Pain Reports最新文献

{"title":"Systemic low-grade C-reactive protein is associated with proximal symptom spread in carpal tunnel syndrome","authors":"Karolina Zvonickova, Amber Rhee, Oliver Sandy-Hindmarch, Dominic Furniss, A. Wiberg, Annina B Schmid","doi":"10.1097/PR9.0000000000001156","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001156","url":null,"abstract":"Supplemental Digital Content is Available in the Text. C-reactive protein serum levels are higher in patients with carpal tunnel syndrome and proximal symptom spread. This suggests an association of extra-territorial symptoms with low-grade inflammation.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The course of acute low back pain: a community-based inception cohort study","authors":"F. Pfeiffer, H. Luomajoki, André Meichtry, Sabina Hotz Boendermaker","doi":"10.1097/PR9.0000000000001152","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001152","url":null,"abstract":"Supplemental Digital Content is Available in the Text. One-year acute low back pain trajectories are determined by initial pain intensity and past episodes, not by psychological factors.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary development of a measure of parental behavioral responses to everyday pains in young children: the PREP","authors":"Perri R. Tutelman, Christine T. Chambers, Jennifer A. Parker, Samantha J. Eisen, Melanie Noel","doi":"10.1097/pr9.0000000000001154","DOIUrl":"https://doi.org/10.1097/pr9.0000000000001154","url":null,"abstract":"Supplemental Digital Content is Available in the Text. The PREP is a relatively short (10 item) measure assessing self-reported observable parent responses to their child's everyday pains.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing spectra of pain psychology treatment design to improve patient access to care","authors":"Rachel V. Aaron, Scott G. Ravyts","doi":"10.1097/PR9.0000000000001144","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001144","url":null,"abstract":"Commentary on: Darnall BD, Burns JW, Hong J, Roy A, Slater K, Poupore-King H, Ziadni MS, You DS, Jung C, Cook KF, Lorig K, Tian L, Mackey SC. Empowered relief, cognitive behavioral therapy and health education for people with chronic pain: a comparison of outcomes at 6-month follow-up for a randomized controlled trial. PAIN Reports 2024;9:e1116.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140748952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sensory testing for assessment of somatosensory function in children and adolescents: a scoping review","authors":"Perri R. Tutelman, Nicole E. MacKenzie, Christine T. Chambers, Siobhan Coffman, Laura Cornelissen, Brittany Cormier, Kristen S. Higgins, Jackie Phinney, Markus Blankenburg, Suellen Walker","doi":"10.1097/PR9.0000000000001151","DOIUrl":"https://doi.org/10.1097/PR9.0000000000001151","url":null,"abstract":"Supplemental Digital Content is Available in the Text. The use of quantitative sensory testing (QST) in pediatric pain research has grown substantially. Future research using comprehensive, standardized QST protocols is needed.","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140747372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort?","authors":"D. Pud, S. Aamar, Bareket Schiff-Keren, Roee Sheinfeld, Silviu Brill, Dror Robinson, Yaakov Fogelman, George Habib, Haggai Sharon, Howard Amital, Boris Boltyansky, S. Haroutounian, Elon Eisenberg","doi":"10.1097/pr9.0000000000001143","DOIUrl":"https://doi.org/10.1097/pr9.0000000000001143","url":null,"abstract":"\u0000 \u0000 \u0000 The use of medicinal cannabis for managing pain expands, although its efficacy and safety have not been fully established through randomized controlled trials.\u0000 \u0000 \u0000 \u0000 This structured, prospective questionnaire-based cohort was aimed to assess long-term effectiveness and safety of cannabis oil extracts in patients with chronic pain.\u0000 \u0000 \u0000 \u0000 Adult Israeli patients licensed to use cannabis oil extracts for chronic pain were followed prospectively for 6 months. The primary outcome measure was change from baseline in average weekly pain intensity, and secondary outcomes were changes in related symptoms and quality of life, recorded before treatment initiation and 1, 3, and 6 months thereafter. Generalized linear mixed model was used to analyze changes over time. In addition, “responders” (≥30% reduction in weekly pain at any time point) were identified.\u0000 \u0000 \u0000 \u0000 The study included 218 patients at baseline, and 188, 154, and 131 at 1, 3, and 6 months, respectively. At 6 months, the mean daily doses of cannabidiol and Δ9-tetrahydrocannabinol were 22.4 ± 24.0 mg and 20.8 ± 30.1 mg, respectively. Pain decreased from 7.9 ± 1.7 at baseline to 6.6 ± 2.2 at 6 months (F(3,450) = 26.22, P < 0.0001). Most secondary parameters also significantly improved. Of the 218 participants, 24% were “responders” but could not be identified by baseline parameters. “Responders” exhibited higher improvement in secondary outcomes. Adverse events were common but mostly nonserious.