Archives of Endocrinology Metabolism最新文献

{"title":"Prognostic factors in the surgical treatment of non-functioning pituitary adenomas: a retrospective cohort study.","authors":"Ana Clara Toschi Aquno, João Lucas Gomes Salgado, Lucas Dos Santos Borgatto, Pedro Tadao Hamamoto Filho, José Vicente Tagliarini, Marco Antonio Zanini, Vania Dos Santos Nunes Nogueira, Adriano Yacubian-Fernandes","doi":"10.20945/2359-4292-2026-0039","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0039","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze preoperative, intraoperative, and postoperative factors that affect the surgical prognosis of non-functioning pituitary adenomas (NFPA) and to determine postoperative complication rates.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study of patients with NFPA who underwent surgery between 1995 and 2024 at a tertiary public hospital in Brazil. Variables analyzed included tumor size, cavernous sinus invasion (Knosp classification), endocrinological status, preoperative clinical features, surgical complications, and outcomes. Statistical significance was set at p ≤ 0.05.</p><p><strong>Results: </strong>Seventy-three patients were included, with a mean age of 53 years and a slight predominance of females. Tumors were classified as macroadenomas (59%) and giant adenomas (41%). The transsphenoidal approach was used in 81% of cases. Partial resection was achieved in 56%, subtotal in 16%, and total in 27%. Immediate postoperative complications included diabetes insipidus (30%), bleeding (11%), hydrocephalus (10%), ischemia (10%), meningitis (6%), and cerebrospinal fluid fistula (11%). Mortality was 9.6%, significantly associated with postoperative hydrocephalus, ischemia, and larger tumor size. Giant tumors were correlated with higher rates of preoperative neurological deficits and postoperative complications. Transcranial surgery was more frequently performed in cases of giant adenomas and was associated with increased rates of ischemia and neurological deficits. Tumor recurrence was observed in 33% of patients over a mean follow-up of 48 months. Tumor size and postoperative complications such as hydrocephalus and ischemia were associated with increased morbidity and mortality.</p><p><strong>Conclusion: </strong>Postoperative hydrocephalus, ischemia, and tumor size are key determinants of mortality in NFPA surgical treatment. Implementing preventive and management strategies targeting these complications could improve patient outcomes, albeit rigorous long-term follow-up is essential due to the high rates of recurrence and reoperation.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep aspects and subclinical hypothyroidism: a four-year follow-up of the ELSA-Brasil study.","authors":"João Ferreira Silva Junior, Aline Silva-Costa, Maria de Jesus Mendes da Fonseca, Isabela Martins Benseñor, Pedro Guatimosim Vidigal, Sandhi Maria Barreto, Rosane Harter Griep, Aline Araújo Nobre","doi":"10.20945/2359-4292-2026-0037","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0037","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies suggest a bidirectional relationship between thyroid dysfunction and sleep disorders. However, prospective evidence regarding the impact of sleep characteristics on subclinical hypothyroidism remains limited. This study aimed to evaluate the association between insomnia symptoms, sleep duration, and sleep debt and the incidence of subclinical hypothyroidism.</p><p><strong>Subjects and methods: </strong>We conducted a prospective cohort analysis of 7,983 euthyroid participants from the second wave (2012-2014) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who were not taking thyroid-related or psychiatric medications. Insomnia symptoms (initial, middle, and terminal), sleep duration, sleep debt, sociodemographic characteristics, and health behaviors were assessed via questionnaires. Subclinical hypothyroidism was defined as thyrotropin >4.0 μIU/mL and normal free thyroxine in the third wave (2016-2018). Crude and adjusted log-binomial regression models estimated relative risks (RR) and 95% confidence intervals (95% CI).</p><p><strong>Results: </strong>The incidence of subclinical hypothyroidism was 6.6% for both sexes. In women, middle insomnia was associated with a 35% reduced risk of subclinical hypothyroidism (RR: 0.65; 95% CI: 0.44-0.92). Among men, sleep debt was linked to a 30% increased incidence (RR: 1.30; 95% CI: 1.01-1.66), and in the continuous model, each additional hour of sleep debt raised the risk by 9% (RR: 1.09; 95% CI: 1.02-1.14).</p><p><strong>Conclusion: </strong>Of the sleep characteristics assessed, middle insomnia due to nocturnal awakenings appeared to be protective against subclinical hypothyroidism among women, while sleep debt increased the risk among men.