Pain Reports最新文献

{"title":"The true experts: codeveloping a preventive psychological intervention for postsurgical pain with patients and caregivers.","authors":"Jana Hochreuter, Emil Kane Nissen, Cosima Locher, Jessica Lee Schleider, Shannon Bhend, Helen Koechlin","doi":"10.1097/PR9.0000000000001445","DOIUrl":"10.1097/PR9.0000000000001445","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 20% of youth undergoing major surgery develop chronic postsurgical pain (CPSP). However, preventive interventions for CPSP have yielded mixed results, partly due to the limited involvement of patients and caregivers in the intervention development process. Single-session interventions (SSI) are well-suited in this context, as they are time- and cost-efficient.</p><p><strong>Objectives: </strong>This study investigates the perioperative needs of patients and caregivers, and utilizes these insights to co-develop a preventive psychological SSI for post-surgical pain.</p><p><strong>Methods: </strong>Two rounds of focus groups were conducted with patients and caregivers to (1) gather information on the perioperative experience of patients and caregivers to develop the content of a preventive SSI, and (2) gather feedback on the draft of the intervention. Participants' experiences were analyzed applying structural content analysis. Based on these results, the content of a digital intervention was developed, which was then presented to participants for evaluation, and feedback was analyzed using participatory observation.</p><p><strong>Results: </strong>Five adolescent patients and four mothers took part in the focus groups. In total, 5 superordinate categories were identified: Consequences of context (i.e., contextual components), looking after yourself (i.e., self-care related components), limitations of healthcare system (i.e., healthcare system-based components), requests for medical staff (i.e., specific expectations directed toward providers) and child as primary focus (i.e., child-focused components). The intervention draft was well accepted by participants, and minor suggestions for improvement were implemented.</p><p><strong>Conclusion: </strong>Our study identifies core topics of importance for patients undergoing major surgery and their caregivers, and informs the development of a preventive psychological intervention.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1445"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep heart rate predicts next-day pain medication use in posttraumatic stress disorder inpatients.","authors":"Gisselle C Tamayo, Ned J Arsenault, Andrea L Jamison, Diana Villasenor, Katherine E Miller, Steven H Woodward","doi":"10.1097/PR9.0000000000001444","DOIUrl":"10.1097/PR9.0000000000001444","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pain and posttraumatic stress disorder (PTSD) are common in Veterans, commonly co-occurring, and are associated with pain medication use.</p><p><strong>Objectives: </strong>Our primary aim in this study was to explore the relationship between sleep heart rate (HR) and respiratory sinus arrhythmia (RSA) on next-day prescription pain medication use in Veterans with PTSD.</p><p><strong>Methods: </strong>Seventy-eight male US military Veterans attending an inpatient treatment program for service-related PTSD were observed over an average of 78 nights. Sleep HR and RSA were recorded using mattress actigraphy, and daily pain medication prescription was obtained from electronic health record.</p><p><strong>Results: </strong>Binary logistic mixed-effects regression models were used to test the associations between sleep HR and RSA on next-day pain medication prescription. These revealed that higher sleep HR was predictive of higher rates of next-day pain medication prescriptions; however, sleep RSA was not. An analysis disaggregating between- and within-persons effects associating sleep HR and next-day pain prescription found evidence of the former but not the latter.</p><p><strong>Conclusion: </strong>These results replicate and extend those of Dudarev et al. (2024) in demonstrating a positive relationship between sleep HR and next-day pain in a new population, Veterans with deployment-related PTSD. They support a role of autonomic arousal in subjective pain and medication-seeking and suggest that hyperarousal may mediate the excess vulnerability of persons with PTSD to pain medication use.