Archives of Endocrinology Metabolism最新文献

{"title":"Genetic or familiar forms of primary hyperparathyroidism: description of a case series with familial isolated hyperparathyroidism and review of the literature.","authors":"Miguel Madeira, Maria Caroline Alves Coelho, Leandro Kasuki, Filipe Barbosa Linhares, Isabel Sampaio Tostes, Rafael Mazzutti Dutra Santana, Raquel Beatriz Gonçalves Muniz, Maria Lucia Fleiuss de Farias, Fernanda Vaisman","doi":"10.20945/2359-4292-2024-0311","DOIUrl":"10.20945/2359-4292-2024-0311","url":null,"abstract":"<p><p>Primaryhyperparathyroidism (PHPT) is a disorder of mineral metabolism caused by inappropriate or excessive secretion of parathyroid hormone. It occurs sporadically in approximately 95% of cases but may also be associated with complex syndromes and/or a familial (i.e., hereditary) history. We report the clinical, laboratory, and genetic profiles of a case series with familial isolated hyperparathyroidism. Diagnosis was established in patients aged 22-41 years (median = 32), and recurrence was identified in four patients (three with adenoma and one with hyperplasia and parathyroid carcinoma). Six family members presented with a heterozygous mutation in the CDC73 gene, and one patient had a copy number variation of undetermined clinical significance in the same gene. In addition, we review the particularities of each condition associated with PHPT, indications for genetic evaluation, and recommendations for follow-up and treatment.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should iodine supplementation be universally recommended for pregnant women in Brazil? A position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM).","authors":"Patrícia de Fátima Dos Santos Teixeira, Célia Regina Nogueira, Cleo Otaviano Mesa, Helton Estrela Ramos, Léa Maria Zanini Maciel, Mariana de Souza Macedo, Nathalie Silva de Morais, Rosalia do Prado Padovani, Rosalinda Yossie Asato de Camargo, Suemi Marui","doi":"10.20945/2359-4292-2025-0170","DOIUrl":"https://doi.org/10.20945/2359-4292-2025-0170","url":null,"abstract":"<p><strong>Background: </strong>A U-shaped relationship exists between maternal urinary iodine concentration (UIC) and the risk of thyroid dysfunction, adverse pregnancy outcomes, and neurological deficits in offspring. Both iodine deficiency and excess should be avoided during pregnancy. The WHO recommends increased iodine intake during pregnancy due to elevated thyroid hormone production and fetal iodine transfer. In countries with universal salt iodization, additional supplementation is generally not advised, although iodization alone may be insufficient. In Brazil, salt iodization has reduced iodine deficiency disorders, but in 2013, regulatory agencies lowered iodine levels in salt due to high population-wide salt intake. Without national surveys, it remains unclear whether current iodine levels in table salt are sufficient for pregnant women.</p><p><strong>Materials and methods: </strong>The clinical questions addressed in this document were derived from stakeholder feedback and input from panel members. The group synthesized the available knowledge on this topic by conducting electronic database searches, reviewing and selecting relevant citations, and critically appraising selected studies.</p><p><strong>Results: </strong>The group recommends exclusive use of regulated iodized salt during pregnancy. Iodine supplementation should be individualized for at-risk pregnant women, including those with chronic gastrointestinal disorders, restricted diets, or malabsorption conditions. Excess iodine intake should be avoided. In alignment with public policies under PNAISAL, health education on appropriate salt use and storage should be reinforced in primary care. Urinary iodine tests should be used for population-level assessment only.</p><p><strong>Conclusion: </strong>These recommendations aim to support clinical decision-making regarding iodine supplementation during pregnancy in Brazil, thereby improving maternal and fetal health outcomes.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e250170"},"PeriodicalIF":2.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.","authors":"Indianara Franciele Porgere, Bruna Martins Rocha, Gustavo Monteiro Escott, Luiza Carolina Fagundes Silva, Priscila Aparecida Correa Freitas, Fabíola Satler, Sandra Pinho Silveiro","doi":"10.20945/2359-4292-2024-0360","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0360","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the putative association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.</p><p><strong>Methods: </strong>In total, 136 healthy men without obesity, aged 18 years or older, were included. Total testosterone was measured by electrochemiluminescence, and sex hormone-binding globulin by chemiluminescence. Calculated free testosterone was obtained by Vermeulen's equation. Insulin resistance index was estimated as triglycerides/HDL ratio.