length and tortuosity over a period of several decades was found. Although specific IA characteristics were not found to significantly affect this trajectory, these changes in the CV may contribute to increases in IA risk with aging. While our longitudinal findings were consistent with previous cross-sectional studies of individuals without IA, it remains to be determined whether the pattern of morphological change we observed is representative of aging within the general population. The model we developed provides a basis for integrating CV morphological change into understanding of aging and disease.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103766"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional cerebellar atrophy related to disability and cognitive progression in multiple sclerosis","authors":"Myrte Strik ,&nbsp;Iris Dekker ,&nbsp;Aurélie Ruet ,&nbsp;Hanneke Hulst ,&nbsp;Mike P. Wattjes ,&nbsp;Frederik Barkhof ,&nbsp;Bernard Uitdehaag ,&nbsp;Joep Killestein ,&nbsp;Menno Schoonheim","doi":"10.1016/j.nicl.2025.103792","DOIUrl":"10.1016/j.nicl.2025.103792","url":null,"abstract":"<div><h3>Objective</h3><div>The implications of cerebellar pathology on clinical disease progression in multiple sclerosis (MS) remain unclear. This study investigated regional cerebellar atrophy related to physical disability and cognitive impairment progression.</div></div><div><h3>Methods</h3><div>We included 331 MS patients and 95 controls (Amsterdam MS Cohort, 229 patients and 58 controls re-evaluated after 5 years). Assessments included baseline MRI, and disability and cognition at baseline and follow up. Cerebellar (sub)cortex was parcellated, volumetric data were determined and related to baseline disability and cognition. Longitudinal progression was explored only for regions with significant baseline correlations.</div></div><div><h3>Results</h3><div>At baseline, patients had mild disability (median EDSS 3.0) and 46% showing mild-to-severe cognitive impairment. At follow-up, 34.5% showed EDSS progression and 26.6% cognitive decline. All global and most regional volumes showed atrophy. Cross-sectionally, atrophy of several regions encompassing both anterior and posterior lobes correlated with both disability and cognition, while some correlated with EDSS only. Additionally, cerebellar nuclei only correlated with cognition. Cerebellar volumes were mainly related to information processing speed, working and verbal memory. Longitudinally, atrophy in the posterior lobe, lobule VI and VIIIb, and vermis VI, correlated with cognitive decline, while no variables correlated with disability progression.</div></div><div><h3>Conclusion</h3><div>Regional cerebellar atrophy in both anterior and posterior lobes correlated with disability and cognitive impairment. Posterior regional atrophy was correlated with longitudinal cognitive decline, but none correlated with disability progression. Further research is required to elucidate these relationships.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103792"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis","authors":"E. Lopez-Soley ,&nbsp;E. Martinez-Heras ,&nbsp;F. Vivo ,&nbsp;A. Calvi ,&nbsp;S. Alba-Arbalat ,&nbsp;L. Romero-Pinel ,&nbsp;S. Martínez-Yélamos ,&nbsp;C. Ramo-Tello ,&nbsp;S. Presas-Rodríguez ,&nbsp;E. Munteis ,&nbsp;J.E. Martínez-Rodríguez ,&nbsp;J. Sastre-Garriga ,&nbsp;E. Anglada ,&nbsp;E.R. Meza-Murillo ,&nbsp;M.J. Arévalo ,&nbsp;R. Sánchez-Carrión ,&nbsp;R. Pelayo ,&nbsp;M. Bernabeu ,&nbsp;N. Sola-Valls ,&nbsp;M. Hervas ,&nbsp;S. Llufriu","doi":"10.1016/j.nicl.2025.103775","DOIUrl":"10.1016/j.nicl.2025.103775","url":null,"abstract":"<div><div>This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer® (GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre- and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 ± 8.8, disease duration 16.8 ± 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (−25 % and −17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (<em>p</em> = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103775"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity abnormalities in clinical variants of progressive supranuclear palsy","authors":"Irene Sintini ,&nbsp;Farwa Ali ,&nbsp;Yehkyoung Stephens ,&nbsp;Heather M. Clark ,&nbsp;Julie A. Stierwalt ,&nbsp;Mary M. Machulda ,&nbsp;Ryota Satoh ,&nbsp;Keith A. Josephs ,&nbsp;Jennifer L. Whitwell","doi":"10.1016/j.nicl.2024.103727","DOIUrl":"10.1016/j.nicl.2024.103727","url":null,"abstract":"<div><div>Progressive supranuclear palsy (PSP) can present with different clinical variants which show distinct, but partially overlapping, patterns of neurodegeneration and tau deposition in a network of regions including cerebellar dentate, superior cerebellar peduncle, midbrain, thalamus, basal ganglia, and frontal lobe. We sought to determine whether disruptions in functional connectivity within this PSP network measured using resting-state functional MRI (rs-fMRI) differed between PSP-Richardson’s syndrome (PSP-RS) and the cortical and subcortical clinical variants of PSP. Structural MRI and rs-fMRI scans were collected for 36 PSP-RS, 25 PSP-cortical and 34 PSP-subcortical participants who met the Movement Disorder Society PSP clinical criteria. Ninety participants underwent flortaucipir-PET scans. MRIs were processed using CONN Toolbox. Functional connectivity between regions of the PSP network was compared between each PSP group and 83 healthy controls, and between the PSP groups, covarying for age. The effect of flortaucipir uptake and clinical scores on connectivity was assessed. Connectivity was reduced in PSP-RS compared to controls throughout the network, involving cerebellar dentate, midbrain, basal ganglia, thalamus, and frontal regions. Frontal regions showed reduced connectivity to other regions in the network in PSP-cortical, particularly the thalamus, caudate and substantia nigra. Disruptions in connectivity in PSP-subcortical were less pronounced, with the strongest disruption between the pallidum and striatum. There was moderate evidence that elevated subcortical flortaucipir uptake correlated with both increased and reduced connectivity between regions of the PSP network. Lower connectivity within the PSP network correlated with worse performance on clinical tests, including PSP rating scale. Patterns of disrupted functional connectivity revealed both variant-specific and shared disease pathways within the PSP network among PSP clinical variants, providing insight into disease heterogeneity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103727"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential tractography identifies a distinct pattern of white matter alterations in essential tremor with or without resting tremor","authors":"Alessia Sarica ,&nbsp;Vera Gramigna ,&nbsp;Fulvia Arcuri ,&nbsp;Marianna Crasà ,&nbsp;Camilla Calomino ,&nbsp;Rita Nisticò ,&nbsp;Maria Giovanna Bianco ,&nbsp;Andrea Quattrone ,&nbsp;Aldo Quattrone","doi":"10.1016/j.nicl.2025.103734","DOIUrl":"10.1016/j.nicl.2025.103734","url":null,"abstract":"<div><div>Essential Tremor (ET) is characterized by action tremor often associated with resting tremor (rET). Although previous studies have identified widespread brain white matter (WM) alterations in ET patients, differences between ET and rET have been less explored. In this study we employed differential tractography to investigate WM microstructural alterations in these tremor disorders.</div><div>We conducted a Diffusion Tensor Imaging (DTI) study on age- and sex-matched cohorts: 25 healthy controls (HC), 30 ET, and 30 rET patients. Differential tractography using DSI Studio was employed to pairwise compare fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) among cohorts.</div><div>ET and rET patients compared to HC exhibited similar widespread MD increase especially in basal ganglia and brainstem projections. WM changes were more pronounced in the left cerebral hemisphere and cerebellum (crus I and II) in ET, while in rET patients WM alterations were prevalent in right cerebral hemisphere and cerebellum crus I. Small FA decrease was found in rET but not in ET patients. ET patients showed changes in the left non-decussating dentato-rubro-thalamic tract (ndDRTT), whereas rET patients showed changes in both left ndDRTT and right decussating DRTT. In conclusion, our findings confirmed the DRTT involvement in essential tremor and demonstrated that ET and rET exhibited similar microstructural WM changes in the brain, with different hemispheric involvement—greater on the left side in ET and on the right side in rET—suggesting that these tremor disorders may be distinct subtypes of the same disease.