Neurophotonics最新文献

{"title":"Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.","authors":"Tien Nhat Nguyen, Reham A Shalaby, Eunbin Lee, Sang Seong Kim, Young Ro Kim, Seonghoon Kim, Hyunsoo Shawn Je, Hyuk-Sang Kwon, Euiheon Chung","doi":"10.1117/1.NPh.12.S1.S14608","DOIUrl":"10.1117/1.NPh.12.S1.S14608","url":null,"abstract":"<p><p>Optical neuroimaging has significantly advanced our understanding of brain function, particularly through techniques such as two-photon microscopy, which captures three-dimensional brain structures with sub-cellular resolution. However, traditional methods struggle to record fast, complex neuronal interactions in real time, which are crucial for understanding brain networks and developing treatments for neurological diseases such as Alzheimer's, Parkinson's, and chronic pain. Recent advancements in ultrafast imaging technologies, including kilohertz two-photon microscopy, light field microscopy, and event-based imaging, are pushing the boundaries of temporal resolution in neuroimaging. These techniques enable the capture of rapid neural events with unprecedented speed and detail. This review examines the principles, applications, and limitations of these technologies, highlighting their potential to revolutionize neuroimaging and improve the diagnose and treatment of neurological disorders. Despite challenges such as photodamage risks and spatial resolution trade-offs, integrating these approaches promises to enhance our understanding of brain function and drive future breakthroughs in neuroscience and medicine. Continued interdisciplinary collaboration is essential to fully leverage these innovations for advancements in both basic and clinical neuroscience.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 Suppl 1","pages":"S14608"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expansion microscopy reveals neural circuit organization in genetic animal models.","authors":"Shakila Behzadi, Jacquelin Ho, Zainab Tanvir, Gal Haspel, Limor Freifeld, Kristen E Severi","doi":"10.1117/1.NPh.12.1.010601","DOIUrl":"10.1117/1.NPh.12.1.010601","url":null,"abstract":"<p><p>Expansion microscopy is a super-resolution technique in which physically enlarging the samples in an isotropic manner increases inter-molecular distances such that nano-scale structures can be resolved using light microscopy. This is particularly useful in neuroscience as many important structures are smaller than the diffraction limit. Since its invention in 2015, a variety of expansion microscopy protocols have been generated and applied to advance knowledge in many prominent organisms in neuroscience, including zebrafish, mice, <i>Drosophila</i>, and <i>Caenorhabditis elegans</i>. We review the last decade of expansion microscopy-enabled advances with a focus on neuroscience.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"010601"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisensory naturalistic decoding with high-density diffuse optical tomography.","authors":"Kalyan Tripathy, Zachary E Markow, Morgan Fogarty, Mariel L Schroeder, Alexa M Svoboda, Adam T Eggebrecht, Bradley L Schlaggar, Jason W Trobaugh, Joseph P Culver","doi":"10.1117/1.NPh.12.1.015002","DOIUrl":"10.1117/1.NPh.12.1.015002","url":null,"abstract":"<p><strong>Significance: </strong>Decoding naturalistic content from brain activity has important neuroscience and clinical implications. Information about visual scenes and intelligible speech has been decoded from cortical activity using functional magnetic resonance imaging (fMRI) and electrocorticography, but widespread applications are limited by the logistics of these technologies.</p><p><strong>Aim: </strong>High-density diffuse optical tomography (HD-DOT) offers image quality approaching that of fMRI but with the silent, open scanning environment afforded by optical methods, thus opening the door to more naturalistic research and applications. Although early visual decoding studies with HD-DOT have been promising, decoding of naturalistic auditory and multisensory stimulus information from HD-DOT data has not been established.</p><p><strong>Approach: </strong>Audiovisual decoding was investigated using HD-DOT data collected from participants who viewed a library of movie clips. A template-matching strategy was used to decode which movie clip a participant viewed based on their HD-DOT data. Factors affecting decoding performance-including trial duration and number of decoding choices-were systematically evaluated.