Archives of Endocrinology Metabolism最新文献

{"title":"The impact of recreational beach tennis associated with nutritional counseling on cardiometabolic risk factors in adolescents: a randomized clinical trial.","authors":"Dalva Muniz Pereira, Nathalia Jung, Rodrigo Pedroso, Gabriel Petry Heck, Luiz Felipe Holstein, Artur Pereira de Oliveira Irigoyen, Clair Rezende Fontana, Rodrigo Ferrari","doi":"10.20945/2359-4292-2026-0124","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0124","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether combining nutritional counseling with recreational sports confers greater improvements in cardiovascular risk factors among adolescents compared to recreational sports alone.</p><p><strong>Subjects and methods: </strong>This 12-week randomized clinical trial included 40 adolescents (aged 11-14 years; 67% female; 45% overweight/obese) randomly assigned to a beach tennis (BT, n = 20) or BT plus nutrition counseling (BT+N, n = 20) group. Sports sessions (BT) were performed twice a week and nutritional counseling (BT+N) once a week. Outcomes assessed at baseline and after 12 weeks included biochemical parameters (high- and low-density lipoprotein, total cholesterol; triglycerides; fasting glucose; and insulin), blood pressure, and body composition. Analyses were performed following the intention-to-treat principle.</p><p><strong>Results: </strong>Both groups showed significantly higher high-density lipoprotein levels (BT: +3.8 mg/dL, p < 0.05; BT+N: +5.9 mg/dL, p < 0.001) and no differences between groups. Fasting glucose decreased only in the BT+N group. Time x group interactions significantly differed between groups for triglycerides (p < 0.01), waist circumference (p < 0.001), body fat percentage (p < 0.05), and systolic blood pressure (p < 0.001), favoring the BT+N group. No significant changes were observed in low-density lipoprotein, total cholesterol, or insulin levels.</p><p><strong>Conclusion: </strong>Recreational BT alone improved some cardiometabolic parameters; however, its combination with nutritional counseling provided broader benefits, underscoring the value of integrated lifestyle interventions for reducing cardiometabolic risk factors in adolescents.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260124"},"PeriodicalIF":1.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of thyroid peroxidase antibodies with thyroid nodules and differentiated thyroid cancer in Graves' disease: a retrospective cohort study.","authors":"Elif Güneş, Mutlu Güneş, Muhammet İlker Kaya, Murat Yüksel, Sümeyye Meinet, Beyza Kibar, Nizameddin Koca, Gökhan Garip, Behiye Oral","doi":"10.20945/2359-4292-2026-0123","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0123","url":null,"abstract":"<p><strong>Objective: </strong>In Graves' disease (GD), thyroid nodules are the principal determinant of differentiated thyroidcaneer(DTC); however, the predictors of nodules and DTC remain uncertain. The role of thyroid peroxidase antibodies (TPOAb) in this context is controversial. Hence, this study aimed to determine whether TPOAb status is associated with thyroid nodules and DTC in GD and to compare the prevalence of DTC across subtypes of hyperthyroid disease.</p><p><strong>Subjects and methods: </strong>We conducted a retrospective cohort study (September 2020-July 2023) including patients with GD (n = 577) and toxic nodular/multinodular goiter (TNG/ TMNG) (n = 216) who had available TPOAb measurements and thyroid ultrasonography. Within the GD cohort, multivariable logistic regression was used to assess associations of TPOAb titer with nodules and DTC.</p><p><strong>Results: </strong>TPOAb positivity was more frequent in GD than in TNG/TMNG (60.4% vs. 7.4%, p < 0.001). Among GD patients, thyroid nodules were detected in 25.8% and were less frequent in TPOAb-positive patients compared with TPOAb-negative patients (8.3% vs. 52.6%, p < 0.001). Within GD, DTC was rare among those without nodular disease (0.93%) but substantially higher in nodular GD (14.1%, p < 0.001), exceeding the prevalence observed in TNG/TMNG (p = 0.009). TPOAb status further stratified DTC risk in GD: DTC was present in 1.15% of TPOAb-positive compared to 9.21% of TPOAb-negative patients (p < 0.001), with 84% of GD-associated DTCs arising in the TPOAb-negative subgroup. Regression analyses showed that TPOAb titer was independently associated with lower frequencies of both DTC and nodules in GD, whereas thyrotropin receptor antibodies levels showed no independent association.