Pain Reports最新文献

Postsurgical tactile-evoked pain: a role for brain-derived neurotrophic factor-tropomyosin receptor kinase B–dependent novel tactile corpuscles 手术后触觉诱发痛：脑源性神经营养因子-肌球蛋白受体激酶 B 依赖性新型触觉团的作用

IF 3.4

Pain Reports Pub Date : 2024-08-08 DOI: 10.1097/pr9.0000000000001169

Kirsten Wilson, Ying Sze, Anna Regan, Chunyi Zhu, Katarzyna Mazur, Atanaska Velichkova, Carole Torsney

{"title":"Postsurgical tactile-evoked pain: a role for brain-derived neurotrophic factor-tropomyosin receptor kinase B–dependent novel tactile corpuscles","authors":"Kirsten Wilson, Ying Sze, Anna Regan, Chunyi Zhu, Katarzyna Mazur, Atanaska Velichkova, Carole Torsney","doi":"10.1097/pr9.0000000000001169","DOIUrl":"https://doi.org/10.1097/pr9.0000000000001169","url":null,"abstract":"\u0000 \u0000 \u0000 Millions of people undergo surgical procedures each year with many developing postsurgical pain. Dynamic allodynia can arise when, for example, clothing brushing close to the surgical site elicits pain. The allodynia circuits that enable crosstalk between afferent tactile inputs and central pain circuits have been studied, but the peripheral tactile drive has not been explored.\u0000 \u0000 \u0000 \u0000 Investigate the innervation of the skin in the rat plantar hindpaw skin–muscle incision model.\u0000 \u0000 \u0000 \u0000 Incision increased epidermal thickness and cell layers and reduced intraepidermal nerve fibre density, identified with PGP9.5 immunostaining. Strikingly, Collagen IV immunostaining revealed the development of dermal protrusions, oriented towards the incision site, that were reminiscent of the dermal papillae that exist in glabrous footpads. S100 immunostaining for lamellar Schwann cells revealed the presence of novel tactile corpuscles (S100-positive bulb) within incision-induced putative dermal papillae. The occurrence of these novel tactile corpuscles coincided with behavioural observations of dynamic allodynia. Tactile corpuscles require brain-derived neurotrophic factor- tropomyosin receptor kinase B (BDNF-TrkB) signalling to form during development, and an increase in BDNF-immunostaining intensity was observed close to the incision site. Local acute administration of TrkB-Fc, to block BDNF-TrkB signalling, reduced, by approximately 50%, both tactile corpuscle size (S100+ bulb area) and dynamic allodynia.\u0000 \u0000 \u0000 \u0000 Surgery induces the development of novel tactile corpuscles in the incision surround, in a BDNF-TrKB–dependent manner, that contributes to postsurgical tactile-evoked pain.\u0000","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of intraoperative tropisetron on postoperative rebound pain after brachial plexus block: a randomized controlled trial 评估术中托品司琼对臂丛神经阻滞术后反跳痛的影响：随机对照试验

IF 4.8

Pain Reports Pub Date : 2024-05-15 DOI: 10.1097/PR9.0000000000001163

Junli Liu, Mingming Liu, Shengnan Shi, Fei Jiang, Ye Zhang, Jing Guo, Xingrui Gong

引用次数: 0

Abstracts from the International Pelvic Pain Society (IPPS) annual scientific meeting on pelvic pain 2023 国际盆腔疼痛学会（IPPS）2023 年盆腔疼痛年度科学会议摘要

IF 4.8

Pain Reports Pub Date : 2024-05-15 DOI: 10.1097/PR9.0000000000001150

Georgine Lamvu

{"title":"Abstracts from the International Pelvic Pain Society (IPPS) annual scientific meeting on pelvic pain 2023","authors":"Georgine Lamvu","doi":"10.1097/PR9.0000000000001150","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001150","url":null,"abstract":"Introduction: Data demonstrating abnormalities in brain structure and functional connectivity have supported the notion that menstrual pain may be related to deficits in central pain processing. We aimed to investigate the role of the triple network model of brain networks implicated in psychiatric disorders in the encoding of the menstrual pain, pain interference, and lifetime burden of menstrual pain in adolescent girls. Methods: One hundred adolescent girls (ages 13–19) completed a 6-minute resting state fMRI and rated menstrual pain and menstrual pain interference. Lifetime burden of menstrual pain reflected the total number of painful menstrual periods. Thirty resting-state networks were estimated using an unsupervised machine learning method for group independent component analysis. Networks of interest included cingulo-opercular salience (SN), central executive (CEN), and default mode (DMN) networks. Dual regression was used to extract subject-specific network maps corresponding to each a priori network. FSL Randomise was used for the estimation of general linear models and inference to test associations between network connectivity and menstrual pain measures ( P , 0.05 corrected). Results: Greater connectivity of SN with amygdala, CEN with lateral orbitofrontal cortex, and CEN with anterior insula was associated with higher menstrual pain. Higher pain interference was associated with greater connectivity between SN and widespread brain areas that share overlap with DMN and CEN. By contrast, higher lifetime burden was associated with reduced connectivity within DMN. Disclosure: Any of the authors act as a consultant, employee, or shareholder of an industry for: Bayer Healthcare, Mahana Therapeutics.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampus diffusivity abnormalities in classical trigeminal neuralgia 典型三叉神经痛的海马扩散异常