\u0000 \u0000 \u0000 \u0000 This prospective cohort demonstrated a modest overall long-term improvement in chronic pain and related symptoms and a reasonable safety profile with the use of relatively low doses of individually titrated Δ9-tetrahydrocannabinol and cannabidiol.\u0000","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140352784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social health in young women with chronic pain.","authors":"Ian A Boggero, Linda Sangalli, Lauryn Brasch, Christopher D King","doi":"10.1097/PR9.0000000000001146","DOIUrl":"10.1097/PR9.0000000000001146","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain may negatively affect social functioning, but no study to date has examined the specific social impact of different chronic pain conditions in young women, and whether living with multiple chronic overlapping pain conditions (COPCs) differently influences social domains.</p><p><strong>Objectives: </strong>This study aimed to assess social functioning (social isolation, hostility, informational support satisfaction, social roles, emotional support, friendships, and family relationships) among young women with chronic pain compared with pain-free controls and to test whether the number of COPCs influenced the extent of social burden.</p><p><strong>Methods: </strong>Participants aged 18 to 30 years with a physician-confirmed diagnoses of migraine, fibromyalgia, or temporomandibular disorder (TMD) and pain-free controls were invited to participate from across the United States. After confirming eligibility, participants completed a 1-hour REDCap online questionnaire assessing social functioning.</p><p><strong>Results: </strong>One hundred four participants (mean age 24.54 ± 3.35 years) were included (n = 26 with TMD, n = 25 with fibromyalgia, n = 25 with migraine, and n = 28 controls). All 3 chronic pain groups combined reported worse functioning than controls on friendship (<i>P</i> = 0.038), social isolation (<i>P</i> = 0.002), and social roles (<i>P</i> < 0.001). There were no differences on social variables between the 3 chronic pain groups (all <i>P'</i>s > 0.05). Compared with those with 3 COPCs, participants with 1 condition reported better family relationships (<i>P</i> = 0.024).</p><p><strong>Conclusions: </strong>Experience of chronic pain-regardless of the specific pain condition-may negatively affect some areas of social functioning in young women.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) reduces daily pain intensity in patients with lumbosacral radiculopathy: a randomized controlled trial.","authors":"Ryan S Wexler, Devon J Fox, Danielle ZuZero, Melissa Bollen, Anand Parikshak, Hannah Edmond, Johnny Lemau, Diane Montenegro, Jillian Ramirez, Sophia Kwin, Austin R Thompson, Hans L Carlson, Lynn M Marshall, Thomas Kern, Scott D Mist, Ryan Bradley, Douglas A Hanes, Heather Zwickey, Courtney K Pickworth","doi":"10.1097/PR9.0000000000001132","DOIUrl":"10.1097/PR9.0000000000001132","url":null,"abstract":"<p><strong>Introduction: </strong>Lumbosacral radiculopathy (LR), also known as sciatica, is a common type of radiating neurologic pain involving burning, tingling, and numbness in the lower extremities. It has an estimated lifetime prevalence as high as 43%.</p><p><strong>Objectives: </strong>The objective of this randomized controlled trial was to evaluate the impact of virtually delivered Mindfulness-Oriented Recovery Enhancement (MORE) on patients with LR during the COVID-19 pandemic.</p><p><strong>Methods: </strong>Potentially eligible patients were identified using electronic health record queries and phone screenings. Participants were then randomized to MORE or treatment-as-usual (TAU) for 8 weeks, with pain intensity assessed daily. At baseline and follow-up visits, participants completed questionnaires assessing the primary outcome, disability, as well as quality of life, depression, mindful reinterpretation of pain, and trait mindfulness.</p><p><strong>Results: </strong>In our study, patients undergoing virtual delivery of MORE had greater improvements in daily pain intensity (<i>P</i> = 0.002) but not in disability (<i>P</i> = 0.09), depression (<i>P</i> = 0.26), or quality of life (<i>P</i> = 0.99 and <i>P</i> = 0.89, SF-12 physical and mental component scores, respectively), relative to TAU patients. In addition, patients in MORE experienced significantly greater increases in mindful reinterpretation of pain (<i>P</i> = 0.029) and trait mindfulness (<i>P</i> = 0.035).