Paula Iso-Markku, Erik J Buchholz, Xin M Tu, Nathan Gillespie, Chandra A Reynolds, Michael J Lyons, William S Kremen, Carol E Franz
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Relationships among age 20 GCA, midlife PA, and cognitive functioning in mid- and late-life were examined with generalized estimating equations.</p><p><strong>Results: </strong>Age 20 GCA was significantly associated with age 56 leisure metabolic equivalent of energy expenditure (MET)-hours of PA (<i>b</i> = 0.14, <i>p</i> = 0.027). Age 56 leisure MET-hours were positively (<i>b</i> = 0.04, <i>p</i> = 0.021) and age 40 vigorous leisure PA was inversely (<i>b</i> = -0.10, <i>p</i> = 0.012) associated with age 68 GCA (<i>b</i> = 0.04, <i>p</i> = 0.021).</p><p><strong>Discussion: </strong>There are reciprocal associations between PA and cognitive functioning.</p><p><strong>Highlights: </strong>Young adult general cognitive ability (GCA) predicts midlife physical activity (PA).Midlife PA and cognition were not associated after adjusting for young adult GCA.Midlife PA is associated with later-life cognition, adjusted for young adult GCA.Work-related PA was inversely associated with later-life cognitive functioning.The relationship between PA and cognitive function is bidirectional.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70169"},"PeriodicalIF":4.4000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373490/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.\",\"authors\":\"Paula Iso-Markku, Erik J Buchholz, Xin M Tu, Nathan Gillespie, Chandra A Reynolds, Michael J Lyons, William S Kremen, Carol E Franz\",\"doi\":\"10.1002/dad2.70169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Research on whether physical activity (PA) is associated with cognition is abundant but very few studies have examined the extent to which prior cognitive ability may account for PA participation in midlife.</p><p><strong>Methods: </strong>Over 800 men self-reported PA at average ages of 40 and 56. 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引用次数: 0
摘要
关于体育活动（PA）是否与认知相关的研究很多，但很少有研究调查了先前的认知能力在多大程度上影响了中年体育活动的参与。方法：800多名男性自报前列腺癌，平均年龄40岁和56岁。一般认知能力（GCA）在平均20岁时进行评估。具体认知能力和GCA分别在平均年龄56岁和68岁时进行评估。用广义估计方程检验20岁GCA、中年PA与中老年认知功能之间的关系。结果：20岁的GCA与56岁的休闲代谢当量能量消耗(MET)-小时PA显著相关（b = 0.14, p = 0.027）。56岁休闲MET-hours与68岁GCA呈正相关（b = 0.04, p = 0.021）， 40岁剧烈休闲PA与68岁GCA呈负相关（b = -0.10, p = 0.012）。讨论：PA与认知功能之间存在相互关联。重点：青壮年一般认知能力（GCA）预测中年身体活动（PA）。调整青年GCA后，中年PA与认知不相关。中年PA与晚年认知相关，对青年GCA进行了调整。与工作相关的PA与晚年认知功能呈负相关。PA与认知功能的关系是双向的。
Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.
Introduction: Research on whether physical activity (PA) is associated with cognition is abundant but very few studies have examined the extent to which prior cognitive ability may account for PA participation in midlife.
Methods: Over 800 men self-reported PA at average ages of 40 and 56. General cognitive ability (GCA) was assessed at an average age of 20. Specific cognitive abilities and GCA were assessed at average ages of 56 and 68. Relationships among age 20 GCA, midlife PA, and cognitive functioning in mid- and late-life were examined with generalized estimating equations.
Results: Age 20 GCA was significantly associated with age 56 leisure metabolic equivalent of energy expenditure (MET)-hours of PA (b = 0.14, p = 0.027). Age 56 leisure MET-hours were positively (b = 0.04, p = 0.021) and age 40 vigorous leisure PA was inversely (b = -0.10, p = 0.012) associated with age 68 GCA (b = 0.04, p = 0.021).
Discussion: There are reciprocal associations between PA and cognitive functioning.
Highlights: Young adult general cognitive ability (GCA) predicts midlife physical activity (PA).Midlife PA and cognition were not associated after adjusting for young adult GCA.Midlife PA is associated with later-life cognition, adjusted for young adult GCA.Work-related PA was inversely associated with later-life cognitive functioning.The relationship between PA and cognitive function is bidirectional.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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