Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献

{"title":"Blood biomarkers for Alzheimer's disease: Reliable change and impacts of renal and blood-brain barrier function.","authors":"Anders Behrens, Peter Anderberg, Johan Sanmartin Berglund, Malena Cianchetta-Sivoriceruti, Ana Luiza Dallora","doi":"10.1002/dad2.70181","DOIUrl":"10.1002/dad2.70181","url":null,"abstract":"<p><strong>Introduction: </strong>Blood-based biomarkers for Alzheimer's disease (AD) have the potential to improve diagnostic accessibility, but their clinical interpretation requires understanding of variability and biological influences.</p><p><strong>Methods: </strong>We repeatedly sampled blood from 57 adults referred for lumbar puncture as part of a cognitive evaluation at a memory clinic. We measured serum phosphorylated- tau-181 (s-p-tau181) and plasma amyloid beta (Aβ)42/40 ratio (p-Aβ42/Aβ40) and evaluated the impact of renal and blood-brain barrier (BBB) function.</p><p><strong>Results: </strong>Test-retest analysis revealed large variability of s-p-tau181 and small for p-Aβ42/Aβ40. Markers of renal function and BBB integrity significantly influenced s-p-tau181 levels, whereas p-Aβ42/Aβ40 was not affected.</p><p><strong>Discussion: </strong>This study emphasizes the need for caution when interpreting longitudinal changes in s-p-tau181. Inter-individual variability is to a large degree due to susceptibility to biological influences where a novel association with integrity of BBB function were identified. These results have implications for the clinical application of blood-based biomarkers in AD diagnostics and monitoring.</p><p><strong>Highlights: </strong>Blood phosphorylated- tau-181 (p-tau181) shows high test-retest variability in memory clinic patients.Blood amyloid beta (Aβ)42/Aβ40 ratio is stable but has poor diagnostic accuracy.Renal function and blood-brain barrier (BBB) integrity affect blood p-tau181 levels.Caution is needed when interpreting longitudinal changes in blood p-tau181.Renal and BBB disorders should be considered when assessing blood p-tau181.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70181"},"PeriodicalIF":4.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical dementia rating scores are associated with plasma phosphorylated tau-217.","authors":"Qi Huang, Erin M Jonaitis, Rachel L Studer, Rachael Wilson, Ramiro Eduardo Rea Reyes, Henrik Zetterberg, Lianlian Du, Bruce P Hermann, Sterling C Johnson, Rebecca E Langhough","doi":"10.1002/dad2.70179","DOIUrl":"10.1002/dad2.70179","url":null,"abstract":"<p><strong>Introduction: </strong>Simple screening tools are critical for assessing Alzheimer's disease (AD)-related pre-dementia changes. This study investigated longitudinal scores from the Quick Dementia Rating System (QDRS), a brief study partner-reported measure, in relation to baseline levels of the AD biomarker plasma pTau217 in individuals unimpaired at baseline.</p><p><strong>Methods: </strong>Data from the Wisconsin Registry for Alzheimer's Prevention (N = 639) were used to examine whether baseline plasma pTau217 (ALZpath assay on Quanterix platform) modified QDRS or Preclinical Alzheimer's Cognitive Composite (PACC3) trajectories (mixed-effects models; time = age). pTau217*age interaction effects (e.g., high vs low pTau217 simple age slopes) were compared across outcomes.</p><p><strong>Results: </strong>Higher baseline pTau217 levels were associated with faster functional (QDRS) and cognitive (PACC3) decline. Effect sizes were similar between PACC3 and QDRS. Exploratory analyses showed increased risk of transitioning to impaired QDRS classifications in those with high-baseline pTau217.</p><p><strong>Discussion: </strong>This study demonstrates the utility of QDRS for tracking pre-dementia AD-related decline.