Pain Reports最新文献

{"title":"Long-term examination of pain and health-related outcomes in people with fibromyalgia before, during, and after COVID-19.","authors":"Benjamin Mosch, Martin Diers","doi":"10.1097/PR9.0000000000001380","DOIUrl":"10.1097/PR9.0000000000001380","url":null,"abstract":"<p><strong>Introduction: </strong>Since the outbreak of COVID-19, many studies have investigated long-term consequences associated to the pandemic. Undoubtedly, restrictions and changes in everyday life during that time have had a broad impact on mental health and well-being, particularly in vulnerable populations, such as chronic pain patients.</p><p><strong>Objectives: </strong>The aim of this study was to examine longitudinal progression of pain-related outcomes in patients with fibromyalgia (FM).</p><p><strong>Methods: </strong>Using a repeated measures design with comparative data acquired before (T1) and during the pandemic (T2), as well as data from a recent survey (T3), this study investigated long-term development of pain symptoms and well-being in FM (N = 75) throughout and beyond the pandemic. For this purpose, longitudinal changes of clinical parameters, such as pain severity, disability, and depressive mood, as well as self-perceived changes of pain, anxiety, depression, and physical activity were assessed.</p><p><strong>Results: </strong>Patients displayed significant self-perceived worsening of pain compared with both preceding survey periods. However, these self-perceived changes were not reflected in longitudinal increases of pain values. Pain-related interference, perceived helplessness, and social activity levels were significant predictors of pain severity at T3, when using only T3 determinants as predictors. On the other hand, with regard to the prepandemic and pandemic period, past pain levels (T1, T2) and affective distress experienced at T2 were significant predictors of T3 pain.</p><p><strong>Conclusions: </strong>These findings emphasize the importance of psychosocial factors for the long-term progression of pain symptoms. In addition, our data suggest remarkable long-term stability of pain symptoms, despite repeated evidence for a self-perceived worsening of pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1380"},"PeriodicalIF":3.1,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural and psychosocial signatures of the comorbidity between pain and affective symptoms.","authors":"Francesco Scarlatti, Ludovic Dormegny-Jeanjean, Roman Schefzik, Jack R Foucher, Tobias Banaschewski, Arun L W Bokde, Rüdiger Brühl, Sylvane Desrivières, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N Smolka, Sarah Hohmann, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Frauke Nees, Emanuel Schwarz, Martin Löffler, Herta Flor","doi":"10.1097/PR9.0000000000001353","DOIUrl":"10.1097/PR9.0000000000001353","url":null,"abstract":"<p><strong>Introduction: </strong>The bidirectional relationship between pain and affective symptoms suggests shared underlying mechanisms. Neurophysiological changes, psychosocial factors, and specifically alterations in instrumental learning likely contribute significantly to their co-occurrence.</p><p><strong>Objectives: </strong>In this study, we aimed to uncover factors associated with the comorbidity between pain and the severity of depressive symptoms and between pain and the severity of anxiety symptoms.</p><p><strong>Methods: </strong>We analyzed psychosocial (n = 624) and neuroimaging (n = 689) data from a European sample of young adults with pain and affective symptoms from the general population. Using multitask learning, we constructed cross-sectional models predicting the coexistence of both symptom domains.</p><p><strong>Results: </strong>Based on blood-oxygen-level-dependent responses during reward feedback, we found a neural pattern associated with the comorbidity between pain and the severity of depressive symptoms, reflecting regionally heterogeneous alterations in reward responsivity. These alterations included stronger negative responses in the caudate nucleus and putamen. In addition, we identified robust psychosocial markers of the comorbidity between pain and the severity of either depressive or anxiety symptoms, among which nonpainful somatic symptoms and persistent rumination showed the most robust association. We further compared the predictive capabilities of psychosocial markers with those of neural processes in instrumental learning and found that neural signatures of reward feedback improved the prediction of a psychosocial signature for the comorbidity between pain and the severity of depressive symptoms.</p><p><strong>Conclusion: </strong>These findings highlight the presence of common mechanisms underlying the comorbidity of pain and affective symptoms, including alterations in the neural responses to reward.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1353"},"PeriodicalIF":4.3,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of cognitive behavioral therapy on attention in patients with fibromyalgia: a randomized controlled trial.","authors":"Savannah Kazemipour, Jolin B Yamin, David Moore, Asimina Lazaridou, Myrella Paschali, Vitaly Napadow, Robert R Edwards, Samantha M Meints","doi":"10.1097/PR9.0000000000001378","DOIUrl":"10.1097/PR9.0000000000001378","url":null,"abstract":"<p><strong>Introduction: </strong>More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is efficacious in treating people with attention deficits, depression, anxiety, and chronic pain (eg, fibromyalgia).</p><p><strong>Objectives: </strong>In this study, we examined the efficacy of CBT for improving attention in patients with fibromyalgia.