疲劳者无休:正常和衰竭心肌舒张钙稳态。

IF 10.3

Physiology (Bethesda, Md.) Pub Date : 2012-10-01 DOI:10.1152/physiol.00021.2012

William E Louch, Mathis K Stokke, Ivar Sjaastad, Geir Christensen, Ole M Sejersted

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引用次数: 68

摘要

心脏收缩后，有效的舒张(舒张)对心室的血液循环至关重要。本文综述了心肌细胞中Ca(2+)稳态如何控制心室舒张，以及Ca(2+)循环的改变如何影响正常和衰竭心脏的舒张功能。这些讨论表明，舒张期不是简单的休息期，而是涉及高度调节和动态的Ca(2+)通量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.

Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca(2+) homeostasis in cardiac muscle cells and how alterations in Ca(2+) cycling affect diastolic function in the normal and failing heart. These discussions illustrate that the diastolic phase is not simply a period of rest but rather involves highly regulated and dynamic Ca(2+) fluxes.

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来源期刊

Physiology (Bethesda, Md.)

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