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70179"},"PeriodicalIF":4.4,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability.","authors":"Lubnaa Abdullah, Ney Alex Alliey, Emma Elizondo, Ney Alliey-Rodriguez, Gladys Maestre, James Hall","doi":"10.1002/dad2.70175","DOIUrl":"10.1002/dad2.70175","url":null,"abstract":"<p><p>There are a relatively small number of investigations into brain aging in those with intellectual and developmental disability (I/DD). This project seeks to (1) characterize the internationally available multi-omics Alzheimer's disease (AD) biomarker studies including those with I/DD, and (2) discuss future research directions. PubMed, Web of Science, and Scopus were searched under the following criteria: cross-sectional or longitudinal AD-omics studies on adults (18 +) with I/DD. 532 studies were identified, 186 studies were evaluated for full-text, 79 studies were excluded, and 117 studies were extracted. Most biological specimens were analyzed in blood, plasma, or serum. Metabolomics, hormonomics, and transcriptomics were most understudied. Sex differences were investigated in nine studies. Two studies included participants with non-Down syndrome neurodevelopmental disorders. European-based city populations were primarily represented across studies. Future studies including a broader range of I/DD presentations, and considering sex differences, comorbidities, and novel biomarkers beta synuclein are interesting future directions.</p><p><strong>Highlights: </strong>Small sample sizes, cross-sectional designs, and few prospective and retrospective studies highlight the need for more rigorous research design.A focus on European-based city populations and Down syndrome (DS) clinical groups prompts the need for inclusive, community-based recruitment methods across broader clinical and ethnic groups.The vesicle-associated membrane protein 2 (VAMP2) shows promise for early detection of synaptic degeneration, potentially across I/DD groups, showing correlations with CSF biomarkers of Alzheimer's disease, axonal injury, and cognitive performance in DS.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70175"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer's disease neuropathology and longitudinal change in subjective cognitive complaints.","authors":"Alisa Bannerjee, Wendy Elkins, Susan M Resnick, Murat Bilgel","doi":"10.1002/dad2.70176","DOIUrl":"10.1002/dad2.70176","url":null,"abstract":"<p><strong>Introduction: </strong>Subjective cognitive complaints often precede declines in objective measures of cognitive performance. Associations of incipient Alzheimer's disease (AD) neuropathology with subjective cognitive complaints may be detectable earlier than associations with neuropsychological testing among cognitively normal individuals.</p><p><strong>Methods: </strong>We examined the independent associations of positron emission tomography measures of amyloid beta and tau pathologies with longitudinal subjective complaints and memory among 91 cognitively normal Baltimore Longitudinal Study of Aging participants using linear mixed effects models. Subjective complaints and memory performance were assessed with the Cognitive Failures Questionnaire and the California Verbal Learning Test, respectively.</p><p><strong>Results: </strong>Greater parahippocampal tau, independent of amyloid, was associated with higher subjective complaints (estimate = 0.25, standard error [SE] = 0.1, <i>P </i>= <math> <mrow><mrow><mspace></mspace> <mn>0.015</mn></mrow> </mrow> </math> ), while greater entorhinal tau corresponded to an attenuated increase in complaints over time (estimate = -0.06, SE = 0.03, <i>P </i>= <math> <mrow><mrow><mspace></mspace> <mn>0.047</mn></mrow> </mrow> </math> ). Hippocampal tau was associated with steeper memory decline (estimate = -0.03, SE = 0.01, <i>P </i>= <math> <mrow><mrow><mspace></mspace> <mn>0.040</mn></mrow> </mrow> </math> ).</p><p><strong>Conclusion: </strong>Subjective cognitive complaints may be a reflection of early cerebral tau pathology in cognitively normal individuals.</p><p><strong>Highlights: </strong>Greater parahippocampal tau was linked with higher subjective cognitive complaints.Entorhinal tau was associated with slower increases in cognitive complaints over time.Subjective complaints may reflect early amyloid and tau in cognitively normal adults.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70176"},"PeriodicalIF":4.