Co-localized optode-electrode design for multimodal functional near infrared spectroscopy and electroencephalography.

Abstract

Significance: Neuroscience of the everyday world requires continuous mobile brain imaging in real time and in ecologically valid environments, which aids in directly translating research for human benefit. Combined functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) studies have increased in demand, as the combined systems can provide great insights into cortical hemodynamics, neuronal activity, and neurovascular coupling. However, fNIRS-EEG studies remain limited in modularity and portability due to restrictions in combined cap designs, especially for high-density (HD) fNIRS measurements.

Aim: We have built and tested custom fNIRS sources that attach to electrodes without decreasing the overall modularity and portability of the probe.

Approach: To demonstrate the design's utility, we screened for any potential interference and performed a HD-fNIRS-EEG measurement with co-located opto-electrode positions during a modified Stroop task.

Results: No observable interference was present from the fNIRS source optodes in the EEG spectral analysis. The performance, fNIRS, and EEG results of the Stroop task supported the trends from previous research. We observed increased activation with both fNIRS and EEG within the regions of interest.

Conclusion: Overall, these results suggest that the co-localization method is a promising approach to multimodal imaging.