Pain Reports最新文献

{"title":"Introduction to the special issue on epigenetic regulation of chronic pain.","authors":"Andrea G Nackley","doi":"10.1097/PR9.0000000000001406","DOIUrl":"10.1097/PR9.0000000000001406","url":null,"abstract":"<p><p>This Special Issue features 6 articles from leaders in the field that elucidate novel epigenetic mechanisms regulating nociception, inflammation, responses to pharmacologic and integrative therapies, and pain disparities among racial/ethnic groups. Together, they highlight the expanding potential of epigenomics to inform mechanistic discovery, guide personalized pain therapeutics, and advance pain equity.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 2","pages":"e1406"},"PeriodicalIF":4.3,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12928944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No significant modulation of pressure pain sensitivity and cardioception after transauricular vagal nerve stimulation.","authors":"Laura Moniek Ronda De Herde, Ken Steffen Frahm, Claus Graff, Thomas Dos Santos Nielsen, Thomas Graven-Nielsen, Hartwig Roman Siebner, Daniel Ciampi de Andrade","doi":"10.1097/PR9.0000000000001387","DOIUrl":"10.1097/PR9.0000000000001387","url":null,"abstract":"<p><strong>Introduction: </strong>Transauricular vagal nerve stimulation (taVNS) is gaining interest as a chronic pain treatment due to its convergence with nociceptive pathways. Although pain-modulation by taVNS has been demonstrated, this research often lacks the use of active control or does not simultaneously explore effects on associated interoceptive pathways or vagal activation.</p><p><strong>Objectives: </strong>This double-blind, active-controlled, cross-over study aimed to corroborate the pain-modulating effect of taVNS whilst further investigating cardioception and vagal-activation markers.</p><p><strong>Methods: </strong>Thirty healthy individuals underwent 20 minutes of continuous 25-Hz electrical stimulation of the left concha cymba (taVNS) or earlobe (active control). Stimulation intensity was individually adjusted at two-thirds between perception and suprapain thresholds. Assessments were obtained before, immediately after, and 30 minutes after stimulation. These included pressure pain sensitivity measures including, pressure pain perception, detection, tolerance thresholds and conditioned pain modulation (CPM) as well as heart rate variability (HRV), pupillometry and cardioception measures.</p><p><strong>Results: </strong>Although stimulation intensities were higher for control stimulation than taVNS (<i>P</i> < 0.001), participants reported no significant differences in subjective perception of stimulation or in their beliefs regarding the effects of the stimulations on the assessments. Compared to control stimulation, taVNS did not significantly modulate pressure pain sensitivity, cardioception, HRV, or pupillometry. Explorative analysis revealed a negative correlation between taVNS-associated changes in CPM and parasympathetic-HRV (<i>P</i> = 0.005), supporting a potential link between pain modulation and vagal activation.</p><p><strong>Conclusion: </strong>Although the findings offer partial support for the proposed vagal mechanism of taVNS, they highlight the limited understanding of which parameters and when stimulation exerts effects.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1387"},"PeriodicalIF":4.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12815542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining mechanisms connecting child maltreatment and interpersonal violence to young adult pain symptoms in women.","authors":"Sarah J Beal, Kim Barnett, Susmita Kashikar-Zuck, Chris King, Constance A Mara, Katie Fox, Mary V Greiner, Jennie G Noll","doi":"10.1097/PR9.0000000000001370","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001370","url":null,"abstract":"<p><strong>Introduction: </strong>Child maltreatment has been linked to elevated pain symptoms and more chronic pain in adults. The hypothalamic-pituitary-adrenal (HPA) axis may be a mechanism connecting maltreatment to pain, where early life stressors are thought to impact HPA axis function, leading to increased inflammation and pain.</p><p><strong>Objectives: </strong>This study explored pathways associated with pain in young adult women with and without maltreatment exposure. Maltreatment was expected to be associated with increased exposure to interpersonal violence, inflammation, and negative affect which, in turn, would be associated with more pain in adulthood.</p><p><strong>Methods: </strong>Fifty women randomly selected from a prospective longitudinal cohort (n = 25 with confirmed child maltreatment, n = 25 demographically similar women without history of maltreatment) completed comprehensive assessments of risk factors for pain, including collecting inflammatory biomarkers.