发布求助
文献互助 智能选刊 最新文献

Physiology (Bethesda, Md.)最新文献

筛选
英文 中文
The role of the gut-brain axis in diseases. 肠脑轴在疾病中的作用。
IF 10.3
Physiology (Bethesda, Md.) Pub Date : 2025-08-19 DOI: 10.1152/physiol.00016.2025
Jing Chen, Yijia Xu, Peng Cao
{"title":"<i>The role of the gut-brain axis in diseases</i>.","authors":"Jing Chen, Yijia Xu, Peng Cao","doi":"10.1152/physiol.00016.2025","DOIUrl":"10.1152/physiol.00016.2025","url":null,"abstract":"<p><p>Accumulating evidence highlights the crucial role of the gut-brain axis in diseases. This bidirectional signaling connects the gastrointestinal tract (GI) and the brain via neural, immune, and endocrine pathways, orchestrating a range of physiological processes. Dysregulation of the gut-brain axis has been related to a variety of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders, as well as to disturbances in emotional regulation, cognition, and feeding-related conditions. The complex molecular interactions underlying this axis are necessary for maintaining homeostasis and overall health. Emerging pharmacological interventions and therapeutic targets have demonstrated potential in modulating gut-brain signaling to influence disease outcomes. This review provides a comprehensive view of the gut-brain axis, detailing its pivotal role in disease pathogenesis and exploring its therapeutic relevance.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 生理学透视- 2025年7月。
Physiology (Bethesda, Md.) Pub Date : 2025-07-01 Epub Date: 2025-06-03 DOI: 10.1152/physiol.00014.2025
Nikki Forrester
{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00014.2025","DOIUrl":"10.1152/physiol.00014.2025","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"306-307"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex. 颈动脉体炎症:在缺氧和抗炎反射中的作用。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-05-01 Epub Date: 2021-12-06 DOI: 10.1152/physiol.00031.2021
Rodrigo Iturriaga, Rodrigo Del Rio, Julio Alcayaga
{"title":"Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex.","authors":"Rodrigo Iturriaga,&nbsp;Rodrigo Del Rio,&nbsp;Julio Alcayaga","doi":"10.1152/physiol.00031.2021","DOIUrl":"https://doi.org/10.1152/physiol.00031.2021","url":null,"abstract":"<p><p>Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physiopathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"128-140"},"PeriodicalIF":8.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly. 体温过低的生理影响:好的、坏的和丑陋的。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-03-01 Epub Date: 2021-10-11 DOI: 10.1152/physiol.00025.2021
Torkjel Tveita, Gary C Sieck
{"title":"Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly.","authors":"Torkjel Tveita,&nbsp;Gary C Sieck","doi":"10.1152/physiol.00025.2021","DOIUrl":"https://doi.org/10.1152/physiol.00025.2021","url":null,"abstract":"<p><p>Hypothermia is defined as a core body temperature of <35°C, and as body temperature is reduced the impact on physiological processes can be beneficial or detrimental. The beneficial effect of hypothermia enables circulation of cooled experimental animals to be interrupted for 1-2 h without creating harmful effects, while tolerance of circulation arrest in normothermia is between 4 and 5 min. This striking difference has attracted so many investigators, experimental as well as clinical, to this field, and this discovery was fundamental for introducing therapeutic hypothermia in modern clinical medicine in the 1950s. Together with the introduction of cardiopulmonary bypass, therapeutic hypothermia has been the cornerstone in the development of modern cardiac surgery. Therapeutic hypothermia also has an undisputed role as a protective agent in organ transplantation and as a therapeutic adjuvant for cerebral protection in neonatal encephalopathy. However, the introduction of therapeutic hypothermia for organ protection during neurosurgical procedures or as a scavenger after brain and spinal trauma has been less successful. In general, the best neuroprotection seems to be obtained by avoiding hyperthermia in injured patients. Accidental hypothermia occurs when endogenous temperature control mechanisms are incapable of maintaining core body temperature within physiologic limits and core temperature becomes dependent on ambient temperature. During hypothermia spontaneous circulation is considerably reduced and with deep and/or prolonged cooling, circulatory failure may occur, which may limit safe survival of the cooled patient. Challenges that limit safe rewarming of accidental hypothermia patients include cardiac arrhythmias, uncontrolled bleeding, and \"rewarming shock.\"</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"69-87"},"PeriodicalIF":8.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39504506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Physiology in Perspective. 透视生理学。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-03-01 DOI: 10.1152/physiol.00001.2022
Christopher England
{"title":"Physiology in Perspective.","authors":"Christopher England","doi":"10.1152/physiol.00001.2022","DOIUrl":"https://doi.org/10.1152/physiol.00001.2022","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"54"},"PeriodicalIF":8.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39653517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovating and Building Momentum for Physiology's Future. 为生理学的未来创新和建立动力。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-01-01 Epub Date: 2021-11-22 DOI: 10.1152/physiol.00042.2021
Jennifer S Pollock, Linda Samuelson, Dee Silverthorn
{"title":"Innovating and Building Momentum for Physiology's Future.","authors":"Jennifer S Pollock,&nbsp;Linda Samuelson,&nbsp;Dee Silverthorn","doi":"10.1152/physiol.00042.2021","DOIUrl":"https://doi.org/10.1152/physiol.00042.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"2-3"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology in Perspective. 透视生理学。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-01-01 Epub Date: 2021-11-22 DOI: 10.1152/physiol.00043.2021
Nikki Forrester
{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00043.2021","DOIUrl":"https://doi.org/10.1152/physiol.00043.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"4"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients. COVID-19患者缺氧- a2 -腺苷能通路的靶向治疗
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2022-01-01 Epub Date: 2021-09-06 DOI: 10.1152/physiol.00010.2021
Katarina Halpin-Veszeleiova, Stephen M Hatfield
{"title":"Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients.","authors":"Katarina Halpin-Veszeleiova,&nbsp;Stephen M Hatfield","doi":"10.1152/physiol.00010.2021","DOIUrl":"https://doi.org/10.1152/physiol.00010.2021","url":null,"abstract":"<p><p>The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"46-52"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39388768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform. 利用类弹性蛋白多肽平台开发的新型蛋白质治疗药物。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2021-11-01 Epub Date: 2021-09-06 DOI: 10.1152/physiol.00026.2021
Gene L Bidwell
{"title":"Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform.","authors":"Gene L Bidwell","doi":"10.1152/physiol.00026.2021","DOIUrl":"https://doi.org/10.1152/physiol.00026.2021","url":null,"abstract":"<p><p>Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"367-381"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39387242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Role of mTOR Signaling for Tubular Function and Disease. mTOR信号在小管功能和疾病中的作用。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2021-11-01 Epub Date: 2021-09-13 DOI: 10.1152/physiol.00021.2021
Florian Grahammer, Tobias B Huber, Ferruh Artunc
{"title":"Role of mTOR Signaling for Tubular Function and Disease.","authors":"Florian Grahammer,&nbsp;Tobias B Huber,&nbsp;Ferruh Artunc","doi":"10.1152/physiol.00021.2021","DOIUrl":"https://doi.org/10.1152/physiol.00021.2021","url":null,"abstract":"<p><p>The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities, i.e. diabetic nephropathy, acute kidney injury or hyperkalemia.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"350-358"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39411838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信