</p><p><strong>Conclusion: </strong>In GD, our study showed that TPOAb positivity was strongly associated with lower prevalence of thyroid nodules and DTC, whereas TPOAb-negative patients constitute a clinically relevant, higher-risk subgroup.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260123"},"PeriodicalIF":1.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of serum fibroblast growth factor 23 (FGF23) and Klotho in diabetic kidney disease and their correlation with coronary artery calcification: a retrospective study.","authors":"Yan Hong, Jiahui Wang, Qiandi Lu, Wenjuan Sun, Jinzhu Sun","doi":"10.20945/2359-4292-2026-0125","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0125","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the association among fibroblast growth factor 23 (FGF23), Klotho, and coronary artery calcification (CAC) in patients with diabetic kidney disease (DKD).</p><p><strong>Subjects and methods: </strong>A total of 176 DKD patients and 160 age-and diabetes-matched controls were retrospectively analyzed. We measured serum FGF23 and Klotho levels by enzyme-linked immunosorbent assay and assessed CAC by CAC scoring. Correlation and receiver operating characteristic analyses were performed to evaluate the associations of these biomarkers with CAC and their ability to discriminate CAC.</p><p><strong>Results: </strong>FGF23 levels were significantly higher and Klotho levels were lower in patients with DKD than in controls. FGF23 correlated negatively with estimated glomerular filtration rate and positively with the albumin-to-creatinine ratio and blood urea nitrogen, whereas Klotho correlated positively with estimated glomerular filtration rate and negatively with albumin-to-creatinine ratio and blood urea nitrogen. In patients with CAC, FGF23 levels were higher and Klotho levels were lower. Receiver operating characteristic analysis showed that both FGF23 and Klotho discriminated CAC, and FGF23 showed a higher area under curve than Klotho. Correlation analysis further confirmed the association of FGF23 and Klotho with CAC severity.</p><p><strong>Conclusion: </strong>FGF23 and Klotho were associated with renal impairment and CAC in patients with DKD and may serve as potential biomarkers of renal and cardiovascular risk.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260125"},"PeriodicalIF":1.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elderly men and women with similar areal bone density show significant differences in bone microstructure and fracture pattern.","authors":"Eduardo Medeiros Ferreira da Gama, Leonardo Vieira, Francisco de Paula Paranhos-Neto, Laura Maria Carvalho Mendonça, Luiza Silva Machado de Andrade, Miguel Madeira, Guilherme Cardenaz de Souza, João Antonio Matheus Guimarães, Maria Eugênia Leite Duarte, Maria Lucia Fleiuss Farias","doi":"10.20945/2359-4292-2026-0126","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0126","url":null,"abstract":"<p><strong>Objective: </strong>To compare bone microarchitecture and fracture patterns between elderly men and women with similar spine and hip bone mineral densities (BMDs).</p><p><strong>Subjects and methods: </strong>Twenty-eight men and 84 age-BMI-BMD-matched women aged 65 years and older with at least one major osteoporotic fracture underwent laboratory tests, dual-energy X-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and trabecular bone score (TBS).</p><p><strong>Results: </strong>There were no sex differences in biochemistry, BMD or lowest T-scores. TBS values were low in 67% of the cohort and significantly correlated with HR-pQCT parameters. At HR-pQCT evaluation, men had greater bones (total area and cortical perimeter at distal radius and tibia) and better trabecular vBMD and microstructure at distal radius, but similar values for cortical vBMD and cortical thickness. When compared with Brazilian age-sex-reference HR-pQCT data from healthy individuals, all parameters tested were numerically lower in the study group. These differences seemed more pronounced in men, particularly for cortical thickness at the distal tibia, where relative deficits reached -46.9% in men and -35.4% in women. There was no sex difference in vertebral fractures, but wrist and shoulder fractures were more common in women (p = 0.006), whereas hip fractures were more common in men (p = 0.03).</p><p><strong>Conclusion: </strong>To achieve similar DXA values, men appear to have greater relative bone deficits than women when compared to age-sex-matched healthy Brazilian population. This study highlights the importance of HR-pQCT to understand sex-specific differences in fracture pattern in the study population.