Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)最新文献_第2页

Modeling variability in tDCS-induced electric fields in depression: age-related comparisons in stratified adolescent and adult samples. 抑郁症中tdcs诱发电场的建模变异性：分层青少年和成人样本中年龄相关的比较。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-03-30 DOI: 10.47626/1516-4446-2025-4418

Mariana Lee Han, Pedro Henrique Rodrigues da Silva, Lais Boralli Razza, Fernanda Rohrsetzer Cunegatto, Beatriz A Cavendish, Paulo Jeng Chian Suen, Helen L Fisher, Brandon A Kohrt, Valeria Mondelli, Johnna R Swartz, Christian Kieling, André Russowsky Brunoni

{"title":"Modeling variability in tDCS-induced electric fields in depression: age-related comparisons in stratified adolescent and adult samples.","authors":"Mariana Lee Han, Pedro Henrique Rodrigues da Silva, Lais Boralli Razza, Fernanda Rohrsetzer Cunegatto, Beatriz A Cavendish, Paulo Jeng Chian Suen, Helen L Fisher, Brandon A Kohrt, Valeria Mondelli, Johnna R Swartz, Christian Kieling, André Russowsky Brunoni","doi":"10.47626/1516-4446-2025-4418","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4418","url":null,"abstract":"Transcranial direct current stimulation (tDCS) has emerged as a safe, cost-effective, and scalable therapeutic strategy, with moderate effects for depression in adult patients. However, there are no published studies on tDCS in children and adolescents with depression. This study is the first to investigate the simulated regional electric fields (EF) in adolescents at risk for or currently experiencing depression. A total of 150 Brazilian adolescents (50 at low risk, 50 at high risk of developing depression, and 50 diagnosed with depression) were drawn from the Identifying Depression Early in Adolescence Risk Stratified Cohort (IDEA-RiSCo) and compared to 51 adults with depression. Employing a tDCS protocol designed for adults, we measured the simulated EF magnitude in the bilateral dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC), both key brain areas involved in depression. Statistically significant differences in EF magnitudes were observed between each adolescent group (low risk, high risk, and diagnosed with depression) and adults with depression, while no significant differences were found among the adolescent groups themselves. By focusing on a population that is often underrepresented in depression research, this study may pave the way for future trials to treat depressive disorder in adolescents with tDCS.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental health burden among multiprofessional health residents: a cross-sectional study at a major academic center in Brazil. 多专业住院医师的心理健康负担：巴西某主要学术中心的横断面研究

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-03-27 DOI: 10.47626/1516-4446-2025-4479

Daniel A M Gagliotti, Francisco Lotufo-Neto, Eduardo C Humes

{"title":"Mental health burden among multiprofessional health residents: a cross-sectional study at a major academic center in Brazil.","authors":"Daniel A M Gagliotti, Francisco Lotufo-Neto, Eduardo C Humes","doi":"10.47626/1516-4446-2025-4479","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4479","url":null,"abstract":"Objective: To assess the prevalence and severity of depressive and anxiety symptoms, as well as associated factors, among residents enrolled in multiprofessional residency programs at a major academic medical center in Brazil.Methods: A cross-sectional, quantitative study was conducted with 106 residents from diverse health professions at the Faculdade de Medicina da Universidade de São Paulo (FMUSP). Participants completed validated instruments assessing depression (PHQ-9), anxiety (GAD-7), quality of life (WHOQOL-BREF), religiosity (DUREL), and sociodemographic characteristics.Results: A high prevalence of psychological distress was observed, with 88.7% of participants presenting moderate to severe depressive symptoms and 46.9% reporting clinically significant anxiety. Lower quality of life scores, particularly in the psychological domain, were strongly correlated with symptom severity. No religiosity dimensions were associated with depressive and anxiety symptoms. Prior psychiatric medication use, higher BMI, and self-identification as white were also associated with increased symptom burden.Conclusion: The findings underscore the substantial mental health challenges faced by multiprofessional residents and highlight the need for institutional policies that promote psychological well-being, improve access to care, and address structural stressors in postgraduate training environments.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality traits in patients with obsessive-compulsive disorder. 强迫症患者的人格特征。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-03-27 DOI: 10.47626/1516-4446-2025-4568

Marcelo C Batistuzzo, Jamila A R Pimentel, Ana M Barchi-Ferreira, Fabiana Campos, Natália Biazotti, Tatiana G Lerman, Antonio P Serafim, Lucas F Carvalho, Marcelo Q Hoexter

引用次数: 0

Sociodemographic variables as predictors of antidepressant treatment outcome in major depressive disorder. 社会人口学变量作为重度抑郁症抗抑郁治疗结果的预测因子。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-03-09 DOI: 10.47626/1516-4446-2025-4665

