Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.

IF 2.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-08-26 DOI:10.20945/2359-4292-2024-0360

Indianara Franciele Porgere, Bruna Martins Rocha, Gustavo Monteiro Escott, Luiza Carolina Fagundes Silva, Priscila Aparecida Correa Freitas, Fabíola Satler, Sandra Pinho Silveiro

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Abstract

Objective: To evaluate the putative association of age and insulin resistance with sex hormone-binding globulin levels in healthy men.

Methods: In total, 136 healthy men without obesity, aged 18 years or older, were included. Total testosterone was measured by electrochemiluminescence, and sex hormone-binding globulin by chemiluminescence. Calculated free testosterone was obtained by Vermeulen's equation. Insulin resistance index was estimated as triglycerides/HDL ratio.

Results: The sample was divided into tertiles according to age (18 to 29; 30 to 49; 50 to 67 years). Sex hormone-binding globulin levels were higher in men > 50 years old compared to those of the second and first tertiles (41 ± 17 versus 35 ± 12 and 29 ± 9 nmol/L; p < 0.001), while values of calculated free testosterone were lower in the older tertile (7.7 ± 1.9 versus 8.8 ± 2.2 and 10.4 ±3.1 ng/dL; p < 0.001). Age did not influence total testosterone levels. Insulin resistance index was inversely and significantly correlated with sex hormone-binding globulin (r = -0.371; p < 0.001).

Conclusion: There is a significant increase in serum sex hormone-binding globulin in older healthy men, highlighting the need for age-specific reference values. Furthermore, insulin resistance seems to reduce this globulin levels, perhaps pointing out low sex hormone-binding globulin as a putative predictor of related chronic diseases.

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健康男性性激素结合球蛋白水平与年龄和胰岛素抵抗的关系

目的：探讨健康男性性激素结合球蛋白水平与年龄和胰岛素抵抗的关系。方法：共纳入136名18岁及以上无肥胖的健康男性。电化学发光法测定睾酮总水平，化学发光法测定性激素结合球蛋白水平。通过Vermeulen方程计算游离睾酮。胰岛素抵抗指数以甘油三酯/高密度脂蛋白比值估算。结果：样本按年龄（18 ~ 29岁、30 ~ 49岁、50 ~ 67岁）进行分类。性激素结合球蛋白水平在50岁以下的男性中高于第二和第一分位（41±17比35±12和29±9 nmol/L， p < 0.001），而计算的游离睾酮值在老年分位中较低（7.7±1.9比8.8±2.2和10.4±3.1 ng/dL, p < 0.001）。年龄对总睾酮水平没有影响。胰岛素抵抗指数与性激素结合球蛋白呈显著负相关（r = -0.371; p < 0.001）。结论：老年健康男性血清性激素结合球蛋白显著升高，提示有必要建立年龄特异性参考值。此外，胰岛素抵抗似乎降低了这种球蛋白水平，这可能表明性激素结合球蛋白水平低是相关慢性疾病的推测预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.