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260126"},"PeriodicalIF":1.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymic hyperplasia in patients with acromegaly: imaging-based assessment and clinical implications.","authors":"Nur Yazdali Koylu, Hasbi Basaran, Busra Firlatan Yazgan, Suleyman Nahit Sendur, Selcuk Dagdelen, Macit Orhan Ariyurek, Tomris Erbas","doi":"10.20945/2359-4292-2026-0122","DOIUrl":"https://doi.org/10.20945/2359-4292-2026-0122","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to compare thymus visibility and volume in patients with acromegaly to those of controls, and to evaluate the correlation between growth hormone (GH), insulin-like growth factor-1 (IGF-1) levels, and thymus volume.</p><p><strong>Subjects and methods: </strong>This cross-sectional case-control study included 66 patients with acromegaly who underwent thoracic computed tomography scans. An age- and sex-matched control group of 65 trauma patients without comorbidities was selected. All thoracic computed tomography scans were reassessed to measure thymus volume using imaging software. Comparisons of thymus volume and assessment of correlation with GH and IGF-1 levels were performed.</p><p><strong>Results: </strong>The acromegaly group (28F/38M) and the control group (27F/38M) had similar sex and age distributions. The thymus was more frequently detectable in the acromegaly group (80.3%) compared to controls (44.6%; p = 0.001). Thymus volume was significantly higher in the acromegaly group (13.1 cm3 [9.7-18.7]) than in the control (10.3 cm3 [4.6-12.3]; p = 0.013). Serum IGF-1 levels were nearly significantly higher in acromegalic patients with a visible thymus compared to those without (visible thymus: 608.5 ng/mL [377.6-921.8]; non-visible thymus: 440.5 ng/mL [201.5-596]; p = 0.054). However, no significant differences were found in GH and IGF-1 upper limit of normal levels. No correlation was found between thymus volume and other parameters.</p><p><strong>Conclusion: </strong>Patients with acromegaly have larger and more frequently visible thymus glands than controls. When a mass is detected in the anterior mediastinum, acromegaly should be considered, especially before invasive procedures.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260122"},"PeriodicalIF":1.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetic foot ulcers on mortality risk: Lessons from a 35-year Brazilian cohort followed at an association of people living with diabetes.","authors":"Carlos Antonio Negrato, Hermelinda Cordeiro Pedrosa, Letícia Alcântara Chaparim, Monize Ferreira Catelli, Lucas Casagrande Passoni Lopes","doi":"10.20945/2359-4292-2026-0121","DOIUrl":"10.20945/2359-4292-2026-0121","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of diabetic foot ulcers (DFUs) on mortality risk in a Brazilian cohort of individuals followed at an association of people living with diabetes mellitus.</p><p><strong>Subjects and methods: </strong>This retrospective, population-based epidemiological study assessed the impact of DFUs on mortality risk in a cohort of Brazilian individuals with types 1 and 2 diabetes mellitus. Data were obtained from medical records covering the period from 1990 to 2024 and included sociodemographic, clinical, laboratory, and therapeutic variables. Survival analyses were conducted using Cox proportional hazards models, with death as the event of interest, and were adjusted for potential confounders.</p><p><strong>Results: </strong>Among the 382 participants included in the final analysis, DFUs, amputations, and diabetic peripheral neuropathy were associated with increased mortality risk by 89%, 123%, and 37%, respectively. Peripheral artery disease showed a modest, but not statistically significant, increase in mortality risk. Patients with DFUs who were not using oral antidiabetic drugs had a 165% higher mortality risk, and those with prior amputations and poor fasting glucose levels had a 41% increased mortality risk.</p><p><strong>Conclusion: </strong>Overall, DFUs were identified as critical predictors of mortality in people living with diabetes mellitus, mostly among those with type 2 diabetes mellitus. The impact of DFUs on mortality risk is multifaceted and context-dependent, highlighting the leading role of prior amputations. These findings underscore the need for targeted early interventions and the implementation of strategies aimed at reducing mortality in this high-risk population.