Journal of fungi (Basel, Switzerland)最新文献_第8页

Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review. 耳念珠菌抗真菌管道研究进展:系统综述。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-28 DOI: 10.3390/jof8111144

Rogelio de J Treviño-Rangel, Gloria M González, Alexandra M Montoya, Olga C Rojas, Mariana Elizondo-Zertuche, Neri A Álvarez-Villalobos

{"title":"Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review.","authors":"Rogelio de J Treviño-Rangel, Gloria M González, Alexandra M Montoya, Olga C Rojas, Mariana Elizondo-Zertuche, Neri A Álvarez-Villalobos","doi":"10.3390/jof8111144","DOIUrl":"https://doi.org/10.3390/jof8111144","url":null,"abstract":"The alarming spread and impact of multidrug-resistant Candida auris infections alongside the limited therapeutic options have prompted the development of new antifungals. These promising agents are currently in different stages of development, offering novel dosing regimens and mechanisms of action. A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing antifungal classes (rezafungin and opelconazole), first-in-class drugs such as ibrexafungerp, manogepix/fosmanogepix, olorofim and tetrazoles (quilseconazole, oteseconazole and VT-1598), as well as other innovative agents like ATI-2307, MGCD290 and VL-2397. From 592 articles retrieved in the primary search, 27 met the eligibility criteria. The most studied agent was manogepix/fosmanogepix (overall MIC90: 0.03 mg/L), followed by ibrexafungerp (overall MIC90: 1 mg/L) and rezafungin (overall MIC mode: 0.25 mg/L), while VT-1598 and ATI-2307 were the least explored drugs against C. auris. All these compounds demonstrated significant improvements in survival and reduction in tissue fungal burden on neutropenic animal models of candidemia due to C. auris. Continual efforts towards the discovery of new treatments against this multidrug-resistant fungus are essential.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Abscisic Acid May Play a Critical Role in the Moderating Effect of Epichloë Endophyte on Achnatherum inebrians under Drought Stress. 脱落酸可能在Epichloë内生菌对干旱胁迫下酒牛膝草的调节作用中起关键作用。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-28 DOI: 10.3390/jof8111140

Xuelian Cui, Wen He, Michael John Christensen, Jinfeng Yue, Fanbin Zeng, Xingxu Zhang, Zhibiao Nan, Chao Xia

{"title":"Abscisic Acid May Play a Critical Role in the Moderating Effect of Epichloë Endophyte on Achnatherum inebrians under Drought Stress.","authors":"Xuelian Cui, Wen He, Michael John Christensen, Jinfeng Yue, Fanbin Zeng, Xingxu Zhang, Zhibiao Nan, Chao Xia","doi":"10.3390/jof8111140","DOIUrl":"https://doi.org/10.3390/jof8111140","url":null,"abstract":"Water scarcity is a major constraint that adversely affects plant development and growth. Abscisic acid (ABA) is a plant stress hormone that is rapidly synthesized and can induce stomatal closure to conserve water, thereby alleviating the drought stress of plants. The Epichloë endophyte enhances the drought tolerance of Achnatherum inebrians (drunken horse grass, DHG). To better understand how the Epichloë endophyte enhances drought tolerance, DHG plants without (EF) and with (EI), an Epichloë endophyte, were grown under 20% and 60% soil water conditions (SWC), and the leaves of the three treatments of EF and EI plants were sprayed with ABA solution (1 mg/L); fluridone (FLU), the ABA biosynthesis inhibitor solution (1 mg/L); and distilled water, respectively. Four-weeks later, the results indicated that the exogenous ABA application promoted plant growth, stomatal conductance, and photosynthetic rate, while the opposite effect occurred with plants sprayed with FLU. The differences between EI and EF plants in tiller number, height, chlorophyll content, stomata conductance, and photosynthetic rate were highest when sprayed with ABA. Thus, it is concluded that ABA might be involved in the moderating effect of Epichloë endophytes on DHG plants exposed to drought by maintaining growth and improving photosynthetic efficiency.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Efficacy of Bovine Nail Membranes as In Vitro Model for Onychomycosis Infected by Trichophyton Species. 牛甲膜作为毛癣菌感染的甲真菌病体外模型的疗效研究。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-27 DOI: 10.3390/jof8111133

Marta Elisabetta Eleonora Temporiti, Marta Guerini, Rebecca Michela Baiguera, Simone Buratti, Anthea Desiderio, Lorenzo Goppa, Paola Perugini, Elena Savino