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1444"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-body vibration decreases pain and cartilage degeneration in male and female mice with osteoarthritis.","authors":"Julia Temp, Melih Özgür Celik, Urszula Zabarylo, Dominika Labuz, Kay Raum, Stefan Zachow, Halina Machelska","doi":"10.1097/PR9.0000000000001442","DOIUrl":"10.1097/PR9.0000000000001442","url":null,"abstract":"<p><strong>Introduction: </strong>Knee osteoarthritis (OA) is a chronic, degenerative joint disorder characterized by cartilage deterioration and persistent pain. Currently, there are no disease-modifying drugs and pharmacological treatments are unsatisfactory for OA.</p><p><strong>Objective: </strong>To investigate the therapeutic effects of whole-body vibration (WBV), a nondemanding physical intervention, on pain behaviors and cartilage morphology in male and female mice with knee OA.</p><p><strong>Methods: </strong>A medial meniscal transection (MMT) was used as a model that mimics meniscal tear-induced knee OA in patients. Animals were exposed to WBV (15-Hz frequency, 332-µm amplitude, 0.3<i>g</i> acceleration) for 15 minutes per day, 5 days per week, for 13 weeks, beginning 3 weeks after MMT, using a custom-made WBV device. Behavioral analysis included assessment of mechanical sensitivity (by von Frey filaments), the hind limb use (by dynamic weight-bearing), heat sensitivity (by Hargreaves test), locomotor activity (in open field boxes), and body weight. Microcomputed tomography was used to examine cartilage morphology.</p><p><strong>Results: </strong>Medial meniscal transection triggered mechanical hypersensitivity, reduced OA limb use, and induced cartilage damage in the medial and lateral compartments of femur and tibia, in both sexes. Whole-body vibration substantially alleviated mechanical hypersensitivity and improved limb use for up to 4 months after MMT, without affecting heat sensitivity, locomotor activity, or body weight. Furthermore, WBV considerably reduced the percentage of subchondral bone denuded of cartilage and increased cartilage thickness in the femur and tibia.</p><p><strong>Conclusion: </strong>These findings highlight the therapeutic potential of WBV as a nonpharmacological approach to relieve pain and restore cartilage integrity in knee OA.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1442"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory fitness and pain severity: Longitudinal associations from the general population-The HUNT study.","authors":"Live Førland Havstad, Astrid Woodhouse, Tormod Landmark, Dorthe Stensvold, Bjarne Nes, Martin Skagseth, Mari Glette","doi":"10.1097/PR9.0000000000001447","DOIUrl":"10.1097/PR9.0000000000001447","url":null,"abstract":"<p><strong>Introduction: </strong>Reduced cardiorespiratory fitness (CRF) is associated with chronic pain, but longitudinal population-based evidence is limited. Whether CRF can prevent pain worsening or promote improvement is unclear.</p><p><strong>Objective: </strong>This study investigated (1) the cross-sectional association between estimated CRF (eCRF) and chronic pain, (2) the longitudinal association between eCRF and changes in pain severity over 11 years, and (3) whether changes in eCRF are associated with changes in pain severity.</p><p><strong>Method: </strong>Data were collected from the Trøndelag Health Study (HUNT) in Norway. Cross-sectional analyses included 18,837 adults from HUNT3 (2006-08), and longitudinal analyses followed participants to HUNT4 (2017-19), stratified by baseline pain status: no or mild (n = 11,517) or moderate/severe chronic pain (n = 5312). Cardiorespiratory fitness was estimated using a validated nonexercise algorithm and categorized into sex- and age-specific quintiles. Logistic regression estimated odds ratios with 95% confidence intervals.</p><p><strong>Results: </strong>Cross-sectionally, higher eCRF was associated with lower odds of chronic pain, with the largest difference between the highest and the lowest quintiles (women: OR 0.56, 95% CI 0.49-0.64; men: OR 0.64, 95% CI 0.53-0.78). Longitudinally, among participants with no or mild pain, both high baseline eCRF and maintained high eCRF were associated with lower odds of pain worsening. Among those with chronic pain, maintaining or increasing eCRF was associated with greater odds of pain reduction, whereas high baseline eCRF showed a nonsignificant trend in the same direction.</p><p><strong>Conclusion: </strong>Higher eCRF was associated with lower odds of chronic pain and with more favorable changes in pain severity in the general population.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1447"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher disease burden and greater small fibre impairment in women with painful diabetic neuropathy.","authors":"Gordon Sloan, Dinesh Selvarajah, Jessica Smith, Shillo Pallai, Marni Greig, M Shaan Goonoo, Thomas Cash, Merhawit A Abera, Sharon Caunt, Iain D Wilkinson, Solomon Tesfaye","doi":"10.1097/PR9.0000000000001443","DOIUrl":"10.1097/PR9.0000000000001443","url":null,"abstract":"<p><strong>Objective: </strong>Although the incidence of Painful-Diabetic Peripheral Neuropathy (Painful-DPN) is higher in women, the underlying reasons for this are not known. This study investigated sex differences in pain and neurological phenotypes in 2 cohorts of patients with Painful-DPN.