Eye and vision (London, England)最新文献

{"title":"Clinical outcomes with a new design in multifocal intraocular lens: a pilot study.","authors":"Jorge L Alió,&nbsp;Pilar Yébana,&nbsp;Mario Cantó,&nbsp;Ana B Plaza,&nbsp;Alfredo Vega,&nbsp;Jorge L Alió Del Barrio,&nbsp;Francisco Lugo","doi":"10.1186/s40662-020-00205-3","DOIUrl":"https://doi.org/10.1186/s40662-020-00205-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical and visual outcomes, quality of near vision and the influence of photic phenomena in patients bilaterally implanted with a new Precizon Presbyopic multifocal intraocular lens (IOL).</p><p><strong>Methods: </strong>In this prospective consecutive case series, 20 eyes of 10 patients were included (mean age 63.80 ± 12.55 years). Uncorrected and corrected visual acuity (far, intermediate and near), subjective refraction, binocular defocus curve, contrast sensitivity (CSV-1000) and quality of vision and satisfaction questionnaires were measured. The follow-up was 12 months after surgery.</p><p><strong>Results: </strong>At 12 months after surgery, uncorrected distance visual acuity (UDVA) improved with surgery (<i>p</i> = 0.001) with a value of 0.08 ± 0.08 logMAR. Uncorrected near visual acuity (UNVA) was 0.22 ± 0.12 logMAR and distance corrected near visual acuity (DCNVA) was 0.16 ± 0.13 logMAR. Intermediate distance visual acuity (UIVA) was 0.22 ± 0.10 logMAR. Contrast sensitivity outcomes were similar to normal population in photopic conditions and slightly reduced in mesopic conditions of lighting. Defocus curve showed that this multifocal IOL was able to provide a visual acuity (VA) equal or better to 0.16 logMAR between defocus levels of + 1.00 to - 2.50 D. Good patient satisfaction was obtained in quality of vision and satisfaction questionnaires outcomes.</p><p><strong>Conclusions: </strong>The Precizon Presbyopic NVA IOL (OPHTEC BV) provides good visual outcomes. This multifocal IOL provides a high percentage of spectacle independence due to good VA at far, intermediate and near distances and satisfactory contrast sensitivity. High patient satisfaction was observed in quality of vision and satisfaction questionnaires with a low percentage of patients manifesting photic phenomena.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"38"},"PeriodicalIF":4.2,"publicationDate":"2020-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00205-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38177737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratolenticular adhesion removal for type 2 Peters anomaly: a case report.","authors":"Zhangliang Li,&nbsp;Rui Zou,&nbsp;Yune Zhao","doi":"10.1186/s40662-020-00203-5","DOIUrl":"https://doi.org/10.1186/s40662-020-00203-5","url":null,"abstract":"<p><strong>Background: </strong>Type 2 Peters anomaly is a rare anterior segment disorder characterized by central corneal leukoma with keratolenticular adhesion and cataract. Performing cataract surgery without corneal tissue transplantation in patients of type 2 Peters anomaly is extremely rare and challenging. We present a case of type 2 Peters anomaly treated by peeling off the adhesion without penetrating keratoplasty (PKP), in which restoration of corneal transparency is observed.</p><p><strong>Case presentation: </strong>An 11-month-old female infant of type 2 Peters anomaly presented with bilateral corneal opacity with distinct demarcation, keratolenticular adhesion and cataract, which was first noted at the age of 3 months. By peeling off the adhesion from corneal endothelium combined with lensectomy and vitrectomy, there was a gradual reduction in corneal opacity and improvement in visual acuity after surgery over a 2-year period. Her visual acuity had improved from light perception preoperatively to 20/50 at the latest follow-up. No sight-threatening postoperative complications were noted.</p><p><strong>Conclusion: </strong>It is safe and effective to peel off the keratolenticular adhesion in patients of type 2 Peters anomaly presented with distinctly demarcated corneal opacity.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"39"},"PeriodicalIF":4.2,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00203-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38163237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutual comparative analysis: a new topography-guided custom ablation protocol referencing subjective refraction to modify corneal topographic data.","authors":"Kaiwei Cao,&nbsp;Lina Liu,&nbsp;Tao Zhang,&nbsp;Ting Liu,&nbsp;Ji Bai","doi":"10.1186/s40662-020-00201-7","DOIUrl":"https://doi.org/10.1186/s40662-020-00201-7","url":null,"abstract":"<p><strong>Background: </strong>Several planning algorithms have been developed for topography-guided custom ablation treatment (T-CAT), but each has its own deficiencies. The purpose of this study is to demonstrate the potential of a novel mutual comparative analysis (MCA) informed by manifest refraction and corneal topographic data and the patient's subjective perception in correcting ametropia.