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brazilian Transition in Differentiated Thyroid Carcinoma Management: A 25-Year Nationwide Analysis of Declining High-Activity Radioiodine Use (2000-2024).","authors":"José Miguel Dora, Leonardo Barbi Walter, André B Zanella, Iuri Goemann, Rafael Selbach Scheffel, Ana Luiza Maia","doi":"10.20945/2359-4292-2026-0038","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0038","url":null,"abstract":"<p><strong>Objective: </strong>To analyze temporal trends in radioiodine (RAI) prescription patterns for differentiated thyroid carcinoma (DTC) in Brazil from 2000 to 2024, assessing adherence to evolving clinical guidelines and identifying opportunities for practice optimization.</p><p><strong>Materials and methods: </strong>This retrospective study utilized data from the Brazilian Unified Health System (Datasus) to evaluate RAI prescriptions, categorized by activity: low (30 and 50 mCi), high (100 and 150 mCi), and very high (200 and 250 mCi). Population-adjusted rates, procedure-adjusted ratios (RAI/oncologic thyroidectomies and RAI/new cases), and activity-level trends were analyzed.</p><p><strong>Results: </strong>Three distinct phases emerged: () 2000-2007, marked by increasing very high-activity RAI use (≥ 200 mCi); () 2008-2015, peak utilization with initial diversification (introduction of 30/50 mCi in 2014); and () 2016-2024, significant de-escalation, with high/very high-activity prescriptions declining by 34.2% and low-activity use increasing by 163%. By 2024, RAI distribution comprised 15.3% very high-, 67.1% high-, and 17.6% low-activity prescriptions. The RAI/new cases ratio fell sharply from 0.63 (2010) to 0.25 (2024), and RAI/oncologic thyroidectomies dropped from 1.22 (2013) to 0.70 (2024), reflecting more selective prescription.</p><p><strong>Conclusion: </strong>Brazilian medical practice has increasingly aligned with international DTC guidelines, showing a decline in RAI use and a shift toward low-to-high RAI activities. This suggests broader adoption of risk-adapted strategies. Notwithstanding, high-dose RAI still predominates, pointing that dissemination of standardized treatment protocols could further enhance DTC care within the Brazilian health system.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of bioimpedance and anthropometric estimates of body fat in patients with mild autonomous cortisol secretion and nonfunctional adrenal incidentalomas.","authors":"Ensar Aydemir, Yasemin Unsal, Coşkun Ates, Semiha Yasar Turk, Soner Cander, Özen Oz Gul, Canan Ersoy, Erdinç Erturk","doi":"10.20945/2359-4292-2026-0040","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0040","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare body composition measurements between patients with nonfunctional adrenal incidentalomas (NFAI) and mild autonomous cortisol secretion (MACS) using bioelectrical impedance analysis (BIA) and anthropometric methods.</p><p><strong>Subjects and methods: </strong>This cross-sectional study included patients diagnosed with MACS or NFAI. Body composition was assessed using BIA, anthropometric measurements, and the Durnin and Womersley (DW) method. Correlation and Bland-Altman analyses were performed to assess the relationship and agreement between the DW method and BIA.</p><p><strong>Results: </strong>Fifty-seven patients (32 with MACS and 25 with NFAI) were included; those with MACS were older (p = 0.004). Post-dexamethasone suppression test cortisol levels (p < 0.001) and the incidence of bilateral tumors (p = 0.017) were higher in MACS patients. No significant differences in body composition parameters were observed between the MACS and NFAI groups. A strong correlation was observed between BIA- and DW-derived fat mass in MACS patients (r = 0.890, p < 0.001). Bland-Altman analysis revealed a slight mean bias for body fat mass of -0.4 kg (limits of agreement: -9.14-8.34 kg) and for body fat percentage of -0.83% (limits of agreement: -11.32-9.66%) between methods.</p><p><strong>Conclusion: </strong>A robust correlation and acceptable agreement was demonstrated between the DW method and BIA for estimating body fat. The DW equation may provide a practical and low-cost alternative for assessing body composition in MACS and NFAI cohorts. Limitations include the lack of a healthy control group and the inability to validate BIA and anthropometric estimates against gold-standard imaging techniques, potentially introducing accuracy bias.