Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)最新文献

{"title":"Neurocognitive and Neurobiological Features of Early-Stage Unmedicated Patients with Bipolar Disorder.","authors":"Signem Oztekin, Fatma Akdeniz Usakli, Arzu Oran, Fatma Taneli, Sophia Frangou, Omer Aydemir","doi":"10.47626/1516-4446-2024-3976","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3976","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this project was to determine young adults who met the criteria of bipolar disorder (BD) but have not yet received diagnosis or treatment; and evaluate the neurocognitive and neurobiological changes by comparing with healthy controls.</p><p><strong>Methods: </strong>The high-risk group for BD was determined by using HCL-32R. After that, participants were interviewed with SCID-I to determine the previously undiagnosed and drug-naive patients (DNP) (n=27). Healthy control (HC) group (n=27) was included to compared with the DNP group. All participants completed a cognitive battery which evaluated executive functioning, attention, working memory and verbal learning. Magnetic Resonance Imaging data in all participants were obtained to compare cortical thickness. TBARS, NO and the antioxidant enzymes SOD and catalase activities were measured to determine the oxidative stress status.</p><p><strong>Results: </strong>The DNP group underperformed in all the tests administered but group differences were significant in the WCST and RVALT. Only catalase levels of oxidative stress markers were significantly higher in patients. DNP group showed significant cortical thinning in various regions of brain.</p><p><strong>Conclusion: </strong>Neurobiological changes and neurocognitive dysfunction are present in the early stage and unmedicated of BD. However longitudinal studies are needed to understand the progression.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation and Cross-cultural Validation of the Flourishing and Secure Flourishing Indexes in the Brazilian Portuguese language.","authors":"Juliane P de B Gonçalves, Marianna de Abreu Costa, Neusa Sica Da Rocha, Gisele Manfro, Willyane de Andrade Alvarenga, Alexander Moreira-Almeida, Bruno Mosqueiro Paz, Marcelo Fleck, Giancarlo Lucchetti, Homero Vallada","doi":"10.47626/1516-4446-2025-4216","DOIUrl":"10.47626/1516-4446-2025-4216","url":null,"abstract":"<p><strong>Objectives: </strong>Flourishing, a holistic concept encompassing multiple domains of well-being, has gained significant interest in recent years. However, validated tools for measuring flourishing, mainly using VanderWeele's framework, remain unavailable for Brazilian Portuguese-speaking populations. This study aimed to translate, culturally adapt, and validate the Flourishing Index (FI) and Secure Flourishing Index (SFI) for the Brazilian Portuguese language through two complementary studies.</p><p><strong>Methods: </strong>The instruments were translated and culturally adapted, following international guidelines for cross-cultural adaptation of Self-Report Measures. In Study 1, psychometric properties were examined using exploratory factor analysis (EFA) in a general population sample (n = 359). Construct validity was assessed by correlating FI/SFI scores with quality of life, depression, anxiety, and post-traumatic growth. In Study 2, confirmatory factor analysis (CFA) was conducted in a sample of individuals with moderate depressive symptoms (n = 252) to confirm the factor structure. Reliability and validity were evaluated in both samples.</p><p><strong>Results: </strong>EFA identified a five-factor structure for FI and a six-factor structure for SFI, consistent with prior studies. Cronbach's alpha ranged from 0.60 to 0.86, supporting internal consistency. CFA confirmed the multidimensional structures with appropriate fit indices (RMSEA<0.08, SRMR<0.08). Construct validity analyses demonstrated significant correlations between FI/SFI and mental health, quality of life, and post-traumatic growth.</p><p><strong>Conclusion: </strong>The FI and SFI demonstrated appropriate psychometric properties in the Brazilian Portuguese language, enabling comprehensive assessments of flourishing in diverse contexts. These validated tools can support flourishing research and intervention evaluation in Brazil.