Pain Reports最新文献

{"title":"Higher self-perceived stress reactivity is associated with increased chronic pain risk.","authors":"Brandon L Boring,&nbsp;Alison Richter,&nbsp;Vani A Mathur","doi":"10.1097/PR9.0000000000001068","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001068","url":null,"abstract":"<p><strong>Introduction: </strong>Experiencing stress can contribute to unfavorable pain experiences, but outcomes vary across individuals. Evidence suggests that a person's specific reactivity to stressful events may influence pain responses. Previous studies measuring physiological stress reactivity have found associations with pain both clinically and in the laboratory. However, the time and cost required for testing physiological stress reactivity may limit clinical application.</p><p><strong>Objective: </strong>Self-reported perception of one's own stress reactivity has been shown to correlate with physiological stress reactivity in relation to health outcomes and may represent a valuable tool in clinical pain assessment.</p><p><strong>Methods: </strong>Using data from the Midlife in the US survey, we selected participants who did not have chronic pain at baseline (n = 1512) and who had data at follow-up 9 years later. Stress reactivity was assessed using a subscale of the Multidimensional Personality Questionnaire. We conducted a binary logistic regression to determine the odds of developing chronic pain, controlling for demographics and other health-related variables.</p><p><strong>Results: </strong>Results indicate that higher reported stress reactivity at baseline increased the odds of developing chronic pain at follow-up (odds ratio (OR) = 1.085, 95% confidence interval (CI) (1.021, 1.153), <i>P</i> = 0.008), with the only other significant predictor being the number of chronic conditions (OR = 1.118, 95% CI (1.045, 1.197), <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Findings provide evidence for the predictive criterion validity of self-reported stress reactivity in the context of chronic pain risk. More generally, with increased need for virtual assessment and care, self-reported stress reactivity may be a useful, time-efficient, and cost-efficient tool for predicting pain outcomes in research and clinical contexts.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 2","pages":"e1068"},"PeriodicalIF":4.8,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/ef/painreports-8-e1068.PMC10036055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non-glutamate-dependent hyperalgesia.","authors":"Marina Ayres Delgado,&nbsp;Luana Assis Ferreira,&nbsp;Bianka Jaciara Dos Santos Gomes,&nbsp;Isis Katarine Orlandi Leite,&nbsp;Marcus Vinícius Gomez,&nbsp;Célio Castro-Junior","doi":"10.1097/PR9.0000000000001062","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001062","url":null,"abstract":"<p><strong>Introduction: </strong>Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon in which exposure to opioids can increase sensitivity to painful stimuli. Currently, several drugs have been used in an attempt to prevent OIH. We design this study to address the effect of preemptive treatment with ketamine, lidocaine, and ascorbic acid in a rat preclinical model of perioperative opioid-induced hyperalgesia.</p><p><strong>Methods: </strong>To reproduce OIH in a model of postoperative pain, rats received successive doses of fentanyl subcutaneously and underwent an incision in the paw. In an attempt to prevent OIH, ketamine, lidocaine, and ascorbic acid were administered before treatment with fentanyl. The von Frey test and the hot-plate test were used to evaluate mechanical allodynia and thermal hyperalgesia, respectively, with a follow-up period from 1 hour up to 7 days after surgery. Spinal cord nerve terminals (synaptosomes) were used to assess glutamate release under our experimental conditions.</p><p><strong>Results: </strong>Consecutive fentanyl injections increased the postoperative pain as indicated by increased thermal hyperalgesia and allodynia 48 hours after incision. Ketamine, lidocaine, and the combination of ketamine + lidocaine were able to prevent thermal hyperalgesia but not mechanical allodynia. Ascorbic acid did not prevent the hyperalgesia induced by fentanyl. We found no correlation between spinal glutamate release and the pharmacological treatments.</p><p><strong>Conclusion: </strong>Fentanyl induced a hyperalgesic effect that last few days in a postoperative model of pain. Hyperalgesic effect was not totally inhibited by ketamine and lidocaine in rats. Increased glutamate release was not the main molecular mechanism of fentanyl-induced hyperalgesia.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 2","pages":"e1062"},"PeriodicalIF":4.8,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalizing digital pain management with adapted machine learning approach.","authors":"Yifat Fundoiano-Hershcovitz,&nbsp;Keren Pollak,&nbsp;Pavel Goldstein","doi":"10.1097/PR9.0000000000001065","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001065","url":null,"abstract":"<p><strong>Introduction: </strong>Digital therapeutics (DT) emerged and has been expanding rapidly for pain management. However, the efficacy of such approaches demonstrates substantial heterogeneity. Machine learning (ML) approaches provide a great opportunity for personalizing the efficacy of DT. However, the ML model accuracy is mainly associated with reduced clinical interpretability. Moreover, classical ML models are not adapted for the longitudinal nature of the DT follow-up data, which may also include nonlinear fluctuations.