{"title":"Efficacy of Bovine Nail Membranes as In Vitro Model for Onychomycosis Infected by Trichophyton Species.","authors":"Marta Elisabetta Eleonora Temporiti, Marta Guerini, Rebecca Michela Baiguera, Simone Buratti, Anthea Desiderio, Lorenzo Goppa, Paola Perugini, Elena Savino","doi":"10.3390/jof8111133","DOIUrl":"https://doi.org/10.3390/jof8111133","url":null,"abstract":"Onychomycosis is a fungal infection caused by different etiologic agents, including dermatophytes that specifically colonize keratin-rich substrates. The aim of this work was to investigate mechanical modifications of bovine membranes (used as an in vitro nail model) placed in contact with Trichophyton species. Trichophyton strains were isolated from toenails specimens. The procedure was set up by spreading T. rubrum,T. interdigitale, and T. mentagrophytes strains on Petri dishes with minimal and rich media; after that, bovine membranes were placed in the center. After 27 days, T. interdigitale and T. mentagrophytes significantly reduced the thickness of the colonized membranes, whereas two T. rubrum strains showed the highest degradation limited to the small colonized area. These results were confirmed by SEM images of the colonization profile on membranes. Mechanical analyses performed on membranes were used as an innovative method to evaluate the thickness and structural integrity of membranes variation following fungal colonization. In conclusion, mechanical analyses of substrate may be used as a procedure for the development of a new onychomycosis diagnosis test in order to develop personalized and strain-specific treatment.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chest Imaging in Systemic Endemic Mycoses. 系统性地方性真菌病的胸部影像学。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-27 DOI: 10.3390/jof8111132

Célia Sousa, Edson Marchiori, Ali Youssef, Tan-Lucien Mohammed, Pratik Patel, Klaus Irion, Romulo Pasini, Alexandre Mançano, Arthur Souza, Alessandro C Pasqualotto, Bruno Hochhegger

引用次数: 3

Biocontrol of Mycotoxigenic Fungi Using Bacteria Isolated from Ecological Vineyard Soils. 从葡萄园生态土壤中分离的细菌对产霉菌毒素真菌的生物防治。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-27 DOI: 10.3390/jof8111136

Paula de la Huerta-Bengoechea, Jéssica Gil-Serna, Clara Melguizo, Antonio J Ramos, Montserrat Prim, Covadonga Vázquez, Belén Patiño

{"title":"Biocontrol of Mycotoxigenic Fungi Using Bacteria Isolated from Ecological Vineyard Soils.","authors":"Paula de la Huerta-Bengoechea, Jéssica Gil-Serna, Clara Melguizo, Antonio J Ramos, Montserrat Prim, Covadonga Vázquez, Belén Patiño","doi":"10.3390/jof8111136","DOIUrl":"https://doi.org/10.3390/jof8111136","url":null,"abstract":"The presence of mycotoxin-producing Aspergillus species in vineyards is a problem for food safety and the economy. In addition, rising temperatures due to climate change are modifying microbial communities, causing the replacement of some fungal species and the rise of mycotoxins such as aflatoxins. The use of microorganisms as biological control agents (BCAs) is one of the most promising strategies to prevent fungal growth and toxin production. In this study, 513 microorganisms were isolated from organic vineyard soils in different regions of Spain. The 480 bacteria and 33 yeasts isolated were sequentially screened to select those with the most suitable characteristics to be used as BCAs. After identifying 16 isolates meeting all requirements, six bacterial isolates were selected to test their potential to control three relevant toxigenic grape fungi in vitro: A. carbonarius, A. niger and A. flavus. Isolates of Arthrobacter sp., Rhodococcus sp. and Bacillus mycoides showed an excellent ability to reduce the growth and mycotoxin concentration of the above-mentioned fungi and represent potential candidates for further study regarding their possible industrial application as a BCA.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Photodynamic Inactivation Effectively Eradicates Candida auris Biofilm despite Its Interference with the Upregulation of CDR1 and MDR1 Efflux Genes. 光动力失活可干扰耳念珠菌CDR1和MDR1外排基因的上调，但可有效根除耳念珠菌生物膜。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-27 DOI: 10.3390/jof8111137

