Neuroimage-Clinical最新文献

{"title":"Individual-level analysis of MRI T2 relaxometry in mild traumatic brain injury: Possible indications of brain inflammation","authors":"Mayan J. Bedggood ,&nbsp;Christi A. Essex ,&nbsp;Alice Theadom ,&nbsp;Samantha J. Holdsworth ,&nbsp;Richard L.M. Faull ,&nbsp;Mangor Pedersen","doi":"10.1016/j.nicl.2024.103647","DOIUrl":"10.1016/j.nicl.2024.103647","url":null,"abstract":"<div><p>Mild traumatic brain injury (mTBI), often called concussion, is a prevalent condition that can have significant implications for people’s health, functioning and well-being. Current clinical practice relies on self-reported symptoms to guide decision-making regarding return to sport, employment, and education. Unfortunately, reliance on subjective evaluations may fail to accurately reflect the resolution of neuropathology, exposing individuals with mTBI to an increased risk of further head trauma. No objective technique currently exists to assess the microstructural alterations to brain tissue which characterise mTBI. MRI-based T2 relaxation is a quantitative imaging technique that is susceptible to detecting fluid properties in the brain and is hypothesised to indicate neuroinflammation. This study aimed to investigate the potential of individual-level T2 relaxometry to evaluate cellular damage from mTBI. 20 male participants with acute sports-related mTBI (within 14 days post-injury) and 44 healthy controls were recruited for this study. Each mTBI participant’s voxel-wise T2 relaxometry map was analysed against healthy control averages using a voxel-wise z-test with false discovery rate correction. Five participants were re-scanned after clinical recovery and results were compared to their acute T2 relaxometry maps to assess reduction in potential neuroinflammation. T2 relaxation times were significantly increased in 19/20 (95 %) mTBI participants compared to healthy controls, in regions including the hippocampus, frontal cortex, parietal cortex, insula, cingulate cortex and cerebellum. Results suggest the presence of increased cerebral fluid in individuals with mTBI. Longitudinal results indicated a reduction in T2 relaxation for all five participants, indicating a possible resolution over time. This research highlights the potential of individual-level T2 relaxometry MRI as a non-invasive method for assessing subtle brain pathology in mTBI. Identifying and monitoring changes in the fluid content in the brain could aid in predicting recovery and developing individualised treatment plans for individuals with mTBI. Future research should validate this measure with other markers of inflammation (e.g. from blood biomarkers) to test whether T2-relaxometry is related to subtle brain inflammation in mTBI. In addition, future research should utilise larger control groups to establish normative ranges and compute robust z-score analyses.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103647"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221315822400086X/pdfft?md5=5bdb5241589bf00c8168d012e1dcc76d&pid=1-s2.0-S221315822400086X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort","authors":"Tuulia Malén ,&nbsp;Severi Santavirta ,&nbsp;Sven De Maeyer ,&nbsp;Jouni Tuisku ,&nbsp;Valtteri Kaasinen ,&nbsp;Tuomas Kankare ,&nbsp;Janne Isojärvi ,&nbsp;Juha Rinne ,&nbsp;Jarmo Hietala ,&nbsp;Pirjo Nuutila ,&nbsp;Lauri Nummenmaa","doi":"10.1016/j.nicl.2024.103578","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103578","url":null,"abstract":"<div><h3>Purpose</h3><p>Aberrant dopaminergic function is linked with motor, psychotic, and affective symptoms, but studies have typically compared a single patient group with healthy controls.</p></div><div><h3>Methods</h3><p>Here, we investigated the variation in striatal (caudate nucleus, nucleus accumbens, and putamen) and thalamic type 2 dopamine receptor (D₂R) availability using [¹¹C]raclopride positron emission tomography (PET) data from a large sample of 437 humans including healthy controls, and subjects with Parkinson’s disease (PD), antipsychotic-naïve schizophrenia, severe violent behavior, pathological gambling, depression, and overweight. We analyzed regional group differences in D₂R availability. We also analyzed the interregional correlation in D₂R availability within each group.</p></div><div><h3>Results</h3><p>Subjects with PD showed the clearest decline in D₂R availability. Overall, the groups showed high interregional correlation in D₂R availability, while this pattern was weaker in violent offenders. Subjects with schizophrenia, pathological gambling, depression, or overweight did not show clear changes in either the regional receptor availability or the interregional correlation.