创伤性神经损伤手术修复后疼痛或无痛神经病变受试者实验性疼痛敏感性的性别差异

IF 3.4 Q2 NEUROSCIENCES
A. Miclescu, Panagiota Gkatziani, Pontus Granlund, Stephen Butler, T. Gordh
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引用次数: 2

摘要

与男性相比,女性神经病变患者在所有实验刺激下都有更高的疼痛强度,但在冷条件刺激后有更快恢复的趋势。摘要简介:性别相关的影响是导致女性更大的疼痛敏感性的因素,并且在许多慢性疼痛状况中,包括神经性疼痛(NP)的患病率更高。目的:目的是分析创伤性神经损伤后神经病变受试者持续疼痛、实验性疼痛强度和条件疼痛调节(CPM)的差异与性别的关系。方法:比较男性(n = 77)和女性(n = 55)以及NP患者(女性31,男性39)和创伤后神经病变无痛患者(女性24,男性38)的内源性疼痛调节。条件性疼痛调节是通过对压力刺激的疼痛评分来评估的,在进行有害条件刺激(CS)之前和之后,将一只手臂浸泡在冷水(4°C)中1分钟。记录患者术后VASmaxc峰值疼痛强度的恢复时间(off Time),并比较男女患者的差异。结果:与男性患者相比,女性患者的持续疼痛强度更大,并且在压痛和冷痛后的实验性疼痛更多。将所有组加在一起,女性在CS后恢复的几率(20%)比男性高0.8倍(95% CI = 0.65-2.9)。男女患者在CPM、休假时间和心理社会变量上均无差异(P < 0.05)。结论:我们对内源性疼痛调节的性别差异的假设仅支持女性患者冷CS后感觉后时间较短的假设。CPM效应的大小没有性别差异。在神经性疼痛和非神经性疼痛的实验疼痛中,女性患者的疼痛强度增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sex-related differences in experimental pain sensitivity in subjects with painful or painless neuropathy after surgical repair of traumatic nerve injuries
Higher pain intensities at all experimental stimuli but a tendency to faster recovery after cold conditioning stimuli were seen in women with neuropathy in comparison with men. Abstract Introduction: Sex-related influences represent a contributor to greater pain sensitivity and have a higher prevalence of many chronic pain conditions, including neuropathic pain (NP), among women. Objectives: The aim was to analyze how differences in ongoing pain, experimental pain intensity, and conditioned pain modulation (CPM) relate to sex in subjects with neuropathy after traumatic nerve injuries. Methods: Endogenous pain modulation was compared between male (n = 77) and female (n = 55) subjects and between subjects with NP (female = 31, male = 39) and pain-free subjects with posttraumatic neuropathy (female = 24, male = 38). Conditioned pain modulation was assessed by pain ratings to pressure stimuli before and after a noxious conditioning stimulus (CS) conducted with one arm submerged in cold water (4°C) for 1 minute. Time of recovery (Time off) of pain intensity from peak VASmaxc after CS was recorded and compared between male and female patients. Results: Greater ongoing pain intensity was found among female patients compared with male patients and more experimental pain after pressure and cold induced pain. Summing all groups together, women had 0.8 times higher odds (20%) of recovering sooner than men after CS (95% CI = 0.65–2.9). No differences in CPM, time off, and psychosocial variables were seen between female and male patients (P < 0.05). Conclusion: Our hypothesis for sex differences in endogenous pain modulation was only supported by a shorter after-sensation time after cold CS in female patients. No sex differences in the magnitude of CPM effect were identified. Increased pain intensity for experimental pain, in both neuropathic pain and neuropathy without pain, was found in female patients.
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来源期刊
Pain Reports
Pain Reports Medicine-Anesthesiology and Pain Medicine
CiteScore
7.50
自引率
2.10%
发文量
93
审稿时长
8 weeks
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