Matúš Štefánek, Lucia Černáková, Jaroslava Dekkerová, Helena Bujdáková

{"title":"Photodynamic Inactivation Effectively Eradicates Candida auris Biofilm despite Its Interference with the Upregulation of CDR1 and MDR1 Efflux Genes.","authors":"Matúš Štefánek, Lucia Černáková, Jaroslava Dekkerová, Helena Bujdáková","doi":"10.3390/jof8111137","DOIUrl":"https://doi.org/10.3390/jof8111137","url":null,"abstract":"Candida auris, in recent years, has emerged as a dangerous nosocomial pathogen. It represents a challenge for effective treatment because of its multiresistance. Photodynamic inactivation (PDI) is a promising way to solve problems with a wide range of resistant microorganisms. This study aimed to use PDI for the eradication of C. auris biofilms. Moreover, the regulation of the CDR1, CDR2, and MDR1 resistance genes was studied. Experiments were performed on 24 h biofilms formed by three clinical isolates of C. auris in vitro. PDI was performed in the presence of the photosensitizer methylene blue (0.25 mM) and samples were irradiated with a red laser (λ = 660 nm, 190 mW/cm2) for 79, 120, and 300 s. To confirm the PDI effect, confocal laser scanning microscopy was performed after treatment. Effective PDI was achieved in all strains. The highest inhibition was observed after 300 s irradiation, with over 90% inhibition compared with the non-irradiated control sample. PDI was observed to upregulate the expression of the CDR1 gene, but mainly the MDR1 gene. Despite this observation, PDI significantly decreased the survival of C. auris biofilm cells and proved to have great potential for the eradication of problematic resistant yeasts.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Acute Lymphoblastic Leukemia and Invasive Mold Infections: A Challenging Field. 急性淋巴细胞白血病和侵袭性霉菌感染:一个具有挑战性的领域。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-26 DOI: 10.3390/jof8111127

Christos Stafylidis, Panagiotis Diamantopoulos, Eleni Athanasoula, Elena Solomou, Amalia Anastasopoulou

{"title":"Acute Lymphoblastic Leukemia and Invasive Mold Infections: A Challenging Field.","authors":"Christos Stafylidis, Panagiotis Diamantopoulos, Eleni Athanasoula, Elena Solomou, Amalia Anastasopoulou","doi":"10.3390/jof8111127","DOIUrl":"https://doi.org/10.3390/jof8111127","url":null,"abstract":"Acute lymphoblastic leukemia (ALL) patients comprise a highly immunocompromised group due to factors associated either with the treatment or the disease itself. Invasive mold infections (IMIs) are considered to be responsible for higher morbidity and mortality rates in patients with hematologic malignancies, including ALL. Defining the exact incidence of IMIs in ALL patients has been rather complicated. The available literature data report a highly variable incidence of IMIs, ranging from 2.2% to 15.4%. Although predisposing factors for IMIs in the setting of ALL are ill-defined, retrospective studies have indicated that a longer duration of neutropenia, treatment with high-dose corticosteroids, and a lack of antimold prophylaxis are associated with an increased risk of IMIs. Additionally, the influence of novel ALL treatments on the susceptibility to fungal infections remains obscure; however, initial data suggest that these treatments may induce prolonged neutropenia and thus an increased risk of IMIs. Administering primary antimold prophylaxis in these patients has been challenging since incorporating azole antifungal agents is troublesome, considering the drug-to-drug interactions (DDIs) and increased toxicity that may occur when these agents are coadministered with vincristine, a fundamental component of ALL chemotherapy regimens. Isavuconazole, along with several novel antifungal agents such as rezafungin, olorofim, and manogepix, may be appealing as primary antimold prophylaxis, given their broad-spectrum activity and less severe DDI potential. However, their use in ALL patients needs to be investigated through more clinical trials. In summary, this review outlines the epidemiology of IMI and the use of antifungal prophylaxis in ALL patients.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mucochytrium quahogii (=QPX) Is a Commensal, Opportunistic Pathogen of the Hard Clam (Mercenaria mercenaria): Evidence and Implications for QPX Disease Management. quahogii mucchytrium (=QPX)是硬蛤的一种共生的机会致病菌:QPX疾病管理的证据和意义