</p><p><strong>Objectives: </strong>This study presents an analytical framework for personalized pain management using piecewise mixed-effects model trees, considering the data dependencies, nonlinear trajectories, and boosting model interpretability.</p><p><strong>Methods: </strong>We demonstrated the implementation of the model with posture biofeedback training data of 3610 users collected during 8 weeks. The users reported their pain levels and posture quality. We developed personalized models for nonlinear time-related fluctuations of pain levels, posture quality, and weekly training duration using age, gender, and body mass index as potential moderating factors.</p><p><strong>Results: </strong>Pain levels and posture quality demonstrated strong improvement during the first 3 weeks of the training, followed by a sustained pattern. The age of the users moderated the time fluctuations in pain levels, whereas age and gender interactively moderated the trajectories in the posture quality. Train duration increased during the first 3 weeks only for older users, whereas all the users decreased the training duration during the next 5 weeks.</p><p><strong>Conclusions: </strong>This analytical framework offers an opportunity for investigating the personalized efficacy of digital therapeutics for pain management, taking into account users' characteristics and boosting interpretability and can benefit from including more users' characteristics.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 2","pages":"e1065"},"PeriodicalIF":4.8,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional study examining the epidemiology of chronic pain in Nepal.","authors":"Cassie Higgins, Saurab Sharma, Inosha Bimali, Tim G Hales, Paul A Cameron, Blair H Smith, Lesley A Colvin","doi":"10.1097/PR9.0000000000001067","DOIUrl":"10.1097/PR9.0000000000001067","url":null,"abstract":"<p><strong>Introduction: </strong>The World Health Organization recognizes chronic pain as a global public health concern; however, there is a bias towards research conducted in relatively affluent nations. There is a dearth of large-scale epidemiological studies in Nepal using rigorously validated, cross-culturally adapted instruments.</p><p><strong>Objectives: </strong>The aim of this study was to examine the prevalence of both chronic pain and chronic pain of predominantly neuropathic origin and their associations with a range of sociodemographic and psychosocial characteristics.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of adults (≥18 years) in all households in Ranipani, Baluwa Village Development Committee, Nepal. All adults (n = 887) were approached, and those consenting, who met the inclusion criteria (n = 520, 58.6%), participated. Questionnaires validated in Nepali were used to examine several constructs: demographics; chronic pain; neuropathic pain; pain catastrophizing; resilience, pain intensity; pain interference; sleep disturbance; and depression.</p><p><strong>Results: </strong>The point prevalence of chronic pain was 53.3% (n = 277). The point prevalence of chronic pain of predominantly neuropathic origin was 12.7% (n = 66). Chronic pain was associated with female gender, older age, and manual labour occupations. Using standardized scoring techniques, compared with available population estimates from other countries, those with chronic pain were associated with lower pain intensity and resilience scores and higher pain catastrophizing, pain interference, and depression scores.</p><p><strong>Conclusion: </strong>These findings are broadly comparable to epidemiological studies from other countries, and these indicate areas for targeting interventions (eg, occupational and mental health). For comparison, more data are needed, from larger population samples in this region.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 2","pages":"e1067"},"PeriodicalIF":3.4,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/a9/painreports-8-e1067.PMC9928837.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10825716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting inclusion, diversity, and equity in pain science.","authors":"Tonya M Palermo, Karen Deborah Davis, Didier Bouhassira, Robert W Hurley, Joel D Katz, Francis J Keefe, Michael Schatman, Dennis C Turk, David Yarnitsky","doi":"10.1097/PR9.0000000000001063","DOIUrl":"10.1097/PR9.0000000000001063","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1063"},"PeriodicalIF":3.4,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global series: Complex regional pain syndrome: abstracts from the International Association for the Study of Pain complex regional pain syndrome SIG virtual symposia 2021.","authors":"Jennifer S Lewis, Muhammad Kashif, Aasam Maan, Daniel Ciampi de Andrade, Michelle Casey, Jee Youn Moon, Chih-Peng Lin, Lena Danielsson, Terence