Archives of Endocrinology Metabolism最新文献

{"title":"Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19.","authors":"Sara Moreira Anunciação, Renata de Oliveira Campos, Fabyan Esberard de Lima Beltrão, Déborah Araújo Morais, Wellington Sousa Tavares de, Fernando Barbosa, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fabio Hecht, Helton Estrela Ramos","doi":"10.20945/2359-4292-2024-0113","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0113","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19.</p><p><strong>Subjects and methods: </strong>A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (), (ii) USC 25-39 μg/L (), and (iii) USC > 39 μg/L (). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels.</p><p><strong>Results: </strong>NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05).</p><p><strong>Conclusion: </strong>The association between low USC and NTIS was evident in this cohort.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e240113"},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation of plasma oxyntomodulin levels from anthropometric measures and metabolic markers in women with polycystic ovary syndrome.","authors":"Rachel C Damasceno, Flávia R Oliveira, Ana Lúcia Cândido, Karina B Gomes, Mariana F Bizzi, Rosana C Azevedo, Fábio V Comim, Fernando M Reis, Ana Luiza Lunardi Rocha","doi":"10.20945/2359-4292-2024-0451","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0451","url":null,"abstract":"<p><strong>Introduction: </strong>Oxyntomodulin (OXM) is a polypeptide hormone of the incretin family, which binds to the glucagon-like peptide 1 receptor, contributing to a reduction in caloric intake, an increase in energy expenditure, and weight loss in obese individuals. Polycystic ovary syndrome (PCOS) is a multifactorial condition characterized by reproductive and metabolic dysfunctions, with a high prevalence among overweight and obese women. This study aimed to investigate the correlation between clinical, anthropometric, endocrine, and metabolic variables and plasma OXM levels in women diagnosed with PCOS.</p><p><strong>Subjects and methods: </strong>This cross-sectional study included 20 women recently diagnosed with PCOS. Participants underwent screening that assessed body measurements, as well as serum/plasma lipids, fasting glucose, fasting insulin, irisin, and total testosterone levels. Plasma OXM concentrations were measured in duplicate using a commercial ELISA kit.</p><p><strong>Results: </strong>OXM levels were positively correlated with age (r = 0.493, p = 0.027); however, they showed no significant correlation with body mass index, waist circumference, lipid accumulation product index, visceral adiposity index, or hormones such as insulin, irisin, and testosterone. Furthermore, plasma OXM levels remained unchanged in a subgroup of patients treated with metformin for 60 days.</p><p><strong>Conclusion: </strong>These findings suggest that plasma OXM levels may not reflect body composition or insulin resistance in women with PCOS.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e240451"},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and genetic analysis of a Brazilian patient with sitosterolemia: a case report.","authors":"Felipe Augusto Azevedo Leão, Leticia Ferreira Gontijo Silveira, Rodrigo Rezende Arantes, Milena Maria Moreira Guimarães","doi":"10.20945/2359-4292-2024-0326","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0326","url":null,"abstract":"<p><p>Sitosterolemia is a rare genetic lipid disorder caused by mutations in the ABCG5/ABCG8, genes. It is characterized by plasmatic plant sterols accumulation, formation of tendon and tuberous xanthomas and early onset coronary artery disease. The differential diagnosis with other congenital dyslipidemias presents significant challenges. We describe a case of a male patient who presented with hypercholesterolemia and tendinous xantomas from the age of 5. The patient was born to consanguineous parents, with no family history of hypercholesterolemia. With the initial hypothesis of cerebrotendinous xanthomatosis, he was treated with chenodeoxycholic acid, which yielded no improvement. Over time, he developed persistent thrombocytopenia and arthralgia, and experienced an acute myocardial infarction at the age of 27. Genetic analysis revealed the previously known p.Trp361*mutation in homozygosity in the ABCG8 gene and was negative for CYP27A1 variants, associated with cerebrotendinous xanthomatosis. The subsequent introduction of a diet with vegetable fats restriction and administration of ezetimibe resulted in an excellent response. The diagnosis of congenital hypercholesterolemia is challenging due to the low prevalence and heterogenous presentation of the condition. This case underscores the importance of clinical suspicion and the confirmation of the molecular diagnosis for a precise therapeutic management.