Neuroimage-Clinical最新文献

{"title":"Alterations of long-range association fibers in patients with anti-N-methyl-D-aspartate receptor encephalitis","authors":"Xiaodong Chen ,&nbsp;Ling Fang ,&nbsp;Yiying Huang ,&nbsp;Yu Huang ,&nbsp;Yi Lu ,&nbsp;Jinhui Wang ,&nbsp;Chunxin Liu ,&nbsp;Huanquan Liao ,&nbsp;Liemin Zhou ,&nbsp;Wei Qiu ,&nbsp;Yaqing Shu","doi":"10.1016/j.nicl.2025.103808","DOIUrl":"10.1016/j.nicl.2025.103808","url":null,"abstract":"<div><h3>Background</h3><div>Patients with anti-NMDAR encephalitis typically exhibit impaired cognitive integration, which relies on the integrity of long-range association fibers connecting diverse brain regions. However, the microstructural integrity of long-range association fibers in this population remains unknown.</div></div><div><h3>Methods</h3><div>Diffusion tensor imaging (DTI) data were collected from 32 patients with anti-NMDAR encephalitis and 30 healthy controls. Patients were further categorized into early and delayed immunotherapy subgroups based on a 2-week threshold for immunotherapy initiation. The diffusion properties of major long-range association fibers were quantified at both the bundle and node levels.</div></div><div><h3>Results</h3><div>Compared with healthy controls, patients exhibited widespread microstructural damage within long-range association fibers, with more severe alterations in the delayed immunotherapy subgroup (FDR-corrected <em>p</em> &lt; 0.05). In this subgroup(n = 14), radial diffusivity (RD) of left inferior fronto-occipital fasciculus (IFOF), left inferior longitudinal fasciculus (ILF), left superior longitudinal fascicles (SLF), and bilateral arcuate fascicles correlated significantly with global cognition (MMSE, FDR-corrected <em>p</em> &lt; 0.05). Notably, RD also strongly correlated with working memory in the delayed immunotherapy subgroup, showing bundle-wise associations for IFOF (left: <em>r =</em> -0.8315, <em>p =</em> 0.0112; right: <em>r =</em> -0.7044, <em>p =</em> 0.0295), ILF (left: <em>r =</em> -0.7473, <em>p =</em> 0.0243), SLF (left: <em>r =</em> -0.7562, <em>p =</em> 0.0243; right<em>: r =</em> -0.6599, <em>p =</em> 0.0391), and arcuate fasciculus (left: <em>r =</em> -0.7240, <em>p =</em> 0.0272; right: <em>r =</em> -0.6835, <em>p =</em> 0.0333), with left-hemisphere predominance confirmed by node-wise analyses of IFOF, ILF, SLF, and arcuate fasciculus (FDR-corrected <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Our findings highlight widespread microstructural damage in long-range association fibers in patients with anti-NMDAR encephalitis, particularly in those with delayed immunotherapy. This damage may serve as the neurophysiological basis for cognitive impairments, with working memory being most affected.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103808"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical spinal cord MRI in ALS individuals: a systematic review and meta-analysis","authors":"Taravat Yazdanian ,&nbsp;Parisa Azimi ,&nbsp;Suma Babu","doi":"10.1016/j.nicl.2025.103832","DOIUrl":"10.1016/j.nicl.2025.103832","url":null,"abstract":"<div><h3>Background</h3><div>Disease tracking and prognostication of amyotrophic lateral sclerosis (ALS) can be quite challenging in people living with ALS, due to the complexity of central nervous system disease biology<strong>.</strong> This systematic review and meta-analysis aim to summarize cervical spinal cord quantitative MRI (qMRI) biomarker changes in individuals with ALS.</div></div><div><h3>Methods</h3><div>PubMed, Scopus, Cochrane Library, and Web of Science databases were searched up to August 2023. The terms used were “ALS”, “cervical spinal cord”, “MRI”,“ diffusion tensor imaging (DTI)”, “ fractional anisotropy (FA)”, “ mean diffusivity (MD) ”,“ magnetization transfer ratio (MTR)”, “ cross-sectional area (CSA)”, “ radial diffusivity (RD) ”, and “ atrophy ”. The Newcastle-Ottawa scale (NOS) was used to assess study quality. We calculated the pooled: 1) Standardized mean difference (SMD) and 95% CIs for comparative assessment of qMRI parameters in ALS individuals and the healthy population. 