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Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. 磷酸二酯酶通过环核苷酸的区隔化维持信号的保真度。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00040.2013
Oliver Lomas, Manuela Zaccolo
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引用次数: 34
Regulation of metabolism: a cross talk between gut microbiota and its human host. 代谢调节:肠道菌群与其宿主之间的串扰。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00023.2012
Rémy Burcelin
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引用次数: 51
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium. 疲劳者无休:正常和衰竭心肌舒张钙稳态。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00021.2012
William E Louch, Mathis K Stokke, Ivar Sjaastad, Geir Christensen, Ole M Sejersted
{"title":"No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.","authors":"William E Louch,&nbsp;Mathis K Stokke,&nbsp;Ivar Sjaastad,&nbsp;Geir Christensen,&nbsp;Ole M Sejersted","doi":"10.1152/physiol.00021.2012","DOIUrl":"https://doi.org/10.1152/physiol.00021.2012","url":null,"abstract":"<p><p>Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca(2+) homeostasis in cardiac muscle cells and how alterations in Ca(2+) cycling affect diastolic function in the normal and failing heart. These discussions illustrate that the diastolic phase is not simply a period of rest but rather involves highly regulated and dynamic Ca(2+) fluxes.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"308-23"},"PeriodicalIF":8.4,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00021.2012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30946057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 68
Design principles for life. 生活的设计原则。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00036.2012
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引用次数: 0
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