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 3","pages":"e240326"},"PeriodicalIF":1.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 pandemic on the incidence of central precocious puberty: A PRISMA-ScR-COMPLIANT scoping review.","authors":"Amanda Veiga Cheuiche, Marcelo Garroni Teixeira, Candice Moro, Gustavo Guimarães, Liliane Salvador, Mauro Antônio Czepielewski, Leila Cristina Pedroso de, Sandra Pinho Silveiro","doi":"10.20945/2359-4292-2024-0300","DOIUrl":"10.20945/2359-4292-2024-0300","url":null,"abstract":"<p><p>Puberty is a biological maturation process that involves genetic, nutritional, environmental, ethnic, and lifestyle factors. During the coronavirus 2019 (COVID-19) pandemic, an increase in referrals for central precocious puberty (CPP) assessment was observed in clinical practice. The aim of this review was to evaluate the incidence of CPP in different countries before and during the COVID-19 pandemic. A PRISMA-ScR-compliant scoping review was performed in the MEDLINE and Embase databases using \"puberty\" and \"COVID-19\" as search terms. Exclusion criteria were an identifiable organic cause of CPP, genetic disorders or peripheral precocious puberty. The study was registered in OSF. A total of 26 studies with participants from 11 countries were included. Twenty-five studies found a 1.3- to 5-fold increase in the incidence of CPP in girls. In boys, 4 studies found no significant difference in the number of cases, 3 studies found a 2.8- to 3.4-fold increase, and 1 study detected a 75% decrease. Twelve studies reported an increase in the use of electronic devices, sedentary lifestyles, higher Z-scores for weight and body mass index, increased sleep disturbances, and a lower age at the onset of puberty. Seven studies found no significant differences in clinical and laboratory parameters between the pandemic and pre-pandemic periods. There was an increase in the incidence of precocious puberty among girls during the COVID-19 pandemic. This finding was not consistently observed in boys. Increased screen time, reduced physical activity, psychological stress, changes in diet and sleep habits, and the direct effects of SARS-CoV-2 may have caused these results.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240300"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral precocious puberty in girls with McCune-Albright syndrome: a case series.","authors":"Aline Guimarães Faria, Luciana R Montenegro, Alexander Augusto Lima Jorge, Regina Matsunaga Martin, Maria Candida Barisson Villares Fragoso, Flavia R Tinano, Carlos E Seraphim, Ana Pinheiro Machado Canton, Larissa G Gomes, Gabriel A Martos-Moreno, Irene Tarjuelo García, Atilano Carcavilla, Mireia Tirado-Capistros, Nadja Cristhina Souza-Pinto, Jesús Argente, Ana Claudia Latronico, Berenice Bilharinho Mendonca, Vinicius Nahime Brito","doi":"10.20945/2359-4292-2024-0459","DOIUrl":"10.20945/2359-4292-2024-0459","url":null,"abstract":"<p><strong>Objective: </strong>To describe the follow-up of girls with peripheral precocious puberty (PPP) due to McCune-Albright syndrome (MAS).</p><p><strong>Subjects and methods: </strong>Data from 18 females, including anthropometric and reproductive outcomes, were evaluated. Genetic analysis was performed on DNA from peripheral leukocytes via digital PCR.</p><p><strong>Results: </strong>Clinical manifestations of PPP were isolated thelarche, thelarche plus vaginal bleeding, or isolated vaginal bleeding in 44.5%, 33.3%, and 22.2%, respectively, at an early age (3.3 ± 1.6 years). At diagnosis, basal LH and FSH levels were suppressed in 100% and 72.2% of cases, respectively, and estradiol ranged from prepubertal to high levels. The mean bone age advancement was 2.3 ± 1.9 years. Treatment included medroxyprogesterone acetate, tamoxifen, aromatase inhibitors, and ketoconazole, individually or in combination for 5 ± 2.14 years, with partial or complete control of puberty. Secondary central precocious puberty was diagnosed in 57.1% (8/14) of the patients. Fibrous dysplasia was diagnosed in 11 patients and managed with bisphosphonates for those with bone pain. The mean adult height was 155.1 ± 8.7 cm (-1.17 SDS) in 10 patients. Menarche occurred at a mean age of 12.2 ± 1.04 years, 70% reported regular menstrual cycles and only one female desired pregnancy. Genetic diagnosis was established in 52.9% (9/17) of the patients.</p><p><strong>Conclusion: </strong>Medical treatment of PPP was effective in girls with MAS and led to preservation of adult height potential, and reproductive function was normal when patients reached adulthood.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240459"},"PeriodicalIF":1.