Chemical & Biomedical Imaging最新文献_第5页

Chemical & Biomedical Imaging Pub Date : 2025-04-28

Qian Sun, Hang Liu, Ying Yang, Shankun Yao, Zhipeng Liu* and Zijian Guo*,

引用次数: 0

Chemical & Biomedical Imaging Pub Date : 2025-04-28

Raul Michael, Tallah Modirzadeh, Tahir Bachar Issa and Patrick Jurney*,

引用次数: 0

Chemical & Biomedical Imaging Pub Date : 2025-04-28

Sarah R. Yassine, León Zendejas Medina, Egor Katkov, Robert Lacasse and Janine Mauzeroll*,

引用次数: 0

Chemical & Biomedical Imaging Pub Date : 2025-04-28

引用次数: 0

Honoring the Contributions of Our Editorial Board Members 表彰编委会成员的贡献

Chemical & Biomedical Imaging Pub Date : 2025-04-15 DOI: 10.1021/cbmi.5c0002610.1021/cbmi.5c00026

Wenxi Lei, Deju Ye and Zijian Guo*,

引用次数: 0

Quantifying the Shape and Stiffness of Single Extracellular Vesicles in Aqueous Solution via Membrane Diffusivity Measurements. 通过膜扩散率测量定量水溶液中单个细胞外囊泡的形状和刚度。

IF 5.7

Chemical & Biomedical Imaging Pub Date : 2025-04-09 eCollection Date: 2025-09-22 DOI: 10.1021/cbmi.5c00011

Yihan Wang, Huihui Gao, Chu Han, Liu Liu, Jingwen Deng, Hangwei Fan, Zirui Zhou, Mengyao Zhang, Xiaohui Zhang, Feiyang Cheng, Xiang Zhan, Hao Ge, Yan-Ling Liu, Xinwei Zhang, Wei-Hua Huang, Wei Yan, Jing Zhang, Wei Zhang, Limin Xiang

{"title":"Quantifying the Shape and Stiffness of Single Extracellular Vesicles in Aqueous Solution via Membrane Diffusivity Measurements.","authors":"Yihan Wang, Huihui Gao, Chu Han, Liu Liu, Jingwen Deng, Hangwei Fan, Zirui Zhou, Mengyao Zhang, Xiaohui Zhang, Feiyang Cheng, Xiang Zhan, Hao Ge, Yan-Ling Liu, Xinwei Zhang, Wei-Hua Huang, Wei Yan, Jing Zhang, Wei Zhang, Limin Xiang","doi":"10.1021/cbmi.5c00011","DOIUrl":"10.1021/cbmi.5c00011","url":null,"abstract":"Quantifying the shape and stiffness of extracellular vesicles (EVs) is essential for understanding their biophysical properties and roles in intercellular communication. However, achieving single-particle resolution under physiological conditions remains a significant challenge. Here, we introduce an approach that integrates single-molecule diffusivity mapping (SMdM) with diffusion models for spherical and discoidal shapes to quantify the geometric and mechanical properties of individual liposomes and EVs in aqueous solution. Our findings identify charged lipids and cholesterol as critical factors that enhance liposome stiffness, driving their shapes closer to spheres. Applying this method to EVs reveals that those derived from tumor cells exhibit lower stiffness compared to EVs from normal cells, consistent with the biomechanical characteristics of their parent cells. This rapid, high-throughput strategy for characterizing the shape and stiffness of single EVs in aqueous solution offers promising applications in cancer biomarker discovery and the development of EV-based therapeutics.","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 9","pages":"605-614"},"PeriodicalIF":5.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aptamers as a New Frontier in Molecular Cancer Imaging Technologies. 适体：肿瘤分子成像技术的新前沿。

Chemical & Biomedical Imaging Pub Date : 2025-04-09 eCollection Date: 2025-05-26 DOI: 10.1021/cbmi.4c00103

Yingying Li, Tong Shao, Jingyu Kuang, Heqing Yi, Lvyun Zhu, Xue-Qiang Wang

{"title":"Aptamers as a New Frontier in Molecular Cancer Imaging Technologies.","authors":"Yingying Li, Tong Shao, Jingyu Kuang, Heqing Yi, Lvyun Zhu, Xue-Qiang Wang","doi":"10.1021/cbmi.4c00103","DOIUrl":"10.1021/cbmi.4c00103","url":null,"abstract":"Molecular imaging has emerged as a transformative tool in cancer diagnosis, enabling the visualization of biological processes at the cellular and molecular levels. Aptamers, single-stranded oligonucleotides with high affinity and specificity for target molecules, have gained significant attention as versatile probes for molecular imaging due to their unique properties, including small size, ease of modification, low immunogenicity, and rapid tissue penetration. This review explores the integration of aptamers with various imaging agents to enhance cancer diagnosis and therapy. Aptamer-based imaging probes offer high sensitivity and real-time visualization of tumor markers. Aptamer-based fluorescence probes and aptamer-conjugated magnetic resonance imaging (MRI) probes, including gadolinium-based contrast agents, improve tumor targeting and imaging resolution. Additionally, aptamers have been utilized in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging to enhance the specificity of radiotracers for cancer detection. Furthermore, aptamer-targeted ultrasound and computed tomography (CT) imaging demonstrate the potential for noninvasive and precise tumor localization. By leveraging the unique advantages of aptamers, these imaging strategies not only improve diagnostic accuracy but also pave the way for image-guided cancer therapies. This review highlights the significant role of aptamers in advancing molecular imaging and their potential to revolutionize cancer diagnosis and treatment.","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 5","pages":"267-279"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular-Level Insights into the NMR Relaxivity of Gadobutrol Using Quantum and Classical Molecular Simulations. 利用量子和经典分子模拟对Gadobutrol核磁共振弛豫度的分子水平见解。

