Pain Reports最新文献

{"title":"Preliminary study: quantification of chronic pain from physiological data.","authors":"Zhuowei Cheng,&nbsp;Franklin Ly,&nbsp;Tyler Santander,&nbsp;Elyes Turki,&nbsp;Yun Zhao,&nbsp;Jamie Yoo,&nbsp;Kian Lonergan,&nbsp;Jordan Gray,&nbsp;Christopher H Li,&nbsp;Henry Yang,&nbsp;Michael Miller,&nbsp;Paul Hansma,&nbsp;Linda Petzold","doi":"10.1097/PR9.0000000000001039","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001039","url":null,"abstract":"<p><strong>Introduction: </strong>It is unknown if physiological changes associated with chronic pain could be measured with inexpensive physiological sensors. Recently, acute pain and laboratory-induced pain have been quantified with physiological sensors.</p><p><strong>Objectives: </strong>To investigate the extent to which chronic pain can be quantified with physiological sensors.</p><p><strong>Methods: </strong>Data were collected from chronic pain sufferers who subjectively rated their pain on a 0 to 10 visual analogue scale, using our recently developed pain meter. Physiological variables, including pulse, temperature, and motion signals, were measured at head, neck, wrist, and finger with multiple sensors. To quantify pain, features were first extracted from 10-second windows. Linear models with recursive feature elimination were fit for each subject. A random forest regression model was used for pain score prediction for the population-level model.</p><p><strong>Results: </strong>Predictive performance was assessed using leave-one-recording-out cross-validation and nonparametric permutation testing. For individual-level models, 5 of 12 subjects yielded intraclass correlation coefficients between actual and predicted pain scores of 0.46 to 0.75. For the population-level model, the random forest method yielded an intraclass correlation coefficient of 0.58. Bland-Altman analysis shows that our model tends to overestimate the lower end of the pain scores and underestimate the higher end.</p><p><strong>Conclusion: </strong>This is the first demonstration that physiological data can be correlated with chronic pain, both for individuals and populations. Further research and more extensive data will be required to assess whether this approach could be used as a \"chronic pain meter\" to assess the level of chronic pain in patients.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1039"},"PeriodicalIF":4.8,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33496494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics.","authors":"Bijar Ghafouri,&nbsp;Emelie Edman,&nbsp;Marie Löf,&nbsp;Eva Lund,&nbsp;Olof Dahlqvist Leinhard,&nbsp;Peter Lundberg,&nbsp;Mikael Fredrik Forsgren,&nbsp;Björn Gerdle,&nbsp;Huan-Ji Dong","doi":"10.1097/PR9.0000000000001042","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001042","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity is a common comorbidity in fibromyalgia (FM). Both FM and obesity have been connected to low-grade inflammation, although it is possible that previously reported inflammatory alterations in FM primarily may be linked to increased body mass index (BMI).</p><p><strong>Objective: </strong>This study aimed to investigate whether the inflammatory plasma protein profile, muscle blood flow, and metabolism and pain characteristics (clinical parameters and patient-reported outcome measurements) differed between female patients with FM with and without obesity.</p><p><strong>Methods: </strong>Patients with FM underwent clinical examinations, physical tests, and answered questionnaires. They were dichotomized according to BMI (<30 kg/m² [n = 14]; ≥30 kg/m² [n = 13]). Blood samples were collected and analyzed using a panel of 71 inflammatory plasma proteins.</p><p><strong>Results: </strong>There were significant (<i>P</i> < 0.05) differences in blood pressure, pulse, max VO2, pain intensity, physical capacity, and Fibromyalgia Impact Questionnaire between the groups; the obese group had higher blood pressure, pulse, pain intensity, and Fibromyalgia Impact Questionnaire. There were 14 proteins that contributed to the group belonging. The 4 most important proteins for the group discrimination were MIP1β, MCP4, IL1RA, and IL6, which showed higher concentrations in obese patients with FM. Significantly decreased blood flow and increased concentration of pyruvate were detected in obese patients compared with nonobese patients. There was significant correlation between inflammatory proteins and sedentary behavior and health status in obese patients with FM.</p><p><strong>Conclusions: </strong>These findings suggest that metabolism and inflammation interact in female patients with FM with obesity and might cause chronic low-grade inflammation. Screening for obesity and monitoring of BMI changes should be considered in the treatment of patients with FM.