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in cognitive reserve: An impact on progression in subjective cognitive decline?","authors":"Giacomucci Giulia, Moschini Valentina, Ceccarelli Alice, Padiglioni Sonia, Morinelli Carmen, Mazzeo Salvatore, Crucitti Chiara, Galdo Giulia, Emiliani Filippo, Bagnoli Silvia, Ingannato Assunta, Marcantelli Elisa, Nacmias Benedetta, Sorbi Sandro, Bessi Valentina","doi":"10.1002/dad2.70174","DOIUrl":"10.1002/dad2.70174","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated gender differences in cognitive reserve (CR) in subjective cognitive decline (SCD) and examined the impact of gender-CR interaction on the risk of progression to mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>We enrolled 440 SCD patients and estimated CR using premorbid intelligence (<i>Test di Intelligenza Breve</i> [TIB]). To account for socio-cultural differences, patients were stratified by birth cohort (pre-/post-1950). A Markov random-field (MRF) model explored relationships between gender, CR, education, and age. Logistic regression assessed MCI progression risk.</p><p><strong>Results: </strong>Women showed lower TIB scores than men (<i>p </i>< 0.001). The MRF model revealed an inverse connection between TIB and female gender, while no link was observed between TIB and generation. Progression to MCI was predicted by age at onset (<i>p </i>< 0.001), apolipoprotein E (<i>APOE)</i> status (<i>p </i>= 0.002), and TIB (<i>p </i>= 0.018), but not gender.</p><p><strong>Discussion: </strong>Gender has an impact on CR, but not through socio-economic variables. In turn, CR influenced the risk of MCI progression, whereas gender did not.</p><p><strong>Highlights: </strong>Subjective cognitive decline (SCD) women presented lower cognitive reserve (CR) levels than men, despite similar education levels.Social-cultural factors did not explain these gender differences in CR in SCD.The gender-CR interaction was not mediated by social-cultural factors.The risk of progression to mild cognitive impairment (MCI) was influenced by CR but not by gender.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70174"},"PeriodicalIF":4.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the dietary index for gut microbiota and Alzheimer's disease: A cross-sectional study from the National Health and Nutrition Examination Survey (2004 to 2018).","authors":"Jingjing Liu, Shaoqiang Huang","doi":"10.1002/dad2.70170","DOIUrl":"10.1002/dad2.70170","url":null,"abstract":"<p><strong>Introduction: </strong>Emerging evidence implicates gut microbiota (GM), shaped by diet, in Alzheimer's disease (AD) pathogenesis. However, the association between the dietary index for GM (DI-GM) and AD remains unclear.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 28,830 adults aged ≥20 years in the 2004-2018 National Health and Nutrition Examination Survey (NHANES). The DI-GM score, derived from dietary recalls, comprised beneficial to GM score (BGMS) and unfavorable to GM score (UGMS) components. AD was identified via self-report, medications, or death certificates. Multivariable weighted logistic regression, restricted cubic spline, and subgroup analyses were performed.</p><p><strong>Results: </strong>Contrary to expectations, higher DI-GM score and UGMS were associated with increased AD prevalence (DI-GM: odds ratio [OR] = 1.24, 95% CI: 1.02 to 1.52, <i>p</i> = 0.033; UGMS: OR = 1.36, 95% CI: 1.10 to 1.69, <i>p</i> = 0.005).</p><p><strong>Discussion: </strong>The DI-GM was positively associated with AD prevalence, suggesting that imbalanced plant-based diets low in protein or key nutrients may elevate AD risk despite presumed microbiota benefits.</p><p><strong>Highlights: </strong>Higher DI-GM and UGMS were significantly associated with greater AD prevalence in US adults.Restricted cubic spline analyses showed linear and non-linear associations of DI-GM and UGMS with AD, respectively.Results challenge prior assumptions that higher DI-GM scores are uniformly linked to health benefits.Imbalanced plant-based diets low in protein or key nutrients may adversely affect cognitive aging despite presumed microbiota benefits.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70170"},"PeriodicalIF":4.