Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)最新文献

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The psychiatric impact of COVID-19 pandemic on sexual health. COVID-19大流行对性健康的精神病学影响
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2020-1197
Gustavo M Paul, Bruno C Nascimento, João Afif-Abdo, Francisco R Coutinho, Eduardo P Miranda, Carmita H N Abdo
{"title":"The psychiatric impact of COVID-19 pandemic on sexual health.","authors":"Gustavo M Paul, Bruno C Nascimento, João Afif-Abdo, Francisco R Coutinho, Eduardo P Miranda, Carmita H N Abdo","doi":"10.1590/1516-4446-2020-1197","DOIUrl":"https://doi.org/10.1590/1516-4446-2020-1197","url":null,"abstract":"The new coronavirus pandemic has been considered the greatest challenge for the health system in the modern era. Although social distancing and quarantines have been necessary as public health strategies, they may contribute to psychological and mental problems. There is evidence that reduced interpersonal communication may increase the incidence of depression and anxiety and exacerbate pre-existing conditions. In fact, loneliness, denial, anxiety, depression, insomnia and despair have been reported among suspected cases of coronavirus disease (COVID19). In addition, some studies have shown an increased risk of aggressiveness and suicide in infected individuals. Anxiety and depression are commonly seen in men with sexual disorders such as erectile dysfunction and premature ejaculation. Anxious men are more likely to experience performance anxiety, while those with depression tend to report lack of libido. In female patients, depression is strongly linked to hypoactive sexual desire disorder and anxiety has been shown to interfere with arousal and the ability to achieve orgasm. Chronic dyspareunia is 3-10 times more common in women diagnosed with depression or anxiety. Although no published study has directly investigated changes in sexual function and behavior during COVID19, negative effects on sexual health are expected. Previous pandemics have shown that social isolation associated with fear of being infected significantly reduces sexual contact. Pornography consumption has also increased concomitantly with the pandemic. On March 13, 2020, the Pornhub website reported an 11.6% increase in accesses. Excessive masturbation can interfere in a couple’s relationship, leading to growing feelings of isolation and breakups. The spread of COVID-19 through sexual activity is also concerning. Since the virus is present in upper airway fluids, it might be transmissible during sex. The International Society for Sexual Medicine produced a set of recommendations regarding the safety of sexual activity during the pandemic, including that healthy couples in confinement may maintain normal sexual activity. Individuals with respiratory symptoms or immunocompromised partners should abstain from sexual activity. Masturbation is safe as long as hygiene standards are maintained. Alternative sexual activity, such as exchanging messages, pictures or videos by digital means are not risky, and may even be good method for exploring a couple’s sexual fantasies. Therefore, COVID-19 could directly and indirectly impact the sex lives of many couples. Increasing rates of anxiety and depression may translate into higher rates of psychogenic sexual dysfunction. Protective measures to guarantee safe sex might also lead to situational difficulties, especially for those at risk of or with preexisting sexual dysfunction. The medical community must be aware of such phenomena and provide proper counseling, especially during these times, when many traditional psychological support mod","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/4f/bjp-43-01-109.PMC7861171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38233751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Hikikomori and the COVID-19 pandemic: not leaving behind the socially withdrawn. “隐蔽青年”与2019冠状病毒病大流行:不让社交退缩者掉队。
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2020-1145
Thiago H Roza, Daniel T Spritzer, Ary Gadelha, Ives C Passos
