Physiology (Bethesda, Md.)最新文献

{"title":"Physiology in Perspective.","authors":"Christopher England","doi":"10.1152/physiol.00001.2022","DOIUrl":"https://doi.org/10.1152/physiol.00001.2022","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"54"},"PeriodicalIF":8.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39653517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovating and Building Momentum for Physiology's Future.","authors":"Jennifer S Pollock, Linda Samuelson, Dee Silverthorn","doi":"10.1152/physiol.00042.2021","DOIUrl":"https://doi.org/10.1152/physiol.00042.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"2-3"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology in Perspective.","authors":"Nikki Forrester","doi":"10.1152/physiol.00043.2021","DOIUrl":"https://doi.org/10.1152/physiol.00043.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"4"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients.","authors":"Katarina Halpin-Veszeleiova,&nbsp;Stephen M Hatfield","doi":"10.1152/physiol.00010.2021","DOIUrl":"https://doi.org/10.1152/physiol.00010.2021","url":null,"abstract":"<p><p>The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"46-52"},"PeriodicalIF":8.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39388768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform.","authors":"Gene L Bidwell","doi":"10.1152/physiol.00026.2021","DOIUrl":"https://doi.org/10.1152/physiol.00026.2021","url":null,"abstract":"<p><p>Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"367-381"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39387242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mTOR Signaling for Tubular Function and Disease.","authors":"Florian Grahammer,&nbsp;Tobias B Huber,&nbsp;Ferruh Artunc","doi":"10.1152/physiol.00021.2021","DOIUrl":"https://doi.org/10.1152/physiol.00021.2021","url":null,"abstract":"<p><p>The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities, i.e. diabetic nephropathy, acute kidney injury or hyperkalemia.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"350-358"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39411838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology in Perspective.","authors":"Christopher G England","doi":"10.1152/physiol.00040.2021","DOIUrl":"https://doi.org/10.1152/physiol.00040.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"334"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39476945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Road to the 39th IUPS Congress Amid COVID-19 Pandemic: Every Cloud Has a Silver Lining.","authors":"Ulrich Pohl,&nbsp;Julie Y H Chan","doi":"10.1152/physiol.00039.2021","DOIUrl":"https://doi.org/10.1152/physiol.00039.2021","url":null,"abstract":"","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"332-333"},"PeriodicalIF":8.4,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39476947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology in Perspective: Responding to a Changing Environment.","authors":"Gary C Sieck","doi":"10.1152/physiol.00001.2019","DOIUrl":"https://doi.org/10.1152/physiol.00001.2019","url":null,"abstract":"Sitting here in Minnesota in the midst of the 2019 winter, I am not particularly disappointed by temperatures in the mid30s, but I fully understand that this is not normal— or at least not the normal I have experienced for the past 29 years in the Northland. It is far too warm for a Minnesota winter, particularly when this warmer weather persists for days and weeks with average temperatures 3–5 degrees above normal. How can a reasonable person question the reality of global warming? As it goes, the deniers will wait until the next sub-zero day to shout their denials that climate change exists. However, we as scientists all know that it is real—facts are facts! With global warming, it also rains more in Minnesota, with larger more violent storms—storms of the century occurring almost every year. Although we may be experiencing more rain, other parts of the U.S. experience more frequent extreme droughts and devastating fires— fires of the century occurring almost yearly. We are not alone in experiencing these extreme effects of global warming, since storms, droughts, and fires are occurring throughout the world and are undeniable due to the changing environment. Unfortunately, we are dependent on our policymakers to reverse the underlying causes of climate change by decreasing CO2 emissions and reducing our dependence on fossil fuels. We must maintain hope, even while our president questions the value of the recently published National Climate Assessment (November, 2018), declaring himself “not a believer.” However, physiologists can continue the battle by providing insight into how our bodies and life in general respond to these persistent changes in our environment. We can make informed predictive statements about how environmental warming affects our physiology and demonstrate the overall shifts in physiological performance as the environment continues to warm and becomes more extreme with climate change. Hopefully, increasingly detailed data sets can help policymakers understand how humans and all life on our planet are likely to respond to extreme heat, with resulting storms and flooding, drought and fires, and in what ways physiological responses are limited. The first review article in this issue of Physiology examines how animal and human populations respond to extreme heat. A consequence of climate change is the increased frequency and severity of extreme heat or heat waves. Unless carbon emissions are dramatically and immediately reduced, summers at the end of the 21st century are likely to be primarily comprised of days that we would currently consider extreme. In his review (6), Stillman explores the ways in which life is likely to respond. Understanding the limits to physiological responses should help to manage wildlife, predict shifts in species distributions, and shift ways in which human activities are organized to minimize adverse health consequences. It has widely been shown that, during heat waves, human populations experience a","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"84-85"},"PeriodicalIF":8.4,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00001.2019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36934509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Lipotoxicity on Tissue \"Cross Talk\" and Metabolic Regulation.","authors":"Magdalene K Montgomery,&nbsp;William De Nardo,&nbsp;Matthew J Watt","doi":"10.1152/physiol.00037.2018","DOIUrl":"https://doi.org/10.1152/physiol.00037.2018","url":null,"abstract":"<p><p>Obesity-associated comorbidities include non-alcoholic fatty liver disease, Type 2 diabetes, and cardiovascular disease. These diseases are associated with accumulation of lipids in non-adipose tissues, which can impact many intracellular cellular signaling pathways and functions that have been broadly defined as \"lipotoxic.\" This review moves beyond understanding intracellular lipotoxic outcomes and outlines the consequences of lipotoxicity on protein secretion and inter-tissue \"cross talk,\" and the impact this exerts on systemic metabolism.</p>","PeriodicalId":520753,"journal":{"name":"Physiology (Bethesda, Md.)","volume":" ","pages":"134-149"},"PeriodicalIF":8.4,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1152/physiol.00037.2018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36934506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}