Pain Reports最新文献

{"title":"Complex Regional Pain Syndrome: a cross-sectional study of physical symptoms, disability, and psychological health in long term.","authors":"Ellen Lyckegård Finn, Astrid Parinder, Erika Nyman, Lars B Dahlin","doi":"10.1097/PR9.0000000000001180","DOIUrl":"10.1097/PR9.0000000000001180","url":null,"abstract":"<p><strong>Introduction: </strong>Knowledge about long-time residual symptoms, disabilities, and psychological health in complex regional pain syndrome (CRPS) is limited.</p><p><strong>Objectives: </strong>The aim was to evaluate outcome, focusing on physical symptoms, disability, and psychological health, in individuals with CRPS through a cross-sectional survey study.</p><p><strong>Methods: </strong>Individuals with a confirmed diagnosis of CRPS were identified through medical charts and sent validated survey forms (Disabilities of the Arm, Shoulder and Hand-Quick version, Specific Hand Surgery Questionnaire-8 questions, EuroQol 5 Dimensions 3 levels, Life Satisfaction Questionnaire-11, Hospital Anxiety and Depression Scale, Pain Catastrophizing Scale, and Sense of Coherence-29) and complementary questions.</p><p><strong>Results: </strong>Responders (response rate: 99/238, 42%; CRPS type 1: 72%; CRPS type 2: 28%; time since diagnosis median: 59 [34-94] months) reported remaining symptoms and disability (Disabilities of the Arm, Shoulder and Hand-Quick version score: 45 [20-70]) and more improvement in type 1 than in type 2. Only 9% of individuals with CRPS reported no residual pain or discomfort. Approximately 60% had problems in daily activities, 49% had sleeping problems, and 90% experienced moderate-extreme pain with 23% still on sick leave. The Hospital Anxiety and Depression Scale survey revealed significantly higher scores than a Swedish reference population. Individuals with a low Sense of Coherence and high pain catastrophizing had worse disability and were less satisfied with their lives and physical and psychological health. A lower level of education and more anxiety were associated with worsened disability over time.</p><p><strong>Conclusion: </strong>Individuals with CRPS suffer in the long term from pain, sleeping problems, and limitations in daily activities with occurrence of anxiety and depression, resulting in dissatisfaction with many aspects of their lives. A low Sense of Coherence and high pain catastrophizing are associated with a worse outcome. Biopsychosocial aspects should be addressed in clinical practice.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained nerve growth factor-induced C-nociceptor sensitization to electrical sinusoidal stimulation in humans.","authors":"Hans Jürgen Solinski, Martin Schmelz, Roman Rukwied","doi":"10.1097/PR9.0000000000001190","DOIUrl":"10.1097/PR9.0000000000001190","url":null,"abstract":"<p><strong>Introduction: </strong>Injection of recombinant human nerve growth factor (rhNGF) evokes acute heat and prolonged \"polymodal\" (mechanosensitive [CM]) and \"silent\" (mechano<i>in</i>sensitive [CMi]) C-nociceptor sensitization. Both nociceptor classes can be activated differentially using slowly depolarizing electrical sinusoidal stimuli.</p><p><strong>Objectives: </strong>To explore the temporal profile of nociceptor sensitization to heat and mechanical and electrical stimuli in humans after rhNGF.</p><p><strong>Methods: </strong>Recombinant human nerve growth factor (1 µg) and NaCl (0.9%) was injected into human forearm skin (n = 9, 50 µL/injection). Pain ratings (numeric rating scale) to transcutaneous electrical stimuli (1 ms 20 Hz rectangular pulses, 500-ms half-period sine wave [1 Hz] and 4 Hz sine wave pulses [2.5 and 60 seconds]) were assessed at days 3, 21, and 49 after injection, in addition to heat pain thresholds (HPTs, 9 × 9 mm thermode) and mechanical impact pain (4 and 8 m/second).</p><p><strong>Results: </strong>Suprathreshold sinusoidal stimulation for specific CM (1 Hz) and combined CM and CMi (4 Hz) activation resulted in enhanced pain from day 3 post rhNGF and lasted throughout 7 weeks. These temporal dynamics contrasted minimum HPTs at day 3 (normalized by day 49) or mechanical impact pain (developing slowly until day 21 before declining depending on stimulus intensity). Correlation analyses of electrical pain indicated diverging kinetics when assessed for CM with or without concomitant CMi activation at days 3 and 21, which converged 7 weeks post rhNGF.