代谢调节:肠道菌群与其宿主之间的串扰。

IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI:10.1152/physiol.00023.2012

Rémy Burcelin

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引用次数: 51

摘要

近年来肥胖和糖尿病的流行以及个体水平上的多样性可以用肠道微生物群与宿主的关系来解释。来自微生物组的400多万个基因产物可以与免疫系统相互作用，诱导组织代谢感染，这是低度炎症的分子起源，而低度炎症是肥胖和糖尿病发病的特征。

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Regulation of metabolism: a cross talk between gut microbiota and its human host.

The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.

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Physiology (Bethesda, Md.)

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