Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献

{"title":"Disentangling the effects of sex and gender on <i>APOE</i> ɛ4-related neurocognitive impairment.","authors":"Tatiana Dessy, Amina Barhdadi, Marie-Christyne Cyr, Johanna Sandoval, Louis Bherer, Joëlle Rouleau, Sylvie Provost, Louis-Philippe Lemieux Perreault, Marie-Pierre Sylvestre, Sarah A Gagliano Taliun, Marie-Pierre Dubé","doi":"10.1002/dad2.70111","DOIUrl":"https://doi.org/10.1002/dad2.70111","url":null,"abstract":"<p><strong>Introduction: </strong>The apolipoprotein E (<i>APOE</i>) ɛ4 allele is a well-established risk factor for neurocognitive impairment (NCI), with varying impacts between men and women. This study investigates the distinct roles of sex and gender in modifying <i>APOE</i> ɛ4-related NCI.</p><p><strong>Methods: </strong>Biological sex was inferred from sex chromosomes, and a femininity score (FS) was used as a proxy for gender. We analyzed 276,596 UK Biobank participants without prior NCI to assess whether sex and FS modified the effect of <i>APOE</i> ɛ4 on NCI.</p><p><strong>Results: </strong>NCI risk was higher in <i>APOE</i> ɛ4 carriers compared to non-carriers (hazard ratio [HR] = 2.48 in females; HR = 1.96 in males) with significant interaction by sex (<i>P</i> < 0.0001). FS was associated with an increased NCI risk after accounting for sex (HR = 1.07, 95% confidence interval: 1.04-1.10, <i>P</i> < 0.0001) with no significant differences by sex or <i>APOE</i> ɛ4 carrier status.</p><p><strong>Discussion: </strong>Our findings show that <i>APOE</i> ɛ4 increases NCI risk more in females, while FS independently elevates risk across sexes.</p><p><strong>Highlights: </strong>Apolipoprotein E (<i>APOE</i>) ɛ4 increases neurocognitive impairment (NCI) risk, with a greater impact in females (hazard ratio [HR] = 2.48) than males (HR = 1.96).Sex significantly modifies the effect of <i>APOE</i> ɛ4 on NCI (<i>P</i> < 0.0001f).Femininity score increases NCI risk (HR = 1.07) independently of sex and <i>APOE</i> ɛ4.Understanding the distinct sex and gender contributions to <i>APOE</i> ɛ4-related NCI can improve interventions.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70111"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional study of plasma phosphorylated tau 217 in persons without dementia.","authors":"Toni T Saari, Teemu Palviainen, Mikko Hiltunen, Sanna-Kaisa Herukka, Tarja Kokkola, Sari Kärkkäinen, Mia Urjansson, Aino Aaltonen, Aarno Palotie, Heiko Runz, Jaakko Kaprio, Valtteri Julkunen, Eero Vuoksimaa","doi":"10.1002/dad2.70107","DOIUrl":"https://doi.org/10.1002/dad2.70107","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about plasma phosphorylated tau 217 (p-tau217) in individuals without a clinical diagnosis of Alzheimer's disease (AD). We studied associations of plasma p-tau217 with age, sex, education, and genetic risk; estimated the heritability; and conducted a genome-wide association study (GWAS).</p><p><strong>Methods: </strong>A population-based biobank recall study of 65- to 85-year-old twins (<i>N</i> = 697, mean [SD] age 76.2 [4.6] years; 53% women, 154 full pairs) excluding those with AD based on health registry data.</p><p><strong>Results: </strong>Higher p-tau217 level and likelihood of AD neuropathologic change (p-tau217 > 0.42 pg/mL; evident in 39%) were associated with higher age and having an apolipoprotein E (<i>APOE</i>) ε4 allele. Heritability was 0.56 (95% confidence interval [CI]: 0.36-0.79) and GWAS indicated 45 single nucleotide polymorphisms (SNPs) (<i>p </i>< 5 × 10^-08) centered around the <i>APOE</i> locus.</p><p><strong>Discussion: </strong>Our results elucidate the characteristics and genetic associations of p-tau217 in a population-based setting. We found many 65- to 85-year-olds without a clinical diagnosis of AD to have AD neuropathologic change based on plasma p-tau217.</p><p><strong>Highlights: </strong>Plasma phosphorylated tau 217 (p-tau217) is a promising biomarker of Alzheimer's disease (AD).We studied plasma p-tau217 in a population-based sample of 65- to -85-year-olds.We excluded those with a clinical diagnosis of AD.Older age and having an apolipoprotein E (<i>APOE</i>) ε4 allele were associated with higher plasma p-tau217.Heritability of p-tau217 was 56% and a genome-wide association study (GWAS) implicated genes around the <i>APOE</i> region.