</p><p><strong>Results: </strong>Decoding accuracy was 94.2% for four-way decoding utilizing 4 min of data per trial as a starting point. As parameters were made more stringent, decoding performance remained significantly above chance with strong effect sizes down to 15-s trials and up to 32 choices. Comparable decoding accuracies were obtained when cortical sampling was confined to visual and auditory regions and when participants were presented with purely auditory or visual clips.</p><p><strong>Conclusions: </strong>HD-DOT data sample cortical hemodynamics with sufficient resolution and fidelity to support decoding complex, naturalistic, multisensory stimuli via template matching. These results provide a foundation for future studies on more intricate decoding algorithms to reconstruct diverse features of novel naturalistic stimuli from HD-DOT data.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015002"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative simulation of near-infrared light treatment for Alzheimer's disease using patient-individualized optical-parametric phantoms.","authors":"Sihan Dong, Rui Zhang, Jun Xue, Yuanzhen Suo, Xunbin Wei","doi":"10.1117/1.NPh.12.1.015010","DOIUrl":"10.1117/1.NPh.12.1.015010","url":null,"abstract":"<p><strong>Significance: </strong>Alzheimer's disease (AD) is a brain disorder characterized by its multifactorial nature and complex pathogenesis, highlighting the necessity for multimodal and individualized interventions. Among emerging therapies, near-infrared (NIR) light treatment shows promise as a therapeutic modality for AD. However, existing clinical studies lack sufficient data on light dosimetry, parameter optimization, and dose-response.</p><p><strong>Aim: </strong>A versatile framework was developed to enable patient-individualized Monte Carlo simulation. A standardized dataset was established, including digital phantoms derived from 20 AD patients who received NIR light treatment.</p><p><strong>Approach: </strong>The phantoms were synthesized and mapped with multispectral optical parameters, integrating cortical parcellation, subcortical segmentation, and sparse annotation. Structure-related light fluence pathways and dose-response relationships were elucidated using simulation results and cognitive/functional assessments.</p><p><strong>Results: </strong>The capability for enhancing simulation fidelity and exploring dose-response relationships was verified using standard templates and clinical data. Linear independence was identified between changes in activities of daily living scale scores and energy deposition in gray matter.</p><p><strong>Conclusions: </strong>The framework offers a solution toward dose-response analysis, parameter optimization, and safety control in the clinical translation for multiple treatment paradigms, demonstrating promise for individualized, standardized, and precise intervention planning.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015010"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical attenuation coefficient decorrelation-based optical coherence tomography angiography for microvascular evaluation of Alzheimer's disease on mice.","authors":"Ben Xiang, Ning Ding, Huiwen Jiang, Jian Liu, Yao Yu, Jingmin Luan, Yuqian Zhao, Yi Wang, Yanqiu Yang, Cheng Ji, Fengwen Wang, Zhenhe Ma","doi":"10.1117/1.NPh.12.1.015013","DOIUrl":"10.1117/1.NPh.12.1.015013","url":null,"abstract":"<p><strong>Significance: </strong>The deep cortical microvasculature is closely linked to the pathogenesis of Alzheimer's disease (AD). However, tail artifacts from superficial cortical vessels often interfere with detecting deep vessels in optical coherence tomography angiography (OCTA) imaging. A more accurate method to assess deep cortical vasculature is crucial for understanding its relationship with AD onset.</p><p><strong>Aim: </strong>We aim to reduce superficial vessel artifacts in OCTA imaging and improve the visualization and analysis of deep cortical microvasculature in an AD mouse model.</p><p><strong>Approach: </strong>We introduced the optical attenuation coefficient decorrelation (OACD) method for OCTA, effectively reducing tail artifacts from superficial cortex vessels. This method was used to visualize and quantitatively analyze deep cortical microvasculature <i>in vivo</i> in a mouse model of AD.