Pain Reports最新文献

{"title":"Perioperative pregabalin does not alter behavioural or diffuse noxious inhibitory control responses in 2 rat models of chronic pain.","authors":"Francesca Di Domenico, Mateusz W Kucharczyk, Ryan Patel, Kirsty Bannister","doi":"10.1097/PR9.0000000000001450","DOIUrl":"10.1097/PR9.0000000000001450","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple mechanisms contribute to the experience of pain where the use of model organisms to dissect mechanistically sensory regulatory circuitry is a vital component of discovering underlying causes of persistent pain in disease states. Such disease states can be modelled in animals using surgical procedures that, ethically, should involve administration of analgesia. However, since basic pain researchers often wish to measure pain-related events, animals may be denied perioperative analgesia to avoid adversely influencing experimental outcomes.</p><p><strong>Methods: </strong>We conducted a structured review of perioperative analgesia usage in rat spinal nerve ligation (SNL) and cancer-induced bone pain (CIBP) models. Using a combination of behavioural testing and in vivo electrophysiology in the dorsal horn of the spinal cord, we assessed the impact of perioperative pregabalin on nociceptive behaviours in the acute recovery phase, and behavioural and electrophysiological experimental outcomes in the established phase, of rat SNL and CIBP models.</p><p><strong>Results: </strong>A literature search revealed that, for studies using rat models of SNL or CIBP, only 5.37% and 12.69%, respectively, reported the use of perioperative analgesia. We then demonstrated that the use of pregabalin as a perioperative analgesic reduced mechanical hypersensitivity in the acute period after SNL surgery, with no impact on behavioural, electrophysiological, or neuropharmacological outcomes in the established phase of either model.</p><p><strong>Conclusions: </strong>This study challenges the basic science researcher's reasoning that perioperative analgesia confounds neurobiological outcomes. The use of perioperative analgesia should be an important consideration to improve animal welfare in chronic models of pain.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 4","pages":"e1450"},"PeriodicalIF":4.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of depression screening on future depressive symptoms in a persistent pain population: mediation analysis.","authors":"Brendan Mouatt, Tasha R Stanton, G Lorimer Moseley, Aidan G Cashin, Laura E Simons, Hayley B Leake, Felicity A Braithwaite","doi":"10.1097/PR9.0000000000001453","DOIUrl":"10.1097/PR9.0000000000001453","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical guidelines for persistent pain recommend screening for psychosocial factors. However, little is known about whether completing a structured depression questionnaire within a clinical encounter is associated with subsequent depressive symptom trajectories.</p><p><strong>Objective: </strong>To evaluate whether exposure to such a questionnaire is associated with depressive symptoms at 6-month follow-up, and, if so, whether the association remains after removing the effects of referral to, or engagement with, psychological care.</p><p><strong>Methods: </strong>We analysed clinical audit data from patients with persistent pain who were quasi-randomly allocated to complete full depression screening using the Patient Health Questionnaire-9 (PHQ-9) or a pain-knowledge questionnaire. The primary outcome was depressive symptoms at 6-month follow-up, using a validated single-item 0 to 10 mood rating scale. Causal mediation analysis estimated the direct effect of depression screening on follow-up mood by blocking effects of referral to, and engagement with, psychological care.</p><p><strong>Results: </strong>A total of 1779 participants (age [mean ± SD] = 42.7 ± 11.1 years; pain duration [mean ± SD] = 54.3 ± 29.9 months) were included. At 6-month follow-up, mood numerical rating scale scores improved in both groups (PHQ-9 group [n = 886] = -1.3 points [SD = 1.3]; pain-knowledge questionnaire group [n = 893] = -2.0 points [SD = 1.8]); the PHQ-9 group reported less improvement (mean difference = 0.7/10 points, 95% CI = 0.5-0.8). When referral for (n = 646) and engaging with psychological care (n = 466) were blocked, the direct effect remained (0.5/10 points, 95% CI = 0.3-0.6, 0.4/10 points, 95% CI = 0.2-0.6; respectively).</p><p><strong>Conclusion: </strong>Exposure to screening had smaller reduction in depressive symptoms 6 months later than those who completed a pain-knowledge questionnaire, regardless of referral for, or engagement with, psychological care. Future research should examine how assessment processes influence patient sense-making, clinician responses, and referral pathways in pain care.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 4","pages":"e1453"},"PeriodicalIF":4.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Real-world outcomes in spinal cord stimulation: predictors of reported effect and explantation using a comprehensive registry-based approach: Erratum.","authors":"Terje Kirketeig, Emma Söreskog, Trolle Jacobson, Rolf Karlsten, Niklas Zethraeus, Fredrik Borgström","doi":"10.1097/PR9.0000000000001457","DOIUrl":"10.1097/PR9.0000000000001457","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/PR9.0000000000001107.].</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 4","pages":"e1457"},"PeriodicalIF":4.