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70107"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and cortical thickness in ethnically diverse cognitively normal older adults.","authors":"Amaryllis A Tsiknia, Victoria R Tennant, Noelle Lee, Brandon J Hall, Raul Vintimilla, Nalini Hazra, Deydeep Kothapalli, Arthur W Toga, Sid E O'Bryant, Rajesh R Nandy, Alexandra L Clark, Melissa Petersen, Kristine Yaffe, Meredith N Braskie","doi":"10.1002/dad2.70088","DOIUrl":"https://doi.org/10.1002/dad2.70088","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults.</p><p><strong>Methods: </strong>In 2171 cognitively unimpaired older adults, we examined (1) how T2DM related to cortical thickness and hippocampal volume, (2) whether associations were independent of socioeconomic factors and comorbidities, (3) whether associations were driven by hyperglycemia or hyperinsulinemia, and (4) how associations varied by self-reported race/ethnicity.</p><p><strong>Results: </strong>T2DM was correlated with thinner cortex independent of socioeconomic factors and comorbidities, and this was driven by higher hemoglobin A1c (HbA1c). Higher HbA1c levels were correlated with thinner cortex in diabetics and non-diabetics. T2DM-cortical thickness associations were strong and widespread in Hispanic participants, modest and limited to temporal regions in non-Hispanic White participants, and not present in non-Hispanic Black adults.</p><p><strong>Discussion: </strong>T2DM is associated with a thinner cortex, and this is driven by poor glycemic control.</p><p><strong>Highlights: </strong>T2DM is associated with a thinner cortex.The T2DM-cortical thickness relationship is likely driven by poor glucose control.Higher HbA1c levels correlated with thinner cortex in diabetics and non-diabetics.The T2DM-cortical thickness association varied by self-reported ethnicity/race.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70088"},"PeriodicalIF":4.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex variation in the relationship between <i>APOE</i> ε4, cognitive decline, and dementia.","authors":"Eleanor M Kerr, Jennifer A Ailshire, Eileen Crimmins, Katrina M Walsemann","doi":"10.1002/dad2.70053","DOIUrl":"https://doi.org/10.1002/dad2.70053","url":null,"abstract":"<p><strong>Introduction: </strong>We examine if the relationship between apolipoprotein E (<i>APOE)</i> ε4 and cognitive decline and dementia onset differs by sex in non-Hispanic White and Black respondents from the Health and Retirement Study.</p><p><strong>Methods: </strong>We used race-stratified linear mixed models to estimate cognitive decline and Cox proportional hazards models to estimate time to dementia onset. Sex differences were estimated using interaction terms.</p><p><strong>Results: </strong><i>APOE</i> ε4 was associated with cognitive decline (<i>b</i> = -0.4) and dementia onset (hazard ratio [HR] = 1.48) in White adults, and cognitive decline (<i>b</i> = -0.5) in Black adults. The relationship between <i>APOE</i> ε4 and cognitive decline or dementia onset did not differ by sex in either group.</p><p><strong>Discussion: </strong>Our findings question a key hypothesis in the field-that female <i>APOE</i> ε4 carriers experience faster cognitive decline and earlier dementia onset than their male counterparts-and highlight the importance of using probability samples to reduce survivor and participation bias commonly found in genetics research.</p><p><strong>Highlights: </strong>White apolipoprotein E ε4 allele (<i>APOE</i> ε4) carriers had faster cognitive decline and earlier dementia onset.Black <i>APOE</i> ε4 carriers had faster cognitive decline.These patterns did not vary by sex for either Black or White adults.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70053"},"PeriodicalIF":4.