发布求助
文献互助 智能选刊 最新文献

Physiology (Bethesda, Md.)最新文献

筛选
英文 中文
Sex differences in the developmental origins of cardiovascular disease. 心血管疾病发育起源的性别差异。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00045.2013
Suttira Intapad, Norma B Ojeda, John Henry Dasinger, Barbara T Alexander
{"title":"Sex differences in the developmental origins of cardiovascular disease.","authors":"Suttira Intapad,&nbsp;Norma B Ojeda,&nbsp;John Henry Dasinger,&nbsp;Barbara T Alexander","doi":"10.1152/physiol.00045.2013","DOIUrl":"https://doi.org/10.1152/physiol.00045.2013","url":null,"abstract":"<p><p>The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"122-32"},"PeriodicalIF":8.4,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00045.2013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32165988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 70
GLP-1-based strategies: a physiological analysis of differential mode of action. 基于glp -1的策略:不同作用模式的生理分析。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00009.2013
Rémy Burcelin, Pierre Gourdy, Stéphane Dalle
{"title":"GLP-1-based strategies: a physiological analysis of differential mode of action.","authors":"Rémy Burcelin,&nbsp;Pierre Gourdy,&nbsp;Stéphane Dalle","doi":"10.1152/physiol.00009.2013","DOIUrl":"https://doi.org/10.1152/physiol.00009.2013","url":null,"abstract":"<p><p>DPP4 inhibitors and GLP-1 receptor agonists used in incretin-based strategies treat Type 2 diabetes with different modes of action. The pharmacological blood GLP-1R agonist concentration targets pancreatic and some extrapancreatic GLP-1R, whereas DPP4i favors the physiological activation of the gut-brain-periphery axis that could allow clinicians to adapt the management of Type 2 diabetes, according to the patient's pathophysiological characteristics.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"108-21"},"PeriodicalIF":8.4,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00009.2013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32165445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Physiology in perspective: the burden of obesity. 生理学上的透视:肥胖的负担。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00004.2014
Gary Sieck
{"title":"Physiology in perspective: the burden of obesity.","authors":"Gary Sieck","doi":"10.1152/physiol.00004.2014","DOIUrl":"https://doi.org/10.1152/physiol.00004.2014","url":null,"abstract":"Obesity has been described as the biggest health threat facing the Western world, and this statement will probably need to be revised shortly to encompass the entire world. The social and economic impact of this pandemic is enormous. Currently, a third of all Americans are obese, and this may reach","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"86-7"},"PeriodicalIF":8.4,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00004.2014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32165443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Neural mechanisms of cardioprotection. 心脏保护的神经机制。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00037.2013
Andrey Gourine, Alexander V Gourine
{"title":"Neural mechanisms of cardioprotection.","authors":"Andrey Gourine,&nbsp;Alexander V Gourine","doi":"10.1152/physiol.00037.2013","DOIUrl":"https://doi.org/10.1152/physiol.00037.2013","url":null,"abstract":"<p><p>This review highlights the importance of neural mechanisms capable of protecting the heart against lethal ischemia/reperfusion injury. Increased parasympathetic (vagal) activity limits myocardial infarction, and recent data suggest that activation of autonomic reflex pathways contributes to powerful innate mechanisms of cardioprotection underlying the remote ischemic conditioning phenomena.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"133-40"},"PeriodicalIF":8.4,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00037.2013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32165989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. 磷酸二酯酶通过环核苷酸的区隔化维持信号的保真度。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2014-03-01 DOI: 10.1152/physiol.00040.2013
Oliver Lomas, Manuela Zaccolo
{"title":"Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.","authors":"Oliver Lomas,&nbsp;Manuela Zaccolo","doi":"10.1152/physiol.00040.2013","DOIUrl":"https://doi.org/10.1152/physiol.00040.2013","url":null,"abstract":"<p><p>Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"141-9"},"PeriodicalIF":8.4,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00040.2013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32165991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Regulation of metabolism: a cross talk between gut microbiota and its human host. 代谢调节:肠道菌群与其宿主之间的串扰。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00023.2012
Rémy Burcelin
{"title":"Regulation of metabolism: a cross talk between gut microbiota and its human host.","authors":"Rémy Burcelin","doi":"10.1152/physiol.00023.2012","DOIUrl":"https://doi.org/10.1152/physiol.00023.2012","url":null,"abstract":"<p><p>The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"300-7"},"PeriodicalIF":8.4,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00023.2012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30946056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium. 疲劳者无休:正常和衰竭心肌舒张钙稳态。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00021.2012
William E Louch, Mathis K Stokke, Ivar Sjaastad, Geir Christensen, Ole M Sejersted
{"title":"No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.","authors":"William E Louch,&nbsp;Mathis K Stokke,&nbsp;Ivar Sjaastad,&nbsp;Geir Christensen,&nbsp;Ole M Sejersted","doi":"10.1152/physiol.00021.2012","DOIUrl":"https://doi.org/10.1152/physiol.00021.2012","url":null,"abstract":"<p><p>Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca(2+) homeostasis in cardiac muscle cells and how alterations in Ca(2+) cycling affect diastolic function in the normal and failing heart. These discussions illustrate that the diastolic phase is not simply a period of rest but rather involves highly regulated and dynamic Ca(2+) fluxes.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"308-23"},"PeriodicalIF":8.4,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00021.2012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30946057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 68
Design principles for life. 生活的设计原则。
IF 8.4
Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI: 10.1152/physiol.00036.2012
{"title":"Design principles for life.","authors":"","doi":"10.1152/physiol.00036.2012","DOIUrl":"https://doi.org/10.1152/physiol.00036.2012","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"281"},"PeriodicalIF":8.4,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00036.2012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30946054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信