</p><p><strong>Results: </strong>Women who had experienced child maltreatment reported more exposure to interpersonal violence as young adults (χ² [1] = 6.52, <i>P</i> = 0.01). Small effect size differences were observed between women with maltreatment exposure and those without for inflammation in young adulthood (<i>d</i> = 0.29) and negative affect scores (<i>d</i> = 0.47), although not statistically significant. Small-to-moderate effect sizes differences were also observed between women exposed to interpersonal violence and those without interpersonal violence exposure for negative affect (<i>d</i> = 0.62) and inflammation (<i>d</i> = 0.46). Negative affect was significantly associated with experiencing any pain in young adulthood (odds ratio = 1.12, <i>P</i> = 0.03, 95% confidence interval = 1.01, 1.24).</p><p><strong>Conclusion: </strong>Mechanisms connecting maltreatment to pain are complex. Studies that account for the effect-moderating impact of early life stress on inflammatory pathways alongside psychological effects of stress exposures more proximal to pain (eg, interpersonal violence, mood) are needed.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1370"},"PeriodicalIF":4.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral administration of boldine reduces neuropathic pain After spared nerve injury in female mice.","authors":"Jiangping Pan, Carlos A Toro, Christine Chow, Yorley Duarte, Juan C Sáez, Christopher P Cardozo, Wei Zhao","doi":"10.1097/PR9.0000000000001386","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001386","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain is present in approximately 20% of the population and is a major burden to the healthcare system. Approximately 30% to 40% of these patients report neuropathic pain. Neuropathic pain is defined as pain caused by injury or disease of the somatosensory nervous system. Current available treatments for neuropathic pain have limited efficacy and substantial side effects.</p><p><strong>Objective: </strong>To address the need for more effective and safer treatments for neuropathic pain, this study aimed to test whether boldine, a naturally occurring alkaloid, could attenuate neuropathic pain in a murine model of spared nerve injury (SNI).</p><p><strong>Methods: </strong>Von Frey filament test, hot/cold plate test, and dynamic weight-bearing test were used to assess pain phenotypes and functional outcomes after SNI. Multiplex enzyme-linked immunosorbent assay, quantitative PCR, and immunostainings were performed to evaluate cellular and molecular changes after boldine treatment.</p><p><strong>Results: </strong>Oral administration of boldine at 50 mg/kg body weight/day resulted in significant reduction of SNI-induced mechanical and thermal hypersensitivities. Functional outcome measurements showed that boldine corrected SNI-induced weight-bearing deficits. Boldine significantly inhibited SNI-induced elevation of some pain-related inflammatory cytokines/chemokines in the serum. Immunofluorescence studies revealed that boldine reduced the number of reactive astrocytes and inhibited microglia activation in the lumbar spinal cord. In vitro studies showed that boldine inhibited the lipopolysaccharide-induced elevation of inflammatory markers in BV-2 microglial cells.</p><p><strong>Conclusion: </strong>Our findings suggest that boldine may be a promising therapeutic candidate for the treatment of neuropathic pain, possibly through inhibition of glia activation and neuroinflammation.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1386"},"PeriodicalIF":4.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences and pain incidence and multisite trajectories among middle-aged and older Chinese adults.","authors":"Jiajia Li, Heming Pei, Guilan Xie, Gong Chen, Lijun Pei","doi":"10.1097/PR9.0000000000001389","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001389","url":null,"abstract":"<p><strong>Introduction: </strong>Pain is prevalent among middle-aged and older adults, and adverse childhood experiences (ACEs) may contribute to its development; however, mechanisms linking ACEs to pain remain unclear.</p><p><strong>Objectives: </strong>This study investigates the association between ACEs and incident pain and multisite pain trajectories, focusing on mediation by depressive symptoms and social isolation.</p><p><strong>Methods: </strong>We used China Health and Retirement Longitudinal Study data (2011-2020). We analyzed 2 samples: an incidence cohort of pain-free at baseline (n = 9,252) and a trajectory cohort with repeated pain measures (n = 9,935). Pain was assessed at each wave by self-reported presence and multisite pain trajectories. Adverse childhood experiences were measured using a cumulative index of 13 adversities. Cox proportional hazards models, group-based trajectory modeling, and multinomial logistic models estimated associations with incident pain and trajectory group membership. Multiple mediation analyses quantified indirect effects of depressive symptoms and social isolation.</p><p><strong>Results: </strong>We identified 3 multisite pain trajectories: minimal multisite (46.33%), increasing multisite (38.93%), and high multisite (14.74%). Higher ACEs scores (≥4) were associated with increased risk of incident pain (hazard ratio = 1.20, 95% confidence interval [CI]: 1.10-1.32) and membership in high multisite trajectories (odds ratio = 3.97, 95% CI: 3.05-5.17). In parallel mediation models, depressive symptoms mediated up to 28.25% of the ACEs-pain association for high multisite trajectories, whereas social isolation showed minimal effects.