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260121"},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life's Essential 8 score and arterial stiffness in patients with type 2 diabetes.","authors":"Kangbo Li, Xinyu Wu, Qi Qi, Philipp Hillmeister, Ivo Buschmann, Shouling Wu, Quanle Han","doi":"10.20945/2359-4292-2026-0117","DOIUrl":"10.20945/2359-4292-2026-0117","url":null,"abstract":"<p><strong>Objective: </strong>Research examining the connection between Life's Essential 8 score (LE8) and arterial stiffness (AS) in patients with diabetes is currently insufficient. This study aimed to investigate the relationship between cardiovascular health and the development of AS in patients with type 2 diabetes (T2D) in a cohort study.</p><p><strong>Subjects and methods: </strong>A total of 2,685 patients with T2D were enrolled in this study. All patients were divided into four groups based on quartiles of cumulative exposure of LE8 (cum-LE8) score. The study endpoint was increased AS (iAS), which was defined as a brachial - ankle pulse wave velocity ≥ 1800 cm/s. The Kaplan-Meier method was used to determine the cumulative incidence of iAS, while the log-rank test was utilized to evaluate the differences among groups. Cox proportional hazards regression model was applied to investigate the impact of various cum-LE8 groups on the risk of iAS.</p><p><strong>Results: </strong>Over a median follow-up of 9.76 years, we identified 1,375 cases of iAS. The incidence rate of iAS in the quartile 1-4 were 71.02 (64.24-78.52), 67.68 (61.13-74.94), 56.05 (50.28-62.47) and 50.47 (45.05-56.53) per 1000 person-years, respectively. The cumulative incidence of iAS was highest in quartile 1 and gradually decreased from quartile 1 to quartile 4 (log-rank P < 0.01). Compared with quartile 1, the hazard ratios (95% confidence intervals) of quartile 2-4 were 0.69 (0.59-0.80), 0.41 (0.35-0.49), and 0.15 (0.12-0.18), respectively.</p><p><strong>Conclusion: </strong>Attaining a superior long-term cardiovascular health status is related to a reduced risk of iAS.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260117"},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetraethylammonium-Sensitive ventricular repolarization in diabetic rat myocardium: effects of rosiglitazone.","authors":"Servet Kavak, Mehmet Ali Ijik, Mustafa Emre","doi":"10.20945/2359-4292-2026-0120","DOIUrl":"10.20945/2359-4292-2026-0120","url":null,"abstract":"<p><strong>Objective: </strong>To examine ventricular action-potential responses to tetraethylammonium (TEA), a non-selective potassium-channel blocker, in streptozotocin-induced diabetic rats and determine whether rosiglitazone modifies these responses.</p><p><strong>Materials and methods: </strong>Male Wistar rats were assigned to Control (C), Control plus Rosiglitazone (C+RSG), Diabetic (D), or Diabetic plus Rosiglitazone (D+RSG) groups. Diabetes was induced with streptozotocin (45 mg/kg, intravenous). Resting membrane potential (RMP), action potential amplitude (APA), and half-repolarization time (½RT) were recorded from isolated left ventricular papillary muscles before and after TEA administration (2 mmol/L).</p><p><strong>Results: </strong>At week 8, blood glucose was 563 ± 29 mg/dL in diabetic rats and 98 ± 6 mg/dL in controls (p < 0.001). Rosiglitazone reduced the diabetic value to 336 ± 25 mg/dL (p < 0.05 vs. D). TEA increased ½RT from 18 ± 1 to 38 ± 2 ms in controls (+20 ms) and from 60 ± 3 to 65 ± 3 ms in diabetic myocardium (+5 ms). Diabetic preparations had higher post-TEA ½RT because repolarization was prolonged at baseline; however, the absolute TEA-associated increment was smaller than in controls. TEA also increased APA in untreated control and diabetic preparations.</p><p><strong>Conclusion: </strong>Diabetes was associated with marked baseline prolongation of ventricular repolarization. The smaller absolute ½RT increment in diabetic myocardium does not support enhanced TEA responsiveness. Because TEA is non-selective, the findings reflect an integrated response to TEA-sensitive potassium conductances rather than dysfunction of a specific current subtype. Rosiglitazone modified selected electrophysiological responses without normalizing diabetic repolarization.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260120"},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A combined genetic and bioinformatic analysis implicates the CDKN1A rs1059234 variant in differentiated thyroid carcinoma susceptibility.","authors":"Elisangela de Souza Teixeira, Raquel Bueno Barbieri, Larissa Teodoro Rabi, Karina Colombera Peres, Janaina Luisa Leite, Natassia Elena Bufalo, Laura Sterian Ward","doi":"10.20945/2359-4292-2026-0119","DOIUrl":"10.20945/2359-4292-2026-0119","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association of CDKN1A (rs1801270 and rs1059234) and CDKN1B (rs2066827 and rs34330) polymorphisms with differentiated thyroid carcinoma (DTC) risk and to explore potential functional impacts through in silico analyses.