</p><p><strong>Methods: </strong>Two cohort analyses were performed in this retrospective analysis of participants with Painful-DPN recruited to cross-sectional studies: (1) Patient-Reported Outcomes Measures Cohort analysis (n = 184), which assessed neuropathic pain intensity (Numeric Rating Score), neuropathic symptoms (Neuropathic Pain Scale), mood (Hospital Anxiety and Depression Scale), quality of life (Norfolk QoL-DN), and sleep (Medical Outcomes Sleep Study); (2) Neurological Phenotyping Cohort analysis (n = 100), which assessed large- (Neuropathy Impairment Score of the Lower Limb plus Seven Neurophysiological Tests) and small-nerve fibre function. Participants were also divided into irritable (IR) and nonirritable nociceptor phenotypes.</p><p><strong>Results: </strong>In the first cohort analysis, women reported greater neuropathic pain symptom burden, poorer sleep, and higher anxiety prevalence than men. In the second cohort analysis, men had greater large-nerve fibre impairment, whereas women exhibited more severe small-fibre dysfunction. In addition, IR nociceptor phenotypes were more prevalent in women.</p><p><strong>Conclusion: </strong>Women with Painful-DPN experience a greater disease burden, increased small-fibre impairment, and are more likely to have the IR nociceptor phenotype, suggesting potential sex-specific disease mechanisms.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1443"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylglyoxal alters C-fibre activity-dependent slowing and induces heat hyperalgesia in a sex-dependent manner, in rats.","authors":"Atanaska N Velichkova, Menekse Mutlu-Smith, Amy L Hall, Carole Torsney","doi":"10.1097/PR9.0000000000001430","DOIUrl":"10.1097/PR9.0000000000001430","url":null,"abstract":"<p><strong>Introduction: </strong>Raised plasma levels of the glycolytic metabolite methylglyoxal are associated with pain symptoms in patients with diabetic neuropathy. Methylglyoxal can regulate the function of Na_V1.7 and Na_V1.8 ion channels that are involved in the phenomenon of activity-dependent slowing (ADS) in C-fibre nociceptors. C-fibre ADS differs between the sexes and can regulate spinal network function.</p><p><strong>Objective: </strong>Explore the impact of methylglyoxal upon C-fibre ADS and pain sensitivity in both sexes. In addition, investigate the influence of ADS upon the processing of C-fibre inputs, in noxious heat responsive spinal neurons.</p><p><strong>Results: </strong>Compound action potential recording of isolated dorsal roots incubated with methylglyoxal (100 µM, 3 hours) revealed a sex-dependent impact upon C-fibre ADS. In male roots, C-fibre ADS was reduced, whereas in female roots, it was increased. Acute methylglyoxal application (100 µM/1 mM, 10 minutes) did not modify C-fibre ADS. Systemic methylglyoxal administration (5 μg, 3 h prior) induced heat hyperalgesia in male but not female juvenile rats. Patch-clamp recording in spinal slices with attached dorsal roots revealed that length-dependent manipulation of ADS altered action potential firing to stimulus trains in noxious heat responsive Fos-EGFP + spinal neurons.</p><p><strong>Conclusion: </strong>We propose that methylglyoxal sex-dependent regulation of C-fibre ADS influences the spinal processing of noxious heat inputs that may contribute to the male specific induction of heat hyperalgesia after systemic methylglyoxal treatment.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1430"},"PeriodicalIF":4.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease.","authors":"Anne Ritoux, Laura J Grundy, Pravallika Manjappa, Luke W Paine, Jessica Neisen, John E Linley, Ewan St John Smith","doi":"10.1097/PR9.0000000000001446","DOIUrl":"10.1097/PR9.0000000000001446","url":null,"abstract":"<p><strong>Introduction: </strong>Abdominal pain is a significant burden for those living with inflammatory bowel disease (IBD), representing a major unmet clinical need due to the scarcity of effective therapeutic options. The G protein-coupled receptor, protease-activated receptor 2 (PAR2), has emerged as a promising therapeutic target for visceral pain management in IBD.</p><p><strong>Objectives: </strong>We set out to determine signaling mechanisms deployed by PAR2 in the lumbar splanchnic nerve and whether inhibiting PAR2 with the mouse monoclonal antibody (mAb), PAR650097 (mPAR650097) provided therapeutic benefit in dextran sulfate sodium (DSS)-induced colitis.