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Placental insufficiency irrespective of offspring karyotype in maternal Turner syndrome: a case series and literature review.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-24 DOI: 10.20945/2359-4292-2024-0144
Beáta Vida, Gábor Méhes, Olga Török, Mónika Orosz, Zoárd Tibor Krasznai, Attila Jakab, Zsuzsanna Buczkó, Tamás Deli, Péter Juhász
{"title":"Placental insufficiency irrespective of offspring karyotype in maternal Turner syndrome: a case series and literature review.","authors":"Beáta Vida, Gábor Méhes, Olga Török, Mónika Orosz, Zoárd Tibor Krasznai, Attila Jakab, Zsuzsanna Buczkó, Tamás Deli, Péter Juhász","doi":"10.20945/2359-4292-2024-0144","DOIUrl":"10.20945/2359-4292-2024-0144","url":null,"abstract":"<p><p>Turner syndrome is one of the most common aneuploidies. In vitro fertilization with oocyte donation is the usual method of assisted conception, but spontaneous pregnancy can also occur. Although pregnancies in Turner syndrome are widely accepted to be associated with small for gestational age foetuses, neither the causal role of placental insufficiency nor the contribution of maternal and foetal factors is well understood. Between 2009 and 2023, we followed 75 patients diagnosed with Turner syndrome at our university clinic, and four Turner syndrome patients became pregnant (4/75; 5.3%): ten pregnancies with seven live births (7/10; 70%) were reported. Conception was spontaneous in 6/7 patients (86%), and one patient had in vitro fertilization with oocyte donation. Two Turner syndrome patients with karyotype 45,X and two Turner syndrome patients with mosaicism (45,X/46,XX) were identified. Prenatal transabdominal amniocentesis revealed aneuploidy (45,X) in two foetuses. The most common obstetric complication was placental insufficiency, which presented as intrauterine growth restriction and foetal distress. Four early-term deliveries, one late-term delivery, one preterm delivery, and one extremely premature delivery occurred, and all pregnancies were terminated by caesarean section. No severe maternal complications during pregnancy were reported. Only newborns with Turner syndrome had long-term health problems. In Turner syndrome patients, even if pregnancy is conceived spontaneously, no maternal complications occur, and the foetus also has a normal karyotype, there is still a high prevalence of placental insufficiency and foetal compromise. The presented cases highlight the possible role of inherent maternal factors in Turner syndrome-associated intrauterine growth restriction and emphasize the importance of enhanced obstetric surveillance even in apparently uncomplicated Turner syndrome pregnancies.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240144"},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Care of patients with obesity in the Emergency Department: a joint position statement from the Brazilian Association of Emergency Medicine (ABRAMEDE) and the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO).
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-24 DOI: 10.20945/2359-4292-2024-0411
Rafael Lima McGregor von Hellmann, Simone van de Sande-Lee, Maria Edna Melo, Ana Carolina Nader Vasconcelos Messias, Ian Ward Abdalla Maia, Maria Camila Lunardi, Lucas Oliveira Junqueira E Silva, Bruno Halpern
{"title":"Care of patients with obesity in the Emergency Department: a joint position statement from the Brazilian Association of Emergency Medicine (ABRAMEDE) and the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO).","authors":"Rafael Lima McGregor von Hellmann, Simone van de Sande-Lee, Maria Edna Melo, Ana Carolina Nader Vasconcelos Messias, Ian Ward Abdalla Maia, Maria Camila Lunardi, Lucas Oliveira Junqueira E Silva, Bruno Halpern","doi":"10.20945/2359-4292-2024-0411","DOIUrl":"10.20945/2359-4292-2024-0411","url":null,"abstract":"<p><p>This document presents a joint position statement from the Brazilian Association of Emergency Medicine (ABRAMEDE) and the Brazilian Association for the Study of Obesity and Metabolic Syndrome (ABESO) regarding the management of patients with obesity in the Emergency Department. It aimed to provide recommendations for healthcare professionals and policymakers to ensure the provision of appropriate care for patients with obesity, considering their unique needs and the challenges that arise in emergency settings. The position statement addresses key issues such as the need for structural adaptations, specific equipment, and specialized training for healthcare teams. It emphasizes the complexity of emergency care for patients with obesity due to