</p><p><strong>Results: </strong>The sample was divided into tertiles according to age (18 to 29; 30 to 49; 50 to 67 years). Sex hormone-binding globulin levels were higher in men > 50 years old compared to those of the second and first tertiles (41 ± 17 versus 35 ± 12 and 29 ± 9 nmol/L; p < 0.001), while values of calculated free testosterone were lower in the older tertile (7.7 ± 1.9 versus 8.8 ± 2.2 and 10.4 ±3.1 ng/dL; p < 0.001). Age did not influence total testosterone levels. Insulin resistance index was inversely and significantly correlated with sex hormone-binding globulin (r = -0.371; p < 0.001).</p><p><strong>Conclusion: </strong>There is a significant increase in serum sex hormone-binding globulin in older healthy men, highlighting the need for age-specific reference values. Furthermore, insulin resistance seems to reduce this globulin levels, perhaps pointing out low sex hormone-binding globulin as a putative predictor of related chronic diseases.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e240360"},"PeriodicalIF":2.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central glutathione mitigates obesity-induced social phobia: evidence from human and animal studies.","authors":"Yurui He, Kai Xiang, Yanli Chen, Hongfang Zheng, Youde Liu, Jingjing Li, Yan Zhang, Rui Jiang, Jinping Sheng","doi":"10.20945/2359-4292-2025-0016","DOIUrl":"10.20945/2359-4292-2025-0016","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of obesity on social phobia and the therapeutic effect of the antioxidant glutathione on this disorder.</p><p><strong>Methods: </strong>A total of 600 subjects were divided into an Obese Group and a Control Group. Four scales were utilized to determine social phobia, and magnetic resonance spectroscopy was applied to evaluate the central glutathione levels. Multivariate logistic regression was used for analysis. A mouse obesity model was subsequently established using a high-fat diet. Agonists or inhibitors were used to upregulate or downregulate hippocampal glutathione. The social interaction test was used to evaluate the social phobia of the mice, and the ELISA method was used to measure the levels of oxidative stress indicators in the hippocampus. Anova was used for analysis.</p><p><strong>Results: </strong>Compared with the control subjects, obese subjects had higher social phobia scores. A higher central glutathione level was associated with a lower social phobia score. In the animal experiments, obese mice exhibited more social phobia behaviours. When the glutathione level in the hippocampus was increased and decreased, the oxidative stress level in the hippocampus of the mice decreased and increased accordingly, whereas social phobia behaviours were alleviated and exacerbated, respectively.</p><p><strong>Conclusion: </strong>Obesity may induce social phobia. However, the antioxidant glutathione attenuates the central oxidative stress response and alleviates obesity-related social phobia.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e250016"},"PeriodicalIF":2.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of PON1 reduces high glucose induced renal tubular epithelial cell injury by activating PPARγ signaling pathway to alleviate diabetes nephropathy.","authors":"Min Wang, Xiaona Yu, Chunmei Liu, Yuan Liu","doi":"10.20945/2359-4292-2024-0377","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0377","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role of PON1 in diabetic nephropathy and elucidate the underlying mechanisms using a cellular model.</p><p><strong>Materials and methods: </strong>A diabetic nephropathy model was established using high glucose-induced HK-2 cells. Potential target genes and signaling pathways were identified through bioinformatics databases, and PON1 expression was manipulated to interfere with these pathways. The effects of different treatments on cell conditions were systematically evaluated.</p><p><strong>Results: </strong>PON1, the targeted gene in diabetic nephropathy, was significantly downregulated in high glucose-induced cells. The PPARγ signaling pathway was identified as closely associated with PON1, with both PPARα and PPARγ emerging as key regulators within this pathway. We observed significant increases in lactate dehydrogenase activity, malondialdehyde levels, and cell apoptosis, along with notable decreases in superoxide dismutase levels, cell viability, and cell proliferation, in the high glucose-treated group. Additionally, the expression levels of PPARα and PPARγ were also decreased. Overexpression of PON1 (pc-PON1) in the high glucose group mitigated these effects, whereas treatment with the PPARγ antagonist GW9662 reversed the protective changes induced by pc-PON1.</p><p><strong>Conclusion: </strong>Elevated PON1 levels mitigated oxidative stress and inhibited cell death, thereby promoting cell growth and alleviating diabetic nephropathy through activation of the PPARγ signaling pathway.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e240377"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national survey of Brazilian endocrinologists' practices in educating patients with adrenal insufficiency on stress-induced glucocorticoid adjustments.","authors":"Leonardo Vieira Neto, Aline Barbosa Moraes, Giselle Fernandes Taboada","doi":"10.20945/2359-4292-2025-0098","DOIUrl":"https://doi.org/10.20945/2359-4292-2025-0098","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the practices of Brazilian endocrinologists in educating patients with adrenal insufficiency about stress-induced glucocorticoid adjustments.