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic retinopathy and diabetic kidney disease, either isolated or associated, impact on the 10-year risk of cardiovascular disease: are we dealing with similar conditions?","authors":"Clara Krummenauer Maraschin, Janine Alessi, Mateus Augusto Dos Reis, Gabriela Oliveira Gonçalves Molino, Gabriela Heiden Teló, Beatriz D Schaan","doi":"10.20945/2359-4292-2024-0258","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0258","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between diabetic retinopathy, diabetic kidney disease, and the 10-year risk of atherosclerotic cardiovascular disease in patients with diabetes.</p><p><strong>Subjects and methods: </strong>A cross-sectional study was performed involving patients diagnosed with either type 1 or type 2 diabetes mellitus. Participants were classified into four groups: DM (patients without diabetes-related complications), DR (patients with diabetic retinopathy only), DKD (patients with diabetic kidney disease only), and DR + DKD (patients with both diabetic retinopathy and diabetic kidney disease). The primary outcome was the 10-year risk assessment for cardiovascular events, calculated using the American Heart Association's atherosclerotic cardiovascular disease score.</p><p><strong>Results: </strong>A total of 571 patients were selected including 128 with type 1 diabetes (average age of 39.4 ± 15.1 years; 48.4% female) and 443 with type 2 diabetes (average age of 59.5 ± 11.9 years; 66.4% female). Among the participants with type 2 diabetes, the cardiovascular risk was 15.2 ± 14.6% for the DM group, 15.7 ± 10.7% for the DR group, 22.5 ± 16.7% for the DKD group, and 21.5 ± 15.1% for the DR + DKD group, reflecting a significantly higher cardiovascular risk in the groups with renal involvement (P <0.001). For those with type 1 diabetes, the DM group had a risk of 6.1 ± 8.9%, the DR group 8.9 ±11.8%, the DKD group 5.4 ± 8.8%, and the DR + DKD group 6.1 ± 9.5%. The mean difference in risk between the groups was not statistically significant.</p><p><strong>Conclusion: </strong>In patients with type 2 diabetes, those with diabetic kidney disease appeared to have a higher theoretical risk of cardiovascular disease compared to those with only diabetic retinopathy.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240258"},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between weekend catch-up sleep and the risk of diabetic kidney disease.","authors":"Xia Wu, Yunhai Tang, Yayun He, Zhihuan Tang, Yingdan Zhao","doi":"10.20945/2359-4292-2024-0370","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0370","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between weekend catch-up sleep (WCS) and the risk of diabetic kidney disease (DKD). Subjects and.</p><p><strong>Methods: </strong>Data from 1,621 adults aged 18 years or older from the National Health and Nutrition Examination Survey 2017-2020 were obtained for this cross-sectional study. WCS was calculated as the mean weekend sleep duration minus the mean weekday sleep duration. The outcomes were DKD, a reduced estimated glomerular filtration rate (eGFR), and proteinuria. The associations between WCS and DKD, the reduced eGFR or proteinuria were evaluated via a weighted multivariate logistic regression model. Subgroup analyses were performed for different sexes and participants with or without hypertension.</p><p><strong>Results: </strong>A total of 583 diabetic patients had DKD, of whom 198 patients displayed reduced eGFRs and 499 patients had proteinuria. After adjusting for all confounding factors, Group 4 (weekend CUS ≥ 2 and < 3 hours) still had lower odds of DKD [odds ratio (OR) = 0.51, 95% confidence interval (CI): 0.28-0.93] and proteinuria (OR = 0.51, 95% CI: 0.27-0.96). Additionally, subgroup analyses stratified by sex and hypertension consistently revealed connections in female diabetic patients (OR = 0.40, 95% CI: 0.20-0.78 for DKD; OR = 0.47, 95% CI: 0.22-0.97 for proteinuria) and in diabetic patients with hypertension (OR = 0.39, 95% CI: 0.18-0.81 for DKD; OR = 0.38, 95% CI: 0.19-0.77 for proteinuria). However, the fully adjusted model revealed no such association between WCS and a reduced eGFR.</p><p><strong>Conclusion: </strong>WCS was found to decrease the likelihood of developing DKD and proteinuria among American adult patients diagnosed with diabetes, particularly among female patients or those with hypertension.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240370"},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, treatment, and control of diabetes in South America: A systematic review and meta-analysis.","authors":"Jorge Emerson Chachaima-Mar, Alexandra Isabel Ramirez Moreno, Kenjiro Chau Ruiz, Maria Lazo-Porras","doi":"10.20945/2359-4292-2025-0026","DOIUrl":"https://doi.org/10.20945/2359-4292-2025-0026","url":null,"abstract":"<p><p>Theaim of this review is to determine the proportion of awareness, treatment, and control of diabetes in the South American region. A comprehensive search was conducted using PubMed, EMBASE, SCOPUS, and LILACS databases from January 1, 2014, to March 23, 2024. We included observational, population-based studies that assessed the rates of awareness, treatment, and