factors such as difficulties in physical examination, imaging, vascular access, and airway management. The document also discusses the prevalence of obesity, its classification, and its impact on health outcomes. It highlights the association of obesity with numerous comorbidities, including type 2 diabetes, hypertension, cardiovascular diseases, and sleep apnea. Moreover, the statement underscores the need to combat stigma and promote a supportive and respectful healthcare environment for patients with obesity. Recommendations include enhancing Emergency Department infrastructure, ensuring adequate training for professionals, and implementing public policies that support the management of obesity and its comorbidities in emergency settings.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240411"},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of familial partial lipodystrophy type 2 masquerading as Cushing syndrome: Explaining an atypical phenotype by whole-exome sequencing.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-24 DOI: 10.20945/2359-4292-2024-0293
Enid Perez-Dionisio, Silvia Hinojosa-Alvarez, Rocio Alejandra Chavez-Santoscoy, Regina de Miguel-Ibañez, Manuel Garcia-Saenz, Daniel Marrero-Rodriguez, Keiko Taniguchi-Ponciano, Jesus Henandez-Perez, Moises Mercado, Claudia Ramirez-Renteria, Ernesto Sosa-Eroza, Etual Espinosa-Cardenas
{"title":"A case of familial partial lipodystrophy type 2 masquerading as Cushing syndrome: Explaining an atypical phenotype by whole-exome sequencing.","authors":"Enid Perez-Dionisio, Silvia Hinojosa-Alvarez, Rocio Alejandra Chavez-Santoscoy, Regina de Miguel-Ibañez, Manuel Garcia-Saenz, Daniel Marrero-Rodriguez, Keiko Taniguchi-Ponciano, Jesus Henandez-Perez, Moises Mercado, Claudia Ramirez-Renteria, Ernesto Sosa-Eroza, Etual Espinosa-Cardenas","doi":"10.20945/2359-4292-2024-0293","DOIUrl":"10.20945/2359-4292-2024-0293","url":null,"abstract":"<p><p>Familial partial lipodystrophy type 2 is a rare disease, particularly when it is caused by nonclassical gene variants. A high index of suspicion is essential for a timely diagnosis. We present the case of a 32-year-old woman, referred to evaluation of a possible Cushing syndrome, which was clinically and biochemically ruled out. Yet, due to the finding of a rather abnormal fat distribution during physical examination, the diagnosis of lipodystrophy was cogitated. Whole-exome sequencing revealed a missense variant of exon 11 R582H of the gene encoding Laminin A (rs57830985,c.1745G>A, p.Arg582His). The patient presented some clinical and biochemical characteristics discordant with those previously reported in patients harboring other classical variants of this gene.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240293"},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-24 DOI: 10.20945/2359-4292-2024-0373
Aline Marcadenti, Josefina Bressan, Annie Seixas Bello Moreira, Rachel Helena V Machado, Renato Hideo N Santos, Cristiane Kovacs Amaral, Marcelo Macedo Rogero, Vinícius Cooper Capetini, Angela C Bersch-Ferreira
{"title":"Effects of a cardioprotective nutritional program on apolipoproteins and lipids in secondary cardiovascular disease prevention.","authors":"Aline Marcadenti, Josefina Bressan, Annie Seixas Bello Moreira, Rachel Helena V Machado, Renato Hideo N Santos, Cristiane Kovacs Amaral, Marcelo Macedo Rogero, Vinícius Cooper Capetini, Angela C Bersch-Ferreira","doi":"10.20945/2359-4292-2024-0373","DOIUrl":"10.20945/2359-4292-2024-0373","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the impact of the Brazilian Cardioprotective Nutrition Program (BALANCE Program) on the plasma levels of various apolipoproteins (A-I, A-II, B, C-II, C-III, and E) and lipid biomarkers over a three-year follow-up period in individuals undergoing secondary cardiovascular prevention.</p><p><strong>Subjects and methods: </strong>This exploratory analysis included 276 patients aged 45 years or older with a history of cardiovascular disease within the preceding decade. Participants were randomly assigned to one of two groups and monitored over three years: the BALANCE Program group (intervention group; n = 123) and the control (conventional nutritional advice; n = 153). Assessments of clinical and lifestyle data, anthropometry, food intake, plasma apolipoproteins, and lipid profiles were conducted at baseline and at the 3-year follow-up. Intervention adherence was measured utilizing the BALANCE dietary index.