2) Estimate the mean of qMRI parameters for normative values in two groups by CMA software. Heterogeneity and publication bias were determined by the I-squared statistic and funnel plots.</div></div><div><h3>Results</h3><div>Thirty studies, with 1817 participants (35.9 % female) were included in this review, and 29 had a NOS ≥ 5 which indicates high-quality of data overall. The SMD analysis showed (a) significant decrease in CSA along the whole length of cervical cord (C1-C7) (p value &lt; 0.0001), with a preferential thinning of the cervical enlargement region (C4-C6 region) (p value &lt; 0.0001) (b) significant decrease in FA (p value &lt; 0.0001), particularly FA left lateral corticospinal tract (p value &lt; 0.0001) and (c) a significant increase in MD (p value &lt; 0.0001) in ALS individuals compared to controls. The pooled analysis reveals that the mean (SD) values for ALS individuals versus controls for (a) CSA (in mm²) were C1 [73.4 (0.75), 78.5 (0.67), 6.9 % difference]; C2 [70.6 (3.1), 71.5 (3.5), 1.2 % difference]; C3 [69.8(1.5), 74.9 (1.9), 7.3 % difference]; C4 [71.9 (1.8), 77.6 (2.8), 7.9 % difference]; C5 [71.8 (2.5), 79.5 (3.3), 10.7 % difference]; C6 [66.8 (2.7), 73.7 (3.7), 10.3 % difference]; C7 [56.7 (F2.2), 62.1 (2.5), 9.5 % difference]; (b) FA [0.54 (0.03), 0.56 (0.03)]; (c) MD[1.11 (0.18), 0.88(0)]; and (d) FA LLCST [ 0.65 (0.04), 0.77 (0.04)], respectively. The mean (SD) value of the MTR and RD for ALS individuals was 40.3 (2.3), and 0.70 (0.0).</div></div><div><h3>Conclusions</h3><div>qMRI metrics of spinal cord show discriminatory potential between ALS and healthy controls. The selective atrophy of the cervical enlargement (C4–C6) is replicable across multiple studies as seen in this metanalysis and hence is a potential imaging marker for quantifying and tracking lower motor neuron degeneration in ALS.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103832"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic normal pressure hydrocephalus: A sulcal morphometry approach to brain phenotype and clinical response","authors":"Arben Miftari ,&nbsp;Fabrizio Pizzagalli ,&nbsp;Giulia Bommarito ,&nbsp;Stéphane Armand ,&nbsp;Frederic Assal ,&nbsp;Dimitri Van De Ville ,&nbsp;Alessandra Griffa ,&nbsp;Gilles Allali","doi":"10.1016/j.nicl.2025.103816","DOIUrl":"10.1016/j.nicl.2025.103816","url":null,"abstract":"<div><div>Idiopathic normal pressure hydrocephalus (iNPH), the leading cause of reversible dementia in older adults, is characterized by urinary incontinence, gait impairment, cognitive decline, and ventriculomegaly. Neuroradiological features rely on visual assessment, including sulcal characteristics. This study applies automatic sulcal-based morphometry to characterize the sulcal phenotype in iNPH and to distinguish responders from non-responders.</div><div>We analyzed the sulcal morphology in 32 iNPH patients and 41 healthy controls. Patients were categorized as responders (Resp) or non-responders (nResp) based on gait improvement following a cerebrospinal fluid tap test. A generalized linear model identified the iNPH sulcal phenotype, and a Support Vector Machine (SVM) classifier was applied to distinguish iNPH patients from controls, as well as Resp from nResp.</div><div>We found that sulcal depth and widening were the key descriptors of the iNPH brain phenotype. Eight core sulci contributed the most, including compressed central, superior frontal, and frontal intraparietal bilateral sulci, and flattened left calcarine and posterior lateral fissures. An SVM classifier trained on these features effectively differentiated iNPH patients from controls (AUC: 0.933) but had limited accuracy for Resp vs. nResp (AUC: 0.556). Post-hoc analyses showed smaller superior frontal sulcal opening in nResp than in Resp.</div><div>This study identified an iNPH neuroradiological phenotype based on sulcal morphology, emphasizing depth and opening as key markers. SVM classifiers trained on different sulci features performed well in differentiating healthy controls from iNPH patients but was less effective for Resp vs. nResp. Future research should investigate more advanced anatomical landmarks in iNPH.