Event-related potential markers of subjective cognitive decline and mild cognitive impairment during a sustained visuo-attentive task

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2025.103760

A.A. Vergani , S. Mazzeo , V. Moschini , R. Burali , M. Lassi , L.G. Amato , J. Carpaneto , G. Salvestrini , C. Fabbiani , G. Giacomucci , C. Morinelli , F. Emiliani , M. Scarpino , S. Bagnoli , A. Ingannato , B. Nacmias , S. Padiglioni , S. Sorbi , V. Bessi , A. Grippo , A. Mazzoni

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引用次数: 0

Abstract

Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s disease stages lack well-defined electrophysiological correlates, creating a critical gap in the identification of robust biomarkers for early diagnosis and intervention. In this study, we analysed event-related potentials (ERPs) recorded during a sustained visual attention task in a cohort of 178 individuals (119 SCD, 40 MCI, and 19 healthy subjects, HS) to investigate sensory and cognitive processing alterations associated with these conditions. SCD patients exhibited significant attenuation in both sensory (P1, N1, P2) and cognitive (P300, P600, P900) components compared to HS, with cognitive components showing performance-related gains. In contrast, MCI patients did not show a further decrease in any ERP component compared to SCD. Instead, they exhibited compensatory enhancements, reversing the downward trend observed in SCD. This compensation resulted in a non-monotonic pattern of ERP alterations across clinical conditions, suggesting that MCI patients engage neural mechanisms to counterbalance sensory and cognitive deficits. These findings support the use of electrophysiological markers in support of medical decision-making, enhancing personalized prognosis and guiding targeted interventions in cognitive decline.

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持续视觉注意任务中主观认知能力下降和轻度认知障碍的事件相关潜在标记

主观认知衰退（SCD）、轻度认知障碍（MCI）和阿尔茨海默病的阶段缺乏明确的电生理相关性，这在识别早期诊断和干预的强大生物标志物方面造成了重大空白。在这项研究中，我们分析了178名个体（119名SCD， 40名MCI和19名健康受试者，HS）在持续视觉注意任务中记录的事件相关电位（erp），以调查与这些条件相关的感觉和认知加工改变。与HS相比，SCD患者在感觉（P1, N1, P2）和认知（P300, P600, P900）方面均表现出明显的衰减，认知方面表现出与表现相关的提高。相比之下，与SCD相比，MCI患者没有表现出任何ERP成分的进一步下降。相反，它们表现出代偿性增强，逆转了SCD中观察到的下降趋势。这种补偿导致不同临床条件下ERP改变的非单调模式，表明MCI患者参与神经机制来平衡感觉和认知缺陷。这些发现支持使用电生理标志物来支持医疗决策，增强个性化预后，并指导有针对性的干预认知衰退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.