</p><p><strong>Conclusion: </strong>Adverse childhood experiences were linked to incident and multisite pain, largely through depressive symptoms. Targeting psychological health may mitigate the impact of ACEs on pain outcomes, suggesting a need for interventions addressing early-life exposures and mental health interventions in aging populations.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1389"},"PeriodicalIF":4.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world database analysis of the prevalence of pain medication use in the United States.","authors":"Andrea Lopez, Ann M Menzie, Michael Kenderes, Jaime L Rubin","doi":"10.1097/PR9.0000000000001396","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001396","url":null,"abstract":"<p><strong>Introduction: </strong>Pain is a common and burdensome condition associated with significant health care costs and patient morbidity in the United States, yet limited pain prevalence data exists.</p><p><strong>Objectives: </strong>Provide national-level prevalence estimates of acute and chronic pain requiring management with prescription medication in the United States. Examine medication treatment patterns for the overall pain populations and a subset of patients with peripheral neuropathic pain (PNP).</p><p><strong>Methods: </strong>This study used a retrospective cross-sectional design that identified adults receiving treatment for pain in 2022 in the MarketScan Commercial and Medicare Supplemental and the Premier Healthcare Databases. Pain prevalence and medication use were analyzed and extrapolated to the United States population using standardized prevalence estimation methods.</p><p><strong>Results: </strong>Results suggest that approximately 102.1 million (M) people in the United States received prescription pain medication in 2022. Approximately 28.7M people received prescription medications for chronic pain, of which 11.1M (39%) had PNP conditions. Most patients with chronic pain used prescription nonsteroidal anti-inflammatory drugs (NSAIDs; 51%), anticonvulsants (44%), opioids (41%), and antidepressants (40%). Anticonvulsant use was more prominent in PNP (62% of patients had ≥1 prescription). Acute pain was estimated to affect 80.2M adults in the United States; 46.2M people with pain medication administered in-hospital, 43.5M filling prescription pain medications and 9.4M in both settings. Among all acute pain patients, 48% and 42% had evidence of opioid and NSAID use, respectively. Approximately 6.8M patients with chronic pain also experienced an acute pain event in-hospital.</p><p><strong>Conclusion: </strong>Findings show pain, pain medication use, and opioid-use in particular, are highly prevalent in the United States.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1396"},"PeriodicalIF":4.3,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LLMs in Patient-Centric Program Evaluation: Addressing Concerns and Further Considerations.","authors":"Kendra H Oliver, Leah Russell Flaherty","doi":"10.1097/PR9.0000000000001352","DOIUrl":"10.1097/PR9.0000000000001352","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1352"},"PeriodicalIF":4.3,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12757187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical pain intensity is associated with greater cannabis demand among people who regularly use cannabis.","authors":"Nicholas J Bush, Erin Ferguson, Marco Funez-Ponce, Ali Yurasek, Jeff Boissoneault","doi":"10.1097/PR9.0000000000001385","DOIUrl":"10.1097/PR9.0000000000001385","url":null,"abstract":"<p><strong>Objectives: </strong>Individuals with pain may engage in pain self-management by using cannabis, increasing the risk of cannabis-related consequences. Past research has demonstrated that the presence of next-day responsibilities significantly reduced cannabis demand in regular cannabis users. This study determined the association of pain with cannabis demand, and whether pain would attenuate the effect of next-day responsibilities.</p><p><strong>Methods: </strong>This was a secondary analysis of data from a crowdsourced study of cannabis demand among regular cannabis users (N = 172, 41% women). Participants completed 2 conditions of a marijuana purchase task in counterbalanced order. In one, participants imagined they had a job interview the following morning. In the other, no interview was present. Pain was assessed using the Brief Pain Inventory. Mixed GLM analyses examined the effects of task condition (responsibility vs no responsibility) and pain intensity (a continuous measure) on demand indices, including O_max, P_max, Intensity, Elasticity, and Breakpoint.</p><p><strong>Results: </strong>Greater pain intensity was associated with greater O_max, P_max, Intensity, Breakpoint, and Elasticity. Next-day responsibilities were associated with significant reductions in Breakpoint, Intensity, and Elasticity. Next-day responsibilities interacted significantly with sex and pain intensity on elasticity such that for women, pain was associated with lower elasticity in the next-day responsibilities.