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1042"},"PeriodicalIF":4.8,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33496991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach.","authors":"Matthew C Mauck,&nbsp;Aileen F Aylward,&nbsp;Chloe E Barton,&nbsp;Brandon Birckhead,&nbsp;Timothy Carey,&nbsp;Diane M Dalton,&nbsp;Aaron J Fields,&nbsp;Julie Fritz,&nbsp;Afton L Hassett,&nbsp;Anna Hoffmeyer,&nbsp;Sara B Jones,&nbsp;Samuel A McLean,&nbsp;Wolf E Mehling,&nbsp;Conor W O'Neill,&nbsp;Michael J Schneider,&nbsp;David A Williams,&nbsp;Patricia Zheng,&nbsp;Ajay D Wasan","doi":"10.1097/PR9.0000000000001019","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001019","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic low back pain (cLBP) is highly prevalent in the United States and globally, resulting in functional impairment and lowered quality of life. While many treatments are available for cLBP, clinicians have little information about which specific treatment(s) will work best for individual patients or subgroups of patients. The Back Pain Research Consortium, part of the National Institutes of Health Helping to End Addiction Long-term^SM (HEAL) Initiative, will conduct a collaborative clinical trial, which seeks to develop a personalized medicine algorithm to optimize patient and provider treatment selection for patients with cLBP.</p><p><strong>Objective: </strong>The primary objective of this article is to provide an update on evidence-based cLBP interventions and describe the process of reviewing and selecting interventions for inclusion in the clinical trial.</p><p><strong>Methods: </strong>A working group of cLBP experts reviewed and selected interventions for inclusion in the clinical trial. The primary evaluation measures were strength of evidence and magnitude of treatment effect. When available in the literature, duration of effect, onset time, carryover effect, multimodal efficacy, responder subgroups, and evidence for the mechanism of treatment effect or biomarkers were considered.</p><p><strong>Conclusion: </strong>The working group selected 4 leading, evidence-based treatments for cLBP to be tested in the clinical trial and for use in routine clinical treatment. These treatments include (1) duloxetine, (2) acceptance and commitment therapy, (3) a classification-based exercise and manual therapy intervention, and (4) a self-management approach. These interventions each had a moderate to high level of evidence to support a therapeutic effect and were from different therapeutic classes.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1019"},"PeriodicalIF":4.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/af/painreports-7-e1019.PMC9529058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33492407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study.","authors":"Mika Jönsson,&nbsp;Emmanuel Bäckryd,&nbsp;Lena Jonasson,&nbsp;Björn Gerdle,&nbsp;Bijar Ghafouri","doi":"10.1097/PR9.0000000000001036","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001036","url":null,"abstract":"<p><strong>Introduction: </strong>Little is still known about the underlying mechanisms that drive and maintain neuropathic pain (NeuP). Recently, lipids have been implicated as endogenous proalgesic ligands affecting onset and maintenance of pain; however, in the case of NeuP, the relationship is largely unexplored.</p><p><strong>Objectives: </strong>The aim of this study was to investigate the lipoprotein profile in patients with chronic peripheral NeuP compared with healthy controls.</p><p><strong>Methods: </strong>The concentrations of 112 lipoprotein fractions in plasma from patients with NeuP (n = 16) and healthy controls (n = 13) were analyzed using proton nuclear magnetic resonance spectroscopy. A multiplex immunoassay based on an electrochemiluminescent detection method was used to measure the concentration of 71 cytokines in plasma from patients with NeuP (n = 10) and healthy controls (n = 11). Multivariate data analysis was used to identify patterns of protein intercorrelations and proteins significant for group discrimination.</p><p><strong>Results: </strong>We found 23 lipoproteins that were significantly upregulated in patients with NeuP compared with healthy controls. When the influence of cytokines was included in a regression model, 30 proteins (8 cytokines and 22 lipoprotein fractions) were significantly upregulated or downregulated in patients with NeuP. Both conditions presented lipoprotein profiles consistent with inflammation. Body mass index did not affect lipoprotein profiles in either group. No relationship between age and lipoprotein pattern was found in NeuP, but a significant relationship was found in healthy controls.</p><p><strong>Conclusion: </strong>Patients with NeuP presented a lipoprotein profile consistent with systemic low-grade inflammation, like that seen in autoimmune, cardiometabolic, and neuroprogressive diseases. These preliminary results emphasize the importance of chronic low-grade inflammation in NeuP.