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103734"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease","authors":"John McFadden ,&nbsp;Julian Matthews ,&nbsp;Lauren Scott ,&nbsp;Karl Herholz ,&nbsp;Ben Dickie ,&nbsp;Hamied Haroon ,&nbsp;Oliver Sparasci ,&nbsp;Saadat Ahmed ,&nbsp;Natalia Kyrtata ,&nbsp;Geoffrey J.M. Parker ,&nbsp;Hedley C.A. Emsley ,&nbsp;Joel Handley ,&nbsp;Maélène Lohezic ,&nbsp;Laura M. Parkes","doi":"10.1016/j.nicl.2025.103746","DOIUrl":"10.1016/j.nicl.2025.103746","url":null,"abstract":"<div><div>Cerebrovascular disease is an important contributor to dementia with reductions in cerebral blood flow (CBF) potentially compromising oxygen supply. In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO₂). We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO₂, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO₂, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. ATT rose by 132 ms per 10 point increase in QRisk and there was a trend for reduced CBF. Compensatory increases in OEF occurred in association with modified ATT and CBF, preserving CMRO₂. There was no regional variation to these relationships. Cognitive impairment was associated with prolonged ATT. These findings demonstrate the potential use of multi-delay time ASL and Quantitative Susceptibility Mapping for the early detection of cerebrovascular changes and provide evidence for compensatory increases in oxygen extraction in the presence of reduced blood flow.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103746"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143316184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplastic changes in patients with functional seizures following neurobehavioral therapy","authors":"Ayushe A. Sharma ,&nbsp;Jane B. Allendorfer ,&nbsp;Stephen Correia ,&nbsp;Tyler E. Gaston ,&nbsp;Adam Goodman ,&nbsp;Leslie E Grayson ,&nbsp;Noah S. Philip ,&nbsp;W. Curt LaFrance Jr ,&nbsp;Jerzy P. Szaflarski","doi":"10.1016/j.nicl.2025.103774","DOIUrl":"10.1016/j.nicl.2025.103774","url":null,"abstract":"<div><div>Given the high prevalence of functional neurological symptom disorder and its negative effects on the individual, family, and society, the development of interventions to treat it—including the subtype of functional seizures (FS)—is critical.<!--> <!-->Although we have limited understanding of the neurobiological effects of neurobehavioral therapy (NBT), studies indicate that NBT reduces seizures and improves psychological comorbidities in FS. In this study, healthy adults (N = 33) and patients with a history of TBI with (TBI-FS; N = 50) and without FS (TBI-only; N = 50) underwent magnetic resonance imaging (MRI) at 3 T approximately 12 weeks apart. TBI-FS participants underwent up to 12 sessions of NBT between scans. Structural MRI data were analyzed using voxel-based morphometry. A voxelwise repeated measures ANOVA tested changes in grey matter volume (GMV) between groups over time. Following treatment with NBT, TBI-FS participants showed a 1.23 % GMV increase in the left inferior and middle temporal gyri (<em>p</em>_FWE &lt; 0.05) along with a 35.78 % reduction in seizure events and decrease in depressive (<em>p</em> &lt; 0.001) and anxiety (<em>p</em> = 0.01) symptoms. Left temporal GMV increases were directly associated (<em>p</em> = 0.04, r = 0.26) with improvements in overall psychological, social, and occupational functioning (<em>p</em> &lt; 0.001). We observed structural brain changes within the left inferior temporal gyrus following NBT that correspond to functional and psychological improvements in patients with TBI-FS. This work highlights the need for further research into the neurobiological effects of NBT, building on the relationship between NBT and brain plasticity and demonstrating putative targets for interventions.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103774"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}