</p><p><strong>Methods: </strong>This retrospective review included patients with significant preoperative differences in the power or axis of astigmatism according to the manifest refraction and corneal topographic data (power > 0.75 D and/or axis > 10°). T-CAT planning was designed using MCA. Follow-ups were conducted for at least 6 months.</p><p><strong>Results: </strong>Seventy-nine patients (121 eyes) were included. The mean preoperative deviation in the astigmatic power and axis were 0.72 ± 0.43 D and 20.18 ± 23.68°, respectively. The average oculus residual astigmatism (ORA) was 0.81 ± 0.32 D (range: 0.08-1.66 D). Six months postoperatively, the mean spherical equivalent refraction was 0.04 ± 0.42 D, and the mean cylinder was - 0.27 ± 0.24 D. The mean efficacy and safety indices were 1.10 and 1.15, respectively. The uncorrected distance visual acuity in 92% of the eyes was the same or better than the corrected distance visual acuity. The angle of error was ±5° in 61% of eyes and ± 15° in 84% of eyes. Residual astigmatism was ≤0.5 D in 91% of eyes. Optical quality and photopic contrast sensitivity did not change significantly (<i>p</i> > 0.05), and the scotopic contrast sensitivity decreased at 3, 6, and 12 cpd (<i>p</i> < 0.05). The vertical coma and horizontal coma of the anterior corneal surface significantly decreased postoperatively but increased during follow-up.</p><p><strong>Conclusions: </strong>The MCA demonstrated safety, efficacy, accuracy, predictability, and stability and can be used as a complementary and feasible method for T-CAT.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"36"},"PeriodicalIF":4.2,"publicationDate":"2020-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00201-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38145888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and visual outcomes following posterior chamber phakic intraocular lens bilensectomy.","authors":"Veronica Vargas,&nbsp;Jorge L Alió,&nbsp;Rafael I Barraquer,&nbsp;Justin Christopher D' Antin,&nbsp;Cristina García,&nbsp;Francisco Duch,&nbsp;Joan Balgos,&nbsp;Jorge L Alió Del Barrio","doi":"10.1186/s40662-020-00200-8","DOIUrl":"https://doi.org/10.1186/s40662-020-00200-8","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the safety, efficacy, refractive outcomes and causes for bilensectomy (phakic intraocular lens - pIOL - explantation with cataract surgery and pseudophakic intraocular lens implantation) in patients previously implanted with posterior chamber pIOLs.</p><p><strong>Methods: </strong>This multi-center retrospective study included 87 eyes of 55 patients who underwent bilensectomy for posterior chamber pIOL with a follow up time of 12 months. The uncorrected and best corrected distance visual acuities (UDVA, CDVA), endothelial cell density before and after bilensectomy were assessed, as well as the cause of bilensectomy and intra or postoperative complications.</p><p><strong>Results: </strong>There was a statistically significant improvement in uncorrected and best corrected visual acuities after bilensectomy (<i>p</i> = 0.00). The main reason for bilensectomy was cataract development (93.1% of the cases), followed by miscalculation of lens size, and corneal edema. The endothelial cell count remained stable without a statistically significant change after surgery (<i>p</i> = 0.67). The refractive efficacy index was 0.8, none of the patients lost lines of CDVA after surgery, 73% of the patients were within ±1 D (spherical equivalent) of the target refraction. Intraoperative complications were one posterior capsule rupture with the intraocular lens (IOL) implanted in the sulcus, and 3 eyes required the use of pupil expanders for adequate pupil dilation. Postoperatively, one eye developed retinal detachment. The three pIOLs models explanted were the Implantable Collamer Lens (ICL), Implantable Phakic Contact Lens (IPCL) and the Phakic Refractive Lens (PRL).</p><p><strong>Conclusions: </strong>Good safety and visual outcomes were observed 1 year after bilensectomy for posterior chamber phakic intraocular lenses (PC pIOLs). There were few intra and postoperative complications and there was no significant endothelial cell loss after the bilensectomy procedure.