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for white matter uptake improves between tracer agreement in amyloid PET.","authors":"Yinghua Chen, Hillary Protas, Ji Luo, Shan Li, Javad Sohankar, Chen-Ray Pan, Valentina Ghisays, Wendy Lee, Teresa Wu, Ding-Geng Chen, Eric M Reiman, Kewei Chen, Yi Su","doi":"10.1002/dad2.70165","DOIUrl":"10.1002/dad2.70165","url":null,"abstract":"<p><strong>Introduction: </strong>Amyloid positron emission tomography (PET) allows in vivo measurement of amyloid plaque deposition; however, different tracers lead to different results. We test the hypothesis that the variability in amyloid measurements is related to white matter retention, and accounting for this variability can improve agreements.</p><p><strong>Methods: </strong>Data from the Centiloid project was downloaded and processed for four F18 tracer-to-Pittsburgh Compound B (PiB) pairs to obtain mean cortical standardized uptake value ratio (MCSUVR). Three approaches were examined to account for white matter contribution to the MCSUVR. Pearson's correlation was used to assess the between tracer agreements. Steiger's test was used to determine the significance of improvement.</p><p><strong>Results: </strong>Accounting for white matter signal improves the agreement. The regional spread function partial volume correction (RSF PVC) method was most consistent in achieving statistically significant improvements (<i>p</i> < 0.05) for all four tracer pairs.</p><p><strong>Discussion: </strong>Between-tracer agreement of amyloid measure can be improved by accounting for white matter signal. Further investigation is ongoing for additional improvement.</p><p><strong>Highlights: </strong>Analyzing head-to-head data for all four common F18-labeled tracers against Pittsburgh Compound B (PiB).Evaluating three different techniques to correct for white matter signal.Steiger's test to determine the significance of improvements.White matter uptake contributes to the between-tracer measurement difference.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70165"},"PeriodicalIF":4.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic profiling identifies serpin G1, ApoA-II, and LBP as potential biomarkers of dementia in an Egyptian cohort.","authors":"Shimaa A Heikal, Eman M Khedr, Mai Othman, Nesma G Elsheikh, Heba M Tawfik, Hany I Hassanin, Nouran Al-Shehaby, Ashraf Eltaher, Samir Shamma, Ahmed S Mohamed, Mostafa Saber, Abdullah A Lomomba, Esraa Ali, Shady M Safwat, Noha Abo Elfetoh, Gharib Fawi, Noha A Yousri, Mohamed Salama","doi":"10.1002/dad2.70172","DOIUrl":"10.1002/dad2.70172","url":null,"abstract":"<p><strong>Background: </strong>Dementia, including Alzheimer's disease (AD), is a growing concern in Egypt, yet biomarker research in this population is scarce. Identifying serum biomarkers is essential for early diagnosis and understanding disease mechanisms in underrepresented groups.</p><p><strong>Methods: </strong>We performed serum proteomic profiling on 20 Egyptian dementia patients and 10 cognitively unimpaired controls from the Egyptian Dementia Registry using mass spectrometry. Differential protein expression and pathway enrichment analyses were conducted.</p><p><strong>Results: </strong>Of 260 quantified proteins, 21 were significantly different between dementia patients and controls (<i>P</i> < 0.05). Several serine protease inhibitor and immunoglobulin family proteins were downregulated, while apolipoprotein A-II was upregulated in dementia. Enrichment analysis revealed associations with inflammation, complement activation, and lipid metabolism pathways.</p><p><strong>Conclusion: </strong>This is the first serum proteomic study of dementia in an Egyptian cohort, highlighting coordinated changes in protein families involved in inflammation and lipid metabolism, and emphasizing the importance of biomarker research in diverse populations.</p><p><strong>Highlights: </strong>The study presents initial proteomic data from the Egyptian Dementia Registry.The Egyptian population has been underrepresented in the area of dementia research.Serine protease inhibitor G1, apolipoprotein A-II, and lipopolysaccharide binding protein emerged as significant proteins.The work lays the foundation for more understanding of molecular determinants in dementia in the Middle East.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70172"},"PeriodicalIF":4.