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and incidence of fibromyalgia and associated severity in the United States using MarketScan.","authors":"Moninder Kaur, Janek Rudnik, Paul Meisner, Andrew Williams, Bernard Lauwerys","doi":"10.1097/PR9.0000000000001451","DOIUrl":"10.1097/PR9.0000000000001451","url":null,"abstract":"<p><strong>Objective: </strong>Fibromyalgia is characterized by a range of symptoms, the most prominent being chronic widespread pain, fatigue, and unrefreshing sleep. This study estimated the diagnosed annual prevalence, incidence, and severity of fibromyalgia among adults (≥18 years) and the pediatric population (<18 years).</p><p><strong>Methods: </strong>This study used United States (US) claims data obtained from the Merative™ MarketScan^® Commercial (Commercial), Medicare (Medicare), and Multi-State Medicaid (Medicaid) databases.</p><p><strong>Results: </strong>In 2020, the annual prevalence of diagnosed fibromyalgia in adults and the pediatric population (0 to <18 years) was 0.44% (95% confidence interval [CI]: 0.44-0.45) and 0.01% (95% CI: 0.00-0.01), respectively, in Commercial + Medicare and 0.90% (95% CI: 0.89-0.91) and 0.003% (95% CI: 0.002-0.003) in Medicaid. The annual incidence of diagnosed fibromyalgia in adults and the pediatric population (0 to <18 years) in 2020 was 0.12% (95% CI: 0.12-0.12) and 0.003% (95% CI: 0.003-0.004), respectively, in Commercial + Medicare and 0.25% (95% CI: 0.25-0.26) and 0.002% (95% CI: 0.001-0.002) in Medicaid. Among adults with incident diagnosed fibromyalgia and ≥12, ≥24, or ≥36 months of follow-up, the proportion with severe fibromyalgia was 30.8%, 29.2%, and 30.1%, respectively, in Commercial + Medicare, and 37.8%, 39.4%, and 41.7%, respectively, in Medicaid.</p><p><strong>Conclusion: </strong>This study provides an updated overview of the diagnosed annual prevalence, incidence, and severity of fibromyalgia in the US and represents the largest study of this kind using the MarketScan database. Further research is needed to validate algorithms for identifying severe fibromyalgia using real-world data.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 4","pages":"e1451"},"PeriodicalIF":4.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily perceived change among patients with chronic pain: influence of sociodemographic, clinical, and psychological characteristics.","authors":"Jiaqi Bi, Robert N Jamison, Edgar L Ross, Robert R Edwards, Marc O Martel","doi":"10.1097/PR9.0000000000001449","DOIUrl":"10.1097/PR9.0000000000001449","url":null,"abstract":"<p><strong>Objectives: </strong>Clinicians who treat patients with chronic pain often rely on self-report impressions of how things have changed since last seen. The aim of this study was to examine factors that contributed to perceived day-to-day impressions of change among these patients.</p><p><strong>Methods: </strong>Two hundred twenty-two subjects (N = 222) with chronic pain used a smartphone pain application (app) as part of previous clinical trials. All participants completed baseline questionnaires and monitored their daily condition on the app for up to 30 days. They reported their progress every day by rating their pain intensity, activity interference, sleep disturbances, and negative affect and answered whether they perceived their overall condition as having improved or gotten worse on a 0 to 10 visual analogue scale.</p><p><strong>Results: </strong>Multilevel models using lagged analyses showed that current sense of change was significantly influenced by ratings of pain intensity, sleep disturbances, activity interference, and depression and anxiety the day before the rating (<i>P</i> < 0.001). Multilevel logistic regression analyses further showed that previous day sleep problems and negative mood had the greatest influence on perceived worsening the following day (<i>P</i> < 0.05). Those with high pain catastrophizing, younger age, and positive opioid use status were most prone to report their condition worsening.</p><p><strong>Conclusion: </strong>This study highlights the importance of inquiring not only about pain intensity but also about sleep disturbances and mood in understanding changes between clinic visits. Clinicians with access to pain app data have increased opportunities to accurately identify those individuals who are most prone to report perceived worsening.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 4","pages":"e1449"},"PeriodicalIF":4.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postrandomization analgesic escalation and interpretability of spinal cord injury-related neuropathic pain trials.","authors":"Audai Abudayeh, Iakiv Fishchenko","doi":"10.1097/PR9.0000000000001438","DOIUrl":"10.1097/PR9.0000000000001438","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1438"},"PeriodicalIF":4.3,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Abudayeh and Fishchenko.","authors":"Leslie R Morse","doi":"10.1097/PR9.0000000000001439","DOIUrl":"10.1097/PR9.0000000000001439","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1439"},"PeriodicalIF":4.3,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147989899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncontrollability of experimental pain decreases pain intensity and relief pleasantness ratings in a between-group design.","authors":"Marie Habermann, Christian Büchel","doi":"10.1097/PR9.0000000000001448","DOIUrl":"10.1097/PR9.0000000000001448","url":null,"abstract":"<p><strong>Introduction: </strong>A lack of control and resulting psychological helplessness can influence pain perception and learning behavior in novel situations. However, a transfer effect has not been tested directly under laboratory conditions.</p><p><strong>Objective: </strong>Combine the measurement of perceptual changes when pain is uncontrollable with the assessment of changes in learning behavior in a between-subject design informed by learned helplessness theory.