</p><p><strong>Subjects and methods: </strong>This case-control study included 185 DTC patients and 236 healthy controls. Genotyping was performed using TaqMan® assays, and associations with DTC risk and clinicopathological features were assessed via logistic regression. Bioinformatic tools were used to predict the structural and regulatory effects of the studied polymorphisms.</p><p><strong>Results: </strong>The CDKN1A rs1059234 polymorphism showed a statistically significant association with increased DTC risk, particularly for the CT genotype (odds ratio = 6.575; 95% confidence interval: 4.004-10.803; p < 0.0001). In silico analyses suggested that rs1059234 may modify microRNA binding sites within the 3'UTR, potentially modifying the post-transcriptional regulation of CDKN1A. This variant was not correlated with tumor characteristics, including tumor size, histological subtype, or meta-static status. No significant associations were found for rs1801270, rs2066827, or rs34330. Predictions for missense variants (rs1801270 and rs2066827) were inconsistent, with some tools indicating possible destabilizing effects on p21 or p27 protein structure.</p><p><strong>Conclusion: </strong>The CDKN1A rs1059234 polymorphism may represent a candidate susceptibility marker for DTC, possibly through altered post-transcriptional regulation of p21. However, due to the moderate sample size and the absence of functional validation, these findings should be considered hypothesis-generating and require independent replication in larger cohorts with experimental validation. The remaining investigated variants did not meaningfully influence DTC risk in this study.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260119"},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating procollagen type III N-terminal propeptide (P3NP) as a biomarker of sarcopenia in women with type 2 diabetes: a cross-sectional study.","authors":"Thyago Bruno de Lira Dos Santos, Giselle Rabelo Maciel, Francisco Bandeira","doi":"10.20945/2359-4292-2026-0118","DOIUrl":"10.20945/2359-4292-2026-0118","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether circulating procollagen type III N-terminal propeptide (P3NP) improves the diagnosis of dual-energy X-ray absorptiometry (DXA)-defined sarcopenia in women with type 2 diabetes mellitus (T2DM).</p><p><strong>Subjects and methods: </strong>This cross-sectional study enrolled 99 women with T2DM who underwent standardized clinical assessment, handgrip strength testing, and whole-body DXA. Sarcopenia was defined using a DXA-derived fat-free mass index. Multivariable logistic regression models included age, body mass index, glycated hemoglobin (HbA1c), and estimated glomerular filtration rate, with and without log-transformed, z-standardized P3NP. Discriminatory performance was quantified by the area under the curve (AUC) with bootstrap 95% confidence intervals; sensitivity analyses excluded participants with an estimated glomerular filtration rate below 60.</p><p><strong>Results: </strong>P3NP showed weak bivariate correlations with age (p = -0.210) and the Short Physical Performance Battery (p = 0.225). When incorporated into the clinical model, P3NP did not yield a clinically significant improvement (ΔAUC = 0.007). As a sole predictor, P3NP had poor discrimination (AUC 0.53) and was not independently associated with DXA-defined sarcopenia (odds ratio per 1-standard deviation, p > 0.05). Results were consistent after excluding participants with reduced kidney function and across interaction analyses; model calibration was adequate. P3NP absolute values were elevated, with 80.8% above the high threshold (>31 μg/L), and clinical/functional profiles were broadly similar P3NP strata.</p><p><strong>Conclusion: </strong>In women with T2DM, circulating P3NP was not an independent discriminator of DXA-defined sarcopenia and provided no clinically meaningful advantage over standard clinical predictors. Routine screening should continue to rely on assessments of muscle strength, function, and DXA-based body composition, while P3NP may be considered an adjunct marker of extracellular matrix remodeling.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"70 6","pages":"e260118"},"PeriodicalIF":1.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}