Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics.

IF 3.4 Q2 NEUROSCIENCES

Pain Reports Pub Date : 2022-10-04 eCollection Date: 2022-11-01 DOI:10.1097/PR9.0000000000001042

Bijar Ghafouri, Emelie Edman, Marie Löf, Eva Lund, Olof Dahlqvist Leinhard, Peter Lundberg, Mikael Fredrik Forsgren, Björn Gerdle, Huan-Ji Dong

{"title":"Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics.","authors":"Bijar Ghafouri, Emelie Edman, Marie Löf, Eva Lund, Olof Dahlqvist Leinhard, Peter Lundberg, Mikael Fredrik Forsgren, Björn Gerdle, Huan-Ji Dong","doi":"10.1097/PR9.0000000000001042","DOIUrl":null,"url":null,"abstract":"Introduction: Obesity is a common comorbidity in fibromyalgia (FM). Both FM and obesity have been connected to low-grade inflammation, although it is possible that previously reported inflammatory alterations in FM primarily may be linked to increased body mass index (BMI).Objective: This study aimed to investigate whether the inflammatory plasma protein profile, muscle blood flow, and metabolism and pain characteristics (clinical parameters and patient-reported outcome measurements) differed between female patients with FM with and without obesity.Methods: Patients with FM underwent clinical examinations, physical tests, and answered questionnaires. They were dichotomized according to BMI (<30 kg/m2 [n = 14]; ≥30 kg/m2 [n = 13]). Blood samples were collected and analyzed using a panel of 71 inflammatory plasma proteins.Results: There were significant (P < 0.05) differences in blood pressure, pulse, max VO2, pain intensity, physical capacity, and Fibromyalgia Impact Questionnaire between the groups; the obese group had higher blood pressure, pulse, pain intensity, and Fibromyalgia Impact Questionnaire. There were 14 proteins that contributed to the group belonging. The 4 most important proteins for the group discrimination were MIP1β, MCP4, IL1RA, and IL6, which showed higher concentrations in obese patients with FM. Significantly decreased blood flow and increased concentration of pyruvate were detected in obese patients compared with nonobese patients. There was significant correlation between inflammatory proteins and sedentary behavior and health status in obese patients with FM.Conclusions: These findings suggest that metabolism and inflammation interact in female patients with FM with obesity and might cause chronic low-grade inflammation. Screening for obesity and monitoring of BMI changes should be considered in the treatment of patients with FM.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2022-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9534367/pdf/","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/PR9.0000000000001042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 2

Abstract

Introduction: Obesity is a common comorbidity in fibromyalgia (FM). Both FM and obesity have been connected to low-grade inflammation, although it is possible that previously reported inflammatory alterations in FM primarily may be linked to increased body mass index (BMI).

Objective: This study aimed to investigate whether the inflammatory plasma protein profile, muscle blood flow, and metabolism and pain characteristics (clinical parameters and patient-reported outcome measurements) differed between female patients with FM with and without obesity.

Methods: Patients with FM underwent clinical examinations, physical tests, and answered questionnaires. They were dichotomized according to BMI (<30 kg/m² [n = 14]; ≥30 kg/m² [n = 13]). Blood samples were collected and analyzed using a panel of 71 inflammatory plasma proteins.

Results: There were significant (P < 0.05) differences in blood pressure, pulse, max VO2, pain intensity, physical capacity, and Fibromyalgia Impact Questionnaire between the groups; the obese group had higher blood pressure, pulse, pain intensity, and Fibromyalgia Impact Questionnaire. There were 14 proteins that contributed to the group belonging. The 4 most important proteins for the group discrimination were MIP1β, MCP4, IL1RA, and IL6, which showed higher concentrations in obese patients with FM. Significantly decreased blood flow and increased concentration of pyruvate were detected in obese patients compared with nonobese patients. There was significant correlation between inflammatory proteins and sedentary behavior and health status in obese patients with FM.

Conclusions: These findings suggest that metabolism and inflammation interact in female patients with FM with obesity and might cause chronic low-grade inflammation. Screening for obesity and monitoring of BMI changes should be considered in the treatment of patients with FM.

Abstract Image

查看原文本刊更多论文

女性纤维肌痛:炎症血浆蛋白、肌肉血流量和代谢与体重指数和疼痛特征的关系

肥胖是纤维肌痛(FM)的常见合并症。FM和肥胖都与低度炎症有关，尽管先前报道的FM炎症改变可能主要与体重指数(BMI)增加有关。目的:本研究旨在探讨伴有和不伴有肥胖的女性FM患者的炎症血浆蛋白谱、肌肉血流量、代谢和疼痛特征(临床参数和患者报告的结果测量)是否存在差异。方法:对FM患者进行临床检查、体格检查和问卷调查。根据BMI进行二分类(2例[n = 14];≥30 kg/m2 [n = 13])。采集血液样本，用71种炎性血浆蛋白进行分析。结果:两组患者血压、脉搏、最大摄氧量、疼痛强度、体能、纤维肌痛影响问卷差异均有统计学意义(P < 0.05);肥胖组血压、脉搏、疼痛强度和纤维肌痛影响问卷均较高。有14种蛋白质对所属的组有贡献。对群体区分最重要的4种蛋白是MIP1β、MCP4、IL1RA和IL6，在肥胖FM患者中浓度较高。与非肥胖患者相比，肥胖患者的血流量明显减少，丙酮酸浓度明显升高。肥胖FM患者炎症蛋白与久坐行为及健康状况有显著相关性。结论:这些研究结果表明，代谢和炎症在女性FM合并肥胖患者中相互作用，可能导致慢性低度炎症。在治疗FM患者时应考虑筛查肥胖和监测BMI变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