首发神经性厌食症女性青少年静息状态脑功能连通性

IF 3.4 2区医学 Q2 NEUROIMAGING

Neuroimage-Clinical Pub Date : 2025-01-01 DOI:10.1016/j.nicl.2025.103745

Katrien F.M. Bracké , Laura Monteiro Rente Dias , Marisha N. Meijer , Cathelijne P.M. Steegers , Laurinde F. den Heijer , Tess van der Harst , Marjolein H.G. Dremmen , Meike W. Vernooij , Gwen C. Dieleman , Tonya White

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引用次数: 0

摘要

研究表明，患有神经性厌食症（AN）的女性在与认知控制、体感处理和情绪调节相关的大脑区域的功能连通性方面存在差异。然而，以前的研究都是在小样本上进行的，结果不一致。因此，本研究旨在识别与AN核心临床症状相关的异常脑网络，并在大量首次发作AN的青少年中探索其与临床结果的纵向关联。方法将56例首发AN的女性青少年（n = 56）与64例年龄和教育程度匹配的典型发育（TD）青少年（n = 64）进行脑静息状态功能连通性（RS-FC）的功能MRI （fMRI）比较。为了解释体重不足的严重程度，进行了单独的分析，以调查体重不足的AN参与者和TD青少年之间，以及体重不足（n = 30）和体重恢复的AN参与者（n = 26）之间RS-FC的差异。临床结果，即体重指数和饮食失调（ED）症状，在基线和一年随访时进行评估。使用独立成分分析（ICA）提取感兴趣的脑网络：默认模式（DMN），左右额顶叶（FPN）和岛叶（IN）网络。进行线性回归分析以评估AN和TD参与者之间RS-FC的差异，以及评估RS-FC是否与基线和1年随访时的临床症状相关。使用了两个统计模型：模型1调整了年龄和社会经济地位（SES），模型2额外调整了基线焦虑和抑郁症状。结果与TD青少年相比，体重过轻的AN参与者在DMN-IN之间以及FPN-IN之间的RS-FC较低。经多次检验校正后，体重过轻的AN组与体重恢复的AN组，以及整个AN组与TD组之间的RS-FC均无显著差异。RS-FC与基线和1年随访时临床症状的严重程度无关。结论an与体重过轻状态下FPN-IN和DMN-IN之间RS-FC的变化有关。在体重恢复的AN参与者中不再观察到RS-FC的这些变化，强调体重不足对AN中RS-FC的影响。这些大脑网络的变化可能部分解释了AN患者在体重不足状态下认知控制受损以及情绪和行为调节困难的原因。

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Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa

Objective

Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent findings. Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN.

Methods

Functional MRI (fMRI) of brain resting-state functional connectivity (RS-FC) of female adolescents with first-onset AN (n = 56) were compared to age- and education-matched typically developing (TD) adolescents (n = 64). To account for the severity of underweight, separate analyses were performed to investigate differences in RS-FC between underweight AN participants and TD adolescents, as well as between underweight (n = 30) and weight-restored AN (n = 26) participants. Clinical outcomes, i.e. body mass index and eating disorder (ED) symptoms, were assessed at baseline and one-year follow-up. Independent component analyses (ICA) were used to extract the brain networks of interest: the default mode (DMN), left and right frontoparietal (FPN), and the insular (IN) networks. Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms.

Results

Underweight AN participants had lower RS-FC between the DMN-IN, as well as between the FPN-IN compared to the TD adolescents. After correction for multiple testing, no significant differences in RS-FC were found between underweight AN participants and weight-restored AN participants, as well as between the whole AN group and the TD group. RS-FC was not associated with the severity of clinical symptoms at baseline nor at one-year of follow-up.

Conclusion

AN is associated with changes in RS-FC between the FPN-IN and DMN-IN during the underweight state. These changes in RS-FC were no longer observed in weight-restored AN participants, emphasizing the impact of underweight on RS-FC in AN. Changes in these brain networks may partly explain the impaired cognitive control and difficulties with emotion and behavioral regulation in individuals with AN during the underweight state.

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来源期刊

Neuroimage-Clinical NEUROIMAGING-

CiteScore

7.50

自引率

4.80%

发文量

368

审稿时长

52 days

期刊介绍： NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.