</p><p><strong>Conclusion: </strong>Among patients with lumbar radiculopathy, MORE significantly reduced daily pain intensity but did not decrease disability or depression symptoms. Given the long duration of symptoms in our sample, we hypothesize the discrepancy between changes in daily pain intensity and disability is due to fear avoidance behaviors common in patients with chronic pain. As the first trial of a mindfulness intervention in patients with LR, these findings should inform future integrative approaches to LR treatment, particularly when considering the increasing use of virtual interventions throughout the COVID-19 pandemic.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of randomized controlled head-to-head trials of recommended drugs for neuropathic pain.","authors":"Ayda Asadizadeh Sadegh, Nina Lykkegaard Gehr, Nanna Brix Finnerup","doi":"10.1097/PR9.0000000000001138","DOIUrl":"10.1097/PR9.0000000000001138","url":null,"abstract":"<p><p>Neuropathic pain is a challenging chronic pain condition. Limited knowledge exists regarding the relative effectiveness of pharmacological treatments, and differences in trial design and impact of the placebo response preclude indirect comparisons of efficacy between drug classes. The purpose of this systematic review and meta-analysis of head-to-head trials was to compare the efficacy and tolerability of drugs recommended for neuropathic pain. We conducted a systematic review and meta-analysis of direct-comparison double-blind randomized trials. Primary outcomes were mean change in pain intensity and number of responders with a 50% reduction in pain intensity. Secondary outcomes encompassed quality of life, sleep, emotional functioning, and number of dropouts because of adverse events. We included 30 trials (4087 patients), comprising 16 crossover and 14 parallel-group design studies. All studies were conducted in adults, and the majority were investigator-initiated trials. We found moderate-quality evidence for equivalence (no clinically relevant difference) between tricyclic antidepressants (TCA) and gabapentin/pregabalin with a combined mean difference in pain score of 0.10 (95% CI -0.13 to 0.32). We could not document differences between TCA and serotonin-noradrenaline reuptake inhibitors (SNRI), between SNRI and gabapentin/pregabalin, or between opioids and TCA (low quality of evidence). We found more dropouts because of adverse events with SNRI and opioids compared with TCA (low quality of evidence). We did not identify any studies that included topical treatments. This systematic review of direct-comparison studies found evidence for equivalence between TCA and gabapentin/pregabalin and fewer dropouts with TCA than SNRI and opioids.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowered Relief, cognitive behavioral therapy, and health education for people with chronic pain: a comparison of outcomes at 6-month Follow-up for a randomized controlled trial.","authors":"Beth D Darnall, John W Burns, Juliette Hong, Anuradha Roy, Kristin Slater, Heather Poupore-King, Maisa S Ziadni, Dokyoung S You, Corinne Jung, Karon F Cook, Kate Lorig, Lu Tian, Sean C Mackey","doi":"10.1097/PR9.0000000000001116","DOIUrl":"10.1097/PR9.0000000000001116","url":null,"abstract":"<p><strong>Introduction: </strong>We previously conducted a 3-arm randomized trial (263 adults with chronic low back pain) which compared group-based (1) single-session pain relief skills intervention (Empowered Relief; ER); (2) 8-session cognitive behavioral therapy (CBT) for chronic back pain; and (3) single-session health and back pain education class (HE). Results suggested non-inferiority of ER vs. CBT at 3 months post-treatment on an array of outcomes.</p><p><strong>Methods: </strong>Here, we tested the durability of treatment effects at 6 months post-treatment. We examined group differences in primary and secondary outcomes at 6 months and the degree to which outcomes eroded or improved from 3-month to 6-month within each treatment group.</p><p><strong>Results: </strong>Empowered Relief remained non-inferior to CBT on most outcomes, whereas both ER and CBT remained superior to HE on most outcomes. Outcome improvements within ER did not decrease significantly from 3-month to 6-month, and indeed ER showed additional 3- to 6-month improvements on pain catastrophizing, pain bothersomeness, and anxiety. Effects of ER at 6 months post-treatment (moderate term outcomes) kept pace with effects reported by participants who underwent 8-session CBT.</p><p><strong>Conclusions: </strong>The maintenance of these absolute levels implies strong stability of ER effects. Results extend to 6 months post-treatment previous findings documenting that ER and CBT exhibit similarly potent effects on outcomes.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10824382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}