Quek, Rodrigo Díez Tafur, Abdelkarim Aloweidi, Frank Birklein, Lone Knudsen, Andreas Goebel","doi":"10.1097/PR9.0000000000001056","DOIUrl":"10.1097/PR9.0000000000001056","url":null,"abstract":"<p><p>The aim of this IASP complex regional pain syndrome (CRPS) SIG Global Series 2021 was to bring together clinicians including those from developing countries to better understand the clinical presentation of complex regional pain syndrome in countries with less well-published patient populations. The purpose was to learn from each other about the range of treatments, successful outcomes, and challenges experienced. These meeting proceedings comprise abstracts from nine countries that span 4 continents and are summaries of online presentations delivered by speakers representing these countries over the course of 2 symposia. The symposia were attended by a global audience of approximately 360 people. Patients with CRPS were described and treated by clinicians from countries across Asia (Pakistan, Jordan, South Korea, Taiwan, and Singapore), South America (Brazil and Peru), Africa (South Africa), and Europe (Norway). This reflects that CRPS exists across borders, ethnicities, and cultures. These proceedings provide a broader perspective within the international pain community about how we can better understand and treat CRPS across the globe.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1056"},"PeriodicalIF":3.4,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/6b/painreports-8-e1056.PMC9845011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9281799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and subacute postsurgical pain in women with breast cancer: incidence and associations with biopsychosocial predictors-a secondary analysis of a randomized controlled trial.","authors":"Alice Munk,&nbsp;Henrik Børsting Jacobsen,&nbsp;Julie Schnur,&nbsp;Guy Montgomery,&nbsp;Silje Endresen Reme","doi":"10.1097/PR9.0000000000001058","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001058","url":null,"abstract":"<p><strong>Introduction: </strong>Women who undergo breast cancer surgery risk suffering from postsurgical pain long after their surgery. Still, research on postsurgical pain in the subacute phase has been neglected.</p><p><strong>Objective: </strong>This study aims to investigate the incidence, intensity, unpleasantness, and presurgical predictors of acute and subacute postsurgical pain after breast cancer surgery.</p><p><strong>Methods: </strong>The study used an observational design through secondary analyses of the control group in a randomized controlled trial. Data from 102 women undergoing breast cancer surgery were included. Levels of acute and subacute pain intensity and unpleasantness were measured using 100 mm Visual Analogue Scales on the day of surgery and 4 weeks postsurgery. Linear regression analyses were performed to identify presurgical biopsychosocial predictors of acute and subacute postsurgical pain.</p><p><strong>Results: </strong>Average levels of postsurgical pain intensity and unpleasantness were as follows: 22.7 mm for acute pain intensity, 19.0 mm for acute pain unpleasantness, 10.3 mm for subacute pain intensity, and 11.7 mm for subacute pain unpleasantness. Pain expectancy predicted acute pain intensity (R² = 0.04, <i>p</i> = 0.047) and acute unpleasantness (R² = 0.06, <i>p</i> = 0.02). Perceived social support inversely predicted acute pain unpleasantness (R² = 0.04, <i>p</i> = 0.014).</p><p><strong>Conclusion: </strong>Mild and moderate acute pain intensity and unpleasantness are common after breast cancer surgery, whereas levels of subacute pain intensity and unpleasantness are low. Pain expectancy predicts acute postsurgical pain intensity and unpleasantness, whereas expected social support inversely predicts acute postsurgical pain unpleasantness.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1058"},"PeriodicalIF":4.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain concepts of pediatricians: a qualitative survey.","authors":"Cosima Locher,&nbsp;Andreas Wörner,&nbsp;Maria Carlander,&nbsp;Joe Kossowsky,&nbsp;Julia Dratva,&nbsp;Helen Koechlin","doi":"10.1097/PR9.0000000000001060","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001060","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain is a prevalent, yet underrecognized, condition in children and adolescents. A biopsychosocial framework has been widely adopted over the past decades and resulted in a new pain classification in the International Classification of Diseases, 11th revision (ICD-11). Nevertheless, little is known about pediatricians' pain concepts.</p><p><strong>Objectives: </strong>We explored pain concepts of Swiss pediatricians by means of a qualitative analysis.</p><p><strong>Method: </strong>A cross-sectional online survey was sent to clinically active Swiss pediatricians registered with the Swiss Society for Pediatrics. A case vignette of a girl with chronic musculoskeletal pain was presented and pediatricians were asked (1) what they think caused the pain, and (2) how they would explain the pain to the patient and their family. Structuring content analysis was applied to describe major themes within the answers.