</p><p><strong>Methods: </strong>This was a cross-sectional online survey carried out with 280 endocrinologists across Brazil. The survey included demographic questions and ten clinical vignettes assessing knowledge of appropriate glucocorticoid adjustments during various stressful situations. All participants provided informed consent, and the study protocol was approved by the local Ethics Committee. Statistical analysis compared responses based on physician demographics and practice settings.</p><p><strong>Results: </strong>The mean percentage of correct answers was 63.3%. A significant proportion of respondents (41.1%) incorrectly believed that patients should not self-administer intramuscular hydrocortisone during an adrenal crisis. Older physicians tended to provide more conservative (and potentially harmful) glucocorticoid dosing recommendations in certain scenarios. Physicians working in both outpatient and hospital settings demonstrated better knowledge of patient education and emergency glucocorticoid administration.</p><p><strong>Conclusion: </strong>The results of this study revealed moderate adherence to guidelines among Brazilian endocrinologists regarding adrenal insufficiency management and patient education. There is a need for improved education on glucocorticoid self-administration and targeted interventions to address knowledge gaps across different clinical scenarios. Further research is needed to evaluate the impact of these findings on patient outcomes and develop strategies to optimize the management of adrenal insufficiency in Brazil.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e250098"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring thyroid eye disease in Brazil: insights from a single-center study.","authors":"Danilo Villagelin, Nicolas Perini, Roberto Bernardo Santos, João Hamilton Romaldini","doi":"10.20945/2359-4292-2024-0495","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0495","url":null,"abstract":"<p><strong>Objective: </strong>Graves' disease (GD) is the leading cause of hyperthyroidism globally, with 40% of affected individuals developing thyroid eye disease (TED). Treatment options for TED have advanced in recent years. This study aimed to investigate the prevalence of TED at a single center in Brazil, contributing more robust data for cost-analysis studies assessing the financial implications of novel TED treatments. Subjects and.</p><p><strong>Methods: </strong>This study evaluated the clinical histories of 660 patients diagnosed with GD from 1999 to 2019. The patients were categorized into four groups based on the presence and severity of TED.</p><p><strong>Results: </strong>The prevalence of TED within the study population, categorized according to severity, was as follows: absent (n = 325; 49%), mild (n = 221; 33%), moderate to severe (n = 107; 16%), and sight-threatening (n = 7; 1%). A significant correlation was observed between older age at diagnosis, smoking, larger goiters, and the presence and severity of TED.</p><p><strong>Conclusion: </strong>The prevalence of TED identified in this single-center study contributes valuable insights for the design of cost-analysis studies and the assessment of the financial implications of novel treatments for TED within both the public and private healthcare systems in Brazil.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e240495"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying risk factors associated with refractoriness to radioiodine therapy in differentiated thyroid cancer.","authors":"Fernando Barros Costa Ribeiro, Ana Gregória Ferreira Pereira de Almeida, Adriana de Sá Caldas, Gilvan Cortês Nascimento, Rossana Santiago de Sousa Azulay, Conceição de Maria Ribeiro Veiga Parente, Manuel Dos Santos Faria, Marcelo Magalhães, Italo Campinho Braga de Araujo Lima, Carla Souza Pereira Sobral","doi":"10.20945/2359-4292-2025-0032","DOIUrl":"https://doi.org/10.20945/2359-4292-2025-0032","url":null,"abstract":"<p><strong>Objective: </strong>To identify factors potentially associated with radioiodine-refractory disease among patients treated for differentiated thyroid carcinoma at a referral center in Northeastern Brazil.</p><p><strong>Methods: </strong>A total of 554 medical records of patients with differentiated thyroid carcinoma treated between January 2010 and August 2024 were evaluated. Radioiodine-refractory disease tumors were detected in 44 (7.9%) patients. Clinical, laboratory, and radiological data were compared between the radioiodine-refractory disease and non-radioiodine-refractory disease groups to determine factors associated with poor differentiated thyroid carcinoma outcomes.</p><p><strong>Results: </strong>Factors most strongly associated with progression to radioiodine-refractory disease included older age, increased number of surgeries performed, aggressive histological subtypes, larger tumor size, vascular invasion, extrathyroidal extension, compromised margins, lymph node metastasis, distant metastasis at diagnosis and during follow-up, higher malignant tumor classification staging, high risk of recurrence, high thyroglobulin levels prior to radioiodine therapy, higher doses and greater number of radioiodine therapy doses, and higher frequency of incomplete responses within the first year post-treatment.