Alejandro G Szmulewicz, Agustín Ibañez, Diego J Martino

{"title":"Sociodemographic variables as predictors of antidepressant treatment outcome in major depressive disorder.","authors":"Alejandro G Szmulewicz, Agustín Ibañez, Diego J Martino","doi":"10.47626/1516-4446-2025-4665","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4665","url":null,"abstract":"Objective: The aim of this study was to evaluate the influence of sociodemographic variables on remission to an initial trial with citalopram.Methods: A sample of 2,682 patients with major depressive disorder was selected from the first level STAR*D trial database. Several sociodemographic variables available at baseline, as well as clinical variables, were selected a priori (based on literature review) and used to construct models that could predict remission after initiation of citalopram in a 3-month follow-up period.Results: The logistic regression model was selected as the best performing model with the highest accuracy. The sociodemographic variables were as relevant as the clinical variables when predicting the probability of remission to antidepressant treatment. In particular, sociodemographic variables linked to low socioeconomic status were the most significant in decreasing the likelihood of remission. Being older than 25 years old, Black race, and Hispanic ethnicity also had a negative influence on the likelihood of remission to antidepressant.Conclusion: Certain sociodemographic characteristics, particularly those linked to low socioeconomic status, would substantially reduce the likelihood of remission to a first-line treatment for major depressive disorder. The pattern of findings would have potential clinical and therapeutic implications that warrant future research on this topic.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147392056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do first-line treatments for OCD impact brain structure and function? A systematic review. 强迫症的一线治疗会影响大脑结构和功能吗？系统回顾。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-25 DOI: 10.47626/1516-4446-2025-4691

Acácio Moreira-Neto, Renata M F da Silva, Daniel L C Costa, João F A Neto, Marco Echevarria, Eurípedes C Miguel, Marcelo Q Hoexter, Roseli G Shavitt

引用次数: 0

Cerebellar Atrophy Associated With Valproate-Induced Tremor: A Three-Dimensional Volumetric Magnetic Resonance Imaging Based Case Report. 小脑萎缩与丙戊酸盐诱发的震颤相关：基于三维体积磁共振成像的病例报告。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-16 DOI: 10.47626/1516-4446-2025-4758

Melike Ceyhan Balcı Şengül, Muratcan Agaçe, Danış Aygün

引用次数: 0

Mental Health and Well-being of Adolescents and Young Adults from Pre- to COVID-19: the impact of pandemic-related risk factors and the protective role of a cash transfer program. 2019冠状病毒病前至新冠肺炎期间青少年和年轻人的心理健康和福祉：与大流行相关的风险因素的影响以及现金转移支付方案的保护作用

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-15 DOI: 10.47626/1516-4446-2025-4495

Francisco da Silva, Rodolfo Furlan Damiano, Letícia Müller Haas, Sahâmia Martins Ribeiro, Carina de Giusti, Laila Oliveira de Souza, Maurício Scopel Hoffmann, Orestes Vicente Forlenza, Ana Beatriz Ravagnani Salto, Luís Augusto Rohde, Rodrigo Affonseca Bressan, Eurípedes Constantino Miguel, Giovani A Salum, Pedro Mario Pan

{"title":"Mental Health and Well-being of Adolescents and Young Adults from Pre- to COVID-19: the impact of pandemic-related risk factors and the protective role of a cash transfer program.","authors":"Francisco da Silva, Rodolfo Furlan Damiano, Letícia Müller Haas, Sahâmia Martins Ribeiro, Carina de Giusti, Laila Oliveira de Souza, Maurício Scopel Hoffmann, Orestes Vicente Forlenza, Ana Beatriz Ravagnani Salto, Luís Augusto Rohde, Rodrigo Affonseca Bressan, Eurípedes Constantino Miguel, Giovani A Salum, Pedro Mario Pan","doi":"10.47626/1516-4446-2025-4495","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4495","url":null,"abstract":"Objective: Few longitudinal studies have evaluated the COVID-19 pandemic's impact on youth mental health, particularly in low- and middle-income countries where financial vulnerability may heighten risk. This study examined changes in psychopathology and well-being among Brazilian youth during the pandemic and the potential protective role of an emergency cash transfer program.Methods: Data came from 1,385 Brazilian High-Risk Cohort participants evaluated pre-COVID-19 and during the pandemic. Mental health problems and well-being were assessed with the Strengths and Difficulties Questionnaire (SDQ) and the Short Warwick-Edinburgh Mental Well-Being Scale (SWEMWBS), daily well-being was assessed using Ecological Momentary Assessment (EMA) for a subsample. Changes over time were examined using linear mixed-effects models.Results: Participants not exposed to COVID-19 infection (Estimate = -1.25, t = -4.637, p < 0.001) and those reporting no difficulty adhering to social distancing (Estimate = -1.33, t = -4.401, p < 0.001) showed reductions in mental health problems. Youth not receiving emergency cash transfers experienced decreased well-being (Estimate = -0.88, t = -2.766, p = 0.034), while beneficiaries reported more positive affect in EMA subsample (Estimate = -0.25, t = -2.991, p = 0.009).Conclusions: Lower exposure to pandemic-related stressors was associated with better mental health. Emergency cash transfers may have mitigated declines in well-being, highlighting their relevance for supporting youth during crises.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interconnected Cognitive and Neuroimmune Impairments in Schizophrenia: Modulating Effects of Antipsychotic Type, Illness Duration, and Symptom Severity. 精神分裂症中相互关联的认知和神经免疫损伤：抗精神病药物类型、病程和症状严重程度的调节作用。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-13 DOI: 10.47626/1516-4446-2025-4669