{"title":"Hikikomori and the COVID-19 pandemic: not leaving behind the socially withdrawn.","authors":"Thiago H Roza, Daniel T Spritzer, Ary Gadelha, Ives C Passos","doi":"10.1590/1516-4446-2020-1145","DOIUrl":"https://doi.org/10.1590/1516-4446-2020-1145","url":null,"abstract":"dated in Portuguese for the Brazilian cultural context, as well as the impossibility of objectively identifying and measuring tokophobia, make adequate therapeutic guidance difficult. A systematic review and meta-analysis was performed of the risk factors. The perception of tokophobia was assessed among pregnant women and prenatal health care professionals to identify the peculiarities of tokophobia in the Brazilian socio-cultural and clinical-obstetric context. The conceptual and psychometric analysis process allowed the development and validation of the Tokophobia Assessment Questionnaire (Questionário de Avaliação da Partofobia) in Brazilian Portuguese, available from the authors upon request. This research project was approved by the Universidade do Sul de Santa Catarina research ethics committee (protocol 87312818.0.0000.5369). The Tokophobia Assessment Questionnaire has been validated; its reliability was measured with the Pearson correlation coefficient (0.766) and the intraclass correlation coefficient (0.856). Bland-Altman analysis showed a central tendency between the difference and mean of the two Tokophobia Assessment Questionnaire applications in almost the entire sample. The general Cronbach’s alpha was 0.935 (Table 1). The Kappa index was 0.444 and the Pearson correlation coefficient between the first application of the Tokophobia Assessment Questionnaire and the Depression, Anxiety and Stress Scale was 0.607. Exploratory factor analysis identified six factors categorized into conceptual groups: physical repercussions (factor 1); feeling of panic (factor 2); social involvement (factor 3); interference in daily habits (factor 4); pregnancy avoidance (factor 5); self-perception of tokophobia (factor 6) (Table 1). Use of the item response theory demonstrated the suitability of all items (Figure 1). Therefore, the 25-item Tokophobia Assessment Questionnaire is reliable and valid and is the first instrument for assessing the clinical, emotional and psychiatric manifestations of tokophobia. Although developed for the Brazilian population, the instrument may have worldwide applicability.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"114-116"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/01/bjp-43-01-114.PMC7861179.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38405099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results. 反复经颅磁刺激背内侧前额叶皮层后边缘型人格障碍症状的改善:初步结果。
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2019-0591
Angel R Calderón-Moctezuma, Julian V Reyes-López, René Rodríguez-Valdés, Mario Barbosa-Luna, Josefina Ricardo-Garcell, Marbella Espino-Cortés, Nancy Hernández-Chan, Lorena García-Noguez, Georgina Roque-Roque, Gerardo Trejo-Cruz, Sofía Cañizares-Gómez, Hebert Hernández-Montiel
{"title":"Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results.","authors":"Angel R Calderón-Moctezuma,&nbsp;Julian V Reyes-López,&nbsp;René Rodríguez-Valdés,&nbsp;Mario Barbosa-Luna,&nbsp;Josefina Ricardo-Garcell,&nbsp;Marbella Espino-Cortés,&nbsp;Nancy Hernández-Chan,&nbsp;Lorena García-Noguez,&nbsp;Georgina Roque-Roque,&nbsp;Gerardo Trejo-Cruz,&nbsp;Sofía Cañizares-Gómez,&nbsp;Hebert Hernández-Montiel","doi":"10.1590/1516-4446-2019-0591","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-0591","url":null,"abstract":"<p><strong>Objective: </strong>Current treatment for borderline personality disorder (BPD) involves psychological and pharmacological interventions. However, neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) may positively affect BPD symptomatology. The objective of this study was to evaluate the clinical and neuropsychological effects of rTMS on the dorsomedial prefrontal cortex (DMPFC) in BPD patients.</p><p><strong>Methods: </strong>Fourteen patients with BPD were randomized into two groups (active vs. sham) for 15 sessions of rTMS on the DMPFC. Clinical effects were measured using the Borderline Symptoms List (BSL), Clinical Global Impression Scale for BPD (CGI-BPD), Borderline Evaluation of Severity over Time (BEST), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), and Barratt's Impulsiveness Scale (BIS). Neuropsychological effects were determined by a Stop-Signal Task (SST), the Wisconsin Card-Sorting Test (WCST), and the Iowa Gambling Test (IGT).</p><p><strong>Results: </strong>Within-group comparison showed significant differences (p < 0.05) in CGI-BPD (total score and six of nine psychopathologic domains), BEST, HDRS, HARS, and IGT scores for active modality.</p><p><strong>Conclusion: </strong>The 5 Hz-DMPFC rTMS technique was well tolerated and lessened the severity of BPD symptomatology, especially abandonment, affective issues, interpersonal relationships, suicidal behavior, anger, and paranoid ideation. Cognitive improvement was seen in decision-making. Additional studies are needed to fully evaluate the effects of rTMS on BPD symptomatology.</p><p><strong>Clinical trial registration: </strong>NCT03832777.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/80/bjp-43-01-65.PMC7861182.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38432638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Prevalence of psychiatric symptoms among refugee adolescents in Turkey: a controlled study. 土耳其难民青少年中精神症状的流行:一项对照研究