</p></div><div><h3>Conclusion</h3><p>We conclude that the dopaminergic changes in neuropsychiatric conditions might not only affect the overall receptor availability but also how coupled regions are across people. The region-specific receptor availability more profoundly links to the motor symptoms, while the between-region coupling might be disrupted in violence.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103578"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000172/pdfft?md5=f191098ae02f10dff90773ddf0488128&pid=1-s2.0-S2213158224000172-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectivity-based segmentation of the thalamic motor region for deep brain stimulation in essential tremor: A comparison of deterministic and probabilistic tractography","authors":"Evangelia Tsolaki ,&nbsp;Alon Kashanian ,&nbsp;Kevin Chiu ,&nbsp;Ausaf Bari ,&nbsp;Nader Pouratian","doi":"10.1016/j.nicl.2024.103587","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103587","url":null,"abstract":"<div><h3>Objective</h3><p>Deep brain stimulation (DBS) studies have shown that stimulation of the motor segment of the thalamus based on probabilistic tractography is predictive of improvement in essential tremor (ET). However, probabilistic methods are computationally demanding, requiring the need for alternative tractography methods for use in the clinical setting. The purpose of this study was to compare probabilistic vs deterministic tractography methods for connectivity-based targeting in patients with ET.</p></div><div><h3>Methods</h3><p>Probabilistic and deterministic tractography methods were retrospectively applied to diffusion-weighted data sets in 36 patients with refractory ET. The thalamus and precentral gyrus were selected as regions of interest and fiber tracking was performed between these regions to produce connectivity-based thalamic segmentations, per prior methods. The resultant deterministic target maps were compared with those of thresholded probabilistic maps. The center of gravity (CG) of each connectivity map was determined and the differences in spatial distribution between the tractography methods were characterized. Furthermore, the intersection between the connectivity maps and CGs with the therapeutic volume of tissue activated (VTA) was calculated. A mixed linear model was then used to assess clinical improvement in tremor with volume of overlap.</p></div><div><h3>Results</h3><p>Both tractography methods delineated the region of the thalamus with connectivity to the precentral gyrus to be within the posterolateral aspect of the thalamus. The average CG of deterministic maps was more medial-posterior in both the left (3.7 ± 1.3 mm³) and the right (3.5 ± 2.2 mm³) hemispheres when compared to 30 %-thresholded probabilistic maps. Mixed linear model showed that the volume of overlap between CGs of deterministic and probabilistic targeting maps and therapeutic VTAs were significant predictors of clinical improvement.</p></div><div><h3>Conclusions</h3><p>Deterministic tractography can reconstruct DBS thalamic target maps in approximately 5 min comparable to those produced by probabilistic methods that require &gt; 12 h to generate. Despite differences in CG between the methods, both deterministic-based and probabilistic targeting were predictive of clinical improvement in ET.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"41 ","pages":"Article 103587"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000263/pdfft?md5=5ce1474d23ecc3140e45a4dbe12dd792&pid=1-s2.0-S2213158224000263-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139993122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of fNIRS measurement of executive demand during walking with and without dual-task in younger and older adults and people with Parkinson’s disease","authors":"Alexander Kvist ,&nbsp;Lucian Bezuidenhout ,&nbsp;Hanna Johansson ,&nbsp;Franziska Albrecht ,&nbsp;David Moulaee Conradsson ,&nbsp;Erika Franzén","doi":"10.1016/j.nicl.2024.103637","DOIUrl":"10.1016/j.nicl.2024.103637","url":null,"abstract":"<div><h3>Background</h3><p>Walking with a concurrent cognitive task (dual-task walking) can pose a challenge to some populations due to aging or neurodegenerative disease. These tasks require cognitive resources involving the prefrontal cortex and can be studied using functional near-infrared spectroscopy (fNIRS). An important step in understanding fNIRS measures during such walking tasks is validating that measures reflect the demands of the tasks and not confounding sources or movement artifacts.