Suttira Intapad, Norma B Ojeda, John Henry Dasinger, Barbara T Alexander
{"title":"心血管疾病发育起源的性别差异。","authors":"Suttira Intapad, Norma B Ojeda, John Henry Dasinger, Barbara T Alexander","doi":"10.1152/physiol.00045.2013","DOIUrl":null,"url":null,"abstract":"<p><p>The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"122-32"},"PeriodicalIF":10.3000,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00045.2013","citationCount":"70","resultStr":"{\"title\":\"Sex differences in the developmental origins of cardiovascular disease.\",\"authors\":\"Suttira Intapad, Norma B Ojeda, John Henry Dasinger, Barbara T Alexander\",\"doi\":\"10.1152/physiol.00045.2013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.</p>\",\"PeriodicalId\":520753,\"journal\":{\"name\":\"Physiology (Bethesda, Md.)\",\"volume\":\" \",\"pages\":\"122-32\"},\"PeriodicalIF\":10.3000,\"publicationDate\":\"2014-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1152/physiol.00045.2013\",\"citationCount\":\"70\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physiology (Bethesda, Md.)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/physiol.00045.2013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physiology (Bethesda, Md.)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/physiol.00045.2013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sex differences in the developmental origins of cardiovascular disease.
The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.
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