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13104715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide-induced ketoacidosis with hyperglycemia in a patient without diabetes.","authors":"Mendel Shloush, Vania Rodriguez, Victor Guillen, Diego Lugo Baruqui","doi":"10.20945/2359-4292-2026-0028","DOIUrl":"10.20945/2359-4292-2026-0028","url":null,"abstract":"<p><p>Tirzepatide,a dual GLP-1 and GIP receptor agonist, is increasingly used for weight management in both patients with diabetes and patients without diabetes. While gastrointestinal side effects such as nausea are common, severe metabolic complications like ketoacidosis are rare and often overlooked. We report the case of a 38-year-old woman with congenital heart disease who developed acute ketoacidosis with hyperglycemia following five months of tirzepatide therapy. Laboratory findings confirmed high anion gap metabolic acidosis, elevated ketones, and significant hyperglycemia. With supportive care, including intravenous fluids, insulin infusion, and electrolyte replacement, she recovered fully. This represents a rare case of tirzepatide-induced hyperglycemic ketoacidosis in a patient without diabetes. In contrast, the two previously reported cases by Singh and cols. and Iqbal and cols. involved patients without diabetes who developed euglycemic ketoacidosis with normal glucose levels while on tirzepatide. This case underscores the importance of vigilant monitoring for metabolic complications, including hyperglycemia and ketoacidosis, in patients without diabetes, particularly those with comorbidities.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 3","pages":"e260028"},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel activating somatic mutation in EPAS1, coding for HIF-2α, in a patient with a paraganglioma and sickle cell disease.","authors":"Kalyan Mansukhbhai Shekhda, Rishi Iyer, Mercedes Robledo, Viktorija Nara, Tu Vinh Luong, Martyn Caplin, Ashley B Grossman","doi":"10.20945/2359-4292-2026-0027","DOIUrl":"10.20945/2359-4292-2026-0027","url":null,"abstract":"<p><p>Pheochromocytomasand paragangliomas (collectively referred as PPGLs) are highly heritable neoplasms arise from chromaffin cells of neural crest tissues; 40% of patients with PPGLs harbour germline pathogenic variants (PV), which up to 45% of patients exhibit somatic mutations in similar susceptibility genes. Endothelial PAS domain-containing protein-1 [also known as hypoxia inducible factor-2α, HIF-2α] is encoded by EPAS1, and along with other hypoxia-inducible factors (HIFs) acts as a key mediator in the cellular response to hypoxia. Gain-of-function mutations in EPAS1 have been linked to the Pacak-Zhuang syndrome, congenital cyanotic heart disease and sickle cell anaemia. Hypoxia due to chronic anaemia and/or associated nephropathy in patients with sickle cell disease (SCD) may increase the expression of genes related to HIFs, thereby increasing susceptibility to the development of PPGLs. We describe a case of young female with a history of sickle cell anaemia and sickle cell nephropathy who was found to have a para-aortic mass. Histology confirmed the diagnosis of a paraganglioma. She did not exhibit somatic mutations of the common predisposition genes but demonstrated a likely pathogenic activating somatic EPAS1 variant mutation. This case illustrates the predisposition of patients with SCD to PPGLs due to somatic EPAS1 mutations, and should increase awareness of such tumours in these patients.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 3","pages":"e260027"},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?","authors":"Berna Eroğlu Filibeli, Fatima Dedemoglu, Pinar Garipçin, Seyran Bulut, Banu İşbilen Başok, Sefa Kizildağ, Bumin Dündar, Gönül Çatli","doi":"10.20945/2359-4292-2026-0031","DOIUrl":"10.20945/2359-4292-2026-0031","url":null,"abstract":"<p><strong>Objective: </strong>MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men. However, no studies have explored the relationship between this polymorphism and MOTS-c levels in adolescents with polycystic ovary syndrome (PCOS). This study aimed to investigate the differences in MOTS-c levels between adolescents diagnosed with PCOS and those without PCOS, as well as the associations with metabolic parameters. The association between the MOTS-c gene polymorphism and serum MOTS-c levels in adolescents with PCOS was also evaluated.</p><p><strong>Subjects and methods: </strong>Adolescents aged 12-18 diagnosed with PCOS were recruited based on irregular menstrual cycles and clinical/biochemical hyperandrogenism, excluding other conditions. The control group consisted of adolescents with regular menstruation. Serum MOTS-c levels were measured using ELISA, and the m.1382A>C polymorphism was analyzed by sequencing.</p><p><strong>Results: </strong>The study included 121 adolescents with PCOS and 125 healthy controls. The mean serum MOTS-c levels in the PCOS group were higher than in the control group; however, this difference did not reach statistical significance (p = 0.059). There was no significant association between MOTS-c levels and anthropometric or metabolic parameters within the PCOS group (p > 0.05). All participants had the wild-type (A/A) genotype for the m.1382A>C polymorphism.</p><p><strong>Conclusion: </strong></p><p><strong>Results: </strong>indicate that the MOTS-c gene (m.1382A>C) polymorphism shows no significant association with PCOS, and serum MOTS-c levels are comparable between individuals with PCOS and healthy controls, suggesting that MOTS-c may have a minor involvement in the pathophysiology of PCOS.