</p><p><strong>Results: </strong>By the end of the follow-up period, adherence was significantly higher in the intervention group (mean difference BALANCE-control [95% CI]: 2.09 points [-0.19; 4.37]), mainly due to increased consumption of fruits, vegetables, legumes, and low-fat dairy products. There were no significant differences in plasma apolipoprotein levels between the groups throughout the study. Nevertheless, significant reductions were observed in the total cholesterol and non-HDL cholesterol levels in the BALANCE group compared to the control group (mean difference intervention-control [95% CI]: -9.95 mg/dL [-18.5; -1.39] and -8.86 mg/dL [-17.53; -0.2], respectively).</p><p><strong>Conclusion: </strong>Following three years of intervention, despite higher adherence to the BALANCE Program, there were no significant changes in plasma apolipoprotein concentrations or overall lipid biomarkers.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240373"},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MAP17 contributes to the tumorigenesis of papillary thyroid carcinoma by activating the AKT signaling pathway.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-10 DOI: 10.20945/2359-4292-2024-0342
Zhen-Hua Tian, Rui Huang, Gang-Qiang Li, Yong-Xue Zhu
{"title":"MAP17 contributes to the tumorigenesis of papillary thyroid carcinoma by activating the AKT signaling pathway.","authors":"Zhen-Hua Tian, Rui Huang, Gang-Qiang Li, Yong-Xue Zhu","doi":"10.20945/2359-4292-2024-0342","DOIUrl":"10.20945/2359-4292-2024-0342","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the role of membrane-associated protein 17 (MAP17) and the Akt signaling pathway in the progression of papillary thyroid carcinoma (PTC).</p><p><strong>Materials and methods: </strong>We conducted a series of in vitro experiments using PTC cell lines (HTori-3 and TPC-1). Cells were divided into three groups: control, MAP17 inhibitor negative control (NC), and MAP17 inhibitor treatment. Cell viability was assessed at 0, 24, 48, and 72 hours using the Cell Counting Kit-8 (CCK-8) assay. Apoptosis levels were measured by flow cytometry, and protein and mRNA expression of MAP17, phosphorylated Akt (p-AKT), and Akt were analyzed by Western blot and qRT-PCR.</p><p><strong>Results: </strong>Cell viability in the control, MAP17 inhibitor NC, and MAP17 inhibitor groups increased significantly over time (P < 0.05). Notably, in both HTori-3 and TPC-1 cells, the MAP17 inhibitor significantly reduced cell viability compared to the control and NC groups at 24, 48, and 72 hours (P < 0.05). Furthermore, apoptosis levels were significantly higher in the MAP17 inhibitor group compared to the control and NC groups (P < 0.05). Western blot and qRT-PCR analyses revealed that MAP17 and p-Akt protein and mRNA levels were significantly higher in the control and NC groups compared to the MAP17 inhibitor group (P < 0.05). However, no significant differences in total Akt protein or mRNA levels were observed across groups.</p><p><strong>Conclusion: </strong>Our findings suggest that MAP17 and the Akt signaling pathway play a crucial role in promoting the progression of PTC. Inhibition of MAP17 suppresses cell viability and induces apoptosis, indicating that MAP17 may be a promising therapeutic target for PTC. The data also highlight the potential for targeting the MAP17-Akt axis in developing future treatments for PTC.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240342"},"PeriodicalIF":1.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive microarray analysis for the identification of therapeutic targets within HIF-1α signalling networks in diet-induced obesity via hypothalamic inflammation. 在饮食通过下丘脑炎症诱发肥胖症的过程中,通过全面的芯片分析确定 HIF-1α 信号网络中的治疗靶点。
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-03-10 DOI: 10.20945/2359-4292-2024-0098
Hai Guo, Lijuan Ma, Dilihumaier Duolikun, Qiaoling Yao
{"title":"Comprehensive microarray analysis for the identification of therapeutic targets within HIF-1α signalling networks in diet-induced obesity via hypothalamic inflammation.","authors":"Hai Guo, Lijuan Ma, Dilihumaier Duolikun, Qiaoling Yao","doi":"10.20945/2359-4292-2024-0098","DOIUrl":"10.20945/2359-4292-2024-0098","url":null,"abstract":"<p><strong>Objective: </strong>A high-fat diet (HFD) significantly contributes to obesity and alters the neurological function of the brain. This study explored the influence of hypoxia-inducible factor (HIF-1) and its downstream molecules on obesity progression in the context of HFD-induced hypothalamic inflammation.</p><p><strong>Materials and methods: </strong>Utilizing a bioinformatics approach alongside animal models, targets and pathways related to hypothalamic obesity were identified via network analysis, gene target identification, gene ontology analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and subsequent validation in animal models.