</p></div><div><h3>Aim</h3><p>This study aimed to investigate the validity of fNIRS measures of prefrontal cortex activity as an indicator of executive demand during usual walking (single-task) and dual-task walking against clinical and objective measures of motor behavior in young adults, older adults, and people with Parkinson’s disease (PD), by evaluating several validation hypotheses.</p></div><div><h3>Methods</h3><p>In total, 133 participants were recruited from younger adults (18–50 years, n = 42), older adults (≥60 years, n = 49) and people with PD (≥60 years, n = 42). Activity in the prefrontal cortex during walking with and without an auditory Stroop task was measured with fNIRS. A combined hemoglobin measure (correlation-based signal improvement, CBSI) was calculated for use in a region of interest analysis in the dorsolateral prefrontal cortex (dlPFC). Pre-registered hypotheses regarding convergent validity, discriminant validity and known group validity were tested. An exploratory analysis of different hemoglobin measures was also performed.</p></div><div><h3>Results</h3><p>Increases in dlPFC activity were found from single- to dual-task walking in the younger adults group and from rest to single-task walking in the older adults and PD groups. In line with hypotheses, a positive relationship was found between between dlPFC activity during dual-task walking and dual-task cost in the younger adults group, as well as a positive relationship to step time variability during single-task walking and a negative relationship to walking speed during single-task walking in the PD group. However, several clinical and gait measures lacked a relationship with dlPFC activity.</p></div><div><h3>Conclusion</h3><p>The fNIRS results point towards the CBSI measure of dlPFC activity being a valid measure of executive demand during both single and dual-task walking. Some relationships between clinical and gait measures and brain activity during walking need further investigation.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103637"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000767/pdfft?md5=ae07729c75b9b822bf4adc0656c92121&pid=1-s2.0-S2213158224000767-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABAergic imbalance in Parkinson’s disease–related depression determined with MEGA-PRESS","authors":"Xinzi Liu ,&nbsp;Yuxin Li ,&nbsp;Yixiang Mo ,&nbsp;Baoling Chen ,&nbsp;Xusheng Hou ,&nbsp;Jianbin Zhu ,&nbsp;Yongzhou Xu ,&nbsp;Jingyue Xue ,&nbsp;Haitao Wen ,&nbsp;Xianlong Wang ,&nbsp;Zhibo Wen","doi":"10.1016/j.nicl.2024.103641","DOIUrl":"10.1016/j.nicl.2024.103641","url":null,"abstract":"<div><h3>Objective</h3><p>The pathogenesis of depression in patients with Parkinson’s disease (PD) is poorly understood. Therefore, this study aimed to explore the changes in γ-aminobutyric acid (GABA) and glutamate plus glutamine (Glx) levels in patients with PD with or without depression determined using MEscher-GArwood Point Resolved Spectroscopy (MEGA-PRESS).</p></div><div><h3>Materials and methods</h3><p>A total of 83 patients with primary PD and 24 healthy controls were included. Patients with PD were categorized into depressed PD (DPD, <em>n</em> = 19) and nondepressed PD (NDPD, <em>n</em> = 64) based on the 17-item Hamilton Depression Rating Scale. All participants underwent T1-weighted imaging and MEGA-PRESS sequence to acquire GABA+ and Glx values. The MEGA-PRESS sequence was conducted using 18.48 mL voxels in the left thalamus and medial frontal cortex. The GABA+, Glx, and creatine values were quantified using Gannet 3.1 software.</p></div><div><h3>Results</h3><p>The GABA+ and Glx values were not significantly disparate between patients with PD and controls in the thalamus and medial frontal cortex. However, the levels of N-acetyl aspartate/creatine and choline/creatine in the left thalamus were significantly lower in patients with PD than in controls (<em>P</em> = .031, <em>P</em> = .009). The GABA+/Water and GABA+/Creatine in the medial frontal cortex were higher in DPD than in NDPD (<em>P</em> = .001, <em>P</em> = .004). The effects of depression on Glx or other metabolite levels were not evident, and no significant difference in metabolite values was noted in the left thalamus among all groups (<em>P</em> &gt; .05).</p></div><div><h3>Conclusions</h3><p>GABA+ levels increased in the medial frontal cortex in DPD, which may be more closely related to depressive pathology. Thus, alterations in GABAergic function in special brain structures may be related to the clinical manifestations of PD symptoms, and hence mediating this function might help in treating depression in PD.