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss and its relation to cognition in Indian cohort: A behavioral and neuroimaging study.","authors":"Deepashri Agrawal, Palash Kumar Malo, Sadhana Singh, Thomas Gregor Issac","doi":"10.1002/dad2.70106","DOIUrl":"https://doi.org/10.1002/dad2.70106","url":null,"abstract":"<p><strong>Introduction: </strong>Hearing loss (HL) is an unexplored modifiable risk factor that impacts 41% of the Indian population. This study aimed to determine the prevalence of HL, investigate the association between HL and cognitive impairment in older adults, and assess neuronal structures involved in HL and cognitive impairment using behavioral and magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This study assessed 589 individuals aged 45 and above using HearCheck handheld audiometry, cognitive testing, and MRI.</p><p><strong>Results: </strong>Participants with HL are 1.69 times more likely to experience cognitive impairment compared to those without HL. Neuroimaging revealed significantly less gray matter in various temporal and hippocampal regions in individuals with HL and cognitive impairment as compared with normal hearing and normal cognition.</p><p><strong>Discussion: </strong>These findings underscore the importance of exploring the link between sensory impairments, specifically HL, and cognitive impairment, emphasizing the need for preventive strategies in diverse populations.</p><p><strong>Highlights: </strong>A large urban cohort provides insights into hearing and cognitive function.Hearing loss (HL) is associated with a 69% higher likelihood of cognitive impairment.Magnetic resonance imaging (MRI) reveals reduced gray matter (GM) loss in individuals with HL.Comprehensive cognitive and hearing evaluations strengthen findings.Findings align with sensory deprivation and shared risk factor hypotheses.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70106"},"PeriodicalIF":4.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rest-activity rhythm characteristics associated with lower cognitive performance and Alzheimer's disease biomarkers in midlife women.","authors":"Alexandra Paget-Blanc, Rebecca C Thurston, Stephen F Smagula, Yuefang Chang, Pauline M Maki","doi":"10.1002/dad2.70105","DOIUrl":"https://doi.org/10.1002/dad2.70105","url":null,"abstract":"<p><strong>Introduction: </strong>Disrupted rest-activity rhythms (RARs) have been linked to poorer cognitive function and Alzheimer's disease (AD) biomarkers. Here we extend this work to midlife women, who commonly experience menopause-related sleep and cognitive problems.</p><p><strong>Methods: </strong>One hundred ninety-four postmenopausal participants underwent a neuropsychological evaluation, 72 h of wrist actigraphy generating RAR variables, and a blood draw to measure AD biomarkers: phosphorylated tau (p-tau181, p-tau231) and amyloid beta (Aβ40, Aβ42).</p><p><strong>Results: </strong>Lower interdaily stability (IS) and relative amplitude (RA) and higher interdaily variability (IV) and least active 5 h (L5) were associated with worse processing speed, independent of sleep. Adjustment for sleep significantly attenuated the associations of RA with memory. Lower RA was associated with higher p-tau231 level, independent of sleep. Further adjustment for menopause-related factors modestly accounted for the associations between RAR, cognitive measures, and AD biomarkers.</p><p><strong>Discussion: </strong>Weaker RAR, particularly RA, was associated with worse cognitive functions, and higher AD biomarkers levels, possibly linking RAR with AD pathology in women.</p><p><strong>Highlights: </strong>Lower rhythm stability and robustness and higher fragmentation were associated with worse processing speed.Lower robustness was associated with higher levels of phosphorylated tau-231.Menopause factors did not attenuate the association between rest-activity rhythms and cognitive function.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70105"},"PeriodicalIF":4.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-midlife lifestyle and brain and cognitive changes in individuals on the AD versus non-AD continuum.","authors":"Julie E Oomens, Karly A Cody, Lianlian Du, Erin M Jonaitis, Rachel L Studer, Nathaniel A Chin, Sebastian Köhler, Pieter Jelle Visser, Stephanie J B Vos, Rebecca E Langhough, Willemijn J Jansen, Sterling C Johnson","doi":"10.1002/dad2.70101","DOIUrl":"https://doi.org/10.1002/dad2.70101","url":null,"abstract":"<p><strong>Introduction: </strong>We investigated whether a composite measure of late-midlife lifestyle was associated with (1) longitudinal brain changes and (2) cognitive changes when adjusting for these brain changes.