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 3","pages":"e260031"},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cushing's syndrome: a systematic review of psychiatric and cognitive symptoms in case studies.","authors":"Roni Vian da Silva Lhul, Katiúscia Gomes Nunes, Tobias Skrebsky de Almeida, Mauro Antônio Czepielewski, Letícia Sanguinetti Czepielewski","doi":"10.20945/2359-4292-2026-0029","DOIUrl":"10.20945/2359-4292-2026-0029","url":null,"abstract":"<p><strong>Objective: </strong>Cushing's syndrome, characterized by chronic hypercortisolism, is associated with various health risks, including psychiatric symptoms and cognitive impairments. This systematic review of case studies aimed to map and categorize these symptoms.</p><p><strong>Materials and methods: </strong>We hypothesized that a broader range of psychiatric and cognitive manifestations would be observed beyond anxiety, depression, and memory impairment. The review followed PRISMA guidelines and was preregistered in PROSPERO (CRD42024433186). We conducted searches in PsycINFO, Embase, PubMed, and Scopus, identifying 273 potentially relevant studies. After screening, 66 studies were included, comprising 74 cases (81% female; mean age 35.7 years, range 13-81).</p><p><strong>Results: </strong></p><p><strong>Results: </strong>revealed that 93% of cases presented psychiatric complaints, including depression (39.2%), psychosis/schizophrenic symptoms (35.1%), suicidal ideation/attempts (20.3%), anxiety (17.5%), panic attacks (2.7%), and post-traumatic stress disorder (1.4%). Cognitive complaints were reported in 32% of cases, primarily as general cognitive complaints (18.9%), memory impairment (9.5%), and attentional deficits (5.4%). An overlap of psychiatric and cognitive symptoms was observed in 26% of cases.</p><p><strong>Conclusion: </strong>This review underscores the clinical relevance of symptoms such as mania, psychosis, and suicidal behavior in Cushing's syndrome, which are often underreported. Individualized clinical assessment informed by these case studies is crucial for comprehensive management that extends beyond the typical focus on depression and memory. Moreover, greater awareness of the full spectrum of neuropsychiatric manifestations in hypercortisolism is needed.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 3","pages":"e260029"},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized aerobic session modulates key metabolic genes in liver and muscle of male offspring from obese dams.","authors":"Paloma Brasilio Villalta, Laís Angélica de Paula Simino, Thais de Fante, Thomaz Ramalheira Guadagnini, Natalia de Almeida Rodrigues, Fúlvia de Barros Manchado Gobatto, Marcio Alberto Torsoni, Adriana Souza Torsoni","doi":"10.20945/2359-4292-2026-0030","DOIUrl":"10.20945/2359-4292-2026-0030","url":null,"abstract":"<p><strong>Objective: </strong>Exercise interventions can improve parameters in offspring predisposed to metabolic issues. In this study, we investigate whether acute aerobic exercise in offspring can improve metabolism via miRNA modulation in mice programmed by maternal obesity.</p><p><strong>Materials and methods: </strong>Female Swiss mice fed either a standard chow (C) or a high-fat diet (HF) during gestation and lactation were mated with C male mice. Offspring fed the C diet underwent swimming exercise protocols, consisting of water adaptation (14 days), a lactate minimum test, and an aerobic intensity exercise session or no exercise at 84 days of age.</p><p><strong>Results: </strong>Offspring of obese dams (OHF) exhibited increased hepatic glycogen and triglyceride compared to offspring of control dams (OC). However, in offspring of obese dams subjected to an individualized aerobic session (OHF-E), these parameters did not differed from the other groups. Hepatic gene expression analysis showed that miR-122 was upregulated in OHF-E, inversely to Agpat levels. Additionally, OHF exhibited higher miR-370 and lower Cpt1a levels; exercise restored miR-370 and elevated Cpt1a levels in OHF-E. Regarding muscle tissue, exercise reduced Ptp1b expression in OHF-E and increased Hif1a and Pparg, despite no changes observed in miR-206 levels.</p><p><strong>Conclusion: </strong>A single session of exercise significantly affected miRNA and transcript levels related to hepatic lipid and muscle glucose metabolism, suggesting that even one bout of exercise can benefit offspring in the context of maternal metabolic programming. This highlights tissue responsiveness and adaptive capacity, warranting further investigation into its potential as a long-term, non-pharmacological intervention.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 3","pages":"e260030"},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Retraction - LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA.","authors":"","doi":"10.20945/2359-4292-2026-0012","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0012","url":null,"abstract":"","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}