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103641"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000809/pdfft?md5=a32ba540d1ce5e88ab3d43f7c31e05cc&pid=1-s2.0-S2213158224000809-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic hypercortisolism disrupts the principal functional gradient in Cushing’s disease: A multi-scale connectomics and transcriptomics study","authors":"Guosong Shang ,&nbsp;Tao Zhou ,&nbsp;Xiaoteng Yu ,&nbsp;Xinyuan Yan ,&nbsp;Kunyu He ,&nbsp;Bin Liu ,&nbsp;Zhebin Feng ,&nbsp;Junpeng Xu ,&nbsp;Yanyang Zhang ,&nbsp;Xinguang Yu","doi":"10.1016/j.nicl.2024.103652","DOIUrl":"10.1016/j.nicl.2024.103652","url":null,"abstract":"<div><p>Cushing’s disease (CD) represents a state of cortisol excess, serving as a model to investigate the effects of prolonged hypercortisolism on functional brain. Potential alterations in the functional connectome of the brain may explain frequently reported cognitive deficits and affective disorders in CD patients. This study aims to elucidate the effects of chronic hypercortisolism on the principal functional gradient, which represents a hierarchical architecture with gradual transitions across cognitive processes, by integrating connectomics and transcriptomics approaches. Utilizing resting-state functional magnetic resonance imaging data from 140 participants (86 CD patients, 54 healthy controls) recruited at a single center, we explored the alterations in the principal gradient in CD patients. Further, we thoroughly explored the underlying associative mechanisms of the observed characteristic alterations with cognitive function domains, biological attributes, and neuropsychiatric representations, as well as gene expression profiles. Compared to healthy controls, CD patients demonstrated changes in connectome patterns in both primary and higher-order networks, exhibiting an overall converged trend along the principal gradient axis. The gradient values in CD patients’ right prefrontal cortex and bilateral sensorimotor cortices exhibited a significant correlation with cortisol levels. Moreover, the cortical regions showing gradient alterations were principally associated with sensory information processing and higher-cognitive functions, as well as correlated with the gene expression patterns which involved synaptic components and function. The findings suggest that converged alterations in the principal gradient in CD patients may mediate the relationship between hypercortisolism and cognitive impairments, potentially involving genes regulating synaptic components and function.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103652"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000913/pdfft?md5=5659e4f12c30ec5e561ee657c69429ca&pid=1-s2.0-S2213158224000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter abnormalities in aneurysmal and angiographically negative subarachnoid hemorrhage: A diffusion kurtosis imaging study","authors":"Sara Khosdelazad ,&nbsp;Harm J. van der Horn ,&nbsp;Lieke S. Jorna ,&nbsp;Rob J.M. Groen ,&nbsp;Anouk van der Hoorn ,&nbsp;Sandra E. Rakers ,&nbsp;Anne M. Buunk ,&nbsp;Jacoba M. Spikman","doi":"10.1016/j.nicl.2024.103662","DOIUrl":"10.1016/j.nicl.2024.103662","url":null,"abstract":"<div><h3>Objective</h3><p>Aneurysmal subarachnoid hemorrhage (aSAH) and angiographically negative subarachnoid hemorrhage (anSAH) cause an abrupt rise in intracranial pressure, resulting in shearing forces, causing damage to the white matter tracts. This study aims to investigate whole-brain white matter abnormalities with diffusion kurtosis imaging (DKI) after both aSAH and anSAH and explores whether these abnormalities are associated with impaired cognitive functioning.</p></div><div><h3>Methods</h3><p>Five months post-ictus, 34 patients with aSAH, 24 patients with anSAH and 17 healthy controls (HC) underwent DKI MRI scanning and neuropsychological assessment (measuring verbal memory, psychomotor speed, executive control, and social cognition). Differences in DKI measures (fractional anisotropy, mean diffusivity, axial diffusivity [AD], radial diffusivity, and mean kurtosis) were examined using tract-based spatial statistics. Significant voxel masks were then correlated with neuropsychological scores.