Thiago P Fernandes, Zeke Degraff, Fatima M Felisberti, Alisa Viktorovna Karlova, Givago S Souza, Irina I Shoshina, Milena E C Oliveira, Linnea N Dahlgren, Natanael A Santos

{"title":"Interconnected Cognitive and Neuroimmune Impairments in Schizophrenia: Modulating Effects of Antipsychotic Type, Illness Duration, and Symptom Severity.","authors":"Thiago P Fernandes, Zeke Degraff, Fatima M Felisberti, Alisa Viktorovna Karlova, Givago S Souza, Irina I Shoshina, Milena E C Oliveira, Linnea N Dahlgren, Natanael A Santos","doi":"10.47626/1516-4446-2025-4669","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4669","url":null,"abstract":"Objective: Cognitive impairment in schizophrenia (SCZ) is associated with neuroinflammation and neurotrophic dysregulation. The role of pro-inflammatory interleukins and brain-derived neurotrophic factor (BDNF) in cognitive deficits remains unclear. We aimed to examine the associations between IL-1β, IL-2, IL-6, BDNF, and cognitive function in patients with SCZ with typical or atypical antipsychotics.Methods: Participants included 162 healthy controls (mean age = 33.6 ± 2.0 years), 88 patients with SCZ receiving typical antipsychotics (36.4 ± 6.4 years), and 62 receiving atypical antipsychotics (34.0 ± 4.0 years). Cognitive performance was evaluated using a battery of attentional, executive, and visuospatial working memory tasks. Data were analyzed using machine-learning approaches, multivariate statistics, and structural equation modeling.Results: SCZ Patients exhibited marked cognitive impairments alongside lower BDNF concentrations and elevated interleukin levels, with the greatest deviations observed among those receiving typical antipsychotic treatment. Higher medication dosages and longer illness duration were associated with greater cognitive decline and stronger neuroimmune dysregulation.Conclusions: The findings indicate that elevated cytokines and reduced neurotrophic support may contribute to cognitive impairment, whereas persistent cognitive dysfunction can further amplify inflammatory activity. This complexity suggests the need to broaden current assessment approaches and systematically examine biomarkers together with clinical features.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide and self-harm in children and adolescents during the COVID-19 pandemic in Brazil: a time series analysis. 2019冠状病毒病大流行期间巴西儿童和青少年的自杀和自残：时间序列分析

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-07 DOI: 10.47626/1516-4446-2025-4454

Jairo Vinícius Pinto, Luiza Gandolfi de Almeida, Luiz Henrique Lino de Oliveira

{"title":"Suicide and self-harm in children and adolescents during the COVID-19 pandemic in Brazil: a time series analysis.","authors":"Jairo Vinícius Pinto, Luiza Gandolfi de Almeida, Luiz Henrique Lino de Oliveira","doi":"10.47626/1516-4446-2025-4454","DOIUrl":"https://doi.org/10.47626/1516-4446-2025-4454","url":null,"abstract":"Objective: To investigate changes in self-harm notifications and suicide mortality among children and adolescents during the COVID-19 pandemic.Methods: We conducted a time-series analysis using data on self-harm notifications and suicide deaths among individuals aged 5-19 years from the Brazilian Notifiable Diseases Information System and Mortality Information System. Pre-pandemic data (March 2015-February 2020) were used to fit autoregressive integrated moving average models to generate counterfactual estimates for the pandemic period. Observed and expected rates were compared overall and stratified by sex, age, and region. Segmented regression analyses assessed immediate and trend changes following the onset of the pandemic.Results: A total of 176,458 self-harm notifications and 7,609 suicide deaths were recorded. Self-harm notifications were more frequent among females (77.0%), adolescents aged 15-19 years (70.8%). Suicide deaths predominated among males (67.7%) and among adolescents aged 15-19 years (84.1%). The most common methods were self-poisoning for self-harm (58.5%) and hanging for suicide (75.5%). During the pandemic, self-harm notification rates were lower than expected based on pre-pandemic trends (observed: 5.8 per 100,000; expected: 16.4; 95% prediction interval [PI]: 11.9-23.2), with a significant immediate reduction in April 2020. In contrast, suicide mortality rates remained within predicted ranges (observed: 0.23 per 100,000; expected: 0.25; 95% PI: 0.17-0.39). Stratified analyses were consistent overall, except for younger children.Conclusions: The COVID-19 pandemic was associated with marked reductions in self-harm notifications but not with changes in suicide mortality among Brazilian youth, underscoring the importance of continuous surveillance to inform prevention strategies.","PeriodicalId":520767,"journal":{"name":"Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The International MAOI Expert Group: finding therapeutic confidence. 国际MAOI专家组：寻找治疗信心。

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) Pub Date : 2026-02-07 DOI: 10.47626/1516-4446-2025-4777

Peter Ken Gillman, Antonio E Nardi

引用次数: 0