</p><p><strong>Results: </strong>The OACD method significantly reduced superficial vessel artifacts, leading to clearer imaging of the deep cortical vasculature. Quantitative analysis revealed that changes in the deep cortical microvasculature were more pronounced than in the superficial vasculature, suggesting a more direct involvement of the deep vessels in AD progression.</p><p><strong>Conclusions: </strong>The proposed OACD method enhances OCTA imaging by reducing tail artifacts from superficial vessels, facilitating improved assessment of deep cortical microvasculature. These findings suggest that deep cortical vascular changes may play a key role in the pathogenesis of AD, offering potential insights for early detection and monitoring of AD progression.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015013"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting equivalent optical properties for cerebrospinal fluid to improve diffusion-based modeling accuracy in the brain.","authors":"Aiden Vincent Lewis, Qianqian Fang","doi":"10.1117/1.NPh.12.1.015009","DOIUrl":"10.1117/1.NPh.12.1.015009","url":null,"abstract":"<p><strong>Significance: </strong>The diffusion approximation (DA) is used in functional near-infrared spectroscopy (fNIRS) studies despite its known limitations due to the presence of cerebrospinal fluid (CSF). Many of these studies rely on a set of empirical CSF optical properties, recommended by a previous simulation study, that were not selected for the purpose of minimizing DA modeling errors.</p><p><strong>Aim: </strong>We aim to directly quantify the accuracy of DA solutions in brain models by comparing those with the gold-standard solutions produced by the mesh-based Monte Carlo (MMC), based on which we derive updated recommendations.</p><p><strong>Approach: </strong>For both a five-layer head and Colin27 atlas models, we obtain DA solutions by independently sweeping the CSF absorption ( <math> <mrow><msub><mi>μ</mi> <mi>a</mi></msub> </mrow> </math> ) and reduced scattering ( <math> <mrow> <msub><mrow><mi>μ</mi></mrow> <mrow> <msup><mrow><mi>s</mi></mrow> <mrow><mo>'</mo></mrow> </msup> </mrow> </msub> </mrow> </math> ) coefficients. Using an MMC solution with literature CSF optical properties as a reference, we compute the errors for surface fluence, total brain sensitivity, and brain energy deposition, and identify the optimized settings where such error is minimized.</p><p><strong>Results: </strong>Our results suggest that previously recommended CSF properties can cause significant errors (8.7% to 52%) in multiple tested metrics. By simultaneously sweeping <math> <mrow><msub><mi>μ</mi> <mi>a</mi></msub> </mrow> </math> and <math> <mrow> <msubsup><mrow><mi>μ</mi></mrow> <mrow><mi>s</mi></mrow> <mrow><mo>'</mo></mrow> </msubsup> </mrow> </math> , we can identify infinite numbers of solutions that can exactly match DA with MMC solutions for any single tested metric. Furthermore, it is also possible to simultaneously minimize multiple metrics at multiple source/detector separations, leading to our updated recommendation of setting <math> <mrow> <msubsup><mrow><mi>μ</mi></mrow> <mrow><mi>s</mi></mrow> <mrow><mo>'</mo></mrow> </msubsup> <mo>=</mo> <mn>0.15</mn> <mtext>  </mtext> <msup><mrow><mi>mm</mi></mrow> <mrow><mo>-</mo> <mn>1</mn></mrow> </msup> </mrow> </math> while maintaining physiological <math> <mrow><msub><mi>μ</mi> <mi>a</mi></msub> </mrow> </math> for CSF in DA simulations.</p><p><strong>Conclusions: </strong>Our updated recommendation of CSF equivalent optical properties can greatly reduce the model mismatches between DA and MMC solutions at multiple metrics without sacrificing computational speed. We also show that it is possible to eliminate such a mismatch for a single or a pair of metrics of interest.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015009"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice.","authors":"Ryan M Bowen, Jake Lee, Brendon Wang, Keith R Lohse, Hanyang Miao, Jonah A Padawer-Curry, Asher J Albertson, Eric C Landsness, Adam Q Bauer, Jin-Moo Lee","doi":"10.1117/1.NPh.12.S1.S14604","DOIUrl":"10.1117/1.NPh.12.S1.S14604","url":null,"abstract":"<p><strong>Significance: </strong>Stroke is the leading cause of chronic disability in the United States. How stroke size affects post-stroke repair and recovery is poorly understood.</p><p><strong>Aim: </strong>We aim to investigate the effects of stroke size on early repair patterns and determine how early changes in neuronal circuits and networks predict functional outcomes after stroke.