</p></div><div><h3>Results</h3><p>All DKI measures differed significantly between patients with aSAH and HC, but no significant differences were found between patients with anSAH and HC. Although the two SAH groups did not differ significantly on all DKI parameters, effect sizes indicated that the anSAH group might be more similar to HC. Cognitive impairments were found for both SAH groups relative to HC. No significant associations were found between these impairments and white matter abnormalities in the aSAH group, but lower psychomotor speed scores were associated with higher AD values (<em>r</em> = -0.41, <em>p</em> = 0.04) in patients with anSAH.</p></div><div><h3>Conclusions</h3><p>Patients with aSAH showed significant white matter diffusion abnormalities, while the anSAH group, despite cognitive deficits, did not. However, there were no significant differences between the SAH groups, and no correlations between DKI metrics and cognitive measures, except for one test on psychomotor speed in the anSAH group. Overall, this study suggests that while anSAH may not be as severe as aSAH, it is still not a benign condition. Further research with larger anSAH cohorts is necessary to gain a more precise understanding of white matter injuries, particularly regarding their prevalence.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"43 ","pages":"Article 103662"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224001013/pdfft?md5=68040ffed08111e80483307d110f6792&pid=1-s2.0-S2213158224001013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting depression risk in early adolescence via multimodal brain imaging","authors":"Zeus Gracia-Tabuenca ,&nbsp;Elise B. Barbeau ,&nbsp;Yu Xia ,&nbsp;Xiaoqian Chai","doi":"10.1016/j.nicl.2024.103604","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103604","url":null,"abstract":"<div><p>Depression is an incapacitating psychiatric disorder with increased risk through adolescence. Among other factors, children with family history of depression have significantly higher risk of developing depression. Early identification of pre-adolescent children who are at risk of depression is crucial for early intervention and prevention. In this study, we used a large longitudinal sample from the Adolescent Brain Cognitive Development (ABCD) Study (2658 participants after imaging quality control, between 9–10 years at baseline), we applied advanced machine learning methods to predict depression risk at the two-year follow-up from the baseline assessment, using a set of comprehensive multimodal neuroimaging features derived from structural MRI, diffusion tensor imaging, and task and rest functional MRI. Prediction performance underwent a rigorous cross-validation method of leave-one-site-out. Our results demonstrate that all brain features had prediction scores significantly better than expected by chance, with brain features from rest-fMRI showing the best classification performance in the high-risk group of participants with parental history of depression (N = 625). Specifically, rest-fMRI features, which came from functional connectomes, showed significantly better classification performance than other brain features. This finding highlights the key role of the interacting elements of the connectome in capturing more individual variability in psychopathology compared to measures of single brain regions. Our study contributes to the effort of identifying biological risks of depression in early adolescence in population-based samples.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103604"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000433/pdfft?md5=7e468a99735216037dbcb473b424a467&pid=1-s2.0-S2213158224000433-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140539238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-frequency MR elastography reveals altered deep gray matter viscoelasticity in multiple sclerosis","authors":"Christian Kiss ,&nbsp;Sebastian Wurth ,&nbsp;Bettina Heschl ,&nbsp;Michael Khalil ,&nbsp;Thomas Gattringer ,&nbsp;Christian Enzinger ,&nbsp;Stefan Ropele","doi":"10.1016/j.nicl.2024.103606","DOIUrl":"https://doi.org/10.1016/j.nicl.2024.103606","url":null,"abstract":"<div><h3>Introduction</h3><p>Brain viscoelasticity as assessed by magnetic resonance elastography (MRE) has been discussed as a promising surrogate of microstructural alterations due to neurodegenerative processes. Existing studies indicate that multiple sclerosis (MS) is associated with a global reduction in brain stiffness. However, no study to date systematically investigated the MS-related characteristics of brain viscoelasticity separately in normal-appearing white matter (NAWM), deep gray matter (DGM) and T2-hyperintense white matter (WM) lesions.