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1036"},"PeriodicalIF":4.8,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33492408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year mixed-method evaluation of prelicensure health professional student self-reported learning in an interfaculty pain curriculum.","authors":"Craig M Dale,&nbsp;Iacopo Cioffi,&nbsp;Laura Murphy,&nbsp;Sylvia Langlois,&nbsp;Renata Musa,&nbsp;Bonnie Stevens","doi":"10.1097/PR9.0000000000001030","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001030","url":null,"abstract":"<p><strong>Introduction: </strong>Student perspectives on interprofessional pain education are lacking.</p><p><strong>Objectives: </strong>The purpose of this study was to evaluate ratings of knowledge acquisition and effective presentation methods for prelicensure health professional students attending the University of Toronto Centre for the Study of Pain Interfaculty Pain Curriculum (Canada).</p><p><strong>Methods: </strong>A 10-year (2009-2019) retrospective longitudinal mixed-methods approach comprising analysis and integration of quantitative and qualitative data sets was used to evaluate 5 core University of Toronto Centre for the Study of Pain Interfaculty Pain Curriculum learning sessions.</p><p><strong>Results: </strong>A total of 10, 693 students were enrolled (2009-2019) with a mean annual attendance of 972 students (±SD:102). The mean proportion of students rating \"agree/strongly agree\" for knowledge acquisition and effective presentation methods across sessions was 79.3% (±SD:3.4) and 76.7% (±SD:6.0), respectively. Knowledge acquisition or presentation effectiveness scores increased, respectively, over time for 4 core sessions: online self-study pain mechanisms module (<i>P</i> = 0.03/<i>P</i> < 0.001), online self-study opioids module (<i>P</i> = 0.04/<i>P</i> = 0.019), individually selected in-person topical pain sessions (<i>P</i> = 0.03/<i>P</i> < 0.001), and in-person patient or interprofessional panel session (<i>P</i> = 0.03). Qualitative data corroborated rating scores and expanded insight into student expectations for knowledge acquisition to inform real-world clinical practice and interprofessional collaboration; presentation effectiveness corresponded with smaller session size, individually selected sessions, case-based scenarios, embedded knowledge appraisal, and opportunities to meaningfully interact with presenters and peers.</p><p><strong>Conclusion: </strong>This study demonstrated positive and increasing prelicensure student ratings of knowledge acquisition and effective presentation methods across multifaceted learning sessions in an interfaculty pain curriculum. This study has implications for pain curriculum design aimed at promoting students' collaborative, patient-centered working skills.<b>See commentary:</b> Trouvin A-P. \"Ten-year mixed method evaluation of prelicensure health professional student self-reported learning in an interfaculty pain curriculum\": a view on pain education. PAIN Rep 2022;7:e1031.Students attending learning sessions at the University of Toronto Interfaculty Pain Curriculum (2009-2019) in Toronto, Canada, self-report high ratings of knowledge acquisition and effective presentation methods.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1030"},"PeriodicalIF":4.8,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40372590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dropped head syndrome: report of a rare complication after multilevel bilateral cervical radiofrequency neurotomy.","authors":"Harnek S Bajaj,&nbsp;Andrew W Chapman","doi":"10.1097/PR9.0000000000001037","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001037","url":null,"abstract":"<p><strong>Introduction: </strong>Cervical radiofrequency neurotomy is a safe and relatively low-risk procedure commonly used to treat facet joint-mediated axial neck pain. Severe complications are extremely rare and can be avoided with proper technique and appropriate imaging guidance. This article describes the development and subsequent management of a case of dropped head syndrome after cervical radiofrequency neurotomy.</p><p><strong>Methods: </strong>A 77-year-old man with cervicalgia, multilevel facet arthropathy, and a known kyphosis in the setting of cervical degenerative disk disease underwent successful conventional radiofrequency neurotomy to the bilateral C3, C4, and C5 medial branches. No immediate complications were noted.</p><p><strong>Results: </strong>Six weeks subsequent to the procedure, the patient reported difficulty keeping his head erect, and physical examination revealed weakness of the cervical paraspinal musculature, with restriction of active extension to about neutral. A diagnosis of dropped head syndrome was made. The patient was successfully managed with temporary use of soft cervical collar and physical therapy for progressive range of motion and strengthening.