</p><p><strong>Methods: </strong>Sixty-nine women with fibromyalgia (M = 42; SD = 13) were randomly assigned to receive CBT or an education control, and completed computer-based attention tasks and surveys at baseline (before receiving treatment) and at the follow-up (after receiving 8 treatment sessions). We hypothesized that CBT would lead to greater improvement in attention compared with fibromyalgia education. We conducted repeated-measures analyses of variance to examine the effects of time (pre- vs postintervention) and whether CBT resulted in greater improvement (time × condition effects) for attention span, attentional switching, and divided attention.</p><p><strong>Results: </strong>Results indicated an effect of time such that patients in both groups improved from baseline to follow-up for attention span (F = 8.26, <i>P</i> = 0.01) and switch cost response time (F = 4.45, <i>P</i> = 0.04). However, the time by condition interaction was not significant (<i>P</i>s > 0.05), indicating that improvement in attentional performance did not differ across intervention groups.</p><p><strong>Conclusion: </strong>Our results support the possibility of practice effects such that completing tasks that engage attentional processes could serve as potential interventions for attentional deficits observed in fibromyalgia.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1378"},"PeriodicalIF":4.3,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145769923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in pain in 2 large and diverse US databases.","authors":"Soyoung Han, Ariadne Letra, Anna Alessandri-Bonetti, Davis Thomas, Flavia P Kapos, Linda Sangalli","doi":"10.1097/PR9.0000000000001371","DOIUrl":"10.1097/PR9.0000000000001371","url":null,"abstract":"<p><strong>Introduction: </strong>Sex differences have been recognized as significant influences on disease suceptibility and progression.</p><p><strong>Objectives: </strong>This study aimed to assess sex differences in pain prevalence using 2 large and diverse US data sources, <i>All of Us</i> and <i>Epic Cosmos</i>.</p><p><strong>Methods: </strong>Pain concepts, labels used to describe type, chronicity, and body locations in electronic health records, were identified from 254,639 individuals in <i>All of Us</i> and 292,549,808 in <i>Epic Cosmos</i> data. Prevalence ratios (PRs) and 95% confidence intervals comparing the prevalence between females and males were computed to determine sex differences in each pain concept, in each data set. Ratios >1 and <1 denoted higher prevalence among females and males, respectively.</p><p><strong>Results: </strong>The search yielded 195 pain concepts available in both <i>All of Us</i> and <i>Epic Cosmos</i>. Of these, 72.9% in <i>All of Us</i> and 82.6% in <i>Epic Cosmos</i> showed higher prevalence among females. Higher prevalence among men was observed in 8.9% (<i>All of Us</i>) and 13.3% (<i>Epic Cosmos</i>) of pain concepts, mainly involving the chest, lower limbs, and inguinal region. Between 4.1% and 18.2% of the concepts did not show evidence of differences in prevalence by sex. Only one conditions displayed opposing direction in PRs, possibly due to differences in sample composition and/or variation in clinical assignment criteria for pain concepts.</p><p><strong>Conclusion: </strong>Higher pain prevalence among females in the United States was observed for most pain concepts in 2 large and diverse databases. These results underscore the importance of pain research, prevention, and management approaches stratified by sex.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 1","pages":"e1371"},"PeriodicalIF":4.3,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145770004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow-derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy: Erratum.","authors":"Dan Yan, Abba C Zubair, Michael D Osborne, Robert Pagan-Rosado, Jeffrey A Stonec, Vance T Lehman, Nisha C Durand, Eva Kubrova, Zhen Wang, Drew M Witter, Meghan M Baer, Gabriela C Ponce, Alfredo Quiñones-Hinojosa, Wenchun Qu","doi":"10.1097/PR9.0000000000001362","DOIUrl":"10.1097/PR9.0000000000001362","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/PR9.0000000000001181.].</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1362"},"PeriodicalIF":3.1,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12643581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between proinflammatory cytokines and depressive symptoms in adolescents with chronic pain.","authors":"Emma F Gaydos, Katrina Huft, Emma Biggs, Sarah Nelson, Laura E Simons","doi":"10.1097/PR9.0000000000001365","DOIUrl":"10.1097/PR9.0000000000001365","url":null,"abstract":"<p><strong>Objective: </strong>Depressive symptoms and chronic pain commonly co-occur among adolescents and share similar proposed underlying processes, including elevation of proinflammatory cytokines. In this study, we investigate how profiles of 4 commonly measured proinflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) differ between adolescents with primary chronic pain disorders and pain-free peers. We explored relationships between these cytokines and depressive symptoms, perceived distress (PD), pain severity, functional disability (FD), pain catastrophizing (Pcat), and fear of pain (FOP). Potential mediating effects of cytokines on the relationship between depressive symptoms and FD were also examined.</p><p><strong>Methods: </strong>Differences in cytokine profiles between groups were compared through <i>t</i>-tests. Relationships between cytokine profiles and outcomes were assessed through partial correlations. Bootstrapping mediation analysis assessed whether cytokines mediated the relationship between depressive symptoms and functional disability. Our sample included 78 youth (chronic pain n = 54, <i>M</i>age = 14 years; pain-free n = 24; <i>M</i>age = 16 years).</p><p><strong>Results: </strong>We found that (1) IL-6 levels were higher among adolescents with chronic pain than pain-free peers; (2) higher IL-1β and IL-6 levels were associated with greater PD among adolescents with and without pain; (3) among the pain group, higher IL-6 levels were associated with greater PD, pain severity, and FD; (4) among the pain group, higher IL-1β levels were associated with greater depressive symptoms, PD, Pcat, and FOP. Mediation effects were not significant.