</p><p><strong>Approach: </strong>We used wide-field optical imaging, photothrombosis, and the cylinder-rearing assay to examine changes in neuronal circuit and network activity in the context of functional recovery after stroke.</p><p><strong>Results: </strong>Larger strokes ablating <math><mrow><mi>S</mi> <msub><mrow><mn>1</mn></mrow> <mrow><mi>FP</mi></mrow> </msub> </mrow> </math> caused diffuse and widespread forepaw stimulus-evoked cortical activation, including contralesional regions evolving within 4 weeks post-stroke; smaller strokes resulted in more focused ipsilesional activation. Larger strokes decreased neuronal fidelity and bilateral coherence during stimulation of either the affected or unaffected forepaw within this 4-week period. Mice in the larger lesion group demonstrated hyperconnectivity within the contralesional hemisphere at the resting state. Greater degrees of remapping diffusivity, neuronal fidelity degradation, and hyperconnectivity predicted worse 8-week recovery after statistically controlling for the effect of infarct size.</p><p><strong>Conclusions: </strong>These results suggest that diffuse patterns of remapping, and desynchronization and hyperconnectivity of cortical networks, evolving early after stroke may reflect maladaptive plasticity, predicting poor long-term functional recovery.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 Suppl 1","pages":"S14604"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-cost physiology and behavioral monitor for intravital imaging in small mammals.","authors":"Yuntao Li, Alfredo Cardenas-Rivera, Chang Liu, Zhengyi Lu, Jaime Anton, Mohammed Alfadhel, Mohammad A Yaseen","doi":"10.1117/1.NPh.12.1.015004","DOIUrl":"10.1117/1.NPh.12.1.015004","url":null,"abstract":"<p><strong>Significance: </strong>Functional brain imaging experiments in awake animals require meticulous monitoring of animal behavior to screen for spontaneous behavioral events. Although these events occur naturally, they can alter cell signaling and hemodynamic activity in the brain and confound functional brain imaging measurements.</p><p><strong>Aim: </strong>We developed a centralized, user-friendly, and stand-alone platform that includes an animal fixation frame, compact peripheral sensors, and a portable data acquisition system. The affordable, integrated platform can benefit imaging experiments by monitoring animal behavior for motion detection and alertness levels as complementary readouts for brain activity measurements.</p><p><strong>Approach: </strong>A custom acquisition system was designed using a powerful, inexpensive microcomputer. We customized an accelerometer and miniature camera modules for efficient, real-time monitoring of animal motion detection and pupil diameter. We then tested and validated the platform's performance with optical intrinsic signal imaging and GCaMP fluorescence calcium imaging in functional activation experiments in awake mice.</p><p><strong>Results: </strong>The integrated platform shows promise for detecting spontaneous motion and pupil dilation while imaging. Stimulus-induced pupil dilation was found to initiate earlier than cortical hemodynamics with a slower rise time. Compared with neuronal calcium response, stimulus-induced pupil dilation initiated later with a slower rise time.</p><p><strong>Conclusions: </strong>We developed an integrated platform to monitor animal motion and pupil dynamics. The device can be easily coupled and synchronized with optical brain imaging systems to monitor behavior, alertness, and spontaneous motion for awake animal studies.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015004"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zika virus encephalitis causes transient reduction of functional cortical connectivity.","authors":"Shannon C Agner, Lindsey M Brier, Jeremy D Hill, Ethan Y Liu, Annie Bice, Rachel M Rahn, Shengxuan Chen, Joseph P Culver, Robyn S Klein","doi":"10.1117/1.NPh.12.S1.S14603","DOIUrl":"10.1117/1.NPh.12.S1.S14603","url":null,"abstract":"<p><strong>Significance: </strong>Determining the long-term cognitive impact of infections is clinically challenging. Using functional cortical connectivity, we demonstrate that interhemispheric cortical connectivity is decreased in individuals with acute Zika virus (ZIKV) encephalitis. This correlates with decreased presynaptic terminals in the somatosensory cortex. During