</p><p><strong>Methods: </strong>We used linear mixed models to examine whether the LIfestyle for BRAin Health (LIBRA) index was associated with changes in tau, white matter hyperintensity, neurodegeneration, and cognition and whether changes were similar in amyloid positive (A+; > 17 Centiloids) and negative participants.</p><p><strong>Results: </strong>We included 324 individuals from the Wisconsin Registry for Alzheimer's Prevention (39% apolipoprotein E [<i>APOE</i>] <math><mrow><mi>ε</mi></mrow> </math> 4 carrier, 30% A+, prior baseline age 67 [50-75]). The LIBRA index was not associated with biomarker trajectories or the primary cognitive composite outcome trajectory. There were inconsistent effects on secondary domain-specific cognitive trajectories. In contrast, tau and neurodegeneration were strongly associated with cognitive trajectories.</p><p><strong>Discussion: </strong>In the age-range and disease-range studied, lifestyle did not exhibit a meaningful effect on Alzheimer's disease or vascular biomarker accumulation and was not consistently associated with cognitive trajectories.</p><p><strong>Highlights: </strong>In this age-range, the LIfestyle for BRAin Health (LIBRA) index was not associated with biomarker trajectories.The LIBRA index was not consistently associated with cognitive trajectories.Effects of lifestyle, if any, may take more time to manifest.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70101"},"PeriodicalIF":4.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between <i>APOE-TOMM40 '523</i> haplotypes and limbic system white matter microstructure.","authors":"Katelyn E Mooney, Derek B Archer, Aditi Sathe, Timothy J Hohman, Ose Kadiri, Melissa Lamar, Konstantinos Arfanakis, Lei Yu, Lisa L Barnes, Kacie D Deters","doi":"10.1002/dad2.70099","DOIUrl":"10.1002/dad2.70099","url":null,"abstract":"<p><strong>Introduction: </strong>We assessed associations between apolipoprotein E Translocase of Outer Mitochondrial Membrane 40 (<i>APOE-TOMM40)</i>-'523 haplotypes and white matter microstructure (WMM) across limbic tracts important for memory and cognition in non-Hispanic Black and White individuals.</p><p><strong>Methods: </strong>Linear regression models, stratified by <i>APOE</i> and racialized groups, assessed associations between <i>TOMM40</i>-'523-S and limbic tract WMM free-water (FW) and free-water-corrected fractional anisotropy (FAFWcorr).</p><p><strong>Results: </strong>Black-ε4+-one-'523-S carriers had lower FW in the cingulum and inferior longitudinal fasciculus compared to Black-ε4+-no-'523-S carriers. Additionally, Black-ε4+-one-'523-S carriers had lower FW in the cingulum, uncinate, and fornix, and higher FA_FWcorr in the uncinate compared to Black-ε4+-'523-S/S carriers. White-ε3/ε3-'523-S/S carriers had lower FAFWcorr in the cingulum and inferior temporal gyrus compared to White-ε3/ε3-no-'523-S carriers, and lower FAFWcorr in the cingulum compared to White-ε3/ε3-one-'523-S carriers.</p><p><strong>Discussion: </strong>This supports prior work that '523-S is associated with abnormal aging in White-ε3/ε3 carriers, but is potentially risk-mitigating in Black-ε4+ carriers, while suggesting a differential effect by racialized background of <i>APOE</i> on WMM.</p><p><strong>Highlights: </strong>White matter microstructure (WMM) across limbic tracts important for cognition was measured by diffusion MRI.Black apolipoprotein E (APOE) ε4+ carriers with one copy of TOMM40-'523-S had normal aging WMM metrics across several tracts, including the cingulum bundle, uncinate fasciculus, fornix, and inferior longitudinal fasciculus.White APOE ε3/ε3 carriers with two copies of TOMM40-'523-S had abnormal aging WMM metrics in the cingulum bundle and inferior temporal gyrus.APOE associations with aging may differ in racialized groups due to TOMM40-'523-S copy number.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70099"},"PeriodicalIF":4.