control of diabetes. The risk of bias was evaluated as proposed by Hoy and cols. A meta-analysis was performed using the random effects model, and heterogeneity was assessed using the I2 statistic. Additionally, a metaregression analysis was conducted to further explore heterogeneity. Fourteen studies met our eligibility criteria. The disease awareness meta-analysis, which included six studies, revealed that 71.7% (95% CI: 65.2%-77.8%, I2: 94.2%) of participants had a previous diagnosis of diabetes. The disease treatment meta-analysis, which included five studies, indicated that 64.6% (95% CI: 52.9%-75.3%, I2: 98.7%) of participants were receiving some form of treatment for diabetes, and 42.4% (95% CI: 36.0%-49.1%, I2: 96.3%) had their glycemic values within target ranges. All included studies were assessed to have a low risk of bias. In South America, the limited available evidence suggests a significant portion of individuals with diabetes remain untreated and uncontrolled. Numerous countries lack critical information on the diabetes care cascade necessary to inform health policies.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e250026"},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of selenoproteins and proinflammatory cytokines in L-thyroxine-induced hyperthyroid rats: effects of selenium supplementation.","authors":"Aysun Yoldas, Nurten Bahtiyar, Birsen Aydemir, Selmin Toplan","doi":"10.20945/2359-4292-2024-0444","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0444","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the effects of selenium, which is known for its antioxidant and immune-supporting properties, on serum levels of thyroid function markers, selenoproteins, and proinflammatory cytokines in a model of hyperthyroidism.</p><p><strong>Materials and methods: </strong>A total of 48 Wistar albino rats were distributed into 6 groups: a control group; a hyperthyroid group (HT group); a group fed 0.5 mg/kg sodium selenite (Se 1 group); a group fed 1 mg/kg sodium selenite (Se 2 group); a hyperthyroid group fed 0.5 mg/kg sodium selenite (HT + Se 1 group); and a hyperthyroid group fed 1 mg/kg sodium selenite (HT + Se 2 group) added to standard fodder. Serum levels of interleukin (IL)-1β, IL-6, IL-18, tumour necrosis factor alpha (TNF-α), selenoprotein P (SelP), and glutathione peroxidase 1 (GPx1) were measured using ELISAs.</p><p><strong>Results: </strong>IL-Iβ, IL-6, IL-18, and TNF-α levels were increased, but selenium, GPx1, and SelP levels were decreased in the hyperthyroid group compared with those in the control group. Selenium and GPx1 levels were increased, but TNF-α levels were decreased in the HT + Se 1 group compared with those in the HT group. Selenium, SelP, and GPx1 levels were increased, but TNF-α, IL-6, and IL-18 levels were decreased in the HT + Se 2 group compared with those in the HT group.</p><p><strong>Conclusion: </strong>Our results suggest that appropriate doses of selenium may be effective at preventing inflammation and providing protection against oxidative stress in hyperthyroid rats.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240444"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus.","authors":"Luciane Moretto, Eliandra Girardi, Anna Carolina Meireles Vieira, Letícia de Almeida Brondani, Natália Emerim Lemos, Luís Henrique Canani, Marilu Fiegenbaum, Cristine Dieter, Daisy Crispim","doi":"10.20945/2359-4292-2024-0167","DOIUrl":"https://doi.org/10.20945/2359-4292-2024-0167","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between the rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus.</p><p><strong>Methods: </strong>The sample consisted of 740 patients with type 2 diabetes mellitus and diabetic kidney disease (cases) and 303 patients with type 2 diabetes mellitus, but no diabetic kidney disease (controls). The genotyping of the polymorphisms was conducted using real-time polymerase chain reaction with Taqman probes.</p><p><strong>Results: </strong>The frequency of the rs3844492/ARHGAP22 G/G genotype was 16.8% in the control group and 15.7% in cases (p = 0.069). After adjusting for covariables, the presence of the G allele was associated with risk for diabetic kidney disease (OR = 1.435, 95% CI 1.023 - 2.011; p = 0.036), as well as with a decreased estimated glomerular filtration rate (p = 0.012) and elevated creatinine levels (p = 0.009). No difference was observed in the rs741301/ELMO1 genotype frequencies between groups (p = 0.800). However, the presence of the C allele appears to be associated with higher creatinine levels in patients with type 2 diabetes mellitus (p = 0.064).</p><p><strong>Conclusion: </strong>The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with alterations in renal function markers among patients with type 2 diabetes mellitus.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 2","pages":"e240167"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}