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use and climate change: Warming up the debate.","authors":"Gabriella da Silva Monteiro, Maria Angelica Torneli Ribeiro, Vitor Soares Tardelli, Thiago Marques Fidalgo","doi":"10.47626/1516-4446-2025-4319","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4319","url":null,"abstract":"","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Undefined: Methodological Issues in the Genetic Study of Mediumship.","authors":"Yung Gonzaga, Vitor Souza, Leonardo Arcuri","doi":"10.47626/1516-4446-2025-4193","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4193","url":null,"abstract":"","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Tax on Alcoholic Beverages in Brazil: The Next Step for an Effective Tax Policy to Reduce Health Harms.","authors":"Andre Akira Sueno Goldani, Zila Sanchez, Cristhian Ferreira Falleiro, Silvia Bassani Schuch-Goi, Felix Henrique Paim Kessler, Lisia von Diemen","doi":"10.47626/1516-4446-2025-4245","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4245","url":null,"abstract":"","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carol Sonenreich and Depression Psychopathology.","authors":"Felipe S Arruda, Igor Studart","doi":"10.47626/1516-4446-2025-4156","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4156","url":null,"abstract":"","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated movement analysis predicts transition to non-psychotic disorders in individuals at ultra-high risk for psychosis.","authors":"Ana Caroline Lopes-Rocha, Cheryl Mary Corcoran, Felipe Argolo, Andrea Fontes Jafet, Anderson Ara, João Medrado Gondim, Natalia Mansur Haddad, Leonardo Peroni de Jesus, Mauricio Henriques Serpa, Martinus Theodorus van de Bilt, Wagner Farid Gattaz, Guillermo Cecchi, Alexandre Andrade Loch","doi":"10.47626/1516-4446-2024-3919","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-3919","url":null,"abstract":"<p><strong>Objective: </strong>Ultra-high risk (UHR) criteria were developed to identify prodromal symptoms of psychosis, but most individuals do not transition. This highlights the need to identify transition markers like movement analysis. In the first stage of our study, movement analysis differentiated UHR from controls, showing reduced movement and increased erraticism. Our aim is to verify if these variables can predict UHR outcomes after follow-up.</p><p><strong>Methods: </strong>UHR individuals were recorded performing two speech tasks at baseline. Videos were analyzed using motion energy analysis (MEA) for head and torso movements-mean amplitude, frequency, and variability-and manually coded for gesticulation. After follow-up, 7 UHR converted to psychosis, 21 to other DSM-5 disorders (GD), and 18 did not convert (NC).</p><p><strong>Results: </strong>The GD group showed lower torso frequency and higher variability in both regions compared to Psychosis, as well as greater variability for torso when compared with NC. No differences were found between Psychosis and NC. Gesticulation did not differ between groups.</p><p><strong>Conclusions: </strong>Baseline movement variability distinguishes UHR transition outcomes, with higher variability seen in those converting to non-psychotic disorders. This supports the importance of movement analysis as a potential transition marker and suggests that treating UHR individuals as a single group may overlook important information.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Care Utilization and All-cause Mortality among Older Adults with Major Psychiatric Disorders: A 5-year Prospective Multicenter Study.","authors":"Katayoun Rezaei, Marina Sánchez-Rico, Pierre Lavaud, Cécile Hanon, Emmanuel Leleu, Frédéric Limosin, Nicolas Hoertel","doi":"10.47626/1516-4446-2025-4114","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4114","url":null,"abstract":"<p><strong>Objective: </strong>As the population ages, the number of older adults with psychiatric disorders in long-term care facilities is expected to importantly increase. To our knowledge, no study to date has examined the association of long-term care utilization with all-cause mortality among older adults with psychiatric disorders.</p><p><strong>Methods: </strong>In this report, we used data from the \"Cohort of individuals with Schizophrenia, bipolar and major depressive disorder aged 55 years or more (CSA)\", a 5-year prospective multicenter study, to examine this association. All analyses were adjusted for a wide range of potential confounders, including sociodemographic and clinical characteristics, and psychotropic medication use.</p><p><strong>Results: </strong>The prevalence of long-term care utilization was 23.6% (n=132) among 559 older adults with major psychiatric disorders. Living in long-term care utilization was significantly and independently associated with increased all-cause mortality in both the crude (OR=2.54; 95%CI=1.67-3.87; p<0.001) and fully-adjusted multivariable logistic regression models (AOR=1.86; 95%CI=1.10-3.16; p=0.021). This association did not significantly vary across most subgroups defined by sociodemographic and clinical characteristics.