IF 4.8

Pain Reports Pub Date : 2024-04-19 DOI: 10.1097/PR9.0000000000001159

Shaun A Hanycz, Alborz Noorani, P. Hung, M. Walker, Ashley B Zhang, Timur H. Latypov, Mojgan Hodaie

引用次数: 0

Reframing pain: the power of individual and societal factors to enhance pain treatment 重塑疼痛：个人和社会因素对加强疼痛治疗的作用

IF 4.8

Pain Reports Pub Date : 2024-04-19 DOI: 10.1097/PR9.0000000000001161

Rebeccah Slater, Christopher Eccleston, Amanda Williams, Katy Vincent, Mattias Linde, Michael Hurley, William Laughey

引用次数: 0

A domain-oriented approach to characterizing movement-evoked pain 以领域为导向的运动诱发疼痛特征描述方法

IF 4.8

Pain Reports Pub Date : 2024-04-17 DOI: 10.1097/PR9.0000000000001158

J. A. Crow, Verlin Joseph, Guanhong Miao, B. Goodin, K. Sibille, J. Cardoso, Emily J. Bartley, Roland Staud, Roger B. Fillingim, Staja Q. Booker

引用次数: 0

Integrated pain care models and the importance of aligning stakeholder values 综合疼痛护理模式和协调利益相关者价值观的重要性

IF 4.8

Pain Reports Pub Date : 2024-04-17 DOI: 10.1097/PR9.0000000000001160

W. M. Hooten, Miroslav Bačkonja, Kayode A. Williams, John A. Sturgeon, Jacob B. Gross, Sergey Borodianski, Victor Wang, Wen-Jan Tuan, Aleksandra E Zgierska, Tobias Moeller-Bertram, Michael L. Kriegel

引用次数: 0

Investigating the fluctuating nature of post-COVID pain symptoms in previously hospitalized COVID-19 survivors: the LONG-COVID-EXP multicenter study 调查曾住院治疗的 COVID-19 幸存者 COVID 后疼痛症状的波动性：LONG-COVID-EXP 多中心研究

IF 4.8

Pain Reports Pub Date : 2024-04-17 DOI: 10.1097/PR9.0000000000001153

C. Fernández‐de‐las‐Peñas, Oscar J. Pellicer-Valero, J. Martín-Guerrero, Valentín Hernández-Barrera, L. Arendt-Nielsen

引用次数: 0

Non-obese lipedema patients show a distinctly altered quantitative sensory testing profile with high diagnostic potential 非肥胖型脂肪性水肿患者的定量感官测试结果有明显改变，具有很高的诊断潜力

IF 4.8

Pain Reports Pub Date : 2024-04-11 DOI: 10.1097/PR9.0000000000001155

R. Dinnendahl, D. Tschimmel, Vanessa Löw, Manuel Cornely, Tim Hucho

引用次数: 0

Abstracts from the International Pelvic Pain Society (IPPS) annual scientific meeting on pelvic pain 2022 国际骨盆疼痛学会（IPPS）2022 年骨盆疼痛年度科学会议摘要

IF 4.8

Pain Reports Pub Date : 2024-04-11 DOI: 10.1097/PR9.0000000000001130

Grigol Bardin, M. B. Morin

{"title":"Abstracts from the International Pelvic Pain Society (IPPS) annual scientific meeting on pelvic pain 2022","authors":"Grigol Bardin, M. B. Morin","doi":"10.1097/PR9.0000000000001130","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001130","url":null,"abstract":"System—Gynecology section Introduction: The intrauterine device (IUD) is an efficacious, long-acting, reversible contraceptive method that can be used to treat dysmenorrhea and heavy menses. Studies have shown that women experience moderate levels of pain at the time of IUD insertion and that they may decline IUD insertion due to fears of pain. Previous investigations regarding the efficacy of oral analgesics for IUD insertion pain have conflicting results. We hypothesize that a multidose ibuprofen regimen given 24-hours before the insertion of IUD can provide pain relief. Methods: This is a prospective, triple-blind, placebo-controlled study that assesses pain levels with a 10-point visual analog scale (VAS) during speculum insertion, tenaculum insertion, IUD insertion, and 24 hours after insertion. Pain methods used 24 hours after insertion were also assessed. We performed an interval analysis of 27 patients who have completed the trial, without breaking the randomization sequence as enrollment is still ongoing. Results: There is a significant difference in IUD insertion pain scores between multidose ibuprofen group and a placebo group (Group A mean 6.8, SD 1.7, Group B mean 4.3, SD 2.9, P 5 0.01). There was no difference in pain scores at any other time point. Despite a higher pain score at the time of insertion, more women in Group A than in Group B used no pain medications after insertion ( P 5 0.03). Conclusions: There is a difference in pain scores at the time of IUD insertion; however, due to ongoing randomization, we do not know whether it is less in women who took ibuprofen or placebo. Disclosure: Any of the authors","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140713858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0