IF 5.7

Chemical & Biomedical Imaging Pub Date : 2025-04-09 eCollection Date: 2025-09-22 DOI: 10.1021/cbmi.4c00080

Thiago J Pinheiro Dos Santos, Carla C Fraenza, Giselle de Araujo Lima E Souza, Emilia Pelegano-Titmuss, Dilipkumar N Asthagiri, Steven G Greenbaum, Walter G Chapman, Philip M Singer

{"title":"Molecular-Level Insights into the NMR Relaxivity of Gadobutrol Using Quantum and Classical Molecular Simulations.","authors":"Thiago J Pinheiro Dos Santos, Carla C Fraenza, Giselle de Araujo Lima E Souza, Emilia Pelegano-Titmuss, Dilipkumar N Asthagiri, Steven G Greenbaum, Walter G Chapman, Philip M Singer","doi":"10.1021/cbmi.4c00080","DOIUrl":"10.1021/cbmi.4c00080","url":null,"abstract":"MRI is an indispensable diagnostic tool in modern medicine; however, understanding the molecular-level processes governing NMR relaxation of water in the presence of MRI contrast agents remains a challenge, hindering the molecular-guided development of more effective contrast agents. By using quantum-based polarizable force fields, the first-of-its-kind molecular dynamics (MD) simulations of Gadobutrol are reported where the 1H NMR longitudinal relaxivity r 1 of the aqueous phase is determined without any adjustable parameters. The MD simulations of r 1 dispersion (i.e., frequency dependence) show good agreement with measurements at frequencies of interest in clinical MRI. Importantly, the simulations reveal key insights into the molecular level processes leading to r 1 dispersion by decomposing the NMR dipole-dipole autocorrelation function G(t) into a discrete set of molecular modes, analogous to the eigenmodes of a quantum harmonic oscillator. The molecular modes reveal important aspects of the underlying mechanisms governing r 1, such as its multiexponential nature and the importance of the second eigenmodal decay. By simply analyzing the MD trajectories on a parameter-free approach, the Gadobutrol simulations show that the outer-shell water contributes ∼50% of the total relaxivity r 1 compared to the inner-shell water, in contrast to simulations of (nonchelated) gadolinium-aqua where the outer shell contributes only ∼15% of r 1. The deviation between simulations and measurements of r 1 below clinical MRI frequencies is used to determine the low-frequency electron-spin relaxation time for Gadobutrol, in good agreement with independent studies.","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 9","pages":"615-629"},"PeriodicalIF":5.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aptamers as a New Frontier in Molecular Cancer Imaging Technologies 适体：肿瘤分子成像技术的新前沿

Chemical & Biomedical Imaging Pub Date : 2025-04-09 DOI: 10.1021/cbmi.4c0010310.1021/cbmi.4c00103

Yingying Li, Tong Shao, Jingyu Kuang, Heqing Yi, Lvyun Zhu* and Xue-Qiang Wang*,

{"title":"Aptamers as a New Frontier in Molecular Cancer Imaging Technologies","authors":"Yingying Li, Tong Shao, Jingyu Kuang, Heqing Yi, Lvyun Zhu* and Xue-Qiang Wang*, ","doi":"10.1021/cbmi.4c0010310.1021/cbmi.4c00103","DOIUrl":"https://doi.org/10.1021/cbmi.4c00103https://doi.org/10.1021/cbmi.4c00103","url":null,"abstract":"Molecular imaging has emerged as a transformative tool in cancer diagnosis, enabling the visualization of biological processes at the cellular and molecular levels. Aptamers, single-stranded oligonucleotides with high affinity and specificity for target molecules, have gained significant attention as versatile probes for molecular imaging due to their unique properties, including small size, ease of modification, low immunogenicity, and rapid tissue penetration. This review explores the integration of aptamers with various imaging agents to enhance cancer diagnosis and therapy. Aptamer-based imaging probes offer high sensitivity and real-time visualization of tumor markers. Aptamer-based fluorescence probes and aptamer-conjugated magnetic resonance imaging (MRI) probes, including gadolinium-based contrast agents, improve tumor targeting and imaging resolution. Additionally, aptamers have been utilized in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging to enhance the specificity of radiotracers for cancer detection. Furthermore, aptamer-targeted ultrasound and computed tomography (CT) imaging demonstrate the potential for noninvasive and precise tumor localization. By leveraging the unique advantages of aptamers, these imaging strategies not only improve diagnostic accuracy but also pave the way for image-guided cancer therapies. This review highlights the significant role of aptamers in advancing molecular imaging and their potential to revolutionize cancer diagnosis and treatment.","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 5","pages":"267–279 267–279"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbmi.4c00103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent Effect on the Behavior of Single Eosin Y Photoredox Catalyst. 溶剂对单一伊红Y光氧化还原催化剂行为的影响。

IF 5.7

Chemical & Biomedical Imaging Pub Date : 2025-04-08 eCollection Date: 2025-09-22 DOI: 10.1021/cbmi.5c00008

Wenqiao Zhou, Kai Gu, Frank Schultz, Chunming Liu

引用次数: 0