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"34"},"PeriodicalIF":4.2,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00200-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38122455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-year efficacy of all surface laser ablation with cross-linking (ASLA-XTRA) for the treatment of myopia.","authors":"Ioannis M Aslanides,&nbsp;Farhad Hafezi,&nbsp;Shihao Chen,&nbsp;Hatch Mukherjee,&nbsp;Vasileios Selimis,&nbsp;Ilias Maragkos,&nbsp;Nanji Lu,&nbsp;George Kymionis","doi":"10.1186/s40662-020-00198-z","DOIUrl":"https://doi.org/10.1186/s40662-020-00198-z","url":null,"abstract":"<p><strong>Background: </strong>The purpose of our study is to examine the long (5-year) efficacy of the all surface laser ablation (ASLA) combined with accelerated cross-linking (CXL) for the treatment of myopia without the use of mitomycin-C (MMC).</p><p><strong>Methods: </strong>This retrospective study consisted of 202 eyes of 118 myopic (SD: 2.41, range: - 1.50 to - 12.75 D) patients (44 males, 74 females). Mean age was 28.50 years (SD: 6.45, range: 18 to 51 years) that underwent ASLA with accelerated CXL for the treatment of their myopia.</p><p><strong>Results: </strong>The patients underwent routine postoperative assessment on the 1st, 3rd, 7th day and in the 1st, 3rd, 6th and 12th month, 30th month (±6 months), 4th and 5th year. The mean spherical equivalent (SEq) refractive error changed from - 6.41 ± 2.41 D preoperatively to - 0.02 ± 0.53 D at 5 years postoperatively. The haze score was 0.18, 0.25 and 0.28 at 1, 3 and 6 months postoperatively. At 12 months after the treatment, no eyes had significant corneal haze and in all the following postoperative time intervals the haze traces were gone.</p><p><strong>Conclusion: </strong>ASLA combined with accelerated CXL (ASLA-XTRA) appears to be safe, efficacious and offering very good refractive results. The potential additional benefits of this modality are the stabilizing effect of the refraction and its sterilization effect on the treated cornea without the potential side effects of MMC.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"31"},"PeriodicalIF":4.2,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00198-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38047689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging.","authors":"Yune Zhao,&nbsp;Ding Chen,&nbsp;Giacomo Savini,&nbsp;Qing Wang,&nbsp;Hongfang Zhang,&nbsp;Yili Jin,&nbsp;Benhao Song,&nbsp;Rui Ning,&nbsp;Jinhai Huang,&nbsp;Chenyang Mei","doi":"10.1186/s40662-020-00197-0","DOIUrl":"https://doi.org/10.1186/s40662-020-00197-0","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the repeatability and reproducibility of swept-source optical coherence tomography (SS-OCT) and Scheimpflug system and evaluate the agreement between the two systems in measuring multiple corneal regions in children.</p><p><strong>Methods: </strong>Pachymetric and keratometric maps for both systems were evaluated. Central, midperipheral and peripheral corneal thickness (CT), keratometry and astigmatism power vectors were recorded. The three outcomes yielded by the same observer were used to assess intraobserver repeatability. The differences in the mean values provided by each observer were used to evaluate interobserver reproducibility. Within-subject standard deviation, test-retest repeatability (TRT) and coefficient of variation (CoV) were used to analyze the intraobserver repeatability and interobserver reproducibility. Paired T-test and Bland-Altman were used to appraise interdevice agreement.</p><p><strong>Results: </strong>Seventy-eight eyes of 78 children were included. The CoV was ≤2.12 and 1.10%, respectively, for repeatability and reproducibility. TRT and CoV were lower for central and paracentral CT measurements than for peripheral measurements. The SS-OCT device generated higher precision when acquiring CT data, whereas Scheimpflug system showed higher reliability when measuring corneal keratometry. Although the CT readings measured using SS-OCT were significantly thinner than Scheimpflug device (<i>P</i> <  0.001), the central and thinnest CT values were still of high agreement. The interdevice agreement of keratometry measurement was high for the central corneal region and moderate for the paracentral and peripheral areas.</p><p><strong>Conclusions: </strong>The precision of CT measurements by SS-OCT was higher, while the reliability of keratometry measurements by the Scheimpflug system was higher in children. Apart from the measured values in the central corneal region, the thickness and keratometry readings should not be considered interchangeable between the two systems.