</p><p><strong>Conclusions: </strong>In this multicenter prospective observational study of older adults with major psychiatric disorders, long-term care utilization was significantly associated with increased all-cause mortality. Physicians and policy makers should take this association under careful consideration.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-person pronouns as linguistic markers of depression among Brazilian youths.","authors":"Anna Viduani, Victor Cosenza, Helen L Fisher, Claudia Buchweitz, Natália Mota, Jader Piccin, Rivka Pereira, Brandon A Kohrt, Valeria Mondelli, Alastair van Heerden, Ricardo Matsumura Araújo, Christian Kieling","doi":"10.47626/1516-4446-2024-4058","DOIUrl":"https://doi.org/10.47626/1516-4446-2024-4058","url":null,"abstract":"<p><strong>Objective: </strong>Major depressive disorder (MDD) is a leading cause of disability among youth, yet identifying this condition remains challenging. Naturalistic communication offers a promising approach to enhance depression detection. Increased use of first-person singular pronouns (e.g., ''I'') has been linked to MDD, but its applicability to younger, non-English-speaking populations remains unclear.</p><p><strong>Methods: </strong>This study examined first-person pronoun use in Brazilian Portuguese-speaking adolescents with and without MDD and its relationship to self-reported and clinician-rated depressive symptoms. Fifty-two adolescents (13 with and 39 without MDD) from the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo) sample completed remote data collection using a WhatsApp chatbot, responding to questions via audio recordings. Transcripts were analyzed using the Linguistic Inquiry and Word Count (LIWC).</p><p><strong>Results: </strong>The MDD group used significantly more I-pronouns than non-MDD subjects (9.15 vs. 8.02%, t = -2.302, p = 0.026). Self-reported depressive symptomatology correlated with I-pronoun use (rho = 0.366, p = 0.008), but did not reach statistical significance for clinician-rated symptoms (rho = 0.248, p = 0.076).</p><p><strong>Conclusions: </strong>These findings support first-person singular pronouns as a potential linguistic marker of depression among Brazilian adolescents. This is the first study to replicate such results in a young, non-English-speaking sample using spoken speech, suggesting that integrating linguistic analysis with digital tools could enhance early detection efforts, particularly in resource-limited settings. Future research should explore use of I-pronouns alongside other linguistic and acoustic features to refine digital mental health screening approaches.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":"47 ","pages":"e20244058"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism.","authors":"Priscilla Brandi Gomes Godoy,&nbsp;Fernando Mitsuo Sumiya,&nbsp;Leonardo Seda,&nbsp;Elizabeth Shephard","doi":"10.47626/1516-4446-2021-2222","DOIUrl":"https://doi.org/10.47626/1516-4446-2021-2222","url":null,"abstract":"<p><strong>Objective: </strong>Naturalistic and neurophysiological assessments are relevant as outcome measures in autism intervention trials because they provide, respectively, ecologically valid information about functioning and underlying neurocognitive mechanisms. We conducted a systematic review to highlight which specific neurophysiological techniques, experimental tasks, and naturalistic protocols have been used to assess neural and behavioral functioning in autism intervention studies.</p><p><strong>Methods: </strong>Studies were collected from four electronic databases between October 2019 and February 2020: MEDLINE (via PubMed), PsycINFO, LILACS, and Web of Science, and were included if they used structured observational, naturalistic, or neurophysiological measures to assess the efficacy of a nonpharmacological intervention for ASD.</p><p><strong>Results: </strong>Fourteen different measures were used by 64 studies, with the Autism Diagnostic Observation Schedule the most frequently used instrument. Thirty-seven different coding systems of naturalistic measures were used across 51 studies, most of which used different protocols. Twentyfour neurophysiological measures were used in 16 studies, with different experimental paradigms and neurophysiological components used across studies.</p><p><strong>Conclusions: </strong>Cross-study variability in assessing the outcomes of autism interventions may obscure comparisons and conclusions about how different behavioral interventions affect autistic social communication and underlying neurophysiological mechanisms.</p>","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":"532-547"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/b9/bjp-44-05-532.PMC9561836.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40395333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}