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"47 ","pages":"Article 103816"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of resting-state fMRI graph measures in hypoxic encephalopathy after cardiac arrest","authors":"Puck Lange ,&nbsp;Marlous Verhulst ,&nbsp;Anil Man Tuladhar ,&nbsp;Prejaas Tewarie ,&nbsp;Hanneke Keijzer ,&nbsp;Catharina J.M. Klijn ,&nbsp;Cornelia Hoedemaekers ,&nbsp;Michiel Blans ,&nbsp;Bart Tonino ,&nbsp;Frederick J.A. Meijer ,&nbsp;Rick C. Helmich ,&nbsp;Jeannette Hofmeijer","doi":"10.1016/j.nicl.2025.103763","DOIUrl":"10.1016/j.nicl.2025.103763","url":null,"abstract":"<div><h3>Introduction</h3><div>Current multimodal prediction models can determine the prognosis of about half of comatose cardiac arrest patients. We investigated whether whole-brain graph-theoretical measures from early resting-state functional magnetic resonance imaging (fMRI) three days after cardiac arrest discriminate between good and poor outcome and improve outcome prediction.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study on comatose cardiac arrest patients on intensive care units. Resting-state fMRI three days after cardiac arrest was used to quantify whole-brain functional connectivity, global efficiency, clustering coefficient, and modularity. Neurological outcome at six months was classified as good or poor (Cerebral Performance Category 1–2 vs 3–5). Logistic regression models were used to examine between-group differences and study the additional value of graph-theoretical measures to clinical and EEG-based prediction.</div></div><div><h3>Results</h3><div>In seventy included patients (good outcome n = 44, poor n = 26), whole-brain functional connectivity and clustering coefficient (but not global efficiency and modularity) were significantly lower in patients with poor outcome. Connectivity of nodes in posterior brain areas most prominently correlated with outcome. Clustering coefficient showed strong correlation with whole-brain functional connectivity. Patients with continuous EEG patterns differed in whole-brain functional connectivity levels from those with suppressed or epileptiform patterns. Combining functional connectivity or graph measures with clinical and EEG-based predictors slightly improved outcome prediction.</div></div><div><h3>Conclusion</h3><div>fMRI-based whole-brain functional connectivity is a sensitive measure for encephalopathy severity after cardiac arrest, according to relations with established EEG categories and discrimination between good and poor outcome. Additional predictive values for outcome seem small. Graph measures do not provide complementary information.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103763"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reshaped functional connectivity gradients in acute ischemic stroke","authors":"Cemal Koba ,&nbsp;Joan Falcó-Roget ,&nbsp;Alessandro Crimi","doi":"10.1016/j.nicl.2025.103755","DOIUrl":"10.1016/j.nicl.2025.103755","url":null,"abstract":"<div><div>Ischemic brain stroke disrupts blood flow, leading to functional and structural changes associated with behavioral deficits. Importantly, despite this disruption occurring in localized regions, the resulting changes in the functional organization are both high-dimensional and widespread across the human cortex. However, the mechanisms with which these global patterns emerge and the subsequent behavioral deficits they entail, remain largely unexplored. Functional connectivity gradients provide consistent, reproducible, and robust low-dimensional representations of brain function that can be explored to reduce brain heterogeneity to a handful of axes along which brain function is organized. Here, we investigated how stroke disrupts this canonical gradient space by aligning each patient to a control-averaged gradient embedding and computing the distances to the “correct” positions to quantify functional deviations and their contribution to behavioral deficits. Importantly, we explicitly corrected