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab.","authors":"Doris P Molina-Henry, Rema Raman, Andy Liu, Oliver Langford, Joel B Braunstein, Philip B Verghese, Venky Venkatesh, Shobha Dhadda, Michael Irrizary, Joshua D Grill, Keith Johnson, Robert A Rissman, Paul Aisen, Reisa A Sperling","doi":"10.1002/dad2.70164","DOIUrl":"10.1002/dad2.70164","url":null,"abstract":"<p><strong>Introduction: </strong>Consistent predictive performance across racial and ethnic groups is essential to the use of plasma biomarkers as screening tools in preclinical Alzheimer's disease trials.</p><p><strong>Methods: </strong>Logistic regression examined racial and ethnic group differences in plasma eligibility using an algorithm that included Phosphorylated tau217 to non-phosphorylated tau217 ratio, amyloid beta 42/40, age, and apolipoprotein E to predict > 18 Centiloids on amyloid imaging in cognitively unimpaired individuals.</p><p><strong>Results: </strong>Among 6437 participants screened, with non-Hispanic (NH) White as the reference group, odds ratios of plasma ineligibility were 2.88 (95% confidence interval [CI]: 1.40-6.96) for Hispanic Black, 1.60 (95% CI: 1.33-1.92) for Hispanic White, 2.10 (95% CI: 1.37-3.38) for NH Asian, and 1.59 (95% CI: 1.27-2.0) for NH Black participants. Positron emission tomography (PET) eligibility rates did not differ among those who were plasma eligible.</p><p><strong>Discussion: </strong>Differential rates of plasma eligibility, but consistent PET eligibility among plasma-eligible participants, were observed, supporting the use of universal biomarker cutpoints across race and ethnic groups.<b>Highlights:</b> Underrepresented racial and ethnic groups had lower rates of plasma eligibility compared to non-Hispanic White individuals based on a plasma screening algorithm that included the phosphorylated tau 217 ratio.Among plasma-eligible participants, amyloid positron emission tomography eligibility rates did not differ by racial and ethnic group.Plasma biomarker tests may provide equivalent effectiveness for identifying imaging biomarker eligible, cognitively unimpaired individuals across racial and ethnic groups.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70164"},"PeriodicalIF":4.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.","authors":"Paula Iso-Markku, Erik J Buchholz, Xin M Tu, Nathan Gillespie, Chandra A Reynolds, Michael J Lyons, William S Kremen, Carol E Franz","doi":"10.1002/dad2.70169","DOIUrl":"10.1002/dad2.70169","url":null,"abstract":"<p><strong>Introduction: </strong>Research on whether physical activity (PA) is associated with cognition is abundant but very few studies have examined the extent to which prior cognitive ability may account for PA participation in midlife.</p><p><strong>Methods: </strong>Over 800 men self-reported PA at average ages of 40 and 56. General cognitive ability (GCA) was assessed at an average age of 20. Specific cognitive abilities and GCA were assessed at average ages of 56 and 68. Relationships among age 20 GCA, midlife PA, and cognitive functioning in mid- and late-life were examined with generalized estimating equations.</p><p><strong>Results: </strong>Age 20 GCA was significantly associated with age 56 leisure metabolic equivalent of energy expenditure (MET)-hours of PA (<i>b</i> = 0.14, <i>p</i> = 0.027). Age 56 leisure MET-hours were positively (<i>b</i> = 0.04, <i>p</i> = 0.021) and age 40 vigorous leisure PA was inversely (<i>b</i> = -0.10, <i>p</i> = 0.012) associated with age 68 GCA (<i>b</i> = 0.04, <i>p</i> = 0.021).</p><p><strong>Discussion: </strong>There are reciprocal associations between PA and cognitive functioning.</p><p><strong>Highlights: </strong>Young adult general cognitive ability (GCA) predicts midlife physical activity (PA).Midlife PA and cognition were not associated after adjusting for young adult GCA.Midlife PA is associated with later-life cognition, adjusted for young adult GCA.Work-related PA was inversely associated with later-life cognitive functioning.The relationship between PA and cognitive function is bidirectional.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70169"},"PeriodicalIF":4.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}