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of genetic counseling and testing in individuals at high risk of familial Alzheimer's disease from Latin America: a non-randomized controlled trial.","authors":"Pablo M Bagnati, Marisol Londoño Castaño, María Laura Fernández, Beatriz Mora Henao, Patricio Chrem, David Aguillón, Luz Estela Varela, Juan Diego Barbaran, Yudy Leon, Ezequiel Surace, Claudia C Madrigal, Juan Pablo Picasso, Claudia P Ramos, Carlos M Restrepo Fernández, Gabriela Vigo, Laura Ramirez Aguilar, Gabriel Alberto VargasCuadros, Mauricio Arcos-Burgos, Erika Mariana Longoria, Ellen Ziegemeier, Eric McDade, Randall J Bateman, Ricardo F Allegri, Francisco Lopera, Jorge J Llibre-Guerra","doi":"10.1002/dad2.70102","DOIUrl":"10.1002/dad2.70102","url":null,"abstract":"<p><strong>Introduction: </strong>This study involved evaluating a tailored genetic counseling and testing (GCT) protocol for families at risk of autosomal dominant Alzheimer's disease (ADAD) in Latin America (LatAm), focusing on essential cultural and regional adaptations.</p><p><strong>Methods: </strong>We conducted a non-randomized controlled trial among ADAD families in Colombia and Argentina. Participants were categorized based on their decision to learn their genetic status (GS), with further comparisons between mutation-positive versus mutation-negative participants who learned their status. Psychological impacts were measured using validated scales for anxiety and depression.</p><p><strong>Results: </strong>Of the 122 eligible participants, 97 completed the GCT protocol, and 87 opted to learn their GS. There were no clinically significant differences in psychological distress between those who learned their status and those who did not, nor between mutation-positive and mutation-negative individuals.</p><p><strong>Discussion: </strong>The GCT protocol effectively managed psychological impacts in ADAD families and was positively received, demonstrating the importance of culturally adapted GCT protocols.</p><p><strong>Highlights: </strong>We examined the adaptation and efficacy of a GCT protocol in LatAm for families at risk of ADAD.The GCT protocol mitigated psychological distress among at-risk ADAD families.The study confirms the protocol's cultural appropriateness and psychological safety.Future studies should explore the long-term psychological and public health impacts of GCT and use of GCT for treatment options.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70102"},"PeriodicalIF":4.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy-confirmed cohort from China.","authors":"Xiang-Sha Yin, Jianru Sun, Xue Wang, Wei Wu, Zhen Chen, Di Zhang, Yuanyuan Xu, Yongmei Chen, Wenying Qiu, Xiaojing Qian, Jun Ni, Chao Ma","doi":"10.1002/dad2.70100","DOIUrl":"10.1002/dad2.70100","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy-confirmed cohort donated to a human brain bank in Beijing, China.</p><p><strong>Methods: </strong>A total of 483 subjects were neuropathologically evaluated based on standardized protocols. Descriptive statistics and ordinal logistic regression models were used to estimate the correlation between CAA, AD, apolipoprotein E (<i>APOE</i>) genotyping, and cognitive function proximal to death.</p><p><strong>Results: </strong>Neuropathological assessment revealed that 53 of 483 subjects (11%) had CAA without AD, 78 of 483 (16%) had AD without CAA, 98 of 483 (20%) had both CAA and AD, and 254 of 483 (53%) had neither condition. A significant correlation was confirmed between CAA severity and AD. Subjects with both CAA and AD exhibited aggravated cognitive impairment.</p><p><strong>Discussion: </strong>Our results indicate a substantial prevalence of CAA that is frequently comorbid with AD and may exacerbate cognitive decline in the elderly population in China.</p><p><strong>Highlights: </strong>First reporting of cerebral amyloid angiopathy (CAA) based on an autopsy-confirmed cohort from China.The prevalence of CAA was high in the elderly Chinese sample.Age and apolipoprotein E (<i>APOE</i>) ε4 allele were related to the prevalence of CAA.CAA and Alzheimer's disease (AD) were frequently co-occurred and significantly associated.Subjects with both CAA and AD exhibited aggravated cognitive impairment.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70100"},"PeriodicalIF":4.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}