Differential tractography identifies a distinct pattern of white matter alterations in essential tremor with or without resting tremor

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2025.103734

Alessia Sarica , Vera Gramigna , Fulvia Arcuri , Marianna Crasà , Camilla Calomino , Rita Nisticò , Maria Giovanna Bianco , Andrea Quattrone , Aldo Quattrone

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Abstract

Essential Tremor (ET) is characterized by action tremor often associated with resting tremor (rET). Although previous studies have identified widespread brain white matter (WM) alterations in ET patients, differences between ET and rET have been less explored. In this study we employed differential tractography to investigate WM microstructural alterations in these tremor disorders.

We conducted a Diffusion Tensor Imaging (DTI) study on age- and sex-matched cohorts: 25 healthy controls (HC), 30 ET, and 30 rET patients. Differential tractography using DSI Studio was employed to pairwise compare fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) among cohorts.

ET and rET patients compared to HC exhibited similar widespread MD increase especially in basal ganglia and brainstem projections. WM changes were more pronounced in the left cerebral hemisphere and cerebellum (crus I and II) in ET, while in rET patients WM alterations were prevalent in right cerebral hemisphere and cerebellum crus I. Small FA decrease was found in rET but not in ET patients. ET patients showed changes in the left non-decussating dentato-rubro-thalamic tract (ndDRTT), whereas rET patients showed changes in both left ndDRTT and right decussating DRTT. In conclusion, our findings confirmed the DRTT involvement in essential tremor and demonstrated that ET and rET exhibited similar microstructural WM changes in the brain, with different hemispheric involvement—greater on the left side in ET and on the right side in rET—suggesting that these tremor disorders may be distinct subtypes of the same disease.

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鉴别神经束造影鉴别出特发性震颤伴或不伴静息性震颤时白质改变的独特模式。

特发性震颤（ET）的特点是活动性震颤，常伴有静息性震颤（rET）。虽然先前的研究已经发现ET患者脑白质（WM）的广泛改变，但ET和rET之间的差异却很少被探索。在这项研究中，我们采用微分束造影来研究这些震颤障碍的WM微结构改变。我们对年龄和性别匹配的队列进行了弥散张量成像（DTI）研究：25名健康对照（HC）， 30名ET和30名rET患者。采用DSI Studio进行差分神经束造影，两两比较各组间的分数各向异性（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）。与HC相比，ET和rET患者表现出相似的广泛MD增加，特别是基底节区和脑干突起。ET患者的WM变化在左大脑半球和小脑（小腿I和小腿II）更为明显，而rET患者的WM变化普遍发生在右脑半球和小脑小腿I， rET患者的FA略有下降，而ET患者则没有。ET患者表现为左侧非讨论性齿状丘丘脑束（ndDRTT）的改变，而rET患者表现为左侧和DRTT以及右侧讨论性DRTT的改变。总之，我们的研究结果证实了DRTT参与特发性震颤，并证明ET和rET在大脑中表现出相似的微结构WM变化，不同的半球受累- ET在左侧更大，rET在右侧更大-这表明这些震颤疾病可能是同一疾病的不同亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.