</p><p><strong>Results: </strong>HIF-1α has the potential to regulate the immune response by promoting immune infiltration and increasing the population of immune cells, particularly memory CD4 T cells, in the hypothalamus, primarily through its influence on ksr2 expression. Additionally, the analysis predicted five drugs capable of enhancing HIF-1-Ksr2 signalling.</p><p><strong>Conclusion: </strong>In conclusion, targeting Ksr2 with specific drugs represents a potential approach for addressing HFD-induced obesity. These novel findings lay the groundwork for developing dietary supplements and therapeutic interventions.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240098"},"PeriodicalIF":1.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the comment on "Diagnostic value of a computer-assisted diagnosis system for the ultrasound features in thyroid nodules".
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-02-27 DOI: 10.20945/2359-4292-2024-0526
Yiwei Wang
{"title":"Response to the comment on \"Diagnostic value of a computer-assisted diagnosis system for the ultrasound features in thyroid nodules\".","authors":"Yiwei Wang","doi":"10.20945/2359-4292-2024-0526","DOIUrl":"10.20945/2359-4292-2024-0526","url":null,"abstract":"","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240526"},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on the "Diagnostic value of a computer- -assisted diagnosis system for the ultrasound features in thyroid nodules".
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-02-27 DOI: 10.20945/2359-4292-2024-0419
Ahmet Bozer
{"title":"Comment on the \"Diagnostic value of a computer- -assisted diagnosis system for the ultrasound features in thyroid nodules\".","authors":"Ahmet Bozer","doi":"10.20945/2359-4292-2024-0419","DOIUrl":"10.20945/2359-4292-2024-0419","url":null,"abstract":"","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e240419"},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium nutritional status and thyroid dysfunction.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-02-24 DOI: 10.20945/2359-4292-2023-0348
Luciana Sant'Ana Leone de Souza, Renata de Oliveira Campos, Jair de Souza Braga, Joice Dos Santos de Jesus, Helton Estrela Ramos, Sara Moreira Anunciação, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fábio Hecht
{"title":"Selenium nutritional status and thyroid dysfunction.","authors":"Luciana Sant'Ana Leone de Souza, Renata de Oliveira Campos, Jair de Souza Braga, Joice Dos Santos de Jesus, Helton Estrela Ramos, Sara Moreira Anunciação, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fábio Hecht","doi":"10.20945/2359-4292-2023-0348","DOIUrl":"10.20945/2359-4292-2023-0348","url":null,"abstract":"<p><p>Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes to the antioxidant system and is a crucial component of deiodinases, which are selenoproteins that participate in thyroid hormone metabolism. Additionally, this micronutrient exerts a significant impact on thyroid pathophysiology, as low levels of Se lead to reduced activity of glutathione peroxidase, a selenoprotein involved in antioxidative processes, thereby resulting in increased oxidative stress and damage to thyroid tissue. Selenium deficiency (SeD) can cause growth retardation and reproductive failure; in women and children, it may result in Keshan's disease and Kashin-Beck's disease. Research has shown an inverse correlation between Se serum levels and autoimmune thyroiditis in areas with mild SeD. In Graves' disease, Se supplementation has been linked to faster achievement of euthyroidism as well as improvements in quality of life, lessened orbital involvement, and slower ocular progression of the disease. Furthermore, several studies suggest an association between serum SeD and the development of thyroid cancer. Maintaining physiological Se concentrations appears to be related to the prevention of thyroid disease, although current data are insufficient to conclusively support or refute the efficacy of supplementation. Through this narrative review, we aim to present the latest information on the role of selenium in thyroid pathophysiology. To identify relevant literature, specific search strategies were employed in the electronic databases PubMed, Lilacs, and SciELO.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e230348"},"PeriodicalIF":1.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult height of children born small for gestational age treated with growth hormone and gonadotropin-releasing hormone analogs in Southern Brazil.