</p><p><strong>Results: </strong>The following main categories emerged: psychological factors, biological factors, unclear etiology, social context, disorder specific, and multifactorial. Most pediatricians reported the belief that psychological factors explained the pain. However, when explaining the pain to the patient, biological factors were reported most often.</p><p><strong>Conclusion: </strong>There is a discrepancy between pediatricians' conviction that chronic pain is mostly explained by psychological factors and their exploratory model towards patients that focuses on biological factors. Promoting the biopsychosocial framework of chronic pain is key to ensure timely and effective treatment. The new pain classification in the ICD-11 has the potential to increase the use of the biopsychosocial model.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1060"},"PeriodicalIF":4.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/47/painreports-8-e1060.PMC9845015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory processing sensitivity in adolescents reporting chronic pain: an exploratory study.","authors":"Helen Koechlin,&nbsp;Carolina Donado,&nbsp;Cosima Locher,&nbsp;Joe Kossowsky,&nbsp;Francesca Lionetti,&nbsp;Michael Pluess","doi":"10.1097/PR9.0000000000001053","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001053","url":null,"abstract":"<p><strong>Introduction: </strong>Sensory processing sensitivity (SPS) describes a genetically influenced trait characterized by greater <i>depth</i> of information <i>processing</i>, lower sensory threshold, and ease of overstimulation. It is hypothesized that SPS plays a crucial role in the context of chronic pain.<b>Objectives:</b> This exploratory study examined SPS as a correlate of pain intensity and pain-related disability in a sample of adolescents reporting chronic pain.</p><p><strong>Methods: </strong>Adolescents reporting chronic pain were contacted through social media and through specialized pain clinics. Participants completed online questionnaires on their levels of SPS, pain features, emotion regulation, and quality of life. A series of analysis of variances (ANOVAs) were calculated to detect differences between 3 SPS groups (ie, high, medium, and low sensitivity) regarding emotion regulation, quality of life, and pain features. Multiple linear regressions were conducted to predict pain intensity, pain-related disability, and quality of life.</p><p><strong>Results: </strong>In total, 103 participants completed the survey (68.9% female, M_age 17.9). Back pain was the most frequently reported pain location. Proportion of highly sensitive individuals was large (45.68%). The ANOVA revealed significant differences between sensitivity groups related to quality-of-life subscales, namely, for physical (F(2, 100) = 7.42, <i>P</i> < 0.001), emotional (F(2, 100) = 6.11, <i>P</i> < 0.001), and school functioning (F(2, 100) = 3.75, <i>P</i> = 0.03). High sensitivity was not predictive of pain but of health-related quality of life.</p><p><strong>Conclusions: </strong>Our results indicate that SPS is an important and prevalent characteristic to consider in the context of chronic pain in adolescents, specifically regarding the quality of life.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1053"},"PeriodicalIF":4.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10628789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of differential target multiplexed spinal cord stimulation for chronic postsurgical abdominal pain.","authors":"Ryusuke Tanaka,&nbsp;Kenji Shinohara,&nbsp;Yohei Hidai,&nbsp;Chiaki Kiuchi,&nbsp;Satoshi Tanaka,&nbsp;Mikito Kawamata,&nbsp;Junichi Sasao","doi":"10.1097/PR9.0000000000001059","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001059","url":null,"abstract":"<p><strong>Introduction: </strong>Recent advances in stimulation techniques have improved the efficacy and expanded the applicability of spinal cord stimulation (SCS). Among these techniques, there are no reports on the efficacy of differential target multiplexed (DTM) SCS for chronic postsurgical pain (CPSP) after abdominal surgery. Therefore, we present the successful use of DTM SCS for CPSP after distal pancreatectomy.</p><p><strong>Methods: </strong>A 49-year-old man with hypertension and severe chronic low back pain presented with neuropathic CPSP involving the left abdomen in the area of a laparotomy incision. His pain was refractory to conservative treatment and was rated 10 on a numerical rating scale (NRS). He underwent permanent implantation of a pulse generator after a 14-day trial stimulation.</p><p><strong>Results: </strong>Chronic postsurgical pain was well controlled (NRS 1-2) at a 3-month follow-up with DTM SCS.</p><p><strong>Conclusion: </strong>Differential target multiplexed SCS can be a new treatment option for neuropathic CPSP that is resistant to conservative treatment. It is important to further examine the characteristics of CPSP and identify appropriate candidates for the successful use of DTM SCS.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"8 1","pages":"e1059"},"PeriodicalIF":4.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9857349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}