</p></div><div><h3>Methods</h3><p>70 MS patients and 42 healthy volunteers underwent whole-cerebral MRE using a stimulated echo sequence (DENSE) with a low-frequency mechanical excitation at 20 Hertz. The magnitude <span><math><mrow><mo>|</mo><msup><mrow><mi>G</mi></mrow><mrow><mo>∗</mo></mrow></msup><mo>|</mo></mrow></math></span> (Pa) and phase angle <span><math><mi>φ</mi></math></span> (rad) of the complex shear modulus <span><math><msup><mrow><mi>G</mi></mrow><mrow><mo>∗</mo></mrow></msup></math></span> were reconstructed by multifrequency dual elasto-visco (MDEV) inversion and related to structural imaging and clinical parameters.</p></div><div><h3>Results</h3><p>We observed <span><math><mi>φ</mi></math></span> in the thalamus to be higher by 4.3 % in patients relative to healthy controls (1.11 ± 0.07 vs. 1.06 ± 0.07, p &lt; 0.0001). Higher Expanded Disability Status Scale (EDSS) scores were negatively associated with <span><math><mi>φ</mi></math></span> in the basal ganglia (p = 0.01). We measured <span><math><mi>φ</mi></math></span> to be lower in MS lesions compared to surrounding NAWM (p = 0.001), which was most prominent for lesions in the temporal lobe (1.01 ± 0.22 vs. 1.06 ± 0.19, p = 0.003). Age was associated with lower values of <span><math><mrow><mrow><mo>|</mo></mrow><msup><mrow><mi>G</mi></mrow><mrow><mo>∗</mo></mrow></msup><mrow><mo>|</mo></mrow></mrow></math></span> (p = 0.04) and <span><math><mi>φ</mi></math></span> (p = 0.004) in the thalamus of patients. No alteration in NAWM stiffness relative to WM in healthy controls was observed.</p></div><div><h3>Conclusion</h3><p>Low-frequency elastography in MS patients reveals age-independent alterations in the viscoelasticity of deep gray matter at early stages of disease.</p></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"42 ","pages":"Article 103606"},"PeriodicalIF":4.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213158224000457/pdfft?md5=c1a858ebe064c2eaf6577a9879dccac2&pid=1-s2.0-S2213158224000457-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140643887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson’s disease: Stage-specific patterns and dopaminergic correlates","authors":"Chentao He ,&nbsp;Rui Yang ,&nbsp;Siming Rong ,&nbsp;Piao Zhang ,&nbsp;Xi Chen ,&nbsp;Qi Qi ,&nbsp;Ziqi Gao ,&nbsp;Yan Li ,&nbsp;Hao Li ,&nbsp;Frank-Erik de Leeuw ,&nbsp;Anil M. Tuladhar ,&nbsp;Marco Duering ,&nbsp;Rick C. Helmich ,&nbsp;Rick van der Vliet ,&nbsp;Sirwan K.L. Darweesh ,&nbsp;Zaiyi Liu ,&nbsp;Lijuan Wang ,&nbsp;Mengfei Cai ,&nbsp;Yuhu Zhang","doi":"10.1016/j.nicl.2024.103679","DOIUrl":"10.1016/j.nicl.2024.103679","url":null,"abstract":"<div><h3>Background</h3><div>Previous research revealed differences in cerebellar white matter integrity by disease stages, indicating a compensatory role in Parkinson’s disease (PD). However, the temporal evolution of cerebellar white matter microstructure in patients with PD (PwPD) remains unclear.</div></div><div><h3>Objective</h3><div>To unravel temporal evolution of cerebellar white matter and its dopaminergic correlates in PD.</div></div><div><h3>Methods</h3><div>We recruited 124 PwPD from the PPMI study. The participants were divided into two subsets: Subset 1 (n = 41) had three MRI scans (baseline, 2 years, and 4 years), and Subset 2 (n = 106) had at least two MRI scans at baseline, 1 year, and/or 2 years. Free water-corrected diffusion metrics were used to measure the microstructural integrity in cerebellar peduncles (CP), the main white matter tracts connecting to and from the cerebellum. The ACAPULCO processing pipeline was used to assess cerebellar lobules volumes. Linear mixed-effect models were used to study longitudinal changes. We also examined the relationships between microstructural integrity in CP, striatal dopamine transporter specific binding ratio (SBR), and clinical symptoms.</div></div><div><h3>Results</h3><div>Microstructural changes in CP showed a non-linear pattern in PwPD. Free water-corrected fractional anisotropy (FAt) increased in the first two years but declined from 2 to 4 years, while free water-corrected mean diffusivity exhibited the opposite trend. The initial increased FAt in CP correlated with cerebellar regional volume atrophy, striatal dopaminergic SBR decline, and worsening clinical symptoms, but this correlation varied across disease stages.</div></div><div><h3>Conclusions</h3><div>Our findings suggest a non-linear evolution of microstructural integrity in CP throughout the course of PD, indicating the adaptive structural reorganization of the cerebellum simultaneously with progressive striatal dopaminergic degeneration in PD.</div></div>","PeriodicalId":54359,"journal":{"name":"Neuroimage-Clinical","volume":"44 ","pages":"Article 103679"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}