these gradients for stroke-induced hemodynamic lags to further study their contribution. We found that lag correction enhanced the functional connectivity gradients most prominently in the second gradient, on which visual and somatomotor function is concentrated. Additionally, we identified significant functional deviations primarily within somatomotor, visual, and ventral attention networks, correlating with behavioral impairments. We studied the hemispheric asymmetries of these deviations finding that intact hemispheres preserve comparable patterns of asymmetry while damaged ones presented important changes. Lastly, right-sided lesions displayed more localized functional deviations than their contralateral lesions. Overall, we provide evidence that (1) correcting for hemodynamic lags improves gradient accuracy, as indicated by increased percentages of explained variance, and (2) behavioral impairments and hemispheric asymmetries result from a repositioning of region-based connectivity profiles in a low-dimensional interpretable space. This suggests that large-scale brain function alterations manifest in slight, predictable movements along a reduced set of brain axes that are not completely detached from white matter damage.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103755"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrovascular longitudinal atlas: Changes in cerebral arteries in unruptured intracranial aneurysm patients followed with MRA","authors":"Aichi Chien ,&nbsp;Fernando Vinuela ,&nbsp;Viktor Szeder ,&nbsp;Geoffrey Colby ,&nbsp;Reza Jahan ,&nbsp;Anthony Wang ,&nbsp;Satoshi Tateshima ,&nbsp;Gary Duckwiler ,&nbsp;Noriko Salamon","doi":"10.1016/j.nicl.2025.103766","DOIUrl":"10.1016/j.nicl.2025.103766","url":null,"abstract":"<div><h3>Background</h3><div>Patterns of change in cerebrovascular (CV) morphology associated with aging are highly relevant to the incidence and progression of CV disease, particularly stroke. Intracranial aneurysms (IA), a leading cause of hemorrhagic stroke, are linked with factors such as blood flow, arterial stiffness, and inflammation that may also drive other changes in CV morphology. We worked with a cohort of longitudinally-imaged IA patients to construct the first longitudinal atlas of CV morphology and studied its relationship with disease.</div></div><div><h3>Methods</h3><div>110 IA patients, ranging from 19 to 84 years old at IA detection, were monitored using 3D magnetic resonance angiography (MRA) for a mean of 6.11 (2.60) years with 3.6 (1.3) scans per patient. Using 405 image studies, we applied a machine learning diffeomorphic shape analysis to construct a longitudinal atlas of the cerebral arteries which defined a general trajectory of CV morphological change vs. age. This was paired with a centerline analysis to verify changes in individual arteries.</div></div><div><h3>Results</h3><div>Patient characteristics influenced the speed of CV shape change (e.g. diabetes mellitus, faster, p = 0.016), while other factors mapped to older CV age (e.g. hypertension, p = 0.0004). In parallel, we found that groups including autosomal dominant polycystic kidney disease (p = 0.0004), sex (p = 0.005), smoking (p = 0.046), and IA growth (p = 0.020) shared CV morphology characteristics. The centerline analysis validated changes consistent with the longitudinal atlas.</div></div><div><h3>Conclusion</h3><div>A general CV trajectory of increasing artery length and tortuosity over a period of several decades was found. Although specific IA characteristics were not found to significantly affect this trajectory, these changes in the CV may contribute to increases in IA risk with aging. While our longitudinal findings were consistent with previous cross-sectional studies of individuals without IA, it remains to be determined whether the pattern of morphological change we observed is representative of aging within the general population. The model we developed provides a basis for integrating CV morphological change into understanding of aging and disease.