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"32"},"PeriodicalIF":4.2,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00197-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38040322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling of gonioscopic anterior chamber angle grades based on anterior segment optical coherence tomography.","authors":"Yingying Dai,&nbsp;Shaodan Zhang,&nbsp;Meixiao Shen,&nbsp;Yuheng Zhou,&nbsp;Mengyi Wang,&nbsp;Jie Ye,&nbsp;Dexi Zhu","doi":"10.1186/s40662-020-00196-1","DOIUrl":"https://doi.org/10.1186/s40662-020-00196-1","url":null,"abstract":"<p><strong>Background: </strong>To quantitatively assess anterior chamber angle (ACA) structure by anterior segment optical coherence tomography (AS-OCT) and develop a model to evaluate angle width as defined by gonioscopy.</p><p><strong>Methods: </strong>The ACAs of each quadrant were evaluated by gonioscopy, classified by the Scheie grading system, and assigned into one of the three grades: small angle (SA), moderate angle (MA), and large angle (LA). The eyes were imaged by AS-OCT, and ACA structural parameters including angle opening distance at the scleral spur (AODSS) and at 750 μm anterior to the scleral spur (AOD750), trabecular-iris space area at 750 μm anterior to the scleral spur (TISA750), and a newly defined parameter \"light intersection distance\" (LID), were measured. The ACA structural data were used to construct an ordered logistic regression model for assignment of ACAs to one of the three angle grades. The validity of the model was then tested.</p><p><strong>Results: </strong>A total of 169 quadrants from 53 subjects were included in the analysis, of which 111 quadrants were included in the modeling data and 58 in the testing data. In pairwise comparisons of SA, MA, and LA by ANOVA, the measured parameters were as follows: AOD750 (0.174 ± 0.060 vs. 0.249 ± 0.068 vs. 0.376 ± 0.114 mm; <i>P</i> < 0.001), TISA750 (0.075 ± 0.035 vs. 0.117 ± 0.036 vs. 0.181 ± 0.062 mm²; <i>P</i> < 0.001), and LID (- 0.300 ± 0.187 vs. -0.085 ± 0.170 vs. 0.122 ± 0.156 mm; <i>P</i> < 0.001). The ACA grading model based on LID showed a relatively high correction rate of 72.4%, and the model efficiency, calculated using the receiver operating characteristic, showed an area under the curve of 0.740. Weighted kappa statistics showed a good agreement for multiple ACA grades (0.772).</p><p><strong>Conclusions: </strong>The AS-OCT-based multiple ACA grades model was demonstrated as a non-contact approach for ACA assessment with high speed and high spatial resolution, providing guidance for diagnosis of angle closure.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"30"},"PeriodicalIF":4.2,"publicationDate":"2020-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00196-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38027573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography.","authors":"Osama A Sorour,&nbsp;Nihaal Mehta,&nbsp;Caroline R Baumal,&nbsp;Akihiro Ishibazawa,&nbsp;Keke Liu,&nbsp;Eleni K Konstantinou,&nbsp;Sarah Martin,&nbsp;Phillip Braun,&nbsp;A Yasin Alibhai,&nbsp;Malvika Arya,&nbsp;Andre J Witkin,&nbsp;Jay S Duker,&nbsp;Nadia K Waheed","doi":"10.1186/s40662-020-00195-2","DOIUrl":"https://doi.org/10.1186/s40662-020-00195-2","url":null,"abstract":"<p><strong>Background: </strong>To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes.</p><p><strong>Methods: </strong>In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-naïve diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and compared to diabetic control eyes with similar diabetic retinopathy (DR) severity that did not receive anti-VEGF therapy. The morphological characteristics of IRMAs on enface OCTA imaging were graded by masked readers at baseline, then after anti-VEGF therapy in treated eyes or after observation in control eyes. Characterization of interval changes in an IRMA were based on the following parameters: branching, vessel caliber and area of adjacent capillary non-perfusion.</p><p><strong>Results: </strong>The treated group included 45 IRMA foci from 15 eyes of 11 patients, while the control group included 27 IRMA foci from 15 eyes of 14 patients. Following anti-VEGF treatment, enface OCTA demonstrated that 14 foci of IRMA (31%) demonstrated regression with normalization of appearance of the capillary bed, 20 IRMAs (44%) remained unchanged, six IRMAs (13%) progressed with enlargement or development of new IRMAs and five IRMAs (11%) demonstrated complete obliteration defined as IRMA disappearance with advancing capillary drop-out. In the control group, 17 IRMA (63%) remained stable, 8 IRMAs (29.6%) progressed and 2 experienced total obliteration (7.4%). The difference in rank order between the two groups was statistically significant (<i>p</i> = 0.022).</p><p><strong>Conclusions: </strong>In eyes with DR status post anti-VEGF therapy, foci of IRMAs have a variable course demonstrating one of four possible outcomes: regression, stability, progression or complete obliteration. In contrast, none of the untreated control diabetic eyes demonstrated regression of IRMAs, consistent with known progression of DR severity in high risk eyes. Morphologic evaluation of IRMAs with OCTA may help to monitor changes in retinal blood flow as well as the response to anti-VEGF treatment.