</p><p><strong>Methods: </strong>In a first phase, a control group (n = 37) learned how to avoid a painful stimulus and obtain pain relief. The experimental group (n = 40) received the same sequence of painful and relieving stimuli, independent of their behavior, and thereby experienced uncontrollable pain. In a second phase, both groups could learn how to shorten a painful stimulus and induce relief.</p><p><strong>Results: </strong>Pain ratings decreased more steeply in the experimental group, where participants had no control over the stimuli. In addition, relief pleasantness ratings were lower in this group and decreased less. The groups did not differ in any measure of learning behavior.</p><p><strong>Conclusion: </strong>A lack of control over pain resulted in decreased pain and relief ratings. This reduction in perception in uncontrollable situations fits the informational value theory of pain, namely that pain is decreased, if the organism cannot act upon it.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1448"},"PeriodicalIF":4.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal ideation among patients with facial pain disorders.","authors":"Justin M Campbell, Rose Caston, Omid Shoraka, John D Rolston, Shervin Rahimpour","doi":"10.1097/PR9.0000000000001415","DOIUrl":"10.1097/PR9.0000000000001415","url":null,"abstract":"<p><strong>Introduction: </strong>Facial pain can be severely debilitating. Although etiologies vary, facial pain commonly results in diminished quality of life and a pronounced psychosocial burden.</p><p><strong>Objectives: </strong>To determine whether severe facial pain is associated with a heightened risk of suicidal ideation.</p><p><strong>Methods: </strong>We performed a retrospective review of patients with facial pain disorders who, during a presurgical evaluation, completed the Columbia-Suicide Severity Rating Scale and Brief Pain Inventory-Facial (BPI-Facial) scale, which assess suicidal risk and the effect of facial pain on quality of life, respectively. To evaluate the independent association between components of the BPI-Facial scale and suicidal thoughts or behaviors, we constructed a series of multivariable logistic regression models. Further classification and k-means clustering techniques were used to predict individual instances of suicidal ideation and to group distinct phenotypes of facial pain, respectively.</p><p><strong>Results: </strong>We identified 181 patients with facial pain who met the inclusion criteria. The most common cause of facial pain was trigeminal neuralgia (78.5%). Within our cohort, 13.3% of patients reported some degree of suicidal ideation in the Columbia-Suicide Severity Rating Scale questionnaire, a rate approximately 3 times higher than the estimated prevalence in the general adult population. This heightened risk of suicide was associated with considerable pain-related impairments reported in the BPI-Facial scale across the following tested domains: pain intensity, interference in general activities, and interference in face-specific activities.</p><p><strong>Conclusion: </strong>Our results suggest that facial pain can have highly detrimental effects on patient well-being. Moreover, quantifying facial pain-related impairments may assist in developing targeted interventions and longitudinal screening for mitigating the heightened risk of suicide among those with facial pain disorders.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1415"},"PeriodicalIF":4.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor deficits after herpes zoster: a comparative analysis of patient characteristics and sensory changes.","authors":"Elisabeth J M Adriaansen, Jacqueline F M van Dijk, Bart J H Splinter, Lisette M Vernooij, Frank J P M Huygen, Mienke Rijsdijk","doi":"10.1097/PR9.0000000000001440","DOIUrl":"10.1097/PR9.0000000000001440","url":null,"abstract":"<p><strong>Introduction: </strong>Herpes zoster (HZ) predominantly affects sensory nerves and can lead to postherpetic neuralgia. A motor deficit in the corresponding myotome is a rare but severe complication. <b>Objectives:</b> The objective of this study was to further characterize patients with HZ-related motor deficits and to explore potential risk factors.</p><p><strong>Methods: </strong>This retrospective cohort study in the tertiary pain clinic of the University Medical Center Utrecht, includes a comparative analysis of patients presenting with and without motor deficit resulting from HZ. Patient characteristics including psychological distress were assessed using standardized questionnaires, and Quantitative Sensory Testing outcomes were analysed between the 2 groups.</p><p><strong>Results: </strong>The study population included 158 patients with postherpetic neuralgia, of whom 17 patients had motor paralysis. In the motor paralysis group, most were male (94.1%). The median pain intensity was NRS 7, similar in both groups. Anxiety, depression, Pain Catastrophizing Scale, and DN4 scores did not differ significantly between groups. Tampa Scale of Kinesiophobia, indicating kinesiophobia did significantly differ between both groups (<i>P</i> = 0.043). Patients with motor deficit showed distinct sensory profiles characterized by sensory loss in 70.6% of patients compared with 35.5% in the group without motor deficit (<i>P</i> = 0.017).</p><p><strong>Conclusion: </strong>Motor deficit may be more common than we realize and is a serious complication of HZ. Patients who experienced motor deficit as a complication of herpes zoster demonstrated more severe nerve damage, with sensory loss being the most frequent sensory phenotype. More awareness is needed for this serious complication accompanied with research guiding treatment and rehabilitation protocols.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1440"},"PeriodicalIF":4.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}