</p><p><strong>Conclusion: </strong>Consistent with models suggesting pain is a potent antecedent for substance use and highlighting the importance of effective and accessible pain management, individuals reporting greater pain exhibited both greater amplitude (as reflected by Intensity) and persistence (reflected by O_max, P_max, and Breakpoint) of cannabis demand.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1385"},"PeriodicalIF":4.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12737859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health equity for people with pain: from understanding to action.","authors":"Emily Walker, Emma L Karran, Matthew D Jones, Mitchell T Gibbs, Saurab Sharma","doi":"10.1097/PR9.0000000000001364","DOIUrl":"10.1097/PR9.0000000000001364","url":null,"abstract":"<p><strong>Objective: </strong>This article explores the role of social determinants of health in pain care, highlighting their contribution to health inequities and offering strategies for clinicians to respond to these factors in clinical practice.</p><p><strong>Methods: </strong>This clinical update aligns with the 2025 IASP Global Year, which focuses on pain management and education in low- and middle-income countries, as well as low-income settings and priority populations in high-income countries.</p><p><strong>Results: </strong>Social determinants of health-defined as the social, economic, and environmental conditions shaping people's health outcomes and care experiences-follow a social gradient, and disproportionately affect those facing disadvantage and multiple forms of marginalisation. They play a central role in creating health inequities, which are systematic, avoidable, and unfair differences in health between groups. Social determinants of health are upstream influences that create downstream impacts, including individual social risk factors and health-related social needs. Addressing these influences in pain care requires a multi-level approach that considers broader structural conditions alongside individual contexts. Clinicians can take meaningful action by screening for social factors, tailoring care to individuals' social needs, connecting patients with resources, establishing links within and outside the healthcare system, advocating both at the individual and system level, and critically reflecting on their biases, social identity, and the structural forces that shape health.</p><p><strong>Conclusion: </strong>Social determinants of health are central drivers of disparities in health outcomes and pain care. Although clinicians alone cannot address structural injustice, they play a crucial role in recognising and responding to social conditions that influence care, especially for those most affected by inequities.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1364"},"PeriodicalIF":4.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12737865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventral intraspinal microstimulation alters neural population-level nociceptive activity in rats including after spinal cord injury.","authors":"Jacob Graves McPherson, Maria F Bandres","doi":"10.1097/PR9.0000000000001379","DOIUrl":"10.1097/PR9.0000000000001379","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal cord injury (SCI) often results in movement impairments and neuropathic pain.</p><p><strong>Objectives: </strong>The purpose of this study was to determine whether intraspinal microstimulation (ISMS) intended to enhance voluntary movement after SCI modulates neural population-level spinal responsiveness to nociceptive sensory input.</p><p><strong>Methods: </strong>The study was conducted in vivo in 3 cohorts of rats: neurologically intact, chronic SCI without behavioral signs of neuropathic pain, and chronic SCI with neuropathic pain. Nociceptive sensory input was induced by pinches of the plantar surface of the hind paw before, during, and after low frequency (7 Hz), submotor threshold ISMS delivered within or near the motor pools of the L5 spinal segment. Neural population-level responsiveness to nociceptive input was recorded throughout the dorso-ventral extent of the L5 spinal segment using microelectrode arrays.</p><p><strong>Results: </strong>Before ISMS, pinch-evoked multiunit discharge rates did not vary between cohorts, although both SCI cohorts had twice as many pinch-responsive electrodes as the neurologically intact cohort. The percentage of electrodes modulated during ISMS did not differ between cohorts, although excitatory actions were preferential in the SCI cohorts. After ISMS, all cohorts exhibited ≥2X more electrodes with altered pinch responsiveness than during ISMS, with depressive actions predominant in the noninjured cohort.</p><p><strong>Conclusion: </strong>Doubling of the number of electrodes with altered pinch responsiveness after ISMS suggests that ISMS causes a lasting increase in the spatial spread of evoked sensory activity. That this change favored inhibition in 1 cohort is consistent with the possibility of ventral ISMS promoting broad inhibitory control of nociceptive activity.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1379"},"PeriodicalIF":4.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12737858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}