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2020-0916
Mehmet Karadag, Hakan Ogutlu
{"title":"Prevalence of psychiatric symptoms among refugee adolescents in Turkey: a controlled study.","authors":"Mehmet Karadag,&nbsp;Hakan Ogutlu","doi":"10.1590/1516-4446-2020-0916","DOIUrl":"https://doi.org/10.1590/1516-4446-2020-0916","url":null,"abstract":"<p><strong>Objective: </strong>To investigate prevalence of internalized and externalized psychological symptoms and war-related adverse events among a representative secondary-school sample of Syrian refugee adolescents, and to compare levels of depression, anxiety, and stress between Syrian refugee adolescents and Turkish adolescents.</p><p><strong>Methods: </strong>Syrian refugee adolescents (n=70) and Turkish adolescents (n=70) were asked to complete the Depression, Anxiety, and Stress Scales (DASS-42) and Strengths and Difficulties Questionnaire (SDQ).</p><p><strong>Results: </strong>DASS and SDQ scores were significantly different between the two groups; scores in all problem areas were higher in refugees. Loss of a family member increased depression, stress, and total difficulty scored, whereas witnessing death increased anxiety and stress and experiencing multiple events increased depression, anxiety, and total difficulty scores. Maternal years of schooling correlated inversely with SDQ emotional symptoms, conduct problems, and hyperactivity/inattention problem scores. Both parents' years of schooling correlated inversely with SDQ total difficulties scores.</p><p><strong>Conclusion: </strong>Syrian refugee adolescents had higher depression, anxiety, behavioral problems, peer relationship problems, and general difficulties than their Turkish peers. Facilitating refugees' access to mental health services, educating their parents, consulting, and monitoring at-risk children may contribute to reducing psychosocial problems in refugee children.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/0f/bjp-43-01-55.PMC7861173.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38179305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Working during pandemics: the need for mental health efforts to prevent the outbreak of mental disorders at the workplace. 大流行期间的工作:需要开展精神卫生工作,以防止工作场所精神疾病的爆发。
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2020-1120
Antônio G da Silva, Mayra Pinheiro, Letícia M Trés, Leandro F Malloy-Diniz
{"title":"Working during pandemics: the need for mental health efforts to prevent the outbreak of mental disorders at the workplace.","authors":"Antônio G da Silva,&nbsp;Mayra Pinheiro,&nbsp;Letícia M Trés,&nbsp;Leandro F Malloy-Diniz","doi":"10.1590/1516-4446-2020-1120","DOIUrl":"https://doi.org/10.1590/1516-4446-2020-1120","url":null,"abstract":"1 Wilder-Smith A, Freedman DO. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J Travel Med. 2020;27:taaa020. 2 Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020;395:912-20. 3 Li TM, Wong PW. Youth social withdrawal behavior (Hikikomori): a systematic review of qualitative and quantitative studies. Aust N Z J Psychiatry. 2015;49:595-609. 4 Kato TA, Kanba S, Teo AR. Defining pathological social withdrawal: proposed diagnostic criteria for hikikomori. World Psychiatry. 2020; 19:116-7. 5 Pozza A, Coluccia A, Kato T, Gaetani M, Ferretti F. The ‘Hikikomori’ syndrome: worldwide prevalence and co-occurring major psychiatric disorders: a systematic review and meta-analysis protocol. BMJ Open. 2019;9:e025213. 6 Kato TA, Shinfuku N, Tateno M. Internet society, internet addiction, and pathological social withdrawal: the chicken and egg dilemma for internet addiction and Hikikomori. Curr Opin Psychiatry. 2020;33:264-70. 7 Kubo H, Urata H, Sakai M, Nonaka S, Saito K, Tateno M, et al. Development of 5-day Hikikomori intervention program for family members: a single-arm pilot trial. Heliyon. 2020;6:e03011. 8 Wong JC, Wan MJ, Kroneman L, Kato TA, Lo TW, Wong PW, et al. Hikikomori phenomenon in East Asia: regional perspectives, challenges, and opportunities for social health agencies. Front Psychiatry. 2019;10:512. 9 Roza TH, Spritzer DT, Lovato LM, Passos IC. Multimodal treatment for a Brazilian case of Hikikomori. Braz J Psychiatry. 2020;42:455-6. 10 Kato TA, Kanba S, Teo AR. Hikikomori: multidimensional understanding, assessment, and future international perspectives. Psychiatry Clin Neurosci. 