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-26 DOI: 10.3390/jof8111128

Sabrina Geraci-Yee, Jackie L Collier, Bassem Allam

{"title":"Mucochytrium quahogii (=QPX) Is a Commensal, Opportunistic Pathogen of the Hard Clam (Mercenaria mercenaria): Evidence and Implications for QPX Disease Management.","authors":"Sabrina Geraci-Yee, Jackie L Collier, Bassem Allam","doi":"10.3390/jof8111128","DOIUrl":"https://doi.org/10.3390/jof8111128","url":null,"abstract":"Mucochytrium quahogii, commonly known as QPX (Quahog Parasite Unknown), is the causative agent of QPX disease in hard clams (Mercenaria mercenaria), but poor understanding of the relationship between host and pathogen has hindered effective management. To address this gap in knowledge, we conducted a two-year study quantifying the distribution and abundance of M. quahogii in hard clam tissue, pallial fluid, and the environment. M. quahogii was broadly distributed in clams and the environment, in areas with and without a known history of QPX disease. M. quahogii in clams was not strongly related to M. quahogii in the environment. M. quahogii was always present in either the tissue or pallial fluid of each clam, with an inverse relationship between the abundance in the two anatomical locations. This study suggests that the sediment-water interface and clam pallial fluid are environmental reservoirs of M. quahogii and that there is a host-specific relationship between M. quahogii and the hard clam, supporting its classification as a commensal, opportunistic pathogen. There appears to be minimal risk of spreading QPX disease to naïve clam populations because M. quahogii is already present and does not appear to be causing disease in hard clam populations in locations unfavorable for pathogenesis.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waterless Dyeing and In Vitro Toxicological Properties of Biocolorants from Cortinarius sanguineus. 血海棠生物着色剂的无水染色及体外毒理学特性研究。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-26 DOI: 10.3390/jof8111129

Mikko Herrala, Johanna Yli-Öyrä, Anjaína Fernandes de Albuquerque, Natália Oliveira de Farias, Daniel Alexandre Morales, Riikka Räisänen, Harold S Freeman, Gisela Aragão Umbuzeiro, Jaana Rysä

{"title":"Waterless Dyeing and In Vitro Toxicological Properties of Biocolorants from Cortinarius sanguineus.","authors":"Mikko Herrala, Johanna Yli-Öyrä, Anjaína Fernandes de Albuquerque, Natália Oliveira de Farias, Daniel Alexandre Morales, Riikka Räisänen, Harold S Freeman, Gisela Aragão Umbuzeiro, Jaana Rysä","doi":"10.3390/jof8111129","DOIUrl":"https://doi.org/10.3390/jof8111129","url":null,"abstract":"As a part of an ongoing interest in identifying environmentally friendly alternatives to synthetic dyes and in using liquid CO2 as a waterless medium for applying the resulting colorants to textiles, our attention turned to yellow-to-red biocolorants produced by Cortinarius sanguineus fungus. The three principal target anthraquinone colorants (emodin, dermocybin, and dermorubin) were isolated from the fungal bodies using a liquid-liquid separation method and characterized using 700 MHz NMR and high-resolution mass spectral analyses. Following structure confirmations, the three colorants were examined for dyeing synthetic polyester (PET) textile fibers in supercritical CO2. We found that all three biocolorants were suitable for dyeing PET fibers using this technology, and our attention then turned to determining their toxicological properties. As emodin has shown mutagenic potential in previous studies, we concentrated our present toxicity studies on dermocybin and dermorubin. Both colorants were non-mutagenic, presented low cellular toxicity, and did not induce skin sensitization. Taken together, our results indicate that dermocybin and dermorubin possess the technical and toxicological properties needed for consideration as synthetic dye alternatives under conditions that are free of wastewater production.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Candida auris: A Mini Review on Epidemiology in Healthcare Facilities in Asia. 耳念珠菌:亚洲卫生保健机构流行病学综述。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-26 DOI: 10.3390/jof8111126

Nishanthinie Thatchanamoorthy, Velayuthan Rukumani Devi, Samudi Chandramathi, Sun Tee Tay

{"title":"Candida auris: A Mini Review on Epidemiology in Healthcare Facilities in Asia.","authors":"Nishanthinie Thatchanamoorthy, Velayuthan Rukumani Devi, Samudi Chandramathi, Sun Tee Tay","doi":"10.3390/jof8111126","DOIUrl":"https://doi.org/10.3390/jof8111126","url":null,"abstract":"Candida auris, a newly emerging healthcare-associated yeast pathogen from the Metschnikowiaceae family, was first described in the ear canal of an elderly Japanese patient in 2009. The yeast is one of the causative agents of candidemia, which has been linked with nosocomial outbreaks and high mortality rates in healthcare facilities worldwide. Since its first isolation, the occurrence of C. auris in six continents has becomes a grave concern for the healthcare professionals and scientific community. Recent reports showed the identification of five geographically distinct clades and high rates of antifungal resistance associated with C. auris. Till date, there are no effective treatment options, and standardized measures for prevention and control of C. auris infection in healthcare facilities. This leads to frequent therapeutic failures and complicates the eradication of C. auris infection in healthcare facilities. Thus, this review focuses on the recent understanding of the epidemiology, risk factors, diagnosis, transmission and prevention and control strategies of C. auris infection in healthcare facilities in Asia.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13