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103766"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional cerebellar atrophy related to disability and cognitive progression in multiple sclerosis","authors":"Myrte Strik ,&nbsp;Iris Dekker ,&nbsp;Aurélie Ruet ,&nbsp;Hanneke Hulst ,&nbsp;Mike P. Wattjes ,&nbsp;Frederik Barkhof ,&nbsp;Bernard Uitdehaag ,&nbsp;Joep Killestein ,&nbsp;Menno Schoonheim","doi":"10.1016/j.nicl.2025.103792","DOIUrl":"10.1016/j.nicl.2025.103792","url":null,"abstract":"<div><h3>Objective</h3><div>The implications of cerebellar pathology on clinical disease progression in multiple sclerosis (MS) remain unclear. This study investigated regional cerebellar atrophy related to physical disability and cognitive impairment progression.</div></div><div><h3>Methods</h3><div>We included 331 MS patients and 95 controls (Amsterdam MS Cohort, 229 patients and 58 controls re-evaluated after 5 years). Assessments included baseline MRI, and disability and cognition at baseline and follow up. Cerebellar (sub)cortex was parcellated, volumetric data were determined and related to baseline disability and cognition. Longitudinal progression was explored only for regions with significant baseline correlations.</div></div><div><h3>Results</h3><div>At baseline, patients had mild disability (median EDSS 3.0) and 46% showing mild-to-severe cognitive impairment. At follow-up, 34.5% showed EDSS progression and 26.6% cognitive decline. All global and most regional volumes showed atrophy. Cross-sectionally, atrophy of several regions encompassing both anterior and posterior lobes correlated with both disability and cognition, while some correlated with EDSS only. Additionally, cerebellar nuclei only correlated with cognition. Cerebellar volumes were mainly related to information processing speed, working and verbal memory. Longitudinally, atrophy in the posterior lobe, lobule VI and VIIIb, and vermis VI, correlated with cognitive decline, while no variables correlated with disability progression.</div></div><div><h3>Conclusion</h3><div>Regional cerebellar atrophy in both anterior and posterior lobes correlated with disability and cognitive impairment. Posterior regional atrophy was correlated with longitudinal cognitive decline, but none correlated with disability progression. Further research is required to elucidate these relationships.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103792"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis","authors":"E. Lopez-Soley ,&nbsp;E. Martinez-Heras ,&nbsp;F. Vivo ,&nbsp;A. Calvi ,&nbsp;S. Alba-Arbalat ,&nbsp;L. Romero-Pinel ,&nbsp;S. Martínez-Yélamos ,&nbsp;C. Ramo-Tello ,&nbsp;S. Presas-Rodríguez ,&nbsp;E. Munteis ,&nbsp;J.E. Martínez-Rodríguez ,&nbsp;J. Sastre-Garriga ,&nbsp;E. Anglada ,&nbsp;E.R. Meza-Murillo ,&nbsp;M.J. Arévalo ,&nbsp;R. Sánchez-Carrión ,&nbsp;R. Pelayo ,&nbsp;M. Bernabeu ,&nbsp;N. Sola-Valls ,&nbsp;M. Hervas ,&nbsp;S. Llufriu","doi":"10.1016/j.nicl.2025.103775","DOIUrl":"10.1016/j.nicl.2025.103775","url":null,"abstract":"<div><div>This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer® (GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre- and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 ± 8.8, disease duration 16.8 ± 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (−25 % and −17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (<em>p</em> = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"46 ","pages":"Article 103775"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity abnormalities in clinical variants of progressive supranuclear palsy","authors":"Irene Sintini ,&nbsp;Farwa Ali ,&nbsp;Yehkyoung Stephens ,&nbsp;Heather M. Clark ,&nbsp;Julie A. Stierwalt ,&nbsp;Mary M. Machulda ,&nbsp;Ryota Satoh ,&nbsp;Keith A. Josephs ,&nbsp;Jennifer L. Whitwell","doi":"10.1016/j.nicl.2024.103727","DOIUrl":"10.1016/j.nicl.2024.103727","url":null,"abstract":"<div><div>Progressive supranuclear palsy (PSP) can present with different clinical variants which show distinct, but partially overlapping, patterns of neurodegeneration and tau deposition in a network of regions including cerebellar dentate, superior