</p><p><strong>Methods: </strong>We first used ex vivo electrophysiological recordings of mouse lumbar splanchnic nerve to determine how stimulation of PAR2 alters afferent activity and the intracellular signaling mechanisms involved. Second, we used the DSS model of colitis in mice and determined how mPAR650097 altered disease activity, behavior, colon histology, and the activity of nociceptive circuitry.</p><p><strong>Results: </strong>Protease-activated receptor 2 stimulation in the colon activated visceral afferent fibers and sensitized them to mechanical and chemical stimuli. We found that endosomal internalization and protein kinase A/C signaling mediate both activating and sensitizing effects of PAR2 in visceral pain. We further show that inhibiting PAR2 with the mAb mPAR650097 reduces DSS-induced colitis severity and pain. mPAR650097 also reduced several colitis-induced pain correlates at key points along the pain-signaling axis, including peripheral nociceptive neuron signaling and sensitivity, expression of proinflammatory mediators, spinal cord signaling, and, fundamentally, behavior.</p><p><strong>Conclusion: </strong>These findings illustrate that mAb inhibition of PAR2 represents a promising approach to provide relief from abdominal pain in those living with IBD.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1446"},"PeriodicalIF":4.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13098787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal pain trajectories and social context in fibromyalgia.","authors":"Benjamin Mosch, Martin Diers","doi":"10.1097/PR9.0000000000001434","DOIUrl":"10.1097/PR9.0000000000001434","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1434"},"PeriodicalIF":4.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of widespread pain and peak alpha frequency cannot be isolated to a single network.","authors":"Jason Cherin, Natalie McLain, Andrew Schrepf, Larissa V Rodriguez, Jason J Kutch","doi":"10.1097/PR9.0000000000001436","DOIUrl":"10.1097/PR9.0000000000001436","url":null,"abstract":"<p><strong>Introduction: </strong>Peak alpha frequency (PAF), an electroencephalography measure, has gained interest due to its association to pain-related neural processes in both healthy and clinical populations. In healthy groups, PAF derived from the sensorimotor component has strongly correlated with pain sensitivity, but in patient populations, only channel-based methods such as the global average and regions of interest have been investigated. Therefore, the specific role of component-based PAF such as the sensorimotor component and how it compares with channel-based methods remains undefined in chronic pain.</p><p><strong>Objective: </strong>To evaluate the performance of multiple spatial variations of PAF in distinguishing between widespread and localized chronic pelvic pain.</p><p><strong>Methods: </strong>This secondary analysis included 38 individuals with urologic chronic pelvic pain syndrome and were categorized as having widespread (n = 24) or localized (n = 14) pain based on self-reported body maps. Resting-state electroencephalography data were collected, and 4 types of spatial variations were used: global average, region of interest, sensorimotor component, and group independent component analysis.</p><p><strong>Results: </strong>Both the global average and region of interest-based PAF had significantly lower average PAF among individuals in the widespread compared with localized pain groups. There was no significant difference for the sensorimotor component or group independent component analysis-component PAF. Channel-based methods had larger effect sizes compared with the component-based methods when explaining differences in PAF between pain groups.</p><p><strong>Conclusion: </strong>These findings suggest that chronic widespread pain is associated with widely distributed changes in cortical function that cannot be captured in a single component, indicating that it affects multiple distinct neural networks.</p>","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1436"},"PeriodicalIF":4.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The social dimensions of fibromyalgia scientific research: an international classification of functioning, disability, and health-based perspective.","authors":"André Pontes-Silva","doi":"10.1097/PR9.0000000000001433","DOIUrl":"10.1097/PR9.0000000000001433","url":null,"abstract":"","PeriodicalId":52189,"journal":{"name":"Pain Reports","volume":"11 3","pages":"e1433"},"PeriodicalIF":4.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}