2019;73:427-40. 11 Nishida M, Kikuchi S, Fukuda K, Kato S. Jogging therapy for Hikikomori social withdrawal and increased cerebral hemodynamics: a case report. Clin Pract Epidemiol Ment Health. 2016;12:38-42. 12 Gondim FA, Aragão AP, Holanda Filha JG, Messias EL. Hikikomori in Brazil: 29 years of voluntary social withdrawal. Asian J Psychiatr. 2017;30:163-4. 13 Prioste CD, de Siqueira RC. Fetichismo virtual na vida de um Hikikomori brasileiro: um estudo de caso. DOXA: Rev Bras Psicol Educ. 2019;21:4-16. 14 Cellini N, Canale N, Mioni G, Costa S. Changes in sleep pattern, sense of time and digital media use during COVID-19 lockdown in Italy. J Sleep Res. 2020 May 15;e13074. doi: http://10.1111/jsr.13074. Online ahead of print. 15 Li J, Yang Z, Qiu H, Wang Y, Jian L, Ji J, et al. Anxiety and depression among general population in China at the peak of the COVID19 epidemic. World Psychiatry. 2020;19:249-50. 16 Zhou SJ, Zhang LG, Wang LL, Guo ZC, Wang JQ, Chen JC, et al. Prevalence and socio-demographic correlates of psychological health problems in Chinese adolescents during the outbreak of COVID-19. Eur Child Adolesc Psychiatry. 202","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"116-117"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/d9/bjp-43-01-116.PMC7861174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38432639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Association between poor tolerability of antidepressant treatment and brain functional activation in youth at risk for bipolar disorder. 双相情感障碍风险青年抗抑郁治疗耐受性差与脑功能激活之间的关系
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2019-0803
Fabiano G Nery, Sheela L Masifi, Jeffrey R Strawn, Luis R Duran, Wade A Weber, Jeffrey A Welge, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello
{"title":"Association between poor tolerability of antidepressant treatment and brain functional activation in youth at risk for bipolar disorder.","authors":"Fabiano G Nery,&nbsp;Sheela L Masifi,&nbsp;Jeffrey R Strawn,&nbsp;Luis R Duran,&nbsp;Wade A Weber,&nbsp;Jeffrey A Welge,&nbsp;Caleb M Adler,&nbsp;Stephen M Strakowski,&nbsp;Melissa P DelBello","doi":"10.1590/1516-4446-2019-0803","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-0803","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether poor antidepressant tolerability is associated with functional brain changes in children and adolescents of parents with bipolar I disorder (at-risk youth).</p><p><strong>Methods: </strong>Seventy-three at-risk youth (ages 9-20 years old) who participated in a prospective study and had an available baseline functional magnetic resonance imaging (fMRI) scan were included. Research records were reviewed for the incidence of adverse reactions related to antidepressant exposure during follow-up. The sample was divided among at-risk youth without antidepressant exposure (n=21), at-risk youth with antidepressant exposure and no adverse reaction (n=12), at-risk youth with antidepressant-related adverse reaction (n=21), and healthy controls (n=20). The fMRI task was a continuous performance test with emotional distracters. Region-of-interest mean activation in brain areas of the fronto-limbic emotional circuit was compared among groups.</p><p><strong>Results: </strong>Right amygdala activation in response to emotional distracters significantly differed among groups (F3,66 = 3.1, p = 0.03). At-risk youth with an antidepressant-related adverse reaction had the lowest amygdala activation, while at-risk youth without antidepressant exposure had the highest activation (p = 0.004).</p><p><strong>Conclusions: </strong>Decreased right amygdala activation in response to emotional distracters is associated with experiencing an antidepressant-related adverse reaction in at-risk youth. Further studies to determine whether amygdala activation is a useful biomarker for antidepressant-related adverse events are needed.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/a1/bjp-43-01-70.PMC7861172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38432640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy. 认知心理治疗对重度抑郁症患者BDNF Val66Met多态性的影响
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2019-0726
Renata B Peters, Janaína Xavier, Thaíse C Mondin, Taiane de A Cardoso, Fabiana B Ferreira, Liana Teixeira, Kiane Gräeff, Luciana de A Quevedo, Karen Jansen, Luciano D Souza, Jean P Oses, Ricardo T Pinheiro, Ricardo A da Silva, Gabriele Ghisleni