</p><p><strong>Discussion: </strong>Dropped head syndrome is a known, but likely underappreciated, complication of cervical radiofrequency neurotomy, with only 2 other cases reported and published in the literature to our knowledge. Mild cases may resolve with conservative management, but this is a potentially debilitating condition that we recommend should be routinely discussed during procedural consent for cervical radiofrequency neurotomy. Future studies should explore specific mitigating factors to reduce the risk of development of this possible complication.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1037"},"PeriodicalIF":4.8,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9478223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40372592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-OPerative Pain Management, Education & De-escalation (POPPMED), a novel anaesthesiologist-led program, significantly reduces acute and long-term postoperative opioid requirements: a retrospective cohort study.","authors":"Charlotte Heldreich,&nbsp;Ilonka Meyer,&nbsp;Esther Dube,&nbsp;Raymond Hu,&nbsp;William Howard,&nbsp;Natasha Holmes,&nbsp;Nada Maroon,&nbsp;Laurence Weinberg,&nbsp;Chong O Tan","doi":"10.1097/PR9.0000000000001028","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001028","url":null,"abstract":"<p><strong>Introduction: </strong>The opioid tolerant patient requiring surgery is highly likely to be discharged on high Oral Morphine Equivalent Daily Dosages (OMEDDs), with concomitant risk of increased morbidity and mortality.</p><p><strong>Objectives: </strong>We proposed that a single anaesthesiologist-led POPPMED (Peri-Operative Pain Management, Education & De-escalation) service could reduce both short and long-term postoperative patient OMEDDs.</p><p><strong>Methods: </strong>From April 2017, our anaesthesiologist-led POPPMED service, engaged 102 perioperative patients treated with >50mg preoperative OMEDDs. We utilized behavioural interventions; acute opioid reduction and/ or rotation; and regional, multimodal and ketamine analgesia to achieve lowest possible hospital discharge and long term OMEDDs.</p><p><strong>Results: </strong>Patients' preoperative OMEDDs were [median (IQR): 115mg (114mg)], and were representative of an older [age 62 (15) years], high-risk [89% ASA status 3 or 4] patient population. 46% of patients received an acute opioid rotation; 70% received ketamine infusions; and 44% regional analgesia. OMEDDs on discharge [-25mg (82mg), <i>p</i>=0.003] and at 6-12 months [-55mg (105mg ), <i>p</i><0.0001] were significantly reduced; 84% and 87% of patients achieved OMEDD reduction on discharge and at 6-12 months. Patients with >90mg preoperative OMEDDs achieved greater reductions [discharge: 71% of patients, -52 mg (118 mg) <i>p</i><0.0001; 6-12 months: 90% of patients, -90mg (115mg), <i>p</i><0.0001]. On comparison with a pre-POPPMED surgical cohort, Postoperative Day 1-3 11-point Numerical Rating Scale (NRS-11) area under the curve (AUC) measurements at rest and on movement were not significantly different (largest NRS-11:hours AUC difference [median(IQR)] 22 [13], <i>p</i>= 0.24). Hospital length of stay was variably increased.</p><p><strong>Conclusions: </strong>POPPMED achieved sustained OMEDD reductions safely in an older, high-risk opioid tolerant population, with analgesia comparable to a non-POPPMED cohort, and surgery specific effects on length of stay.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1028"},"PeriodicalIF":4.8,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/42/painreports-7-e1028.PMC9400930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33444386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital rehabilitation for hand and wrist pain: a single-arm prospective longitudinal cohort study.","authors":"Fabíola Costa,&nbsp;Dora Janela,&nbsp;Maria Molinos,&nbsp;Robert G Moulder,&nbsp;Jorge Lains,&nbsp;Gerard E Francisco,&nbsp;Virgílio Bento,&nbsp;Vijay Yanamadala,&nbsp;Steven P Cohen,&nbsp;Fernando Dias Correia","doi":"10.1097/PR9.0000000000001026","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001026","url":null,"abstract":"Supplemental Digital Content is Available in the Text. This study supports that a fully remote digital care program is feasible and able to promote high patient engagement in the telerehabilitation of patients with wrist and hand pain. Abstract Introduction: Wrist and hand represent the third most common body part in work-related injuries, being associated with long-term absenteeism. Telerehabilitation can promote access to treatment, patient adherence, and engagement, while reducing health care–related costs. Objective: Report the results of a fully remote digital care program (DCP) for wrist and hand pain (WP). Methods: A single-arm interventional study was conducted on individuals with