</p><p><strong>Conclusion: </strong>Our findings suggest that IL-1β and IL-6 play critical roles in the pain experience. Interleukin-6 is more strongly associated with physical symptoms, and IL-1β is more related to fear-avoidance.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1365"},"PeriodicalIF":4.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12643753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to De Paepe et al.","authors":"Rod S Taylor, Rui V Duarte","doi":"10.1097/PR9.0000000000001349","DOIUrl":"10.1097/PR9.0000000000001349","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1349"},"PeriodicalIF":4.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12643732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capturing individual experiences: advancing core outcome sets in pain. Comment on Taylor et al. (2024).","authors":"Annick L De Paepe, Esther M Pogatzki-Zahn, Whitney Scott","doi":"10.1097/PR9.0000000000001348","DOIUrl":"10.1097/PR9.0000000000001348","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1348"},"PeriodicalIF":3.1,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12643727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145607333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autistic women report high levels of pain, pain-related anxiety, and pain interference.","authors":"Nathan W Haid, Michelle D Failla, Alexandra Sturm","doi":"10.1097/PR9.0000000000001346","DOIUrl":"10.1097/PR9.0000000000001346","url":null,"abstract":"<p><strong>Introduction: </strong>Evidence suggests autistic adults experience pain in different ways compared with nonautistic people. Autistic adults report greater pain-related anxiety, which is associated with increased pain sensitivity, and experience high rates of generalized anxiety. It is not yet clear how generalized anxiety may be related to pain-related anxiety for autistic people. Nonautistic women generally experience more pain sensitivity and pain interference. Thus, autistic women may be at greater risk of experiencing the impact of pain-related anxiety on their daily lives.</p><p><strong>Objectives: </strong>We sought to examine the relationship between pain-related anxiety, generalized anxiety, and pain's interference (eg, daily activities, mood) in autistic women's lives.</p><p><strong>Methods: </strong>The present study included N = 52 autistic adults, assigned female at birth (AFAB), who reported on their pain (Brief Pain Inventory), pain-related anxiety (Pain Anxiety Symptoms Scale-20) and generalized anxiety (Generalized Anxiety Disorder 7-Item scale).</p><p><strong>Results: </strong>In this sample, 65.4% of participants reported pain in the last 24 hours and high rates of pain interference overall. Autistic AFAB people reported high rates of generalized anxiety (11.75 ± 5.19) and pain-related anxiety (48.80 ± 13.54). Only the cognitive pain-related anxiety subscale was significantly correlated with generalized anxiety (<i>r</i> = 0.30, <i>P</i> < 0.05). Total pain-related anxiety was associated with pain interference (enjoyment of life, <i>r</i> = 0.39, <i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Autistic AFAB people are experiencing high rates of pain, pain interference, anxiety, and pain-related anxiety. Given the relationship between pain and anxiety reported for autistic women, therapies that specifically target pain-related anxiety may have profound impacts on autistic women's quality of life.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1346"},"PeriodicalIF":4.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12543225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweet relief or lasting impacts? Review of neonatal pain and sucrose in developing rodents.","authors":"Fermin S Hoq, Colette Newby, Sophie Tremblay, Manon Ranger","doi":"10.1097/PR9.0000000000001345","DOIUrl":"10.1097/PR9.0000000000001345","url":null,"abstract":"<p><p>In the neonatal intensive care unit, preterm infants can experience 7 to 17 painful and stressful procedures daily. Oral sucrose is the standard treatment for procedural pain, but their combined short-term and long-term cumulative effects on brain development remain unclear. Growing concerns about the potential neurodevelopmental consequences of repeated sucrose and pain exposure underscore the need for mechanistic research to understand their interaction during critical periods of brain development. Translational animal models, particularly in rodents, are instrumental in advancing neonatal pain research. Their comparable neurodevelopmental trajectory to human infants and the ability to systematically control pain and sucrose exposures make them valuable tools for investigating both immediate and enduring effects. These models have been refined to replicate clinically relevant procedural pain in the neonatal intensive care unit and have yielded mixed findings. Some studies report that sucrose reduces short-term pain sensitivity and improves early spatial learning, whereas others show impaired short-term memory and long-term reductions in regional brain and white matter volumes. This review synthesizes current literature on translational rodent models of early-life pain and sucrose exposure, highlighting both potential benefits and adverse outcomes. These findings underscore the complexity of using sucrose as an analgesic and the importance of ongoing preclinical research to inform evidence-based neonatal pain management. By critically evaluating the dual impact of pain and sucrose, this work contributes to a deeper understanding of how early interventions shape neurodevelopment and supports the development of safer, more effective strategies for managing pain in this vulnerable population.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"10 6","pages":"e1345"},"PeriodicalIF":4.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}