recovery from ZIKV infection, presynaptic terminals recover, which is associated with recovered interhemispheric connectivity. This supports the contribution of synapses in the cortex to functional networks in the brain, which can be detected by widefield optical imaging. Although myeloid cell and astrocyte numbers are still increased during recovery, RNA transcription of multiple proinflammatory cytokines that increase during acute infection decreases to levels comparable to mock-infected mice during recovery. These findings also suggest that the immune response and cytokine-mediated neuroinflammation play significant roles in the integrity of brain networks during and after viral encephalitis.</p><p><strong>Aim: </strong>We hypothesized that widefield optical imaging would allow us to assess functional cortical network disruption by ZIKV, including hippocampal-cortical networks.</p><p><strong>Approach: </strong>We use widefield optical imaging to measure cortical functional connectivity (FC) in mice during acute infection with, and recovery from, intracranial infection with a mouse-adapted strain of ZIKV.</p><p><strong>Results: </strong>Acute ZIKV infection leads to high levels of myeloid cell activation, with loss of neurons and presynaptic termini in the cerebral cortex and associated loss of FC primarily within the somatosensory cortex. During recovery, neuron numbers, synapses, and FC recover to levels near those of healthy mice. However, hippocampal injury and impaired spatial cognition persist. The magnitude of activated myeloid cells during acute infection predicted both recovery of synapses and the degree of FC recovery after recovery from ZIKV infection.</p><p><strong>Conclusions: </strong>These findings suggest that a robust inflammatory response may contribute to the health of functional brain networks after recovery from infection.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 Suppl 1","pages":"S14603"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Site- and electroencephalogram-frequency-specific effects of 800-nm prefrontal transcranial photobiomodulation on electroencephalogram global network topology in young adults.","authors":"Shu Kang, Lin Li, Sadra Shahdadian, Anqi Wu, Hanli Liu","doi":"10.1117/1.NPh.12.1.015011","DOIUrl":"10.1117/1.NPh.12.1.015011","url":null,"abstract":"<p><strong>Significance: </strong>Transcranial photobiomodulation (tPBM) is an optical intervention that effectively enhances human cognition. However, limited studies have reported the effects of tPBM on electrophysiological brain networks.</p><p><strong>Aim: </strong>We aimed to investigate the site- and electroencephalogram (EEG)-frequency-specific effects of 800-nm prefrontal tPBM on the EEG global network topology of the human brain, so a better understanding of how tPBM alters EEG brain networks can be achieved.</p><p><strong>Approach: </strong>A total of 26 healthy young adults participated in the study, with multiple visits when either active or sham tPBM interventions were delivered to either the left or right forehead. A 19-channel EEG cap recorded the time series before and after the 8-min tPBM/sham. We used graph theory analysis (GTA) and formulated adjacency matrices in five frequency bands, followed by quantification of normalized changes in GTA-based global topographical metrics induced by the respective left and right tPBM/sham interventions.</p><p><strong>Results: </strong>Statistical analysis indicated that the effects of 800-nm prefrontal tPBM on the EEG global topological networks are both site- and EEG-frequency-dependent. Specifically, our results demonstrated that the left 800-nm tPBM primarily enhanced the alpha network efficiency and information transmission, whereas the right 800-nm tPBM augmented the clustering ability of the EEG topological networks and improved the formation of small-worldness of the beta waves across the entire brain.</p><p><strong>Conclusions: </strong>The study concluded that 800-nm prefrontal tPBM can enhance global connectivity patterns and information transmission in the human brain, with effects that are site- and EEG-frequency-specific. To further confirm and better understand these findings, future research should correlate post-tPBM cognitive assessments with EEG network analysis.</p>","PeriodicalId":54335,"journal":{"name":"Neurophotonics","volume":"12 1","pages":"015011"},"PeriodicalIF":4.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}