{"title":"<i>The role of the gut-brain axis in diseases</i>.","authors":"Jing Chen, Yijia Xu, Peng Cao","doi":"10.1152/physiol.00016.2025","DOIUrl":null,"url":null,"abstract":"<p><p>Accumulating evidence highlights the crucial role of the gut-brain axis in diseases. This bidirectional signaling connects the gastrointestinal tract (GI) and the brain via neural, immune, and endocrine pathways, orchestrating a range of physiological processes. Dysregulation of the gut-brain axis has been related to a variety of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders, as well as to disturbances in emotional regulation, cognition, and feeding-related conditions. The complex molecular interactions underlying this axis are necessary for maintaining homeostasis and overall health. Emerging pharmacological interventions and therapeutic targets have demonstrated potential in modulating gut-brain signaling to influence disease outcomes. This review provides a comprehensive view of the gut-brain axis, detailing its pivotal role in disease pathogenesis and exploring its therapeutic relevance.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":""},"PeriodicalIF":10.3000,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiology (Bethesda, Md.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1152/physiol.00016.2025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Accumulating evidence highlights the crucial role of the gut-brain axis in diseases. This bidirectional signaling connects the gastrointestinal tract (GI) and the brain via neural, immune, and endocrine pathways, orchestrating a range of physiological processes. Dysregulation of the gut-brain axis has been related to a variety of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders, as well as to disturbances in emotional regulation, cognition, and feeding-related conditions. The complex molecular interactions underlying this axis are necessary for maintaining homeostasis and overall health. Emerging pharmacological interventions and therapeutic targets have demonstrated potential in modulating gut-brain signaling to influence disease outcomes. This review provides a comprehensive view of the gut-brain axis, detailing its pivotal role in disease pathogenesis and exploring its therapeutic relevance.
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