WP applying for a DCP. Primary outcome was the mean change in the Numerical Pain Rating Scale after 8 weeks (considering a minimum clinically important change of 30%). Secondary outcomes were: disability (Quick Disabilities of the Arm, Shoulder, and Hand questionnaire), analgesic intake, surgery intention, mental health (patient health questionnaire [PHQ-9] and generalized anxiety disorder [GAD-7]), fear-avoidance beliefs (FABQ-PA), work productivity and activity impairment, and engagement. Results: From 189 individuals starting the DCP, 149 (78.8%) completed the intervention. A significant pain improvement was observed (51.3% reduction (2.26, 95% CI 1.73; 2.78)) and 70.4% of participants surpassing minimum clinically important change. This change correlated with improvements in disability (52.1%), FABQ-PA (32.2%), and activities impairment recovery (65.4%). Improvements were also observed in other domains: surgery intent (76.1%), mental health (67.0% in anxiety and 72.7% in depression), and overall productivity losses (68.2%). Analgesic intake decreased from 22.5% to 7.1%. Mean patient satisfaction score was 8.5/10.0 (SD 1.8). Conclusions: These findings support the feasibility and utility of a fully remote DCP for patients with WP. Clinically significant improvements were observed in all health-related and productivity-related outcomes, alongside very high patient adherence rates and satisfaction. This study strengthens that management of WP is possible through a remote DCP, decreasing access barriers and potentially easing health care expenditure.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":" ","pages":"e1026"},"PeriodicalIF":4.8,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/90/painreports-7-e1026.PMC9394689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40416872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-specific genes contribute to chronic but not to acute back pain.","authors":"Andrey V Bortsov, Marc Parisien, Samar Khoury, Amy E Martinsen, Marie Udnesseter Lie, Ingrid Heuch, Kristian Hveem, John-Anker Zwart, Bendik S Winsvold, Luda Diatchenko","doi":"10.1097/PR9.0000000000001018","DOIUrl":"10.1097/PR9.0000000000001018","url":null,"abstract":"<p><strong>Introduction: </strong>Back pain is the leading cause of disability worldwide. Although most back pain cases are acute, 20% of acute pain patients experience chronic back pain symptoms. It is unclear whether acute pain and chronic pain have similar or distinct underlying genetic mechanisms.</p><p><strong>Objectives: </strong>To characterize the molecular and cellular pathways contributing to acute and chronic pain states.</p><p><strong>Methods: </strong>Cross-sectional observational genome-wide association study.</p><p><strong>Results: </strong>A total of 375,158 individuals from the UK Biobank cohort were included in the discovery of genome-wide association study. Of those, 70,633 (19%) and 32,209 (9%) individuals met the definition of chronic and acute back pain, respectively. A total of 355 single nucleotide polymorphism grouped into 13 loci reached the genome-wide significance threshold (5x10^-8) for chronic back pain, but none for acute. Of these, 7 loci were replicated in the Nord-Trøndelag Health Study (HUNT) cohort (19,760 chronic low back pain cases and 28,674 pain-free controls). Single nucleotide polymorphism heritability was 4.6% (P=1.4x10^-78) for chronic back pain and 0.81% (P=1.4x10-8) for acute back pain. Similar differences in heritability estimates between acute and chronic back pain were found in the HUNT cohort: 3.4% (P=0.0011) and 0.6% (P=0.851), respectively. Pathway analyses, tissue-specific heritability enrichment analyses, and epigenetic characterization suggest a substantial genetic contribution to chronic but not acute back pain from the loci predominantly expressed in the central nervous system.</p><p><strong>Conclusion: </strong>Chronic back pain is substantially more heritable than acute back pain. This heritability is mostly attributed to genes expressed in the brain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"7 5","pages":"e1018"},"PeriodicalIF":3.4,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/91/painreports-7-e1018.PMC9371560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Remote management of musculoskeletal pain: a pragmatic approach to the implementation of video and phone consultations in musculoskeletal practice: Erratum.","authors":"","doi":"10.1097/PR9.0000000000001022","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001022","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/PR9.0000000000000878.].</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"7 4","pages":"e1022"},"PeriodicalIF":4.8,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/c2/painreports-7-e1022.PMC9281950.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40580151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}