</p><p><strong>Conclusions: </strong>Exceptionally long sensitization of CM and CMi nociceptors by rhNGF, uncovered by suprathreshold electrical sinusoidal stimulation, indicates a signal transduction-independent long-lasting hyperexcitability of C-nociceptors that clinically may contribute to rhNGF-maintained chronic inflammatory pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight, height, waist circumference: association with knee osteoarthritis findings from the osteoarthritis initiative.","authors":"Lisa H Antoine, Kristen Allen Watts, Deanna D Rumble, Taylor Buchanan, Andrew Sims, Burel R Goodin","doi":"10.1097/PR9.0000000000001187","DOIUrl":"10.1097/PR9.0000000000001187","url":null,"abstract":"<p><strong>Introduction: </strong>Global prevalence of knee osteoarthritis is more than 300 million. Uncontrollable risk factors include age, sex, and height. Controllable risk factors include trauma, weight, and waist circumference.</p><p><strong>Objectives: </strong>Our goal was to determine the association between knee osteoarthritis and anthropometric measures that include weight, height, and waist circumference.</p><p><strong>Methods: </strong>Using 4,602 participants (45-79 years) from the Osteoarthritis Initiative, we analyzed the association between knee osteoarthritis and anthropometry collectively and by sex. We calculated female and male tertiles (3 groups) for anthropometry.</p><p><strong>Results: </strong>Anthropometric measures were correlated with knee osteoarthritis (<i>P</i> ≤ 0.05) except the correlation between height and activities and height and quality of life. When comparing female weight tertiles, there were associations (<i>P</i>'s < 0.001) between knee osteoarthritis and weight, but when comparing male weight tertiles, these associations were primarily between the lowest weight and highest weight groups. There were significant associations between knee osteoarthritis and height among female tertiles, with no differences among male tertiles. There were knee osteoarthritis/waist circumference tertile associations (<i>P</i>'s < 0.001) for the lowest and highest waist circumference groups.</p><p><strong>Conclusion: </strong>Higher weight in female participants was a stronger predictor of increases in knee osteoarthritis discomforts when compared to waist circumference, while weight and waist circumference were almost equivalent in predicting increases in knee osteoarthritis for male participants. Height did not predict increases in knee osteoarthritis with the exception of female symptoms and quality of life. Quality of life for both sexes was the most unfavorable with female participants reporting a more unfavorable quality of life than male participants.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postsurgical tactile-evoked pain: a role for brain-derived neurotrophic factor-tropomyosin receptor kinase B–dependent novel tactile corpuscles","authors":"Kirsten Wilson, Ying Sze, Anna Regan, Chunyi Zhu, Katarzyna Mazur, Atanaska Velichkova, Carole Torsney","doi":"10.1097/pr9.0000000000001169","DOIUrl":"https://doi.org/10.1097/pr9.0000000000001169","url":null,"abstract":"\u0000 \u0000 \u0000 Millions of people undergo surgical procedures each year with many developing postsurgical pain. Dynamic allodynia can arise when, for example, clothing brushing close to the surgical site elicits pain. The allodynia circuits that enable crosstalk between afferent tactile inputs and central pain circuits have been studied, but the peripheral tactile drive has not been explored.\u0000 \u0000 \u0000 \u0000 Investigate the innervation of the skin in the rat plantar hindpaw skin–muscle incision model.\u0000 \u0000 \u0000 \u0000 Incision increased epidermal thickness and cell layers and reduced intraepidermal nerve fibre density, identified with PGP9.5 immunostaining. Strikingly, Collagen IV immunostaining revealed the development of dermal protrusions, oriented towards the incision site, that were reminiscent of the dermal papillae that exist in glabrous footpads. S100 immunostaining for lamellar Schwann cells revealed the presence of novel tactile corpuscles (S100-positive bulb) within incision-induced putative dermal papillae. The occurrence of these novel tactile corpuscles coincided with behavioural observations of dynamic allodynia. Tactile corpuscles require brain-derived neurotrophic factor- tropomyosin receptor kinase B (BDNF-TrkB) signalling to form during development, and an increase in BDNF-immunostaining intensity was observed close to the incision site. Local acute administration of TrkB-Fc, to block BDNF-TrkB signalling, reduced, by approximately 50%, both tactile corpuscle size (S100+ bulb area) and dynamic allodynia.\u0000 \u0000 \u0000 \u0000 Surgery induces the development of novel tactile corpuscles in the incision surround, in a BDNF-TrKB–dependent manner, that contributes to postsurgical tactile-evoked pain.