{"title":"BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy.","authors":"Renata B Peters,&nbsp;Janaína Xavier,&nbsp;Thaíse C Mondin,&nbsp;Taiane de A Cardoso,&nbsp;Fabiana B Ferreira,&nbsp;Liana Teixeira,&nbsp;Kiane Gräeff,&nbsp;Luciana de A Quevedo,&nbsp;Karen Jansen,&nbsp;Luciano D Souza,&nbsp;Jean P Oses,&nbsp;Ricardo T Pinheiro,&nbsp;Ricardo A da Silva,&nbsp;Gabriele Ghisleni","doi":"10.1590/1516-4446-2019-0726","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-0726","url":null,"abstract":"<p><strong>Objective: </strong>Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism's moderation effect on resilience scores in response to cognitive therapy.</p><p><strong>Method: </strong>A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis.</p><p><strong>Results: </strong>The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008).</p><p><strong>Conclusion: </strong>Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"22-28"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/5b/bjp-43-01-22.PMC7861181.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38405098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Suicide attempts in Chinese Han patients with schizophrenia: cognitive, demographic, and clinical variables. 中国汉族精神分裂症患者的自杀企图:认知、人口统计学和临床变量
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2021-02-01 eCollection Date: 2020-01-01 DOI: 10.1590/1516-4446-2020-0900
Qilong Dai, Dongmei Wang, Jiesi Wang, Huang Xu, Elena C Andriescue, Hanjing E Wu, Meihong Xiu, Dachun Chen, Xiangyang Zhang
{"title":"Suicide attempts in Chinese Han patients with schizophrenia: cognitive, demographic, and clinical variables.","authors":"Qilong Dai,&nbsp;Dongmei Wang,&nbsp;Jiesi Wang,&nbsp;Huang Xu,&nbsp;Elena C Andriescue,&nbsp;Hanjing E Wu,&nbsp;Meihong Xiu,&nbsp;Dachun Chen,&nbsp;Xiangyang Zhang","doi":"10.1590/1516-4446-2020-0900","DOIUrl":"https://doi.org/10.1590/1516-4446-2020-0900","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to investigate the lifetime suicide attempt rate, clinical characteristics and cognitive function of Chinese patients with chronic schizophrenia who had attempted suicide.</p><p><strong>Methods: </strong>We collected data from 908 schizophrenia inpatients about suicide attempts through interviews with the patients and their families, as well as through medical records. All patients were assessed with the Positive and Negative Syndrome Scale, the Rating Scale for Extrapyramidal Side Effects, the Abnormal Involuntary Movement Scale, and the Repeated Battery for the Assessment of Neuropsychological Status.</p><p><strong>Results: </strong>Of this sample, 97 (10.68%) had attempted suicide. Patients who had attempted suicide were younger, had longer illness duration, and more severe general psychopathology and depressive symptoms than those who had not. Logistic regression analysis confirmed that suicide attempts were correlated with age, smoking, and depression. No cognitive performance differences were observed between patients who had and had not attempted suicide.</p><p><strong>Conclusions: </strong>In China, patients with chronic schizophrenia may have a higher prevalence of lifetime suicide attempts than the general population. Some demographic and clinical variables were related to suicide attempts in patients with chronic schizophrenia.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/38/bjp-43-01-29.PMC7861187.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37929142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Prevention of suicide in older adults. 预防老年人自杀。
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2019-07-01 Epub Date: 2019-07-29 DOI: 10.1590/1516-4446-2019-0448
Mihir Upadhyaya, Leo Sher
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引用次数: 1
Generalized anxiety disorder: advances in neuroimaging studies. 广泛性焦虑障碍:神经影像学研究进展。
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2019-07-01 DOI: 10.1590/1516-4446-2019-4106
Marianna de Abreu Costa, Gisele Gus Manfro
{"title":"Generalized anxiety disorder: advances in neuroimaging studies.","authors":"Marianna de Abreu Costa,&nbsp;Gisele Gus Manfro","doi":"10.1590/1516-4446-2019-4106","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-4106","url":null,"abstract":"Generalized anxiety disorder: advances in neuroimaging studies Marianna de Abreu Costa,0000-0003-0303-943X Gisele Gus Manfro0000-0002-0109-7591 Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Programa de Transtornos de Ansiedade, Hospital de Clı́nicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"279"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/27/bjp-41-04-279.PMC6804307.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40452007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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