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"29"},"PeriodicalIF":4.2,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00195-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38023413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iStent inject trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma: early clinical experience.","authors":"Tanner J Ferguson,&nbsp;Zachary Dockter,&nbsp;Adam Bleeker,&nbsp;Kayla L Karpuk,&nbsp;Justin Schweitzer,&nbsp;Mitch J Ibach,&nbsp;John P Berdahl","doi":"10.1186/s40662-020-00194-3","DOIUrl":"https://doi.org/10.1186/s40662-020-00194-3","url":null,"abstract":"<p><strong>Background: </strong>Retrospective, consecutive case series to evaluate the implantation of two second-generation trabecular microbypass stents in combination with cataract surgery in a real-world, clinical setting.</p><p><strong>Methods: </strong>The series included 56 eyes implanted with the iStent inject device with phacoemulsification. The series consisted of eyes with primary open-angle glaucoma (<i>n</i> = 52) and pseudoexfoliative glaucoma (<i>n</i> = 4). Primary outcome measures included intraocular pressure (IOP) and number of glaucoma medications. Safety outcomes included the need for secondary surgical intervention and the incidence of IOP spikes ≥10 mmHg and ≥ 15 mmHg.</p><p><strong>Results: </strong>IOP was reduced by 21% to 14.7 ± 2.9 mmHg (<i>p</i> < 0.01) at 6 months postoperative from 18.7 ± 5.8 mmHg at baseline. Preoperatively, the mean number of glaucoma medications was 1.5 ± 0.9 and reduced by 39% to 0.9 ± 1.2 (<i>p</i> < 0.01) at 6 months. At 6 months, 68% of eyes had an IOP ≤15 mmHg, increased from 30% at baseline. 55% of eyes were medication-free at 6 months, up from 18% at baseline. There were no severe postoperative complications. No eyes underwent an additional glaucoma procedure.</p><p><strong>Conclusions: </strong>Implantation of the iStent inject device with concomitant cataract surgery effectively provides a sustained reduction in IOP with a markedly improved medication burden out to 6 months postoperative. The safety profile is excellent.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"28"},"PeriodicalIF":4.2,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00194-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38006645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal transplantation outcomes after the extrusion of an intrastromal keratoprosthesis: a pilot study.","authors":"Chiara Fariselli,&nbsp;Ibrahim Toprak,&nbsp;Olena Al-Shymali,&nbsp;Jorge L Alio Del Barrio,&nbsp;Jorge L Alio","doi":"10.1186/s40662-020-00193-4","DOIUrl":"https://doi.org/10.1186/s40662-020-00193-4","url":null,"abstract":"<p><p>This short report includes 5 eyes of 5 patients (mean age 63.2 ± 12 years) who underwent a tectonic keratoplasty [deep anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK)] in order to rehabilitate the eye after the extrusion of the non-perforating keratoprosthesis (Kpro) KeraKlear (KeraMed, USA). The non-perforating Kpro was extruded after a mean period of 21.4 ± 21.8 months due to melting. In two cases, the keratoplasty was performed the same day of the non-perforating Kpro removal due to a severe melting, while in the other three cases it was performed one to 3 months later. Two eyes received a DALK, but in 3 eyes a macroscopic Descemet membrane perforation forced the conversion into a PK. The mean follow-up period after the keratoplasty was 16.8 ± 6.6 months. No cases of rejection were recorded. All the 5 eyes achieved \"anatomical success\" (transparent graft, with no signs of infection or inflammation). Two eyes showed limited \"functional success\" because the achievement of the best visual potential was prevented by the development of glaucomatous optic atrophy during the follow-up period. In conclusion, this short report presents an unexpected success of a keratoplasty performed with a tectonic purpose after the extrusion of the non-perforating Kpro because the corneal graft remained transparent, without neovascularization or scarring during the follow-up period. This initial evidence shows some encouraging results regarding graft survival rate and the achievement of a useful visual rehabilitation with keratoplasty after a non-perforating Kpro failure instead of repeating the Kpro implantation.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"26"},"PeriodicalIF":4.2,"publicationDate":"2020-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-020-00193-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}