\u0000","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141929210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of intraoperative tropisetron on postoperative rebound pain after brachial plexus block: a randomized controlled trial","authors":"Junli Liu, Mingming Liu, Shengnan Shi, Fei Jiang, Ye Zhang, Jing Guo, Xingrui Gong","doi":"10.1097/PR9.0000000000001163","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001163","url":null,"abstract":"Tropisetron does not affect the incidence of rebound pain; patient-controlled analgesia with opioids could be considered for rebound pain management after peripheral nerve block.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the International Pelvic Pain Society (IPPS) annual scientific meeting on pelvic pain 2023","authors":"Georgine Lamvu","doi":"10.1097/PR9.0000000000001150","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001150","url":null,"abstract":"Introduction: Data demonstrating abnormalities in brain structure and functional connectivity have supported the notion that menstrual pain may be related to deficits in central pain processing. We aimed to investigate the role of the triple network model of brain networks implicated in psychiatric disorders in the encoding of the menstrual pain, pain interference, and lifetime burden of menstrual pain in adolescent girls. Methods: One hundred adolescent girls (ages 13–19) completed a 6-minute resting state fMRI and rated menstrual pain and menstrual pain interference. Lifetime burden of menstrual pain reflected the total number of painful menstrual periods. Thirty resting-state networks were estimated using an unsupervised machine learning method for group independent component analysis. Networks of interest included cingulo-opercular salience (SN), central executive (CEN), and default mode (DMN) networks. Dual regression was used to extract subject-specific network maps corresponding to each a priori network. FSL Randomise was used for the estimation of general linear models and inference to test associations between network connectivity and menstrual pain measures ( P , 0.05 corrected). Results: Greater connectivity of SN with amygdala, CEN with lateral orbitofrontal cortex, and CEN with anterior insula was associated with higher menstrual pain. Higher pain interference was associated with greater connectivity between SN and widespread brain areas that share overlap with DMN and CEN. By contrast, higher lifetime burden was associated with reduced connectivity within DMN. Disclosure: Any of the authors act as a consultant, employee, or shareholder of an industry for: Bayer Healthcare, Mahana Therapeutics.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampus diffusivity abnormalities in classical trigeminal neuralgia","authors":"Shaun A Hanycz, Alborz Noorani, P. Hung, M. Walker, Ashley B Zhang, Timur H. Latypov, Mojgan Hodaie","doi":"10.1097/PR9.0000000000001159","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001159","url":null,"abstract":"Patients with trigeminal neuralgia have microstructural abnormalities in the hippocampus and its subfields demonstrated by reduced fractional anisotropy.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing pain: the power of individual and societal factors to enhance pain treatment","authors":"Rebeccah Slater, Christopher Eccleston, Amanda Williams, Katy Vincent, Mattias Linde, Michael Hurley, William Laughey","doi":"10.1097/PR9.0000000000001161","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001161","url":null,"abstract":"The effectiveness of analgesics can be increased if synergistic behavioural, psychological, and pharmacological interventions are provided within a supportive environment.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A domain-oriented approach to characterizing movement-evoked pain","authors":"J. A. Crow, Verlin Joseph, Guanhong Miao, B. Goodin, K. Sibille, J. Cardoso, Emily J. Bartley, Roland Staud, Roger B. Fillingim, Staja Q. Booker","doi":"10.1097/PR9.0000000000001158","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001158","url":null,"abstract":"Supplemental Digital Content is Available in the Text. Weighted Correlation Network Analysis identified mechanical factors and pain modulation to be the most relevant to movement-evoked pain. More research should explicate other biopsychosocial characteristics.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated pain care models and the importance of aligning stakeholder values","authors":"W. M. Hooten, Miroslav Bačkonja, Kayode A. Williams, John A. Sturgeon, Jacob B. Gross, Sergey Borodianski, Victor Wang, Wen-Jan Tuan, Aleksandra E Zgierska, Tobias Moeller-Bertram, Michael L. Kriegel","doi":"10.1097/PR9.0000000000001160","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001160","url":null,"abstract":"Sustained widespread deployment of clinically and cost-effective models of integrated pain care could be bolstered by optimally aligning shared stakeholder values.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}