IF 1.6 4区 医学
Archives of Endocrinology Metabolism Pub Date : 2025-02-24 DOI: 10.20945/2359-4292-2023-0513
Luís Eduardo Cruvinel Pinto, Adriane de Andre Cardoso-Demartini, Julienne Angela Ramires de Carvalho, Gabriela de Carvalho Kraemer, Rosana Marques Pereira, Aline Scheidemantel, Gabriel Junqueira Soares, Suzana Nesi-França
{"title":"Adult height of children born small for gestational age treated with growth hormone and gonadotropin-releasing hormone analogs in Southern Brazil.","authors":"Luís Eduardo Cruvinel Pinto, Adriane de Andre Cardoso-Demartini, Julienne Angela Ramires de Carvalho, Gabriela de Carvalho Kraemer, Rosana Marques Pereira, Aline Scheidemantel, Gabriel Junqueira Soares, Suzana Nesi-França","doi":"10.20945/2359-4292-2023-0513","DOIUrl":"10.20945/2359-4292-2023-0513","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate adult height and identify the factors contributing to its achievement in patients born small for gestational age (SGA) treated with recombinant human growth hormone (rhGH).</p><p><strong>Subjects and methods: </strong>This retrospective study includes data of SGA children treated at a pediatric endocrinology center. Inclusion criteria were SGA birth (birth length and/or weight < -1.28 standard deviation score (SDS), absence of catch-up growth by the age of four years, rhGH treatment for more than 12 months, and recorded adult height. Birth size SDS was calculated using Intergrowth-21st (gestational age ≥ 33 weeks) or Fenton (<33 weeks) standards. Patients with uncontrolled chronic diseases, genetic syndromes, or growth hormone deficiency were excluded. An increase of 0.6 SDS or more was considered a positive response.</p><p><strong>Results: </strong>Twenty-four patients (14 boys) were included, with an average gestational age of 38.0 (range: 33.0-40.0) weeks, birth weight of -1.3 ± 0.9 SDS, and birth length of -2.4 ± 0.7 SDS. They were treated with rhGH starting at an average age of 10.3 ± 2.6 years for a duration of 5.4 ± 2.3 years. Height SDS increased from -2.6 ± 0.4 SDS to -1.2 ± 0.6 SDS, which was comparable to the target height SDS (-1.3 ± 0.9; p = 0.3). Although 18 children were classified as good responders, 6 did not achieve a final height SDS > -2.0. Adult height was correlated with the increment in height SDS and growth velocity during the first year of treatment. No significant differences were observed between children classified as SGA by birth weight or length < 10th percentile and those by weight or length < -2.0 SDS.</p><p><strong>Conclusion: </strong>In this cohort of children born SGA with short stature, rhGH treatment effectively improved adult height. Given the diverse causes of being born SGA, the response to rhGH therapy may vary.</p>","PeriodicalId":54303,"journal":{"name":"Archives of Endocrinology Metabolism","volume":"69 1","pages":"e230513"},"PeriodicalIF":1.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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