</p><p><strong>Conclusion: </strong>Identifying possible factors associated with radioiodine-refractory disease development may allow early diagnosis and a more effective treatment.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e250032"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the fasting triglyceride glucose index with pulse wave velocity vary by age and gender.","authors":"Yen-Fu Chen, Yi-Chih Chang, Wen-Cheng Li, Po-Ya Lin, Yi-Hsuan Chen, Yi-Chuan Chen, Ting-An Yang, Jo-Hsuan Chen","doi":"10.20945/2359-4292-2025-0115","DOIUrl":"https://doi.org/10.20945/2359-4292-2025-0115","url":null,"abstract":"<p><strong>Objective: </strong>This study determined the optimal cutoff point for the triglyceride-glucose (TyG) index for predicting subclinical atherosclerosis (SA). Subjects and.</p><p><strong>Methods: </strong>Overall, 10,039 participants (5,598 men and 4,441 women) aged > 18 years were recruited from Xiamen Chang Gung Hospital. Demographic information was provided, and the TyG index was calculated. The TyG index was categorized into quartiles, and SA was assessed by measuring brachial-ankle pulse wave velocity (baPWV). The cutoff point for the TyG index was determined via receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>SA incidence increased with increasing TyG index in both men (from 5.929% in Group I to 10.579% in Group IV; P < 0.001) and women (from 2.074% in Group I to 14.955% in Group IV; P < 0.001). Multivariate linear regression analysis revealed that a higher TyG index was associated with an elevated risk of SA in men (odds ratio [OR] 4.028, 95% confidence interval [CI] 2.811-5.711) and women (OR 2.599, 95% CI 1.86-5.543). ROC curve analysis revealed that the area under the curve was 0.572 (95% CI = 0.541-0.602; P < 0.001) for men and 0.694 (95% CI = 0.668-0.721; P < 0.001) for women. The optimal TyG index cutoff points for predicting subclinical atherosclerosis were 8.961 for men (sensitivity, 46.5%; specificity, 67.9%) and 8.254 for women (sensitivity, 79.7%; specificity, 49.9%).</p><p><strong>Conclusion: </strong>The TyG index is a composite indicator of dyslipidemia and hyperglycemia. In clinical practice, women with TyG index values above the cutoff should be further evaluated for the underlying pulse wave velocity.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e250115"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-590-5p mediates mitochondrial respiration, proliferation, and apoptosis in thyroid carcinoma cells via fibroblast growth factor receptor substrate 2.","authors":"Penghui Wang, Xiaoli Hou, Wei Sun, Jiajie Chen, Yasen Cao, Hong Cheng","doi":"10.20945/2359-4292-2024-0410","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0410","url":null,"abstract":"<p><strong>Objective: </strong>Thyroid carcinoma (TC) is the most common cancer of the endocrine system. Dysregulation of microRNA-590-5p (miR-590-5p) has been associated with various malignancies. Targeting mitochondrial respiration is beneficial in treating TC. This study aims to evaluate the role of miR-590-5p in the proliferation and apoptosis of TC cells via mediating mitochondrial respiration.</p><p><strong>Materials and methods: </strong>Reverse transcription quantitative polymerase chain reaction (qRT-PCR) was used to analyze differential expression of miR-590-5p in TC and para-cancerous tissues, normal thyrocytes, and TC cell lines. TC cells were transfected with agomiRNA negative control (agomiR-NC) or agomiRNA-590-5p (agomiR-590-5p). Cell counting kit 8 (CCK-8) assays, JC-1 staining, reactive oxygen species (ROS) measurements, and flow cytometry were used to detect cell proliferation, mitochondrial membrane potential (MMP), ROS levels, and apoptosis, respectively. The targeting relationship between miR-590-5p and fibroblast growth factor receptor substrate 2 (FRS2) was verified using dual-luciferase reporter assay. The role of miR-590-5p in tumor growth was analyzed in mouse xenograft tumors.</p><p><strong>Results: </strong>miR-590-5p was expressed at low levels in TC tissues and cells relative to normal tissues. Overexpression of miR-590-5p reduced TC cell proliferation, enhanced apoptosis, and inhibited mitochondrial respiration. miR-590-5p suppressed FRS2 transcription in TC cells. Overexpression of FRS2 reversed the effects of miR-590-5p overexpression, limiting mitochondrial respiration and proliferation, and promoting apoptosis. In vivo, overexpression of miR-590-5p suppressed xenograft tumor growth in mice by reducing the transcription of FRS2.</p><p><strong>Conclusion: </strong>miR-590-5p was poorly expressed in TC. Overexpression of miR-590-5p limited TC cell proliferation and promoted apoptosis by reducing mitochondrial respiration via decreased transcription of FRS2.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 4","pages":"e240410"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}