cerebellar peduncle, midbrain, thalamus, basal ganglia, and frontal lobe. We sought to determine whether disruptions in functional connectivity within this PSP network measured using resting-state functional MRI (rs-fMRI) differed between PSP-Richardson’s syndrome (PSP-RS) and the cortical and subcortical clinical variants of PSP. Structural MRI and rs-fMRI scans were collected for 36 PSP-RS, 25 PSP-cortical and 34 PSP-subcortical participants who met the Movement Disorder Society PSP clinical criteria. Ninety participants underwent flortaucipir-PET scans. MRIs were processed using CONN Toolbox. Functional connectivity between regions of the PSP network was compared between each PSP group and 83 healthy controls, and between the PSP groups, covarying for age. The effect of flortaucipir uptake and clinical scores on connectivity was assessed. Connectivity was reduced in PSP-RS compared to controls throughout the network, involving cerebellar dentate, midbrain, basal ganglia, thalamus, and frontal regions. Frontal regions showed reduced connectivity to other regions in the network in PSP-cortical, particularly the thalamus, caudate and substantia nigra. Disruptions in connectivity in PSP-subcortical were less pronounced, with the strongest disruption between the pallidum and striatum. There was moderate evidence that elevated subcortical flortaucipir uptake correlated with both increased and reduced connectivity between regions of the PSP network. Lower connectivity within the PSP network correlated with worse performance on clinical tests, including PSP rating scale. Patterns of disrupted functional connectivity revealed both variant-specific and shared disease pathways within the PSP network among PSP clinical variants, providing insight into disease heterogeneity.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103727"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential tractography identifies a distinct pattern of white matter alterations in essential tremor with or without resting tremor","authors":"Alessia Sarica ,&nbsp;Vera Gramigna ,&nbsp;Fulvia Arcuri ,&nbsp;Marianna Crasà ,&nbsp;Camilla Calomino ,&nbsp;Rita Nisticò ,&nbsp;Maria Giovanna Bianco ,&nbsp;Andrea Quattrone ,&nbsp;Aldo Quattrone","doi":"10.1016/j.nicl.2025.103734","DOIUrl":"10.1016/j.nicl.2025.103734","url":null,"abstract":"<div><div>Essential Tremor (ET) is characterized by action tremor often associated with resting tremor (rET). Although previous studies have identified widespread brain white matter (WM) alterations in ET patients, differences between ET and rET have been less explored. In this study we employed differential tractography to investigate WM microstructural alterations in these tremor disorders.</div><div>We conducted a Diffusion Tensor Imaging (DTI) study on age- and sex-matched cohorts: 25 healthy controls (HC), 30 ET, and 30 rET patients. Differential tractography using DSI Studio was employed to pairwise compare fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) among cohorts.</div><div>ET and rET patients compared to HC exhibited similar widespread MD increase especially in basal ganglia and brainstem projections. WM changes were more pronounced in the left cerebral hemisphere and cerebellum (crus I and II) in ET, while in rET patients WM alterations were prevalent in right cerebral hemisphere and cerebellum crus I. Small FA decrease was found in rET but not in ET patients. ET patients showed changes in the left non-decussating dentato-rubro-thalamic tract (ndDRTT), whereas rET patients showed changes in both left ndDRTT and right decussating DRTT. In conclusion, our findings confirmed the DRTT involvement in essential tremor and demonstrated that ET and rET exhibited similar microstructural WM changes in the brain, with different hemispheric involvement—greater on the left side in ET and on the right side in rET—suggesting that these tremor disorders may be distinct subtypes of the same disease.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"45 ","pages":"Article 103734"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}